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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

5-(2-Bromoethyl)-2,3-dihydrobenzofuran Manufacturer/High quality/Best price/In stock

Cas:127264-14-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-(2-Bromoethyl)-2,3-Dihydrobenzofuran supplier in China

Cas:127264-14-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

5-(2-Bromoethyl)-2,3-dihydrobenzofuran CAS NO.127264-14-6

Cas:127264-14-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 5-(2-Bromoethyl)-2,3-Dihydrobenzofuran

Cas:127264-14-6

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-(2-bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 5-(2-Bromoethyl)-2,3-dihydrobenzofuran

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 127264-14-6 with fast shipping

Cas:127264-14-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

5-(2-Bromoethyl)-2,3-dihydrobenzofuran/ LIDE PHARMA- Factory supply / Best price

Cas:127264-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

5-(2-Bromoethyl)-2,3-dihydrobenzofuran 127264-14-6

Cas:127264-14-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-(2-Bromoethyl)-2,3-dihydrobenzofuran 127264-14-6

Cas:127264-14-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

5-(2-Bromoethyl)-2,3-dihydrobenzofuran CAS:127264-14-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

5-(2-Bromoethyl)-2,3-dihydrobenzofuran CAS:127264-14-6

Cas:127264-14-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5-(2-Bromoethyl)-2,3-Dihydrobenzofuran

Cas:127264-14-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

5-(2-Bromoethyl)-2,3-dihydrobenzofuran CAS NO.127264-14-6

Cas:127264-14-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

5-(2-Bromoethyl)-2,3-dihydrobenzofuran cas no.127264-14-6 0.98

Cas:127264-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

5-(2-Bromoethyl)-2,3-dihydrobenzofuran CAS 127264-14-6

Cas:127264-14-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

5-(2-BROMOETHYL)-2,3-DIHYDROBENZOFURAN

Cas:127264-14-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 5-(2-Bromoethyl)-2,3-Dihydrobenzofuran

Cas:127264-14-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

5-(2-Bromoethyl)-2,3-Dihydrobenzofuran;cas.127264-14-6Appearance:White to off white powder Storage:Store in an airtight container, protected from light. Package:according to customers' requirements Application:Darifenacin intermediaate Transportation

5-(2-Bromoethyl)-2,3-Dihydrobenzofuran;cas.127264-14-6

Cas:127264-14-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:0

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: 5-(2-Bromoethyl)-2,3-Dihydrobenzofuran CAS No.: 127264-14-6 Molecule Formula:C10H11BrO Molecule Weight:227.10 Purity: 99.0% Package: 25kg/drum Description:Pale-yellow to whtie crystalline powder Manufacture Standards:En

Lower Price 5-(2-Bromoethyl)-2,3-Dihydrobenzofuran

Cas:127264-14-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

5-(2-Bromoethyl)-2,3-dihydrobenzofuran CAS NO.127264-14-6

Cas:127264-14-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

5-(2-Bromoethyl)-2,3-dihydrobenzofuran

Cas:127264-14-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

5-(2-Bromoethyl)-2,3-dihydrobenzofuran CAS NO.127264-14-6

Cas:127264-14-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

5-(2-hydroxyethyl)-2,3-dihydrobenzofuran
87776-76-9

5-(2-hydroxyethyl)-2,3-dihydrobenzofuran

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
With carbon tetrabromide; triphenylphosphine In dichloromethane at 20℃; for 63h;84%
With phosphorus tribromide In chloroform Reflux;75.9%
73%
2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one
151427-19-9

2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Stage #1: 2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one With sodium tetrahydroborate In tetrahydrofuran at 5 - 10℃; for 1h; Inert atmosphere;
Stage #2: With aluminum (III) chloride In tetrahydrofuran at 45 - 50℃; for 4h; Inert atmosphere;
74%
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
943034-50-2

2-(2,3-dihydrobenzofuran-5-yl)ethylchloride

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
With sodium bromide In acetone for 48h; Heating / reflux;
1-(2,3-dihydrobenzofuran-5-yl)ethanone
90843-31-5

1-(2,3-dihydrobenzofuran-5-yl)ethanone

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C
1.2: 6 h / 0 - 5 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere
2.2: 4 h / 45 - 50 °C / Inert atmosphere
View Scheme
2,3-Dihydrobenzofuran
496-16-2

2,3-Dihydrobenzofuran

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere
1.2: 0.5 h / 0 - 5 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C
2.2: 6 h / 0 - 5 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere
3.2: 4 h / 45 - 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / dichloromethane / 1 h / 0 - 10 °C
1.2: 10 - 20 °C
2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux
3.1: phosphorus tribromide / chloroform / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane / 1 h / 0 - 10 °C
1.2: 10 - 20 °C
2.1: water; sodium hydroxide / 20 °C
3.1: hydrazine hydrate; sodium hydroxide / 90 - 100 °C
4.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux
5.1: phosphorus tribromide / chloroform / Reflux
View Scheme
2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone
64089-34-5

