Product Name

Synthetic route

3',4'-dideoxy-3',4'-didehydro kanamycin B
63770-47-8

3',4'-dideoxy-3',4'-didehydro kanamycin B

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In water98%
With platinum(IV) oxide; hydrogen; acetic acid In water at 20℃; for 24h; Temperature;96%
penta-N-acetyldibekacin
108050-24-4

penta-N-acetyldibekacin

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
With hydrazine hydrate at 100℃; for 72h;70%
O-3-acetamido-2,4,6-tri-O-benzyl-3-deoxy-α-D-glucopyranosyl-(1->6)-1,3,2',6'-tetrakis-N-benzyloxycarbonylgentamine C1a
79384-36-4

O-3-acetamido-2,4,6-tri-O-benzyl-3-deoxy-α-D-glucopyranosyl-(1->6)-1,3,2',6'-tetrakis-N-benzyloxycarbonylgentamine C1a

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
With ammonia; sodium In tetrahydrofuran at -80℃; for 0.75h;1%
N-[(2S,5R,6R)-5-Amino-6-((3aS,4R,5S,7R,7aS)-5,7-diamino-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-4-yloxy)-tetrahydro-pyran-2-ylmethyl]-acetamide

N-[(2S,5R,6R)-5-Amino-6-((3aS,4R,5S,7R,7aS)-5,7-diamino-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-4-yloxy)-tetrahydro-pyran-2-ylmethyl]-acetamide

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: Na2CO3 / H2O; dioxane
2: 80 percent aq. AcOH / 60 °C
3: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
4: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
5: methanol
6: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
7: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
(2R,3S,4S,5R,6R)-4-(2,4-Dinitro-phenylamino)-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3,5-diol

(2R,3S,4S,5R,6R)-4-(2,4-Dinitro-phenylamino)-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3,5-diol

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: BaO, Ba(OH)2*8H2O / dimethylformamide
2: 6 N aq. HCl, AcOH / 90 °C
3: 25 percent HBr / CHCl3 / 5 °C
4: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
5: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
6: methanol
7: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
8: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
{(1R,2S,3R,4R,5S)-4-[(2R,3R,6S)-6-(Acetylamino-methyl)-3-ethoxycarbonylamino-tetrahydro-pyran-2-yloxy]-5-ethoxycarbonylamino-2,3-dihydroxy-cyclohexyl}-carbamic acid ethyl ester
113922-91-1

{(1R,2S,3R,4R,5S)-4-[(2R,3R,6S)-6-(Acetylamino-methyl)-3-ethoxycarbonylamino-tetrahydro-pyran-2-yloxy]-5-ethoxycarbonylamino-2,3-dihydroxy-cyclohexyl}-carbamic acid ethyl ester

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
2: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
3: methanol
4: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
5: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
{(3aS,4R,5S,7R,7aS)-4-[(2R,3R,6S)-6-(Acetylamino-methyl)-3-ethoxycarbonylamino-tetrahydro-pyran-2-yloxy]-7-ethoxycarbonylamino-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-yl}-carbamic acid ethyl ester

{(3aS,4R,5S,7R,7aS)-4-[(2R,3R,6S)-6-(Acetylamino-methyl)-3-ethoxycarbonylamino-tetrahydro-pyran-2-yloxy]-7-ethoxycarbonylamino-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-yl}-carbamic acid ethyl ester

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 80 percent aq. AcOH / 60 °C
2: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
3: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
4: methanol
5: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
6: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
((2R,3S,4S,5R,6R)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-bromo-tetrahydro-pyran-4-yl)-(2,4-dinitro-phenyl)-amine
113886-46-7

((2R,3S,4S,5R,6R)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-bromo-tetrahydro-pyran-4-yl)-(2,4-dinitro-phenyl)-amine

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
2: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
3: methanol
4: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
5: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
(3R,4S,5S,6R)-3,5-Bis-benzyloxy-6-benzyloxymethyl-4-(2,4-dinitro-phenylamino)-tetrahydro-pyran-2-ol
41624-06-0

(3R,4S,5S,6R)-3,5-Bis-benzyloxy-6-benzyloxymethyl-4-(2,4-dinitro-phenylamino)-tetrahydro-pyran-2-ol

