As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:133099-07-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:133099-07-7
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to off-white powder Storage:-20°C Freezer Package:10g/b
Cas:133099-07-7
Min.Order:10 Gram
FOB Price: $10.0 / 20.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:133099-07-7
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryAdvantage: 1.Place of Origin China with Super quality by reasonable price. 2.Fast delivery by safe express way to all the country. 3.Has a number of highly qualified engineers and experts to provide guidance for reagents. 4.When you meet pr
Cas:133099-07-7
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:133099-07-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:133099-07-7
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:133099-07-7
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:133099-07-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:133099-07-7
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:133099-07-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryproduct name: Darifenacin Hydrobromide CAS NO.: 133099-07-7 Molecular Formula: C28H29BrN2O2 ASSAY:99% MIN Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Genito-Urinary T
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
Cas:133099-07-7
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate
Cas:133099-07-7
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryDarifenacin hydrobromide CAS:133099-07-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:133099-07-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:133099-07-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,
Cas:133099-07-7
Min.Order:20 Metric Ton
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:133099-07-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:133099-07-7
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:133099-07-7
Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:133099-07-7
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:133099-07-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:133099-07-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:133099-07-7
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as a medica
Cas:133099-07-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:133099-07-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: Darifenacin Hydrobromide CAS No.:133099-07-7 Molecule Formula:C28H31BrN2O2 Molecule Weight:507.46 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:133099-07-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:133099-07-7
Min.Order:0
Negotiable
Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:133099-07-7
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiry2,3-dihydro-5-(2-bromoethyl)benzofuran
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In water; toluene at 100℃; for 15.25h; Stage #2: With hydrogen bromide In water; toluene Product distribution / selectivity; | 93.2% |
Stage #1: (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In 2-methyltetrahydrofuran; water at 60 - 70℃; Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In 2-methyltetrahydrofuran; water for 16h; Heating / reflux; Stage #3: With hydrogen bromide In 2-methyltetrahydrofuran; water at 0 - 20℃; for 2h; Product distribution / selectivity; | 90.67% |
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In water; butanone at 75℃; for 6h; Stage #2: With hydrogen bromide In water; butanone at 0 - 5℃; for 2h; Product distribution / selectivity; | 84.92% |
(S)-2-{1-[2-(benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: (S)-2-{1-[2-(benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide With hydrogen; acetic acid; palladium 10% on activated carbon at 45 - 50℃; for 6 - 7h; Stage #2: With hydrogen bromide In water; butan-1-ol Product distribution / selectivity; | 85% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium hydroxide; triethylmethylammonium chloride In water; butanone at 75℃; for 6h; Heating / reflux; Stage #2: With hydrogen bromide In water; butanone | 84.92% |
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium carbonate In acetonitrile at 70 - 75℃; for 2h; Stage #2: With hydrogen bromide In water; acetone at 0 - 25℃; Product distribution / selectivity; | |
With potassium carbonate In acetonitrile |
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium carbonate In water at 101 - 103℃; for 2.5 - 5h; Stage #2: With hydrogen bromide In water; butan-1-ol Product distribution / selectivity; | 77.2% |
darifenacin
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
With hydrogen bromide In water; acetone at 0 - 20℃; for 7h; | 75% |
With hydrogen bromide In water; acetone | 65% |
With hydrogen bromide In water; acetone for 1.25 - 2.33333h; Product distribution / selectivity; |
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: (-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide With potassium hydroxide; tert-Amyl alcohol at 60℃; for 22 - 23h; Heating / reflux; Stage #2: With hydrogen bromide In water; butanone Product distribution / selectivity; | 72% |
Stage #1: (-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide With potassium hydroxide In tert-Amyl alcohol at 60 - 108℃; Stage #2: With water Stage #3: With hydrogen bromide In acetic acid; acetone at 20℃; | 72% |
Stage #1: (-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide With potassium hydroxide In iso-butanol at 105 - 110℃; for 50h; Stage #2: With hydrogen bromide; acetic acid In acetone for 1h; Stage #3: With sodium hydroxide; water; hydrogen bromide; acetic acid Product distribution / selectivity; more than 3 stages; | 27.5% |
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With sodium hydroxide; water In ethyl acetate at 25 - 35℃; for 0.25h; Stage #2: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride With triethylamine at 95℃; for 15h; Stage #3: With hydrogen bromide In water; acetone for 1h; Product distribution / selectivity; | 70% |
Stage #1: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium carbonate In water at 101 - 103℃; for 2 - 5h; Stage #2: With hydrogen bromide In water; butan-1-ol Product distribution / selectivity; |
2,3-dihydro-5-(2-bromoethyl)benzofuran
