Product Name: Desacetylcolchicine d-tartrate (CAS NO.49720-72-1)
Molecular Formula: C24H29NO11
Molecular Weight: 507.4872g/mol
Mol File: 49720-72-1.mol
Boiling point: 626.6 °C at 760 mmHg
Flash Point: 287 °C
Enthalpy of Vaporization: 92.74 kJ/mol
Vapour Pressure: 1.29E-15 mmHg at 25°C
H-Bond Donor: 5
H-Bond Acceptor: 12
Rotatable Bond Count: 7
Topological Polar Surface Area: 195
Heavy Atom Count: 36
Complexity: 772
Defined Atom StereoCenter Count: 3
Covalently-Bonded Unit Count: 2
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | parenteral | 9500ug/kg (9.5mg/kg) | Progress in Medical Chemistry. Vol. 9, Pg. 1, 1973. | |
human | TDLo | oral | 200ug/kg/7D-I (0.2mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA | Cancer Chemotherapy Reports, Part 1. Vol. 56, Pg. 263, 1972. |
mouse | LD50 | intraperitoneal | 70520ug/kg (70.52mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
mouse | LD50 | parenteral | 8mg/kg (8mg/kg) | Progress in Medical Chemistry. Vol. 9, Pg. 1, 1973. | |
rat | LD50 | parenteral | 3mg/kg (3mg/kg) | Progress in Medical Chemistry. Vol. 9, Pg. 1, 1973. |
Poison by parenteral and intraperitoneal routes. Human systemic effects by ingestion: nausea or vomiting, leukopenia and thrombocytopenia. When heated to decomposition it emits toxic fumes of NOx.
Desacetylcolchicine d-tartrate ,its CAS NO. is 49720-72-1,the synonyms is Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (S)-, tartrate (1:1) ; Colchicine, deacetyl-, L-tartrate ; Colchicinic acid, O,O',O'',O'''-tetramethyl-, tartrate (6CI) ; TMCA methyl ester d-tartrate, hydrate ; Trimethylcolchicinic acid, methyl ether, L-tartrate .
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