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 25 percent HBr / CHCl3 / 5 °C
2: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
3: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
4: methanol
5: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
6: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
((2R,3S,4S,5R,6R)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-4-yl)-(2,4-dinitro-phenyl)-amine

((2R,3S,4S,5R,6R)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-4-yl)-(2,4-dinitro-phenyl)-amine

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 6 N aq. HCl, AcOH / 90 °C
2: 25 percent HBr / CHCl3 / 5 °C
3: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
4: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
5: methanol
6: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
7: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
{(3aS,4R,5S,7R)-4-[(2R,3R,6S)-6-(Acetylamino-methyl)-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy]-6-hydroxy-2,2-dimethyl-7-nitro-hexahydro-benzo[1,3]dioxol-5-yl}-carbamic acid benzyl ester

{(3aS,4R,5S,7R)-4-[(2R,3R,6S)-6-(Acetylamino-methyl)-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy]-6-hydroxy-2,2-dimethyl-7-nitro-hexahydro-benzo[1,3]dioxol-5-yl}-carbamic acid benzyl ester

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: NaOAc
2: 56 percent / NaBH4 / aq. ethanol / 0.5 h / 5 °C
3: H2 / Raney Ni (T-4) / 760 Torr
4: Na2CO3 / H2O; dioxane
5: 80 percent aq. AcOH / 60 °C
6: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
7: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
8: methanol
9: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
10: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
N-{(2S,5R,6R)-5-Amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-tetrahydro-pyran-2-ylmethyl}-acetamide

N-{(2S,5R,6R)-5-Amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-tetrahydro-pyran-2-ylmethyl}-acetamide

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanol
2: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
3: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
Acetic acid (4R,6S,7R,7aS)-7-[(2R,3R,6S)-6-(acetylamino-methyl)-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy]-6-benzyloxycarbonylamino-2,2-dimethyl-4-nitro-hexahydro-benzo[1,3]dioxol-5-yl ester
113886-52-5, 113973-82-3, 113973-83-4, 113974-87-1

Acetic acid (4R,6S,7R,7aS)-7-[(2R,3R,6S)-6-(acetylamino-methyl)-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy]-6-benzyloxycarbonylamino-2,2-dimethyl-4-nitro-hexahydro-benzo[1,3]dioxol-5-yl ester

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 56 percent / NaBH4 / aq. ethanol / 0.5 h / 5 °C
2: H2 / Raney Ni (T-4) / 760 Torr
3: Na2CO3 / H2O; dioxane
4: 80 percent aq. AcOH / 60 °C
5: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
6: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
7: methanol
8: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
9: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
N-[(1R,2S,3S,4R,5S)-5-Acetylamino-4-[(2R,3R,6S)-3-acetylamino-6-(acetylamino-methyl)-tetrahydro-pyran-2-yloxy]-2-((2S,3R,4S,5S,6R)-4-acetylamino-3,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-cyclohexyl]-acetamide

N-[(1R,2S,3S,4R,5S)-5-Acetylamino-4-[(2R,3R,6S)-3-acetylamino-6-(acetylamino-methyl)-tetrahydro-pyran-2-yloxy]-2-((2S,3R,4S,5S,6R)-4-acetylamino-3,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-cyclohexyl]-acetamide

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
2: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
C56H71N7O19
113886-47-8

C56H71N7O19

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
2: methanol
3: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
4: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
[(2R,3R,6S)-6-(Acetylamino-methyl)-2-((1R,2S,4R,6R)-2-benzyloxycarbonylamino-3,5,6-trihydroxy-4-nitro-cyclohexyloxy)-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester
113886-44-5, 113973-81-2, 113973-84-5, 113974-86-0, 113974-88-2

