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Name
DEXTROPROPOXYPHENE NAPSYLATE HYDRATE
- EINECS
- CAS No. 26570-10-5
- Density g/cm3
- Solubility
- Melting Point
- Formula C10H8O3S•C22H29NO2•H2O
- Boiling Point 444°Cat760mmHg
- Molecular Weight 565.731
- Flash Point 130.6°C
- Transport Information
- Appearance
- Safety Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also d-PROPOXYPHENE HYDROCHLORIDE and SULFONATES.
- Risk Codes
-
Molecular Structure
- Hazard Symbols 3
- Synonyms d-PROPOXYPHENE NAPSYLATE HYDRATE;S-9700;d-4-DIMETHYLAMINO-3-METHYL-1,2-DIPHENYL-2-PROPIONOXYBUTANENAPHTHALENE-2-SULPHONATE HYDRATE;
- PSA 101.52000
- LogP 7.37850
Darvon-N Chemical Properties
IUPAC Name: [(2S,3R)-4-(Dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate; naphthalene-2-sulfonic acid; hydrate
Synonyms of Darvon-N (CAS NO.26570-10-5) : (+)- Propoxyphene napsylate ; 2-Naphthalenesulfonic Acid compound with (aS)-a-((1R)-2-(Dimethylamino)-1-methylethyl)-a-phenylbenzeneethanol Propanoate (1:1) Monohydrate ; Doloxene ; Naphthalene-2-sulfonic acid - (2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propanoate hydrate (1:1:1) ; Propoxyphene Napsylate (anhydrous)
InChI:InChI=1/C22H29NO2.C10H8O3S.H2O/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10;/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13);1H2/t18-,22+;;/m1../s1
CAS NO:26570-10-5
Molecular Formula:C32H39NO6S
Molecular Weight :565.7202
Molecular Structure :.png)
Flash Point: 130.6 °C
Enthalpy of Vaporization: 70.17 kJ/mol
Boiling Point: 444 °C at 760 mmHg
Vapour Pressure: 4.43E-08 mmHg at 25°C
Darvon-N Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | oral | 100mg/kg (100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971. |
| cat | LDLo | subcutaneous | 800mg/kg (800mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971. |
| dog | LDLo | oral | 800mg/kg (800mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971. |
| dog | LDLo | subcutaneous | 1200mg/kg (1200mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971. |
| guinea pig | LDLo | oral | 400mg/kg (400mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971. |
| guinea pig | LDLo | subcutaneous | 800mg/kg (800mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971. |
| mouse | LD50 | intraperitoneal | 171mg/kg (171mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971. | |
| mouse | LD50 | oral | 973mg/kg (973mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 359, 1971. |
| mouse | LD50 | subcutaneous | 749mg/kg (749mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971. |
| rabbit | LDLo | oral | 800mg/kg (800mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2043, 1971. |
| rat | LD50 | intraperitoneal | 56mg/kg (56mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971. |
| rat | LD50 | oral | 485mg/kg (485mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971. |
| rat | LD50 | subcutaneous | 169mg/kg (169mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1011, 1971. |
Darvon-N Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. When Darvon-N (CAS NO.26570-10-5) is heated to decomposition ,it emits toxic fumes of SOx and NOx. See also d-PROPOXYPHENE HYDROCHLORIDE and SULFONATES.
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