2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C
2: sodium bromide / acetone / 48 h / Heating / reflux
View Scheme
ethyl 2( 2,3-dihydro-1-benzofuran-5-yl)oxoacetate
79002-49-6

ethyl 2( 2,3-dihydro-1-benzofuran-5-yl)oxoacetate

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: water; sodium hydroxide / 20 °C
2: hydrazine hydrate; sodium hydroxide / 90 - 100 °C
3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux
4: phosphorus tribromide / chloroform / Reflux
View Scheme
C10H7O4(1-)*Na(1+)

C10H7O4(1-)*Na(1+)

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrazine hydrate; sodium hydroxide / 90 - 100 °C
2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux
3: phosphorus tribromide / chloroform / Reflux
View Scheme
2,3-dihydrobenzofuran-5-acetic acid
69999-16-2

2,3-dihydrobenzofuran-5-acetic acid

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 10 °C / Reflux
2: phosphorus tribromide / chloroform / Reflux
View Scheme
4-hydroxyphenylacetate
156-38-7

4-hydroxyphenylacetate

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium iodide; sodium hydroxide / dimethyl sulfoxide / 50 - 80 °C
2: toluene-4-sulfonic acid / Reflux; Large scale
3: polyphosphoric acid / toluene / 105 - 110 °C
4: sodium hydroxide; water / methanol / 25 - 30 °C
5: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr
6: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
7: phosphorus tribromide / chloroform / Reflux
View Scheme
Multi-step reaction with 7 steps
1: potassium iodide; sodium hydroxide / dimethyl sulfoxide / 50 - 80 °C
2: toluene-4-sulfonic acid / Reflux; Large scale
3: polyphosphoric acid / toluene / 105 - 110 °C
4: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr
5: sodium hydroxide; water / methanol / 25 - 60 °C
6: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
7: phosphorus tribromide / chloroform / Reflux
View Scheme
4-((2,2-dimethoxy)ethoxy)phenylacetic acid

4-((2,2-dimethoxy)ethoxy)phenylacetic acid

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: toluene-4-sulfonic acid / Reflux; Large scale
2: polyphosphoric acid / toluene / 105 - 110 °C
3: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr
4: sodium hydroxide; water / methanol / 25 - 60 °C
5: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
6: phosphorus tribromide / chloroform / Reflux
View Scheme
Multi-step reaction with 6 steps
1: toluene-4-sulfonic acid / Reflux; Large scale
2: polyphosphoric acid / toluene / 105 - 110 °C
3: sodium hydroxide; water / methanol / 25 - 30 °C
4: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr
5: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
6: phosphorus tribromide / chloroform / Reflux
View Scheme
methyl 4-((2,2-dimethoxy)ethoxy)phenylacetate

methyl 4-((2,2-dimethoxy)ethoxy)phenylacetate

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: polyphosphoric acid / toluene / 105 - 110 °C
2: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr
3: sodium hydroxide; water / methanol / 25 - 60 °C
4: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
5: phosphorus tribromide / chloroform / Reflux
View Scheme
Multi-step reaction with 5 steps
1: polyphosphoric acid / toluene / 105 - 110 °C
2: sodium hydroxide; water / methanol / 25 - 30 °C
3: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr
4: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
5: phosphorus tribromide / chloroform / Reflux
View Scheme
methyl 2-(benzofuran-5-yl)acetate
121638-36-6

methyl 2-(benzofuran-5-yl)acetate

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide; water / methanol / 25 - 30 °C
2: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr
3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
4: phosphorus tribromide / chloroform / Reflux
View Scheme
Multi-step reaction with 4 steps
1: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 65 - 70 °C / 3040.2 - 3800.26 Torr
2: sodium hydroxide; water / methanol / 25 - 60 °C
3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
4: phosphorus tribromide / chloroform / Reflux
View Scheme
benzofuran-5-yl-acetic acid
142935-60-2

benzofuran-5-yl-acetic acid

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; hydrogen / methanol; water / 60 - 65 °C / 6080.41 - 7600.51 Torr
2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
3: phosphorus tribromide / chloroform / Reflux
View Scheme
methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate
155852-41-8

methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; water / methanol / 25 - 60 °C
2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 10 °C / Reflux
3: phosphorus tribromide / chloroform / Reflux
View Scheme
styrene
292638-84-7

styrene

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

1-benzyl-4-iodo-5-methylpyridin-2(1H)-one

1-benzyl-4-iodo-5-methylpyridin-2(1H)-one

(E)-1-benzyl-3-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-5-methyl-4-styrylpyridin-2(1H)-one

