Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:127264-14-6
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:127264-14-6
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:127264-14-6
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:127264-14-6
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Type:Manufacturers
inquiryProduct Description Product website: http://www.finerchem.com Product Name 5-(2-Bromoethyl)-2,3-dihydrobenzofuran
Cas:127264-14-6
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:127264-14-6
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Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:127264-14-6
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:127264-14-6
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
Cas:127264-14-6
Min.Order:10 Gram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:127264-14-6
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inquiry5-(2-Bromoethyl)-2,3-dihydrobenzofuran CAS:127264-14-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q
Cas:127264-14-6
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater
Cas:127264-14-6
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inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Cas:127264-14-6
Min.Order:10 Kilogram
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Type:Trading Company
inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:127264-14-6
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Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:127264-14-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:127264-14-6
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:127264-14-6
Min.Order:10 Gram
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inquiry5-(2-Bromoethyl)-2,3-Dihydrobenzofuran;cas.127264-14-6Appearance:White to off white powder Storage:Store in an airtight container, protected from light. Package:according to customers' requirements Application:Darifenacin intermediaate Transportation
Cas:127264-14-6
Min.Order:1 Gram
Negotiable
Type:Other
inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
Cas:127264-14-6
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Trading Company
inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Product name: 5-(2-Bromoethyl)-2,3-Dihydrobenzofuran CAS No.: 127264-14-6 Molecule Formula:C10H11BrO Molecule Weight:227.10 Purity: 99.0% Package: 25kg/drum Description:Pale-yellow to whtie crystalline powder Manufacture Standards:En
Cas:127264-14-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:127264-14-6
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:127264-14-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:127264-14-6
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiry5-(2-hydroxyethyl)-2,3-dihydrobenzofuran
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
With carbon tetrabromide; triphenylphosphine In dichloromethane at 20℃; for 63h; | 84% |
With phosphorus tribromide In chloroform Reflux; | 75.9% |
73% |
2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Stage #1: 2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one With sodium tetrahydroborate In tetrahydrofuran at 5 - 10℃; for 1h; Inert atmosphere; Stage #2: With aluminum (III) chloride In tetrahydrofuran at 45 - 50℃; for 4h; Inert atmosphere; | 74% |
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
With sodium bromide In acetone for 48h; Heating / reflux; |
1-(2,3-dihydrobenzofuran-5-yl)ethanone
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere 2.2: 4 h / 45 - 50 °C / Inert atmosphere View Scheme |
2,3-Dihydrobenzofuran
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere 1.2: 0.5 h / 0 - 5 °C / Inert atmosphere 2.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C 2.2: 6 h / 0 - 5 °C 3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere 3.2: 4 h / 45 - 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 1 h / 0 - 10 °C 1.2: 10 - 20 °C 2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux 3.1: phosphorus tribromide / chloroform / Reflux View Scheme | |
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / dichloromethane / 1 h / 0 - 10 °C 1.2: 10 - 20 °C 2.1: water; sodium hydroxide / 20 °C 3.1: hydrazine hydrate; sodium hydroxide / 90 - 100 °C 4.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux 5.1: phosphorus tribromide / chloroform / Reflux View Scheme |
2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C 2: sodium bromide / acetone / 48 h / Heating / reflux View Scheme |
ethyl 2( 2,3-dihydro-1-benzofuran-5-yl)oxoacetate
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: water; sodium hydroxide / 20 °C 2: hydrazine hydrate; sodium hydroxide / 90 - 100 °C 3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux 4: phosphorus tribromide / chloroform / Reflux View Scheme |
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrazine hydrate; sodium hydroxide / 90 - 100 °C 2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux 3: phosphorus tribromide / chloroform / Reflux View Scheme |
2,3-dihydrobenzofuran-5-acetic acid
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux 2: phosphorus tribromide / chloroform / Reflux View Scheme |
4-hydroxyphenylacetate
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: potassium iodide; sodium hydroxide / dimethyl sulfoxide / 50 - 80 °C 2: toluene-4-sulfonic acid / Reflux; Large scale 3: polyphosphoric acid / toluene / 105 - 110 °C 4: sodium hydroxide; water / methanol / 25 - 30 °C 5: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr 6: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 7: phosphorus tribromide / chloroform / Reflux View Scheme | |
Multi-step reaction with 7 steps 1: potassium iodide; sodium hydroxide / dimethyl sulfoxide / 50 - 80 °C 2: toluene-4-sulfonic acid / Reflux; Large scale 3: polyphosphoric acid / toluene / 105 - 110 °C 4: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr 5: sodium hydroxide; water / methanol / 25 - 60 °C 6: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 7: phosphorus tribromide / chloroform / Reflux View Scheme |
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: toluene-4-sulfonic acid / Reflux; Large scale 2: polyphosphoric acid / toluene / 105 - 110 °C 3: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr 4: sodium hydroxide; water / methanol / 25 - 60 °C 5: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 6: phosphorus tribromide / chloroform / Reflux View Scheme | |
Multi-step reaction with 6 steps 1: toluene-4-sulfonic acid / Reflux; Large scale 2: polyphosphoric acid / toluene / 105 - 110 °C 3: sodium hydroxide; water / methanol / 25 - 30 °C 4: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr 5: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 6: phosphorus tribromide / chloroform / Reflux View Scheme |
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: polyphosphoric acid / toluene / 105 - 110 °C 2: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr 3: sodium hydroxide; water / methanol / 25 - 60 °C 4: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 5: phosphorus tribromide / chloroform / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: polyphosphoric acid / toluene / 105 - 110 °C 2: sodium hydroxide; water / methanol / 25 - 30 °C 3: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr 4: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 5: phosphorus tribromide / chloroform / Reflux View Scheme |
