Diethyl sulfoxide supplier

Name
DIETHYL SULFOXIDE
EINECS
CAS No. 70-29-1
Article Data56
CAS DataBase
Density 1.02g/cm³
Solubility
Melting Point 14°C
Formula C4H10 O S
Boiling Point 212°C at 760 mmHg
Molecular Weight 106.189
Flash Point 82°C
Transport Information
Appearance
Safety Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by intravenous route. When heated to decomposition it emits toxic fumes of SO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Ethylsulfoxide (6CI,8CI); 1,1'-Sulfinylbis(ethane); Diethyl sulfoxide; Diethylsulphoxide; NSC 139125
PSA 36.28000
LogP 1.64060

Synthetic route

: 352-93-2
diethyl sulphide

: 70-29-1
diethyl sulphide

Conditions

Conditions	Yield
With oxygen; isobutyraldehyde; tris(1,3-bis(p-methoxyphenyl)-1,3-propanedionato)nickel(II) In acetonitrile at 60℃; for 21h;	100%
With lithium perchlorate; Re(O)(2-(2'-hydroxyphenyl)-2-oxazoline)2Cl In [D3]acetonitrile; water-d2 at 20℃; for 4h;	100%
With dihydrogen peroxide In water; acetonitrile at 24.84℃; for 1.66667h;	100%

: 352-93-2
diethyl sulphide

: 600-18-0
2-Oxobutyric acid

A: 70-29-1
diethyl sulphide

B: 124-38-9
carbon dioxide

C: 802294-64-0
propionic acid

Conditions

Conditions	Yield
With oxygen; methylene blue In pyridine; acetonitrile for 2h; Irradiation;	A 100% B n/a C 52%

...Expand

: 352-93-2
diethyl sulphide

: 218794-58-2
benzophenone oxide O-<1-hydroperoxy-3,3-(dimethoxycarbonyl)-1-phenyl-2-propenyl> ether

A: 70-29-1
diethyl sulphide

B: 574-66-3
Benzophenone oxime

C: 64677-34-5
methyl 2-carbomethoxy-4-methylphenyl-4-oxo-2-butenoate

Conditions

Conditions	Yield
In tetrachloromethane for 0.5h; Product distribution;	A n/a B 98% C 97%

...Expand

: 352-93-2
diethyl sulphide

: 1821-02-9
2-oxopentanoic acid

A: 70-29-1
diethyl sulphide

B: 124-38-9
carbon dioxide

C: 107-92-6
butyric acid

Conditions

Conditions	Yield
With oxygen; methylene blue In pyridine; acetonitrile for 2h; Irradiation;	A 92% B n/a C 19%

...Expand

: 352-93-2
diethyl sulphide

: 611-73-4
Benzoylformic acid

A: 70-29-1
diethyl sulphide

B: 597-35-3
diethylsulfone

C: 124-38-9
carbon dioxide

D: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With oxygen; 5,15,10,20-tetraphenylporphyrin In benzene for 2h; Irradiation;	A 88% B 10% C n/a D 38%
With oxygen; 5,15,10,20-tetraphenylporphyrin In benzene for 2h; Mechanism; Irradiation; other solvents and sensitizer;	A 88% B 10% C n/a D 38%

...Expand

: 352-93-2
diethyl sulphide

: 127-17-3
2-oxo-propionic acid

A: 70-29-1
diethyl sulphide

B: 597-35-3
diethylsulfone

C: 124-38-9
carbon dioxide

D: 64-19-7
acetic acid

Conditions

Conditions	Yield
With oxygen; methylene blue In pyridine; acetonitrile for 2h; Irradiation;	A 65% B 3% C n/a D 64%

...Expand

: 925-90-6
ethylmagnesium bromide

: 499140-11-3
benzyl (2S,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxylate

A: 70-29-1
diethyl sulphide

B: (1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-ethanesulfinate

Conditions

Conditions	Yield
In dichloromethane at -78℃;	A n/a B 46%

...Expand

: 925-90-6
ethylmagnesium bromide

: 499140-12-4
benzyl (2R,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxilate

