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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Darifenacin hydrobromide Manufacturer/High quality/Best price/In stock

Cas:133099-07-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Darifenacin supplier in China

Cas:133099-07-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to off-white powder Storage:-20°C Freezer Package:10g/b

Manufacturer supply Darifenacin hydrobromide CAS 133099-07-7 with good quality

Cas:133099-07-7

Min.Order:10 Gram

FOB Price: $10.0 / 20.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Darifenacin

Cas:133099-07-7

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Darifenacin hydrobromide 133099-07-7 GMP Manufacturer

Cas:133099-07-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Advantage: 1.Place of Origin China with Super quality by reasonable price. 2.Fast delivery by safe express way to all the country. 3.Has a number of highly qualified engineers and experts to provide guidance for reagents. 4.When you meet pr

Darifenacin HBr CAS No.: 133099-07-7

Cas:133099-07-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Darifenacin Hydrobromide

Cas:133099-07-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

133099-07-7 Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 133099-07-7 with competitive price

Cas:133099-07-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Darifenacin Hydrobromide Manufacturer For Treatment Of Urinary Incontinence

Cas:133099-07-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Darifenacin hydrobromide/ LIDE PHARMA- Factory supply / Best price

Cas:133099-07-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

product name: Darifenacin Hydrobromide CAS NO.: 133099-07-7 Molecular Formula: C28H29BrN2O2 ASSAY:99% MIN Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Genito-Urinary T

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

99%min Darifenacin Hydrobromide 133099-07-7

Cas:133099-07-7

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

High quality Darifenacin hydrobromide 99%

Cas:133099-07-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Darifenacin hydrobromide CAS:133099-07-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Darifenacin hydrobromide CAS:133099-07-7

Cas:133099-07-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

CAS NO.: 1758-25-4 CAS NO.: 133099-07-7

Cas:133099-07-7

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

darifenacin hydrobromide 133099-07-7

Cas:133099-07-7

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Darifenacin supplier in China

Cas:133099-07-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Darifenacin Hydrobromide Manufacturer For Treatment Of Urinary Incontinence

Cas:133099-07-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as a medica

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Darifenacin hydrobromide

Cas:133099-07-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Darifenacin Hydrobromide CAS No.:133099-07-7 Molecule Formula:C28H31BrN2O2 Molecule Weight:507.46 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Best Quality Darifenacin Hydrobromide

Cas:133099-07-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferDarifenacin hydrobromide

Cas:133099-07-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Darifenacinhydrobromide

Cas:133099-07-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In water; toluene at 100℃; for 15.25h;
Stage #2: With hydrogen bromide In water; toluene Product distribution / selectivity;
93.2%
Stage #1: (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In 2-methyltetrahydrofuran; water at 60 - 70℃;
Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In 2-methyltetrahydrofuran; water for 16h; Heating / reflux;
Stage #3: With hydrogen bromide In 2-methyltetrahydrofuran; water at 0 - 20℃; for 2h; Product distribution / selectivity;
90.67%
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In water; butanone at 75℃; for 6h;
Stage #2: With hydrogen bromide In water; butanone at 0 - 5℃; for 2h; Product distribution / selectivity;
84.92%
(S)-2-{1-[2-(benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide
133033-99-5

(S)-2-{1-[2-(benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: (S)-2-{1-[2-(benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide With hydrogen; acetic acid; palladium 10% on activated carbon at 45 - 50℃; for 6 - 7h;
Stage #2: With hydrogen bromide In water; butan-1-ol Product distribution / selectivity;
85%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
134002-25-8

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium hydroxide; triethylmethylammonium chloride In water; butanone at 75℃; for 6h; Heating / reflux;
Stage #2: With hydrogen bromide In water; butanone
84.92%
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium carbonate In acetonitrile at 70 - 75℃; for 2h;
Stage #2: With hydrogen bromide In water; acetone at 0 - 25℃; Product distribution / selectivity;
With potassium carbonate In acetonitrile
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
943034-50-2

2-(2,3-dihydrobenzofuran-5-yl)ethylchloride

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium carbonate In water at 101 - 103℃; for 2.5 - 5h;
Stage #2: With hydrogen bromide In water; butan-1-ol Product distribution / selectivity;
77.2%
darifenacin
133099-04-4

darifenacin

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water; acetone at 0 - 20℃; for 7h;75%
With hydrogen bromide In water; acetone65%
With hydrogen bromide In water; acetone for 1.25 - 2.33333h; Product distribution / selectivity;
(-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide

