Diethyl dipropylmalonate supplier

Name
Diethyl dipropylmalonate
EINECS 227-998-2
CAS No. 6065-63-0
Article Data13
CAS DataBase
Density 0.976 g/cm³
Solubility
Hazard Symbols UN NO.
Synonyms Malonicacid, dipropyl-, diethyl ester (7CI,8CI); Propanedioic acid, dipropyl-, diethylester (9CI); Diethyl 2,2-dipropylmalonate; Diethyl dipropylmalonate; NSC 163902
PSA 52.60000
LogP 2.69920

Synthetic route

: 3195-24-2
diallylmalonic acid diethyl ester

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

Conditions

Conditions	Yield
With 6C53H32O8(4-)13Zr(4+)18O(2-)8Co(2+)8H(1-); hydrogen In tetrahydrofuran at 23℃; under 30003 Torr; for 36h; Catalytic behavior; Mechanism; Reagent/catalyst;	100%
With sodium tetrahydroborate; ruthenium trichloride In tetrahydrofuran; water at 20℃; for 1h;	93%
With 6C53H32O8(4-)13Zr(4+)18O(2-)8Co(2+)8Cl(1-); hydrogen; sodium triethylborohydride In tetrahydrofuran at 23℃; under 30402 Torr; for 36h; Catalytic behavior; Time; Glovebox; Inert atmosphere;	100 %Spectr.
With fac-[Mn(1,2-bis(di-isopropylphosphino)ethane)(CO)3(CH2CH2CH3)]; hydrogen In diethyl ether at 25℃; under 37503.8 Torr; for 18h;	75 %Chromat.
With hydrogen In water at 60℃; under 22502.3 Torr; for 18h; Autoclave; Green chemistry;

: 1439866-82-6
diethyl 2-(3-iodopropyl)-2-propylmalonate

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

Conditions

Conditions	Yield
With [Ir(2-phenylpyridine)-2-(4,4’-di-tert-butyl-2,2’-bipyridine)]PF6; N-ethyl-N,N-diisopropylamine In acetonitrile at 25℃; for 5h; Irradiation;	88%

: 106-94-5
propyl bromide

: 2163-48-6
diethyl propylmalonate

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 10h; Heating;	83%

: 107-08-4
1-iodo-propane

: 2163-48-6
diethyl propylmalonate

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

Conditions

Conditions	Yield
With caesium carbonate In butanone at 70℃; for 15h;	70%

: 106-94-5
propyl bromide

: 105-53-3
diethyl malonate

A: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

B: 616-62-6
n-propylmalonic acid

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride for 16h;	A 48% B 41%

...Expand

: 107-08-4
1-iodo-propane

: 105-53-3
diethyl malonate

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

Conditions

Conditions	Yield
With zinc

: 107-08-4
1-iodo-propane

: 105-53-3
diethyl malonate

A: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

B: 2163-48-6
diethyl propylmalonate

Conditions

Conditions	Yield
With zinc

...Expand

: 107-08-4
1-iodo-propane

: 105-53-3
diethyl malonate

A: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

B: 2163-48-6
diethyl propylmalonate

...Expand

: 105-53-3
diethyl malonate

6-ethoxy-4-cyano-5-methyl-hex-2ξ-enoic acid ethyl ester: 6-ethoxy-4-cyano-5-methyl-hex-2ξ-enoic acid ethyl ester

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 93 percent / NaOEt / ethanol / 7 h / Heating 2: 83 percent / NaOEt / ethanol / 10 h / Heating View Scheme

: 101268-55-7
4,4-bis(ethoxycarbonyl)-1-hepten-6-yne

A: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

B: 1114376-78-1
diethyl cis-3,4-dimethylcyclopentane-1,1-dicarboxylate

: diethyl (3R,4R)-3,4-dimethylcyclopentane-1,1-dicarboxylate

Conditions

Conditions	Yield
With (IPr2,6-(2,6-iPr2C6H3N=CMe)2C5H3N)Fe(N2)2; hydrogen In benzene at 23℃; under 3040.2 Torr; for 3h; Inert atmosphere; optical yield given as %de;	A 25.9 %Chromat. B n/a C n/a

...Expand

: 2163-48-6
diethyl propylmalonate

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydride; hydrogen / mineral oil; tetrahydrofuran / 12 h / 0 - 20 °C 2: [Ir(2-phenylpyridine)-2-(4,4’-di-tert-butyl-2,2’-bipyridine)]PF6; N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 25 °C / Irradiation View Scheme

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 17356-08-0
thiourea

: 99167-62-1
5,5-di-n-propyl-2-thiobarbituric acid

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 50℃; for 12h;	96%
With sodium ethanolate
With ethanol; sodium ethanolate at 100℃;

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 24765-54-6
2,2-di-n-propyl-1,3-propanediol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h;	92%
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride In diethyl ether

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 57-13-6
urea

: 2217-08-5
5,5-dipropylbarbituric acid

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 12h; Heating;	23%
With sodium ethanolate at 100℃; im geschlossenen Gefaess;
With sodium ethanolate at 100℃; im geschlossenen Gefaess;