methyl 2-(benzofuran-5-yl)acetate
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide; water / methanol / 25 - 30 °C 2: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr 3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 4: phosphorus tribromide / chloroform / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr 2: sodium hydroxide; water / methanol / 25 - 60 °C 3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 4: phosphorus tribromide / chloroform / Reflux View Scheme |
benzofuran-5-yl-acetic acid
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr 2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 3: phosphorus tribromide / chloroform / Reflux View Scheme |
methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide; water / methanol / 25 - 60 °C 2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux 3: phosphorus tribromide / chloroform / Reflux View Scheme |
styrene
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate In 1,4-dioxane at 105℃; for 36h; Inert atmosphere; | 96% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
bromobenzene
Conditions | Yield |
---|---|
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction; | 95% |
With nickel(II) bromide dimethoxyethane; [Ir(dF(CF3)ppy)2(phen)]PF6; Bathocuproine; diisopropylamine; magnesium bromide In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; Glovebox; Sealed tube; Irradiation; regioselective reaction; | 87% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In water; toluene at 100℃; for 15.25h; Stage #2: With hydrogen bromide In water; toluene Product distribution / selectivity; | 93.2% |
Stage #1: (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In 2-methyltetrahydrofuran; water at 60 - 70℃; Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In 2-methyltetrahydrofuran; water for 16h; Heating / reflux; Stage #3: With hydrogen bromide In 2-methyltetrahydrofuran; water at 0 - 20℃; for 2h; Product distribution / selectivity; | 90.67% |
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In water; butanone at 75℃; for 6h; Stage #2: With hydrogen bromide In water; butanone at 0 - 5℃; for 2h; Product distribution / selectivity; | 84.92% |
Conditions | Yield |
---|---|
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction; | 90% |
Conditions | Yield |
---|---|
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction; | 90% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 3-(S)-(+)-(1-cyano-1,1-diphenylmethyl)pyrrolidine hydrobromide With potassium carbonate In water at 75℃; for 4h; Stage #2: With hydrogen bromide In water | 89.93% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
Conditions | Yield |
---|---|
Stage #1: 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane With bis(cyclopentadienyl)titanium dichloride; lithium methanolate In tert-butyl methyl ether for 0.5h; Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In tert-butyl methyl ether at 60℃; under 760.051 Torr; for 24h; Inert atmosphere; | 89% |
Stage #1: 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane With bis(cyclopentadienyl)titanium dichloride; lithium methanolate In tert-butyl methyl ether for 0.5h; Inert atmosphere; Glovebox; Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In tert-butyl methyl ether at 60℃; for 24h; Sealed tube; | 89% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
(2-bromo-2-fluoroethyl)benzene
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2,6-bis(4,5-dihydro-1H-imidazol-2-yl)pyridine; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 88% |
Conditions | Yield |
---|---|
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0); zinc In N,N-dimethyl acetamide at 80℃; for 12h; | 87% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium hydroxide; triethylmethylammonium chloride In water; butanone at 75℃; for 6h; Heating / reflux; Stage #2: With hydrogen bromide In water; butanone | 84.92% |
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium carbonate In acetonitrile at 70 - 75℃; for 2h; Stage #2: With hydrogen bromide In water; acetone at 0 - 25℃; Product distribution / selectivity; | |
With potassium carbonate In acetonitrile |
succinic acid anhydride
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0); zinc In N,N-dimethyl acetamide at 80℃; for 12h; | 82% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; | 75% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
1-bromo-3,4,5-trimethoxybenzene
Conditions | Yield |
---|---|
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction; | A 75% B n/a |
Conditions | Yield |
---|---|
With nickel(II) iodide; C17H20N2O2; lithium bromide; zinc In 1-methyl-pyrrolidin-2-one at 30℃; for 24h; regioselective reaction; | 75% |
Conditions | Yield |
---|---|
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction; | 73% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
fenofibrate
Conditions | Yield |
---|---|
With 2.9-dimethyl-1,10-phenanthroline; nickel(II) perchlorate hexahydrate; tetrabutylammomium bromide In N,N-dimethyl acetamide at 20℃; for 10h; Glovebox; Sealed tube; Electrochemical reaction; Inert atmosphere; regioselective reaction; | 72% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
5-bromo-2-(4-morpholinyl)pyridine
Conditions | Yield |
---|---|
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction; | 69% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
ethyl 4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; ethyl 4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylate With potassium carbonate; potassium iodide In acetonitrile Reflux; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether; water Inert atmosphere; | 52% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
(3S)-pyrrolidin-3-yl-cyclopentyl(hydroxy)phenyl acetate
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile for 8h; Heating / reflux; | 50% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile for 8h; Heating / reflux; | 46% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
C19H22N2O
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile Heating / reflux; | 45% |
Conditions | Yield |
---|---|
With norborn-2-ene; palladium diacetate; potassium carbonate at 80℃; for 18h; Inert atmosphere; | 28% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
darifenacin
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 2h; Heating / reflux; | 9% |
With potassium phosphate In water; toluene at 20 - 90℃; for 3.5h; Product distribution / selectivity; | |
With potassium carbonate In water; toluene at 20 - 90℃; for 3.5h; Product distribution / selectivity; | |
With potassium phosphate In cyclohexane; water at 20 - 90℃; for 3.5h; Product distribution / selectivity; | |
With potassium hydroxide In acetonitrile at 40 - 50℃; for 18h; Product distribution / selectivity; |
2,3-dihydro-5-(2-bromoethyl)benzofuran
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C 2: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / acetonitrile 2: ammonia / methanol / 5 - 7 h / 28 - 45 °C 3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C View Scheme |
2,3-dihydro-5-(2-bromoethyl)benzofuran
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile Heating / reflux; |
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