(-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: (-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide With potassium hydroxide; tert-Amyl alcohol at 60℃; for 22 - 23h; Heating / reflux;
Stage #2: With hydrogen bromide In water; butanone Product distribution / selectivity;
72%
Stage #1: (-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide With potassium hydroxide In tert-Amyl alcohol at 60 - 108℃;
Stage #2: With water
Stage #3: With hydrogen bromide In acetic acid; acetone at 20℃;
72%
Stage #1: (-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide With potassium hydroxide In iso-butanol at 105 - 110℃; for 50h;
Stage #2: With hydrogen bromide; acetic acid In acetone for 1h;
Stage #3: With sodium hydroxide; water; hydrogen bromide; acetic acid Product distribution / selectivity; more than 3 stages;
27.5%
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
943034-50-2

2-(2,3-dihydrobenzofuran-5-yl)ethylchloride

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
134002-25-8

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With sodium hydroxide; water In ethyl acetate at 25 - 35℃; for 0.25h;
Stage #2: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride With triethylamine at 95℃; for 15h;
Stage #3: With hydrogen bromide In water; acetone for 1h; Product distribution / selectivity;
70%
Stage #1: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium carbonate In water at 101 - 103℃; for 2 - 5h;
Stage #2: With hydrogen bromide In water; butan-1-ol Product distribution / selectivity;
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
2: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile
2: ammonia / methanol / 5 - 7 h / 28 - 45 °C
3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
(S)-darifenamine

(S)-darifenamine

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: (S)-darifenamine With sodium tetrahydroborate In ethanol at 20℃; for 3h;
Stage #2: With water In ethanol
Stage #3: With hydrogen bromide In water; butan-1-ol Product distribution / selectivity;
darifenacin hydrobromide

darifenacin hydrobromide

A

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

B

(3R)-2-{1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide hydrobromide
1092800-15-1

(3R)-2-{1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide hydrobromide

Conditions
ConditionsYield
Purification / work up; Resolution of enanthiomeric mixture;A 50.8 - 51.8 %Chromat.
B 48.0 - 49.0 %Chromat.
(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

2-(2,3-dihidrobenzofuran-5-yl)ethyl tosylate
79679-49-5

2-(2,3-dihidrobenzofuran-5-yl)ethyl tosylate

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate; 2-(2,3-dihidrobenzofuran-5-yl)ethyl tosylate With potassium carbonate In acetonitrile at 25 - 70℃; Inert atmosphere;
Stage #2: With hydrogen bromide In dichloromethane; water at 5 - 30℃; pH=2 - 9;
5-(2-hydroxyethyl)-2,3-dihydrobenzofuran
87776-76-9

5-(2-hydroxyethyl)-2,3-dihydrobenzofuran

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere
2.1: potassium carbonate / acetonitrile / 25 - 70 °C / Inert atmosphere
2.2: 5 - 30 °C / pH 2 - 9
View Scheme
(S)-2,2-diphenyl-2-[1-(tert-butyloxycarbonyl)-3-pyrrolidinyl]acetonitrile
1189753-52-3

(S)-2,2-diphenyl-2-[1-(tert-butyloxycarbonyl)-3-pyrrolidinyl]acetonitrile

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / methanol / 7 h / 20 - 30 °C
2.1: sulfuric acid / 12 h / 85 - 90 °C
3.1: ethanol / 1 h
4.1: potassium carbonate / water / 0.5 h / 25 - 30 °C
4.2: 12 h / 25 - 75 °C
5.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C
View Scheme
(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetonitrile
133099-11-3

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetonitrile

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid / 12 h / 85 - 90 °C
2.1: ethanol / 1 h
3.1: potassium carbonate / water / 0.5 h / 25 - 30 °C
3.2: 12 h / 25 - 75 °C
4.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid / 10 h / 95 - 100 °C
1.2: 25 - 30 °C
2.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
3.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
134002-25-8

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ethanol / 1 h
2.1: potassium carbonate / water / 0.5 h / 25 - 30 °C
2.2: 12 h / 25 - 75 °C
3.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
2: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1: water / 50 - 60 °C
2: potassium hydroxide / acetonitrile / 25 - 45 °C
3: hydrogen bromide / acetone / 10 - 25 °C
View Scheme
1-(2,3-dihydrobenzofuran-5-yl)ethanone
90843-31-5

