Diethyl butylmalonate supplier

Name
Diethyl butylmalonate
EINECS 205-089-1
CAS No. 133-08-4
Article Data65
CAS DataBase
Density 0.994 g/cm³
Solubility 330mg/L at 20℃
Melting Point 119oC
Formula C₁₁H₂₀O₄
Boiling Point 237.5 °C at 760 mmHg
Molecular Weight 216.277
Flash Point 93.9 °C
Transport Information
Appearance clear colourless liquid
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Malonicacid, butyl-, diethyl ester (6CI,7CI,8CI);Propanedioic acid, butyl-, diethylester (9CI);Butylmalonic acid diethyl ester;Butylpropanedioic acid diethylester;Diethyl 2-butylmalonate;Diethyl n-butylmalonate;Diethyl a-butylmalonate;Ethylbutylmalonate;NSC 4565;
PSA 52.60000
LogP 1.91900

Synthetic route

: 109-65-9
1-bromo-butane

: 105-53-3
diethyl malonate

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With potassium carbonate; perhydrodibenzo-18-crown-6; Aliquat In toluene at 80℃; for 5h;	92%
With 18-crown-6 ether; Hexamethyldisiloxane; Aliquat 336; potassium carbonate at 90℃; for 4h; Solvent; Inert atmosphere; Green chemistry;	88%
With sodium ethanolate In ethanol for 2h; Heating;	87%

: 109-73-9
N-butylamine

: 105-53-3
diethyl malonate

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
Stage #1: diethyl malonate With copper(l) chloride for 1.5h; Large scale; Stage #2: N-butylamine for 10h; Time; Reflux; Large scale;	92%

: 109-65-9
1-bromo-butane

: 105-53-3
diethyl malonate

A: 596-75-8
diethyl dibutylmalonate

B: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With sodium ethanolate In ethanol	A 4% B 75%
tetrabutyl phosphonium bromide; potassium carbonate at 170℃; under 20 Torr; Product distribution; other catalysts, other compounds, other products;

...Expand

: 105-53-3
diethyl malonate

: 71-36-3
butan-1-ol

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With tributylphosphine; 4,7-dimethyl-3,5,7-hexahydro-1,2,4,7-tetrazocin-3,8-dione In benzene for 24h; Ambient temperature;	64%
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In benzene 1) 0 deg C, 10 min, 2) RT, 24 h;	21%

: 109-65-9
1-bromo-butane

: 996-82-7, 34727-00-9, 73177-21-6
sodium diethylmalonate

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With ethanol Darst.;

: 109-65-9
1-bromo-butane

: 996-82-7
sodium diethylmalonate

: 133-08-4
diethyl butylmalonate

: 13937-11-6
diethyl butylidenemalonate

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With ethanol; nickel under 73550.8 - 95616 Torr; Hydrogenation;
With palladium on activated charcoal; ethanol under 73550.8 - 147102 Torr; Hydrogenation;
With diethyl ether; nickel under 73550.8 - 95616 Torr; Hydrogenation;

: 123-66-0
Ethyl hexanoate

: 95-92-1
oxalic acid diethyl ester

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With sodium ethanolate at 50 - 60℃; under 100 Torr; unter Abdestillieren des entstehenden Aethanols und Erhitzen des Reaktinsprodukts unter vermindertem Druck auf 160grad;

: 123-66-0
Ethyl hexanoate

: 141-52-6
sodium ethanolate

: 105-58-8
Diethyl carbonate

A: diethyl 2-(1-ethyl-butyl)malonate

B: 133-08-4
diethyl butylmalonate

...Expand

: 123-66-0
Ethyl hexanoate

: 105-58-8
Diethyl carbonate

A: 596-76-9
ethyl-butyl-malonic acid diethyl ester

B: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With sodium ethanolate
With sodium ethanolate

...Expand

: 92173-10-9
(4E)-ethyl 2-ethoxycarbonyl-2,4-hexadienoate

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal

: 109-69-3
n-Butyl chloride

: 105-53-3
diethyl malonate

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
(i) Na, Et2O, (ii) /BRN= 1730909/; Multistep reaction;
K2CO3+5percent Carbowax 6000 at 170℃; under 20 Torr; Yield given;
With ethanol; 4-tert-Butylcatechol; sodium for 2h; Heating;

: 542-69-8
1-iodo-butane

: 105-53-3
diethyl malonate

A: 596-75-8
diethyl dibutylmalonate

B: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
K2CO3+5percent Carbowax 6000 at 170℃; under 20 Torr; Yield given. Yields of byproduct given;