A: 70-29-1
diethyl sulphide

B: (1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-ethanesulfinate

Conditions

Conditions	Yield
In dichloromethane at -78℃;	A n/a B 46%

...Expand

: 60-29-7
diethyl ether

: 625-01-4
ethyl chlorosulfate

: 925-90-6
ethylmagnesium bromide

A: 352-93-2
diethyl sulphide

B: 70-29-1
diethyl sulphide

...Expand

: 60-29-7
diethyl ether

: 625-01-4
ethyl chlorosulfate

: ethylmagnesium bromide

A: 352-93-2
diethyl sulphide

B: 70-29-1
diethyl sulphide

...Expand

: 625-01-4
ethyl chlorosulfate

: 925-90-6
ethylmagnesium bromide

A: 352-93-2
diethyl sulphide

B: 70-29-1
diethyl sulphide

Conditions

Conditions	Yield
With diethyl ether Zersetzen mit Wasser und Essigsaeure;

...Expand

: 110-00-9
furan

: 925-90-6
ethylmagnesium bromide

: 112921-53-6
ethyl (2-bromo)phenyl sulfoxide

A: 573-57-9
1,4-dihydronaphthalene-1,4-epoxide

B: 70-29-1
diethyl sulphide

Conditions

Conditions	Yield
1.) THF, 60 deg C, 11 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 352-93-2
diethyl sulphide

: 86428-23-1, 78377-89-6
3-(4-nitrophenyl)-2-(phenylsulfonyl)-1,2-oxaziridine

: 70-29-1
diethyl sulphide

Conditions

Conditions	Yield
In chloroform-d1 Kinetics; Competition Oxidation Rate;

: 352-93-2
diethyl sulphide

: 70284-20-7
potassium N-bromo-p-toluenesulfonamide

A: 70-29-1
diethyl sulphide

B: 13553-69-0
S,S-Diethyl-N-p-tolylsulfonylsulfilimin

C: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
With Britton-Robinson buffer In methanol; water at 20℃; Rate constant; Mechanism; Product distribution; NaOH, pH = 12.70; also in unbuffered solution;

...Expand

: 352-93-2
diethyl sulphide

A: 70-29-1
diethyl sulphide

B: 597-35-3
diethylsulfone

Conditions

Conditions	Yield
With oxygen; 5,10,15,20-tetrakisphenylporphyrin In tetrahydrofuran at -39℃; for 1.08333h; Product distribution; Irradiation; photositised oxygenation of further cyclic and acyclic sulfides;
With oxygen; rose bengal In acetone at 23 - 24℃; Kinetics; Rate constant; Irradiation; other solvents, other temperature;
With molecular sieve; dihydrogen peroxide In acetone for 90h; Product distribution; Heating; other thioethers; var. reaction times and temp.;

: 3839-88-1, 57083-05-3, 57083-06-4
di-p-tolylsulfur diimide

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; further catalysts; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 3839-89-2, 66085-13-0, 66085-14-1, 66085-15-2
diphenylsulfur diimide

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 62-53-3
aniline

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 2648-43-3, 57083-07-5, 57155-78-9
bis(p-chlorophenyl)sulfur diimide

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 3839-86-9
N,N'-dip-bromophenylsulfodiimide

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 106-40-1
4-bromo-aniline

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 15148-19-3
1,3-bis(p-nitrophenyl)-2-thia-1,3-diazaallene

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 100-01-6
4-nitro-aniline

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 17426-08-3
N,N'-bis-(3-nitro-phenyl)-sulfur diimide

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 99-09-2
3-nitro-aniline

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 23721-53-1
4,4'-(λ4-sulfanediylidenediamino)-bis-benzoic acid diethyl ester

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 94-09-7
p-aminoethylbenzoate

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 19349-01-0
N,N'-di-m-tolyl-sulfur diimide

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 108-44-1
1-amino-3-methylbenzene