[(2R,3R,6S)-6-(Acetylamino-methyl)-2-((1R,2S,4R,6R)-2-benzyloxycarbonylamino-3,5,6-trihydroxy-4-nitro-cyclohexyloxy)-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: d-10-camphorsulfonic acid / dimethylformamide
2: NaOAc
3: 56 percent / NaBH4 / aq. ethanol / 0.5 h / 5 °C
4: H2 / Raney Ni (T-4) / 760 Torr
5: Na2CO3 / H2O; dioxane
6: 80 percent aq. AcOH / 60 °C
7: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
8: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
9: methanol
10: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
11: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
{(3aS,4R,5S,7R,7aS)-4-[(2R,3R,6S)-6-(Acetylamino-methyl)-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-7-nitro-hexahydro-benzo[1,3]dioxol-5-yl}-carbamic acid benzyl ester
113886-45-6, 113973-80-1

{(3aS,4R,5S,7R,7aS)-4-[(2R,3R,6S)-6-(Acetylamino-methyl)-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-7-nitro-hexahydro-benzo[1,3]dioxol-5-yl}-carbamic acid benzyl ester

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: H2 / Raney Ni (T-4) / 760 Torr
2: Na2CO3 / H2O; dioxane
3: 80 percent aq. AcOH / 60 °C
4: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
5: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
6: methanol
7: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
8: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
methyl-β-kanopyranosaminide
14133-36-9

methyl-β-kanopyranosaminide

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: Na2CO3 / H2O; acetone
2: BaO, Ba(OH)2*8H2O / dimethylformamide
3: 6 N aq. HCl, AcOH / 90 °C
4: 25 percent HBr / CHCl3 / 5 °C
5: 77 percent / AgClO4, sym-collidine / benzene; dioxane / 0.5 h / 24 °C
6: 1.) Dowex 1*2(OH- form); 2.) Ba(OH)2*8H2O / 1.) acetone, H2O; 2.) dioxane, H2O
7: methanol
8: H2 / 5 percent Pd/C / acetic acid / 1900 Torr
9: 70 percent / 80 percent aq. NH2NH2 / 72 h / 100 °C
View Scheme
3-acetamido-2,4,6-tri-O-benzyl-3-deoxy-α-D-glucopyranosyl chloride
22860-43-1

3-acetamido-2,4,6-tri-O-benzyl-3-deoxy-α-D-glucopyranosyl chloride

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 3.7 g / silver toluene-p-sulphonate / benzene; CH2Cl2 / 1.) 40 deg C, 24 h, 2.) 25 deg C, 72 h
2: 1 percent / ammonia, sodium / tetrahydrofuran / 0.75 h / -80 °C
View Scheme
(1S,2R,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(aminomethyl)tetrahydropyran-2-yl]oxy-cyclohexane-1,2-diol
35025-95-7

(1S,2R,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(aminomethyl)tetrahydropyran-2-yl]oxy-cyclohexane-1,2-diol

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 87 percent / aq. sodium hydrogencarbonate / methanol / 25 °C
2: 3.7 g / silver toluene-p-sulphonate / benzene; CH2Cl2 / 1.) 40 deg C, 24 h, 2.) 25 deg C, 72 h
3: 1 percent / ammonia, sodium / tetrahydrofuran / 0.75 h / -80 °C
View Scheme
1,3,2',6'-tetrakis-N-benzyloxycarbonylgentamine C1a
42801-36-5

1,3,2',6'-tetrakis-N-benzyloxycarbonylgentamine C1a

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 3.7 g / silver toluene-p-sulphonate / benzene; CH2Cl2 / 1.) 40 deg C, 24 h, 2.) 25 deg C, 72 h
2: 1 percent / ammonia, sodium / tetrahydrofuran / 0.75 h / -80 °C
View Scheme
1,3,2',6',3''-penta-N-benzylsulfonyl-2''-O-benzylsulfonyl-3',4'-dideoxykanamycin B-3'-ene
84039-25-8

1,3,2',6',3''-penta-N-benzylsulfonyl-2''-O-benzylsulfonyl-3',4'-dideoxykanamycin B-3'-ene

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / sodium, ethanol / liquid ammonia / 0.67 h / -60 - -55 °C
2: 98 percent / hydrogen / platinum oxide / H2O
View Scheme
1,3,2',6',3''-penta-N-benzylsulfonyl-2''-O-benzylsulfonyl-4'',6''-O-cyclohexylidene-3',4'-dideoxykanamycin B-3'-ene
84039-24-7