...Expand

: 1912-32-9
n-butyl methanesulfonate

: 105-53-3
diethyl malonate

A: 596-75-8
diethyl dibutylmalonate

B: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
K2CO3+5percent Carbowax 6000 at 170℃; under 20 Torr; Yield given. Yields of byproduct given;

...Expand

: 105-58-8
Diethyl carbonate

ethylcaproate: ethylcaproate

A: 596-76-9
ethyl-butyl-malonic acid diethyl ester

B: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With sodium ethanolate beim Abdestillieren des entstehenden Aethanols;
With sodium ethanolate beim Abdestillieren des entstehenden Aethanols;

...Expand

: 64-17-5
ethanol

: 412017-45-9
butyl-dichloromethyl-malonic acid diethyl ester

: 141-52-6
sodium ethanolate

A: 133-08-4
diethyl butylmalonate

B 3ξ-ethoxy-2-butyl-acrylic acid ethyl ester: 3ξ-ethoxy-2-butyl-acrylic acid ethyl ester

...Expand

: 1575-76-4
2-butyl-2-ethoxycarbonylpenten-4-oic acid ethyl ester

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
With dibromobis(triphenylphosphine)nickel(II); triethylaluminum In toluene at 20℃; for 24h; Product distribution; Further Variations:; Reagents; Reaction partners; time;	92 % Spectr.
With triethylaluminum; Fe(III)bis(imidazolonyl)pyridine)Cl3 In toluene at 20℃; for 24h;	59 % Spectr.

: 3377-20-6
diethyl methylenemalonate

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: naphthalen-2-yl-phenyl-amine / diethyl ether 2: H2 / Pd-C View Scheme

: 105-53-3
diethyl malonate

n-butyl halide: n-butyl halide

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran; paraffin oil at 0 - 20℃; for 0.5h; Stage #2: n-butyl halide In tetrahydrofuran; paraffin oil at 20℃; for 3h;

: 542-69-8
1-iodo-butane

: 105-53-3
diethyl malonate

: 133-08-4
diethyl butylmalonate

Conditions

Conditions	Yield
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: 1-iodo-butane In tetrahydrofuran; N,N-dimethyl-formamide for 24h; Reflux;

: 133-08-4
diethyl butylmalonate

: 2612-26-2
2-butylpropane-1,3-diol

Conditions

Conditions	Yield
Stage #1: diethyl butylmalonate With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; ethanol at 20 - 30℃; for 1.5h; Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water at 20℃; for 1h;	99%
With lithium aluminium tetrahydride In diethyl ether at 20℃; for 3.33333h; Reflux;	92%
With lithium aluminium tetrahydride	88%

: 122586-72-5
1-methoxy-2,2,6,6-tetramethylpiperidin-4-ol

: 133-08-4
diethyl butylmalonate

: 122586-71-4
di-(1-methoxy-2,2,6,6-tetramethylpiperidin-4-yl) n-butylmalonate

Conditions

Conditions	Yield
With acetic acid In 5,5-dimethyl-1,3-cyclohexadiene; n-heptane	98%

: 22980-23-0
5-oxabicyclo<2.2.0>hex-2-en-6-one

: 133-08-4
diethyl butylmalonate

: 1356686-88-8
(1S,4S)-4-(1-ethoxy-2-(ethoxycarbonyl)-1-oxohexan-2-yl)cyclobut-2-enecarboxylic acid

Conditions

Conditions	Yield
Stage #1: diethyl butylmalonate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; Inert atmosphere; Stage #2: 5-oxabicyclo<2.2.0>hex-2-en-6-one With bis(η3-allyl-μ-chloropalladium(II)); (R)-4-(tert-butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole In tetrahydrofuran; diethyl ether; mineral oil at 40℃; for 1.5h; Inert atmosphere; stereoselective reaction;	98%

: 133-08-4
diethyl butylmalonate

: 22085-89-8
butyl propanediamide

Conditions

Conditions	Yield
With ammonia In methanol Ambient temperature;	97%
With methanol; ammonia; sodium methylate
With ammonia

: 50-01-1
guanidine hydrochloride

: 133-08-4
diethyl butylmalonate

: 98647-80-4
2-amino-5-butylpyrimidine-4,6-diol

Conditions

Conditions	Yield
Stage #1: guanidine hydrochloride; diethyl butylmalonate With sodium In ethanol at 20℃; for 4h; Inert atmosphere; Stage #2: In ethanol for 1h; Inert atmosphere; Reflux;	97%
With sodium In ethanol Inert atmosphere;	97%
With sodium carbonate In water at 60℃; for 0.5h; Reagent/catalyst; Sonication;	72%