(E)-1-benzyl-3-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-5-methyl-4-styrylpyridin-2(1H)-one

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate In 1,4-dioxane at 105℃; for 36h; Inert atmosphere;96%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

bromobenzene
108-86-1

bromobenzene

5-(1-phenylethyl)-2,3-dihydrobenzofuran

5-(1-phenylethyl)-2,3-dihydrobenzofuran

Conditions
ConditionsYield
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction;95%
With nickel(II) bromide dimethoxyethane; [Ir(dF(CF3)ppy)2(phen)]PF6; Bathocuproine; diisopropylamine; magnesium bromide In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; Glovebox; Sealed tube; Irradiation; regioselective reaction;87%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In water; toluene at 100℃; for 15.25h;
Stage #2: With hydrogen bromide In water; toluene Product distribution / selectivity;
93.2%
Stage #1: (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In 2-methyltetrahydrofuran; water at 60 - 70℃;
Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In 2-methyltetrahydrofuran; water for 16h; Heating / reflux;
Stage #3: With hydrogen bromide In 2-methyltetrahydrofuran; water at 0 - 20℃; for 2h; Product distribution / selectivity;
90.67%
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium hydroxide; triethylmethylammonium chloride In water; butanone at 75℃; for 6h;
Stage #2: With hydrogen bromide In water; butanone at 0 - 5℃; for 2h; Product distribution / selectivity;
84.92%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

4-Bromodiphenyl ether
101-55-3

4-Bromodiphenyl ether

C22H20O2

C22H20O2

Conditions
ConditionsYield
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction;90%
5-bromo-1H-indole
10075-50-0

5-bromo-1H-indole

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

C18H17NO

C18H17NO

Conditions
ConditionsYield
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction;90%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

3-(S)-(+)-(1-cyano-1,1-diphenylmethyl)pyrrolidine hydrobromide

3-(S)-(+)-(1-cyano-1,1-diphenylmethyl)pyrrolidine hydrobromide

(-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide

(-)-3S-(1-carbonitrile-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide

Conditions
ConditionsYield
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 3-(S)-(+)-(1-cyano-1,1-diphenylmethyl)pyrrolidine hydrobromide With potassium carbonate In water at 75℃; for 4h;
Stage #2: With hydrogen bromide In water
89.93%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
25015-63-8

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

2-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
Stage #1: 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane With bis(cyclopentadienyl)titanium dichloride; lithium methanolate In tert-butyl methyl ether for 0.5h;
Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In tert-butyl methyl ether at 60℃; under 760.051 Torr; for 24h; Inert atmosphere;
89%
Stage #1: 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane With bis(cyclopentadienyl)titanium dichloride; lithium methanolate In tert-butyl methyl ether for 0.5h; Inert atmosphere; Glovebox;
Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In tert-butyl methyl ether at 60℃; for 24h; Sealed tube;
89%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

(2-bromo-2-fluoroethyl)benzene
151588-78-2

(2-bromo-2-fluoroethyl)benzene

C18H19FO

C18H19FO

Conditions
ConditionsYield
With nickel(II) bromide dimethoxyethane; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2,6-bis(4,5-dihydro-1H-imidazol-2-yl)pyridine; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;88%
glutaric anhydride,
108-55-4

glutaric anhydride,

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

C14H18O3

C14H18O3

Conditions
ConditionsYield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0); zinc In N,N-dimethyl acetamide at 80℃; for 12h;87%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
134002-25-8

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium hydroxide; triethylmethylammonium chloride In water; butanone at 75℃; for 6h; Heating / reflux;
Stage #2: With hydrogen bromide In water; butanone
84.92%
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide With potassium carbonate In acetonitrile at 70 - 75℃; for 2h;
Stage #2: With hydrogen bromide In water; acetone at 0 - 25℃; Product distribution / selectivity;
With potassium carbonate In acetonitrile
succinic acid anhydride
108-30-5

succinic acid anhydride

2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

5-(2,3-dihydro-benzofuran-5-yl)-valeric acid

5-(2,3-dihydro-benzofuran-5-yl)-valeric acid

Conditions
ConditionsYield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0); zinc In N,N-dimethyl acetamide at 80℃; for 12h;82%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

3-methyl-2,3,4,6-tetrahydro-1H-benzo[c][2,7]naphthyridin-5-one

3-methyl-2,3,4,6-tetrahydro-1H-benzo[c][2,7]naphthyridin-5-one

C23H24N2O2

C23H24N2O2

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;75%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

1-bromo-3,4,5-trimethoxybenzene
2675-79-8

1-bromo-3,4,5-trimethoxybenzene

A

C19H22O4

C19H22O4

B

C19H22O4

C19H22O4

Conditions
ConditionsYield
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction;A 75%
B n/a
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