1,3,2',6',3''-penta-N-benzylsulfonyl-2''-O-benzylsulfonyl-4'',6''-O-cyclohexylidene-3',4'-dideoxykanamycin B-3'-ene

dibecacin
34493-98-6

dibecacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 600 mg / acetic acid / 0.5 h / 90 °C
2: 84 percent / sodium, ethanol / liquid ammonia / 0.67 h / -60 - -55 °C
3: 98 percent / hydrogen / platinum oxide / H2O
View Scheme
dibecacin
34493-98-6

dibecacin

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3',4'-dideoxy-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)kanamycin B
78740-48-4

3',4'-dideoxy-1,3,2',6',3''-pentakis(N-tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
With triethylamine In water at 60℃; for 0.666667h;96%
With triethylamine In 1,4-dioxane at 60℃; for 1.5h;90%
dibecacin
34493-98-6

dibecacin

benzyl chloroformate
501-53-1

benzyl chloroformate

1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-3',4'-dideoxykanamycin B
142859-98-1

1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-3',4'-dideoxykanamycin B

Conditions
ConditionsYield
With sodium carbonate In water; acetone92%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

dibecacin
34493-98-6

dibecacin

1,3,2',6',3”-penta-N-(trimethylsilyl)-2",4”,6”-tri-O-(trimethylsilyl)-3',4'-dideoxy-3',4'-didehydro kanamycin B

1,3,2',6',3”-penta-N-(trimethylsilyl)-2",4”,6”-tri-O-(trimethylsilyl)-3',4'-dideoxy-3',4'-didehydro kanamycin B

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile at 90℃; for 16h; Temperature; Time;73%
dibecacin
34493-98-6

dibecacin

C18H38N5O11P

C18H38N5O11P

Conditions
ConditionsYield
With pyruvate kinase; recombinant Enterococcus faecium aminoglycoside 2''-phosphotransferase type IIa N196D/D268N mutant; potassium chloride; phosphoenolpyruvate trianion; ATP; NADH; magnesium chloride; lactate dehydrogenase pH=7.5; Kinetics; Reagent/catalyst; aq. HEPES buffer; Enzymatic reaction;

DIBEKACIN Chemical Properties

Product Name: Dibekacin (CAS NO.34493-98-6)


Molecular Formula: C18H37N5O8
Molecular Weight: 451.52g/mol
Mol File: 34493-98-6.mol
Einecs: 252-064-6
Appearance: Yellowish powder
Boiling point: 727.7 °C at 760 mmHg
Flash Point: 393.9 °C
Density: 1.46 g/cm3
Surface Tension: 84.5 dyne/cm
Enthalpy of Vaporization: 121.32 kJ/mol
Vapour Pressure: 1.9E-24 mmHg at 25°C
XLogP3-AA: -5.8
H-Bond Donor: 9
H-Bond Acceptor: 13

DIBEKACIN Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 373mg/kg (373mg/kg)   Journal of Pharmacobio-Dynamics. Vol. 4, Pg. 356, 1981.
mouse LD50 intraperitoneal 11960ug/kg (11.96mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 intravenous 8950ug/kg (8.95mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 oral 763mg/kg (763mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 subcutaneous 15980ug/kg (15.98mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 intraperitoneal 16760ug/kg (16.76mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 intravenous 12510ug/kg (12.51mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 oral > 6950mg/kg (6950mg/kg)   Japanese Journal of Antibiotics. Vol. 26, Pg. 221, 1973.
rat LD50 subcutaneous 23870ug/kg (23.87mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.

DIBEKACIN Consensus Reports

EPA Genetic Toxicology Program.

DIBEKACIN Safety Profile

Poison by intraperitoneal, subcutaneous, intramuscular, and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. An antibacterial agent. When heated to decomposition it emits toxic fumes of NOx.

DIBEKACIN Specification

 Dibekacin ,its CAS NO. is 34493-98-6,the synonyms is (2r,3r,4s,5s,6r)-4-Amino-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol ; 6-o-(3-Amino-3-deoxy-α-d-glucopyranosyl)-4-o-(2,6-diamino-2,3,4,6-tetradeoxy-α-d-erythro-hexopyranosyl)-2-deoxy-d-streptamine .

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