: 22980-23-0
5-oxabicyclo<2.2.0>hex-2-en-6-one

: 133-08-4
diethyl butylmalonate

: 1356686-15-1
(1R,4S)-4-(1-ethoxy-2-(ethoxycarbonyl)-1-oxohexan-2-yl)cyclobut-2-enecarboxylic acid

Conditions

Conditions	Yield
Stage #1: diethyl butylmalonate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; Inert atmosphere; Stage #2: 5-oxabicyclo<2.2.0>hex-2-en-6-one With bis(η3-allyl-μ-chloropalladium(II)); C83H118NO8P In tetrahydrofuran; diethyl ether; mineral oil at 0℃; for 1h; Inert atmosphere; stereoselective reaction;	96%

: 141-86-6
2,6-Diaminopyridine

: 133-08-4
diethyl butylmalonate

: 120537-82-8
7-amino-3-n-butyl-1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine

Conditions

Conditions	Yield
In diphenylether for 0.5h; Heating;	95%

: 3216-47-5
3-chloromethylbenzothiophene

: 133-08-4
diethyl butylmalonate

: 2-butyl-2-(3H-inden-1-ylmethyl)-malonic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: diethyl butylmalonate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 3-chloromethylbenzothiophene In N,N-dimethyl-formamide at 20℃; for 4h;	95%

: 3749-51-7
4-hydroxy-6-methyl-2-pyridone

: 133-08-4
diethyl butylmalonate

: 955377-03-4
C13H15NO4

Conditions

Conditions	Yield
In diphenylether Heating;	95%

: 695-34-1
2-Amino-4-methylpyridine

: 133-08-4
diethyl butylmalonate

: 955-28-2
3-n-Butyl-8-methyl-4H-pyrido<1,2-a>pyrimidine-2,4-dione

Conditions

Conditions	Yield
In ethanol at 160 - 180℃;	93%

: 133-08-4
diethyl butylmalonate

: 174003-49-7
1,4-bis(4-methylaminophenoxy)butane

: 175440-90-1
C32H40N2O6

Conditions

Conditions	Yield
1.) 180-200 deg C, 0.5 h, 2.) 270-285 deg C;	93%

: 133-08-4
diethyl butylmalonate

: 58567-07-0
diethyl 2-butyl-2-hydroxymalonate

Conditions

Conditions	Yield
With iodine; sodium acetate In tetrahydrofuran; water at 35℃; for 5h; Time; Irradiation; Green chemistry;	93%

: 134-32-7
1-amino-naphthalene

: 133-08-4
diethyl butylmalonate

: 1513883-05-0
3-butyl-4-hydroxybenzo[h]quinolin-2(1H)-one

Conditions

Conditions	Yield
at 180℃;	93%

: 133-08-4
diethyl butylmalonate

: 836-42-0
4-benzyloxybenzyl chloride

: 197299-13-1
diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate

Conditions

Conditions	Yield
Stage #1: diethyl butylmalonate With sodium hydride In N,N-dimethyl-formamide; toluene at 40℃; Stage #2: 4-benzyloxybenzyl chloride In N,N-dimethyl-formamide; toluene at 20℃;	92%

: 24463-19-2
anthracenylmethyl chloride

: 133-08-4
diethyl butylmalonate

: diethyl 2-(9-anthrylmethyl)-2-butylmalonate

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran Heating;	92%

: 35168-62-8
2,5-dibromomethyl-p-xylene

: 133-08-4
diethyl butylmalonate

: 1268257-83-5
2-[4-(2,2-bis-ethoxycarbonyl-hexyl)-2,5-dimethylbenzyl]-2-butylmalonic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: diethyl butylmalonate With sodium ethanolate In ethanol at 20℃; for 0.5h; Inert atmosphere; Stage #2: 2,5-dibromomethyl-p-xylene In ethanol for 3h; Reflux; Inert atmosphere;	92%
Stage #1: diethyl butylmalonate With sodium In ethanol at 20℃; for 0.5h; Inert atmosphere; Stage #2: 2,5-dibromomethyl-p-xylene In ethanol for 3h; Inert atmosphere; Reflux;	92%

: 5807-14-7
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

: 133-08-4
diethyl butylmalonate

: C14H21N3O2

Conditions

Conditions	Yield
Heating;	91%

: 133-08-4
diethyl butylmalonate

: 29263-85-2
butyl-chloro-malonic acid diethyl ester

Conditions

Conditions	Yield
With manganese triacetate; lithium chloride In acetic acid for 0.683333h; Heating;	90%
With chlorine at 80℃;