1-(2,3-dihydrobenzofuran-5-yl)ethanone

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C
1.2: 6 h / 0 - 5 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere
2.2: 4 h / 45 - 50 °C / Inert atmosphere
3.1: potassium carbonate / water / 0.5 h / 25 - 30 °C
3.2: 12 h / 25 - 75 °C
4.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C
View Scheme
2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one
151427-19-9

2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere
1.2: 4 h / 45 - 50 °C / Inert atmosphere
2.1: potassium carbonate / water / 0.5 h / 25 - 30 °C
2.2: 12 h / 25 - 75 °C
3.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C
View Scheme
2,3-Dihydrobenzofuran
496-16-2

2,3-Dihydrobenzofuran

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere
1.2: 0.5 h / 0 - 5 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C
2.2: 6 h / 0 - 5 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere
3.2: 4 h / 45 - 50 °C / Inert atmosphere
4.1: potassium carbonate / water / 0.5 h / 25 - 30 °C
4.2: 12 h / 25 - 75 °C
5.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C
View Scheme
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
943034-50-2

2-(2,3-dihydrobenzofuran-5-yl)ethylchloride

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium bromide / acetone / 48 h / Heating / reflux
2: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium bromide / acetone / 48 h / Heating / reflux
2: potassium carbonate / acetonitrile
3: ammonia / methanol / 5 - 7 h / 28 - 45 °C
4: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / water / 0.33 h / 25 - 60 °C / pH 12 - 14
2: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
(S)-diphenyl-[1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-acetonitrile
133099-09-9

(S)-diphenyl-[1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-acetonitrile

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen bromide / water; phenol / 4 h / Heating / reflux
2.1: sulfuric acid / 10 h / 95 - 100 °C
2.2: 25 - 30 °C
3.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
4.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
2,2-diphenyl-2-((S)-pyrrolidin-3-yl)-acetic acid methyl ester
1072227-71-4

2,2-diphenyl-2-((S)-pyrrolidin-3-yl)-acetic acid methyl ester

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile
2: ammonia / methanol / 5 - 7 h / 28 - 45 °C
3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
methyl 2,2-diphenyl-2-((S)-1-tosyl-pyrrolidin-3-yl)-acetate
1072227-66-7

methyl 2,2-diphenyl-2-((S)-1-tosyl-pyrrolidin-3-yl)-acetate

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen bromide; acetic acid
2: potassium carbonate / acetonitrile
3: ammonia / methanol / 5 - 7 h / 28 - 45 °C
4: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester
1072227-73-6

2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / methanol / 5 - 7 h / 28 - 45 °C
2: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
Diphenylacetonitrile
86-29-3

Diphenylacetonitrile

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium hydroxide / N,N-dimethyl-formamide / 2 h
1.2: 5 h / 95 - 100 °C
2.1: hydrogen bromide / water; phenol / 4 h / Heating / reflux
3.1: sulfuric acid / 10 h / 95 - 100 °C
3.2: 25 - 30 °C
4.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
5.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
methyl 2,2-diphenylacetate
3469-00-9

methyl 2,2-diphenylacetate

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydride / toluene / 1 h / 55 - 60 °C
1.2: 3 h / 25 - 30 °C / Heating / reflux
2.1: hydrogen bromide; acetic acid
3.1: potassium carbonate / acetonitrile
4.1: ammonia / methanol / 5 - 7 h / 28 - 45 °C
5.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone
64089-34-5

2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C
2: sodium bromide / acetone / 48 h / Heating / reflux
3: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
4: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C
2: sodium bromide / acetone / 48 h / Heating / reflux
3: potassium carbonate / acetonitrile
4: ammonia / methanol / 5 - 7 h / 28 - 45 °C
5: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
C2H2O4*C18H18N2

C2H2O4*C18H18N2

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide; water / 0.25 h / 50 - 60 °C / pH 12
2.1: sulfuric acid / 10 h / 95 - 100 °C
2.2: 25 - 30 °C
3.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
4.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-ol
1190695-09-0

(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-ol

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triphenylphosphine; benzoic acid; diethylazodicarboxylate / toluene / 0 - 20 °C
1.2: 5 h / 20 °C
2.1: triethylamine / dichloromethane / -10 - 20 °C
3.1: sodium hydride / toluene / 2 h / Reflux
3.2: 9 h / Reflux
4.1: tetrabutylammomium bromide; potassium hydroxide / iso-butanol / 48 h / Reflux
5.1: hydrogen bromide / water; acetone
View Scheme
(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

darifenacin
133099-04-4

darifenacin

Conditions
ConditionsYield
With sodium hydroxide In water at 20 - 25℃; pH=12;

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