Demecolcine supplier | CasNO.477-30-5

Name
DEMECOLCINE
EINECS 207-514-6
CAS No. 477-30-5
Article Data5
CAS DataBase
Density 1.21g/cm³
Solubility
Melting Point 73-75°C
Formula C21H25 N O5
Boiling Point 625.5°Cat760mmHg
Molecular Weight 371.433
Flash Point 332.1°C
Transport Information UN 2811
Appearance
Safety Poison by ingestion, intraperitoneal, parenteral, intravenous, and intramuscular routes. Human systemic effects by ingestion: (skin and appendages) hair effects. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes R25
Molecular Structure
Hazard Symbols
Synonyms Benzo[a]heptalen-9(5H)-one,6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-; Colchamine (6CI,7CI);Colchicine, N-deacetyl-N-methyl- (8CI); Colchicine, N-deacetyl-N-methyl-, (-)-(7CI); (-)-Colchamine; (-)-Demecolcine; Alkaloid H 3, from Colchicum antumnale;C 12669; Ciba 12669A; Colcemid; Colchamin; Deacetyl-N-methylcolchicine;Deacetylmethylcolchicine; Demecolcin; Demecolcine; Desacetylmethylcolchicine;Desmecolcine; Kolchamin; N-Deacetyl-N-methylcolchicine;N-Desacetyl-N-methylcolchicine; N-Methyl-N-deacetylcolchicine;N-Methyl-N-desacetylcolchicine; N-Methyltri-O-methylcolchicinic acid; NSC 3096;Omain; Omaine; Reichstein's F; Santavy's substance F; Substance F
PSA 66.02000
LogP 3.34580

Demecolcine Chemical Properties

Chemistry informtion about N-Methyl-N-Desacetylcolchicine (CAS NO.477-30-5) is:
IUPAC Name: 1,2,3,10-Tetramethoxy-7-(Methylamino)-6,7-Dihydro-5h-Benzo[A]Heptalen-9-One ; (7s)-1,2,3,10-Tetramethoxy-7-(Methylamino)-6,7-Dihydro-5h-Benzo[A]Heptalen-9-One
Synonyms: N-Deacetyl-N-Methylcolchicine ; N-Desacetyl-N-Methylcolchicine ; N-Methyl-N-Deacetyl-Colchicine ; Colcemid ; Colcemide(R) ; Colcemid(R) ; Colchamine ; Demecolcin
Product Categories: All Inhibitors ; Inhibitors
MF: C₂₁H₂₅NO₅
MW: 371.43
EINECS: 207-514-6
Melting Point: 73-75°C
Density: 1.21 g/cm³
Flash Point: 332.1 °C
Boiling Point: 625.5 °C at 760 mmHg
Vapour Pressure: 1.46E-15 mmHg at 25°C
Enthalpy of Vaporization: 92.6 kJ/mol
Storage temp.: 2-8°C
Following is the molecular structure of N-Methyl-N-Desacetylcolchicine (CAS NO.477-30-5) is:

Demecolcine Uses

N-Methyl-N-Desacetylcolchicine (CAS NO.477-30-5) can be used as an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal.

Demecolcine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	200ug/kg (0.2mg/kg)	skin and appendages (skin): hair: other	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 184, 1969.
mouse	LD50	intramuscular	87mg/kg (87mg/kg)		Journal of Medicinal Chemistry. Vol. 24, Pg. 257, 1981.
mouse	LD50	intraperitoneal	35mg/kg (35mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 559, 1957.
mouse	LD50	intravenous	56mg/kg (56mg/kg)	behavioral: somnolence (general depressed activity) behavioral: muscle weakness gastrointestinal: "hypermotility, diarrhea"	Pharmacology and Toxicology. English translation of FATOAO. Vol. 20, Pg. 284, 1957.
mouse	LD50	oral	25530ug/kg (25.53mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat	LD50	intravenous	1700ug/kg (1.7mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
rat	LD50	parenteral	1700ug/kg (1.7mg/kg)		Recent Results in Cancer Research. Vol. 52, Pg. 76, 1975.

Demecolcine Consensus Reports

EPA Genetic Toxicology Program.

Demecolcine Safety Profile

Poison by ingestion, intraperitoneal, parenteral, intravenous, and intramuscular routes. Human systemic effects by ingestion: (skin and appendages) hair effects. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes:
Toxic T
Very T+
Risk Statements:
R25 :Toxic if swallowed.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements:
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: GH0800000
F:
F 8: Photosensitive.
F 10: Keep under argon.
F 23 Sensitive to air.
HazardClass: 6.1(a)
PackingGroup: II

Demecolcine Specification

N-Methyl-N-Desacetylcolchicine (CAS NO.477-30-5) is a faintly yellow crystalline powder.

Product Name

DEMECOLCINE