: 1603-41-4
(5-methyl-pyridin-2-yl)amine

: 133-08-4
diethyl butylmalonate

: 954-76-7
3-butyl-7-methyl-pyrido[1,2-a]pyrimidine-2,4-dione

Conditions

Conditions	Yield
In ethanol at 160 - 180℃;	89%

: 133-08-4
diethyl butylmalonate

: 534-59-8
n-butylmalonic acid

Conditions

Conditions	Yield
With water; sodium hydroxide Reflux;	89%
With sodium hydroxide In water at 20℃; for 4h; Reflux;	85%
With sodium hydroxide In water for 4h; Reflux;	71%

: 75753-36-5
6H-6-oxo-3-bromo-5-(p-toluidino)anthra<1,9-cd>isoxazole

: 133-08-4
diethyl butylmalonate

: 2-Butyl-2-(6-oxo-5-p-tolylamino-6H-anthra[1,9-cd]isoxazol-3-yl)-malonic acid diethyl ester

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 30 - 35℃; for 20h;	87%

: 94447-78-6
2-Methylpyrimido<1,6-a>benzimidazole-1,3-(2H,5H)-dione

: 133-08-4
diethyl butylmalonate

: 136296-04-3
4-Hydroxy-2-methyl-5-butyl-1H,6H-2,6a,10b-triazafluoranthene-1,3,6(2H)-trione

Conditions

Conditions	Yield
With trichlorophenol at 280℃; for 0.5h;	87%

: 6245-50-7
4-[4-(4-aminophenoxy)butoxy]aniline

: 133-08-4
diethyl butylmalonate

: 175440-87-6
C30H36N2O6

Conditions

Conditions	Yield
1.) 180-200 deg C, 0.5 h, 2.) 270-285 deg C;	87%

: 133-08-4
diethyl butylmalonate

: 55023-36-4
7,9-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-ylamine

: 1210052-87-1
4-hydroxy-7,9-dimethyl-3-(n-butyl)pyrido[3',2':4,5]thieno[2,3-e]pyrimido[3,2-c]pyrimidin-2-one

Conditions

Conditions	Yield
In diphenylether Reflux;	86%

: 32501-94-3
(ethynylsulfonyl)benzene

: 133-08-4
diethyl butylmalonate

: (Z)-3,3-bis(ethoxycarbonyl)-1-benzenesulfonyl-1-heptene

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran 1.) 25 deg C, 1 h; 2.) -78 deg C, 2 h; 3.) 20 deg C, 12 h;	85%

: 107-15-3
ethylenediamine

: 133-08-4
diethyl butylmalonate

: 159832-38-9
N1,N3‐bis(2‐aminoethyl)‐2‐butylmalondiamide

Conditions

Conditions	Yield
for 72h; Ambient temperature;	85%

: 5418-95-1
2-guanidinobenzimidazole

: 133-08-4
diethyl butylmalonate

: 2-(1H-Benzoimidazol-2-ylamino)-5-butyl-6-hydroxy-3H-pyrimidin-4-one

Conditions

Conditions	Yield
In diphenylether at 200 - 220℃;	85%

Diethyl butylmalonate Chemical Properties

Molecular Structure:

Molecular Formula: C₁₁H₂₀O₄
Molecular Weight: 216.2741
IUPAC Name: Diethyl 2-butylpropanedioate
Synonyms of Propanedioic acid,2-butyl-, 1,3-diethyl ester (CAS NO.133-08-4): AI3-06356 ; EINECS 205-089-1 ; Diethyl butylmalonate ; Propanedioic acid, butyl-, diethyl ester
CAS NO: 133-08-4
Classification Code: Pharmaceutical Intermediates ; TheMalonateRamificationProducts ; C10 to C11 ; Carbonyl Compounds ; Esters
Index of Refraction: 1.433
Molar Refractivity: 56.51 cm³
Molar Volume: 217.4 cm³
Surface Tension: 31.8 dyne/cm
Density: 0.994 g/cm³
Flash Point: 93.9 °C
Enthalpy of Vaporization: 47.43 kJ/mol
Boiling Point: 237.5 °C at 760 mmHg
Vapour Pressure: 0.0447 mmHg at 25°C

Diethyl butylmalonate Uses

Propanedioic acid,2-butyl-, 1,3-diethyl ester (CAS NO.133-08-4) is used as the organic synthesis intermediate, it is mainly used in the medicine manufacture, it is always a fever medicine and so on analgesic phenylbutazone raw materials.

Diethyl butylmalonate Safety Profile

Safety Statements of Propanedioic acid,2-butyl-, 1,3-diethyl ester (CAS NO.133-08-4): 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
HS Code: 29171990

Product Name

Diethyl butylmalonate

Synthetic route

Diethyl butylmalonate Chemical Properties

Diethyl butylmalonate Uses

Diethyl butylmalonate Safety Profile

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