: 917-64-6
methyl magnesium iodide

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 99-66-1
valproic acid

Conditions

Conditions	Yield
und durch Behandeln des Reaktionprodukts mit Barytwasser, neben Aceton;

: 917-64-6
methyl magnesium iodide

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

A: 99-66-1
valproic acid

B: 67-64-1
acetone

Conditions

Conditions	Yield
Verseifung des Reaktionsproduktes;

...Expand

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 1670-14-0
benzamidine monohydrochloride

: 2-phenyl-5,5-dipropyl-1H-pyrimidine-4,6-dione

Conditions

Conditions	Yield
With sodium ethanolate at 70℃;

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: methylmagnesium iodide

A: 99-66-1
valproic acid

B: 67-64-1
acetone

Conditions

Conditions	Yield
Verseifung des Reaktionsprodukts;

...Expand

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 59-88-1
phenylhydrazine hydrochloride

: 1-phenyl-4,4-dipropyl-pyrazolidine-3,5-dione

Conditions

Conditions	Yield
With ethanol; sodium ethanolate at 160℃;

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 342618-11-5
4,4-dipropyl-pyrazolidine-3,5-dione

Conditions

Conditions	Yield
With hydrazine hydrochloride; sodium ethanolate
With sodium ethanolate; hydrazine hydrate

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 258264-00-5
monoethyl α,α-dipropylmalonate

Conditions

Conditions	Yield
With potassium hydroxide Kaliumsalz entsteht;
With ethanol; sodium hydroxide at 20℃; for 12h;

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 95-54-5
1,2-diamino-benzene

: 3,3-dipropyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

Conditions

Conditions	Yield
With sodium ethanolate

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 99-66-1
valproic acid

Conditions

Conditions	Yield
(i) aq. KOH, (ii) (decarboxylation); Multistep reaction;

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 90728-92-0
dimethyl 2,2-propylmalonamide

Conditions

Conditions	Yield
With sodium methylate; formamide In methanol Heating;

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 141-52-6
sodium ethanolate

hydrazine hydrochloride: hydrazine hydrochloride

: 342618-11-5
4,4-dipropyl-pyrazolidine-3,5-dione

Conditions

Conditions	Yield
at 100 - 110℃;

...Expand

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

ZnCl2: ZnCl2

A: 74-85-1
ethene

B: 17022-31-0
ethyl 2-propylpentanoate

...Expand

: 60-29-7
diethyl ether

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

potassium: potassium

A: 17022-31-0
ethyl 2-propylpentanoate

B: 258264-00-5
monoethyl α,α-dipropylmalonate

C CO: CO

...Expand

: 60-29-7
diethyl ether

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

sodium: sodium

A: 17022-31-0
ethyl 2-propylpentanoate

B: 258264-00-5
monoethyl α,α-dipropylmalonate

C CO: CO

...Expand

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 100-63-0
phenylhydrazine

A: dipropyl-malonic acid mono-(N'-phenyl-hydrazide)

B 1-phenyl-3.5-dioxo-4.4-dipropyl-pyrazolidine: 1-phenyl-3.5-dioxo-4.4-dipropyl-pyrazolidine

Conditions

Conditions	Yield
With sodium ethanolate

...Expand

: 6065-63-0
2,2-dipropyl-malonic acid diethyl ester

: 101082-35-3
1-<2-Diaethylamino-aethoxy>-2,2-dipropyl-propanol-(3)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether 2: (i) Na, benzene, (ii) /BRN= 605300/ View Scheme

Diethyl dipropylmalonate Chemical Properties

Molecular Structure:

Molecular Formula: C1₃H₂₄O₄
Molecular Weight: 244.3273
IUPAC Name: Diethyl 2,2-dipropylpropanedioate
Synonyms of Propanedioic acid,2,2-dipropyl-, 1,3-diethyl ester (CAS NO.6065-63-0): EINECS 227-998-2 ; Diethyl dipropylmalonate
CAS NO: 6065-63-0
Classification Code: Pharmaceutical Intermediates ; TheMalonateRamificationProducts
Index of Refraction: 1.438
Molar Refractivity: 65.79 cm³
Molar Volume: 250.1 cm³
Surface Tension: 31.7 dyne/cm
ensity: 0.976 g/cm³
Flash Point: 113.7 °C
Enthalpy of Vaporization: 50.07 kJ/mol
Boiling Point: 262.9 °C at 760 mmHg
Vapour Pressure: 0.0106 mmHg at 25°C

Diethyl dipropylmalonate Uses

Propanedioic acid,2,2-dipropyl-, 1,3-diethyl ester (CAS NO.6065-63-0) is used as a raw material for medicine and pesticide intermediates.

Diethyl dipropylmalonate Safety Profile

Safety Statements of Propanedioic acid,2,2-dipropyl-, 1,3-diethyl ester (CAS NO.6065-63-0): 24/25
S24/25: Avoid contact with skin and eyes.

Product Name

Diethyl dipropylmalonate

Synthetic route

Diethyl dipropylmalonate Chemical Properties

Diethyl dipropylmalonate Uses

Diethyl dipropylmalonate Safety Profile

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