Cyclopentyl bromide
137-43-9

Cyclopentyl bromide

C15H19BrO

C15H19BrO

Conditions
ConditionsYield
With nickel(II) iodide; C17H20N2O2; lithium bromide; zinc In 1-methyl-pyrrolidin-2-one at 30℃; for 24h; regioselective reaction;75%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

N-(4-bromophenyl)benzamide
7702-38-7

N-(4-bromophenyl)benzamide

C23H21NO2

C23H21NO2

Conditions
ConditionsYield
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction;73%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

fenofibrate
49562-28-9

fenofibrate

isopropyl2-(4-(4-(1-(2,3-dihydrobenzofuran-5-yl)ethyl)benzoyl)phenoxy)-2-methylpropanoate

isopropyl2-(4-(4-(1-(2,3-dihydrobenzofuran-5-yl)ethyl)benzoyl)phenoxy)-2-methylpropanoate

Conditions
ConditionsYield
With 2.9-dimethyl-1,10-phenanthroline; nickel(II) perchlorate hexahydrate; tetrabutylammomium bromide In N,N-dimethyl acetamide at 20℃; for 10h; Glovebox; Sealed tube; Electrochemical reaction; Inert atmosphere; regioselective reaction;72%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

5-bromo-2-(4-morpholinyl)pyridine
200064-11-5

5-bromo-2-(4-morpholinyl)pyridine

C19H22N2O2

C19H22N2O2

Conditions
ConditionsYield
With nickel(II) iodide; Bathocuproine; tetrabutylammomium bromide; zinc at 20℃; regioselective reaction;69%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

ethyl 4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylate
1423014-09-8

ethyl 4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylate

ethyl 1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrochloride

ethyl 1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrochloride

Conditions
ConditionsYield
Stage #1: 2,3-dihydro-5-(2-bromoethyl)benzofuran; ethyl 4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylate With potassium carbonate; potassium iodide In acetonitrile Reflux; Inert atmosphere;
Stage #2: With hydrogenchloride In diethyl ether; water Inert atmosphere;
52%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

(3S)-pyrrolidin-3-yl-cyclopentyl(hydroxy)phenyl acetate
719278-77-0

(3S)-pyrrolidin-3-yl-cyclopentyl(hydroxy)phenyl acetate

(3S)-1-[[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrolidin-3-yl]cyclopentyl(hydroxy)phenyl acetate

(3S)-1-[[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrolidin-3-yl]cyclopentyl(hydroxy)phenyl acetate

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 8h; Heating / reflux;50%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

(3S)-pyrrolidin-3-yl-(2R)-cyclopentyl(hydroxy)phenyl acetate

(3S)-pyrrolidin-3-yl-(2R)-cyclopentyl(hydroxy)phenyl acetate

(3S)-1-[[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrolidin-3-yl](2R)-cyclopentyl(hydroxy)phenyl acetate

(3S)-1-[[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrolidin-3-yl](2R)-cyclopentyl(hydroxy)phenyl acetate

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 8h; Heating / reflux;46%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

C19H22N2O
910108-52-0

C19H22N2O

2-{(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]piperidin-3-yl}-2,2-diphenylacetamide

2-{(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]piperidin-3-yl}-2,2-diphenylacetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Heating / reflux;45%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

5-methoxylindole
1006-94-6

5-methoxylindole

C19H19NO2

C19H19NO2

Conditions
ConditionsYield
With norborn-2-ene; palladium diacetate; potassium carbonate at 80℃; for 18h; Inert atmosphere;28%
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
134002-25-8

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

darifenacin
133099-04-4

darifenacin

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 2h; Heating / reflux;9%
With potassium phosphate In water; toluene at 20 - 90℃; for 3.5h; Product distribution / selectivity;
With potassium carbonate In water; toluene at 20 - 90℃; for 3.5h; Product distribution / selectivity;
With potassium phosphate In cyclohexane; water at 20 - 90℃; for 3.5h; Product distribution / selectivity;
With potassium hydroxide In acetonitrile at 40 - 50℃; for 18h; Product distribution / selectivity;
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

(S)-darifenacin hydrobromide
133099-07-7

(S)-darifenacin hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
2: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile
2: ammonia / methanol / 5 - 7 h / 28 - 45 °C
3: hydrogen bromide / water; acetone / 2.25 - 12 h / 0 - 30 °C
View Scheme
2,3-dihydro-5-(2-bromoethyl)benzofuran
127264-14-6

2,3-dihydro-5-(2-bromoethyl)benzofuran

C21H26N2O

C21H26N2O

2-{(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]piperidin-3-yl}-N,N-dimethyl-2,2-diphenylacetamide

2-{(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]piperidin-3-yl}-N,N-dimethyl-2,2-diphenylacetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Heating / reflux;

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