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 2: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / acetonitrile 2: ammonia / methanol / 5 - 7 h / 28 - 45 °C 3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: (S)-darifenamine With sodium tetrahydroborate In ethanol at 20℃; for 3h; Stage #2: With water In ethanol Stage #3: With hydrogen bromide In water; butan-1-ol Product distribution / selectivity; |
A
(S)-darifenacin hydrobromide
B
(3R)-2-{1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide hydrobromide
Conditions | Yield |
---|---|
Purification / work up; Resolution of enanthiomeric mixture; | A 50.8 - 51.8 %Chromat. B 48.0 - 49.0 %Chromat. |
2-(2,3-dihidrobenzofuran-5-yl)ethyl tosylate
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate; 2-(2,3-dihidrobenzofuran-5-yl)ethyl tosylate With potassium carbonate In acetonitrile at 25 - 70℃; Inert atmosphere; Stage #2: With hydrogen bromide In dichloromethane; water at 5 - 30℃; pH=2 - 9; |
5-(2-hydroxyethyl)-2,3-dihydrobenzofuran
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere 2.1: potassium carbonate / acetonitrile / 25 - 70 °C / Inert atmosphere 2.2: 5 - 30 °C / pH 2 - 9 View Scheme |
(S)-2,2-diphenyl-2-[1-(tert-butyloxycarbonyl)-3-pyrrolidinyl]acetonitrile
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogenchloride / methanol / 7 h / 20 - 30 °C 2.1: sulfuric acid / 12 h / 85 - 90 °C 3.1: ethanol / 1 h 4.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 4.2: 12 h / 25 - 75 °C 5.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C View Scheme |
(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetonitrile
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sulfuric acid / 12 h / 85 - 90 °C 2.1: ethanol / 1 h 3.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 3.2: 12 h / 25 - 75 °C 4.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid / 10 h / 95 - 100 °C 1.2: 25 - 30 °C 2.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 3.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ethanol / 1 h 2.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 2.2: 12 h / 25 - 75 °C 3.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 2: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: water / 50 - 60 °C 2: potassium hydroxide / acetonitrile / 25 - 45 °C 3: hydrogen bromide / acetone / 10 - 25 °C View Scheme |
1-(2,3-dihydrobenzofuran-5-yl)ethanone
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere 2.2: 4 h / 45 - 50 °C / Inert atmosphere 3.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 3.2: 12 h / 25 - 75 °C 4.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C View Scheme |
2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere 1.2: 4 h / 45 - 50 °C / Inert atmosphere 2.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 2.2: 12 h / 25 - 75 °C 3.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C View Scheme |
2,3-Dihydrobenzofuran
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere 1.2: 0.5 h / 0 - 5 °C / Inert atmosphere 2.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C 2.2: 6 h / 0 - 5 °C 3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere 3.2: 4 h / 45 - 50 °C / Inert atmosphere 4.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 4.2: 12 h / 25 - 75 °C 5.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C View Scheme |
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium bromide / acetone / 48 h / Heating / reflux 2: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium bromide / acetone / 48 h / Heating / reflux 2: potassium carbonate / acetonitrile 3: ammonia / methanol / 5 - 7 h / 28 - 45 °C 4: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / water / 0.33 h / 25 - 60 °C / pH 12 - 14 2: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
(S)-diphenyl-[1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-acetonitrile
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogen bromide / water; phenol / 4 h / Heating / reflux 2.1: sulfuric acid / 10 h / 95 - 100 °C 2.2: 25 - 30 °C 3.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 4.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
2,2-diphenyl-2-((S)-pyrrolidin-3-yl)-acetic acid methyl ester
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / acetonitrile 2: ammonia / methanol / 5 - 7 h / 28 - 45 °C 3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
methyl 2,2-diphenyl-2-((S)-1-tosyl-pyrrolidin-3-yl)-acetate
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogen bromide; acetic acid 2: potassium carbonate / acetonitrile 3: ammonia / methanol / 5 - 7 h / 28 - 45 °C 4: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonia / methanol / 5 - 7 h / 28 - 45 °C 2: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
Diphenylacetonitrile
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium hydroxide / N,N-dimethyl-formamide / 2 h 1.2: 5 h / 95 - 100 °C 2.1: hydrogen bromide / water; phenol / 4 h / Heating / reflux 3.1: sulfuric acid / 10 h / 95 - 100 °C 3.2: 25 - 30 °C 4.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 5.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
methyl 2,2-diphenylacetate
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydride / toluene / 1 h / 55 - 60 °C 1.2: 3 h / 25 - 30 °C / Heating / reflux 2.1: hydrogen bromide; acetic acid 3.1: potassium carbonate / acetonitrile 4.1: ammonia / methanol / 5 - 7 h / 28 - 45 °C 5.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C 2: sodium bromide / acetone / 48 h / Heating / reflux 3: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 4: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C 2: sodium bromide / acetone / 48 h / Heating / reflux 3: potassium carbonate / acetonitrile 4: ammonia / methanol / 5 - 7 h / 28 - 45 °C 5: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydroxide; water / 0.25 h / 50 - 60 °C / pH 12 2.1: sulfuric acid / 10 h / 95 - 100 °C 2.2: 25 - 30 °C 3.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 4.1: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-ol
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triphenylphosphine; benzoic acid; diethylazodicarboxylate / toluene / 0 - 20 °C 1.2: 5 h / 20 °C 2.1: triethylamine / dichloromethane / -10 - 20 °C 3.1: sodium hydride / toluene / 2 h / Reflux 3.2: 9 h / Reflux 4.1: tetrabutylammomium bromide; potassium hydroxide / iso-butanol / 48 h / Reflux 5.1: hydrogen bromide / water; acetone View Scheme |
(S)-darifenacin hydrobromide
darifenacin
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20 - 25℃; pH=12; |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View