Conditions | Yield |
---|---|
durch fraktionierte Krystallisation des d-weinsaeuren Salzes; das Salz des d-Histidins krystallisiert zuerst aus; |
Conditions | Yield |
---|---|
durch gaerende Hefe; | |
Verfuettern an Kaninchen wird im Harn ausgeschieden; |
Conditions | Yield |
---|---|
With hydrogenchloride; water at 150 - 160℃; Trennung des erhaltenen Racemats ueber das Lg-Tartrat; |
Conditions | Yield |
---|---|
durch Einw. von gaerender Hefe; |
Nα-acetyl-D-histidine
D-histidin
Conditions | Yield |
---|---|
With hydrogenchloride; water |
D-histidin
Conditions | Yield |
---|---|
With water Produkt ist Hydrochlorid; | |
With L-amino acid oxide ase from the toxin of crotalus adamanteus |
D-histidin
Conditions | Yield |
---|---|
With water fraktionierte Krystallisation; |
N-acetylhistidine
D-histidin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: enzymesubstance from pig's kidney 2: water; HCl View Scheme |
iso-butanol
D-histidin
Conditions | Yield |
---|---|
With CO In tetrahydrofuran; hydrogenchloride |
Conditions | Yield |
---|---|
With CO; (PPh3)2PdCl2 In tetrahydrofuran; hydrogenchloride |
R-(-)-Histidinmethylester
D-histidin
Conditions | Yield |
---|---|
With Streptomyces spp. 83D12 D-aminopeptidase In dimethyl sulfoxide at 20℃; for 0.0833333h; pH=6.5; aq. buffer; Enzymatic reaction; |
Conditions | Yield |
---|---|
With hydrogenchloride In water at 170℃; for 0.333333h; Microwave irradiation; |
Conditions | Yield |
---|---|
In ethanol; water for 48h; Reflux; | 95% |
D-histidin
Conditions | Yield |
---|---|
With formaldehyd; palladium dihydroxide In water; hydrogen | 94.5% |
Conditions | Yield |
---|---|
In methanol for 48h; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
Stage #1: D-histidin With hydrogenchloride; sodium nitrite Stage #2: methanol With hydrogenchloride Fischer esterification; Reflux; | 90% |
Conditions | Yield |
---|---|
With triethylamine In ethanol at 60℃; | 71% |
Conditions | Yield |
---|---|
Stage #1: D-histidin With potassium hydroxide In tetrahydrofuran at 0℃; Stage #2: 1,3,5-benzene tris(carbonyl chloride) With potassium hydroxide In tetrahydrofuran at 0 - 20℃; | 67% |
Conditions | Yield |
---|---|
With triethylamine In ethanol at 60℃; | 64% |
Conditions | Yield |
---|---|
Stage #1: 2-Picolinic acid; nickel(II) chloride hexahydrate In methanol; water Stage #2: D-histidin With potassium hydroxide In methanol; water at 20℃; for 2h; | 63% |
Conditions | Yield |
---|---|
Stage #1: D-histidin; 3-formyl-9-hexylcarbazole With lithium hydroxide monohydrate In methanol at 80℃; for 12h; Stage #2: With sodium tetrahydroborate In methanol at 20℃; | 62% |
Conditions | Yield |
---|---|
Stage #1: 2-Picolinic acid; copper(II) choride dihydrate In methanol; water Stage #2: D-histidin With potassium hydroxide In methanol; water at 20℃; for 2h; | 61% |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 25℃; for 0.666667h; Pictet-Spengler Synthesis; | 49.8% |
Conditions | Yield |
---|---|
With perchloric acid In water at 20℃; | 48.4% |
Conditions | Yield |
---|---|
for 72h; pH=3 - 4; Darkness; | 44% |
Conditions | Yield |
---|---|
With acetic acid |
D-histidin
(R)-2-hydroxy-3-(1(3)H-imidazol-4-yl)-propionic acid
Conditions | Yield |
---|---|
With hydrogenchloride; silver nitrate |
D-histidin
R-(+)-4-(2-Amino-3-hydroxypropyl)-imidazol
Conditions | Yield |
---|---|
/BRN= 81955/; |
bufotalin 3-hemisuberate p-nitrophenyl ester
D-histidin
bufotalin 3-suberoyl-D-histidine ester
Conditions | Yield |
---|---|
In pyridine; water for 12h; Ambient temperature; | 8 mg |
The D-Histidine, with its cas register number 351-50-8, has the IUPAC name of (2R)-2-amino-3-(1H-imidazol-5-yl)propanoic acid. And it also has other names as h-d-his-oh; histidine, d-; d-alpha-amino-beta-imidazolepropionic acid; d-alpha-amino-beta-(4-imidazolyl)propionic acid; d-2-amino-3-(4-imidazolyl)propionic acid; d-his-oh; d-histidine; d-his.
The physical characteristics of this chemical could be summarized as: (1)ACD/LogP: -1.27; (2)ACD/LogD (pH 5.5): -4.54; (3)ACD/LogD (pH 7.4): -3.82; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 47.36; (12)Index of Refraction: 1.614; (13)Molar Refractivity: 38.01 cm3; (14)Molar Volume: 108.9 cm3; (15)Polarizability: 15.07 ×10-24 cm3; (16)Surface Tension: 79.6 dyne/cm; (17)Density: 1.423 g/cm3; (18)Flash Point: 231.3 °C; (19)Enthalpy of Vaporization: 75.79 kJ/mol; (20)Boiling Point: 458.9 °C at 760 mmHg; (21)Vapour Pressure: 3.25E-09 mmHg at 25°C.
This is a kind of white crystalline powder, and its water Solubility is 42 g/L (25 ºC). Being a kind of harmful chemical, it may cause damage to health. And it is harmful by swallowed and is very toxic by inhalation, in contact with skin or if swallowed. Besides, it is irritating to eyes and respiratory system. You could also go to WGK Germany 3 to obtain more safety information. When store it, it should be kept in room temperature.
D-Histidine is commonly used as intermediates of fine chemicals and pharmaceutical. As to its product categories, there are various, including amino acid derivatives; histidine [his, h]; amino acids and derivatives; alpha-amino acids; amino acids; biochemistry; amino acids.
In addition, you could refer to the following information to obtain the molecular structure:
SMILES:O=C(O)[C@H](N)Cc1cncn1
InChI:InChI=1/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m1/s1
InChIKey:HNDVDQJCIGZPNO-RXMQYKEDBE
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