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 70-29-1
diethyl sulfoxide radical cation

: 70-29-1
diethyl sulphide

Conditions

Conditions	Yield
With hydrogenchloride In water at 18℃; Equilibrium constant; Irradiation;

: C12H8Cl2N2S

A: 60-29-7
diethyl ether

B: 70-29-1
diethyl sulphide

C: 108-42-9
3-chloro-aniline

Conditions

Conditions	Yield
With ethanol; copper dichloride at 22℃; Rate constant; pseudo-first-order rate constants for ethanolysis reactions;

...Expand

: 59624-45-2
3-acetyl-2-methoxy-5-phenylfuran

A: 70-29-1
diethyl sulphide

B: 75519-88-9
methyl (Z)-2-acetyl-3-benzoylacrylate

Conditions

Conditions	Yield
With methanol; diethyl sulphide; oxygen; methylene blue 1.) irradiation, 2.) CCl4, 10 min; Yield given. Multistep reaction;

: 352-93-2
diethyl sulphide

A: 70-29-1
diethyl sulphide

B: 6237-61-2
(E)-2-benzoylbut-2-enedioic acid dimethyl ester

Conditions

Conditions	Yield
With methanol; oxygen; methylene blue; methyl 2-methoxy-5-phenyl-furan-4-carboxylate 1.) irradiation, 2.) MeOH, 15 min; Yield given. Multistep reaction;

: 115852-13-6
methyl 2-methoxy-5-phenyl-furan-3-carboxylate

A: 70-29-1
diethyl sulphide

B: 64677-34-5
methyl 2-carbomethoxy-4-methylphenyl-4-oxo-2-butenoate

Conditions

Conditions	Yield
With methanol; diethyl sulphide; oxygen; methylene blue 1.) irradiation, 2.) methanol, 30 min; Yield given. Multistep reaction;

: dihydrogen hexachloroplatinate(IV) hexahydrate

: 70-29-1
diethyl sulphide

: tetraethylammonium chloride

: tetraethylammonium diethylsulfoxidopentachloroplatinate

Conditions

Conditions	Yield
In acetonitrile	93%

...Expand

: 70-29-1
diethyl sulphide

: 352-93-2
diethyl sulphide

Conditions

Conditions	Yield
With 1,4-dibromo-butane; zinc at 80℃; for 0.5h;	90%
With hexamethyldisilathiane In dichloromethane at 60℃; for 6h;	87%
durch Penicillium brevicaule;
With sodium hydroxide; chloroform; tetrabutyl-ammonium chloride In chloroform at 25℃; Mechanism; var. times;
With triethylsilane; dihydrogen hexachloroplatinate at 150℃; for 40h; Product distribution; Ni catalysts, oth. reagent;

: 70-29-1
diethyl sulphide

: 597-35-3
diethylsulfone

Conditions

Conditions	Yield
With potassium superoxide; 2-Nitrobenzenesulfonyl chloride In acetonitrile at -30℃; for 5h;	89%
With dipotassium peroxodisulfate In water at 60℃; Kinetics; Thermodynamic data; Mechanism; further temperature; ΔE(excit), ΔS(excit); effect of oxygen and concentration on the rate;
bei der Oxydation;
With chloroform; ozone at 0℃;
With tetrachloromethane; ozone

: dihydrogen hexachloroplatinate(IV) hexahydrate

: 70-29-1
diethyl sulphide

: 896-33-3
ethyltriphenylphosphonium chloride

: triphenylethylphosphonium diethylsulfoxidopentachloroplatinate

Conditions

Conditions	Yield
In acetonitrile	86%

...Expand

: 10025-99-7
potassium tetrachloroplatinate(II)

: 70-29-1
diethyl sulphide

: 1044254-31-0, 72557-00-7
[Pt(diethyl sulphoxide)I2]2

Conditions

Conditions	Yield
With potassium iodide In water treatment of K2PtCl4 with KI for 5 min, addn. of 1 equiv. sulfoxide (pptn.); filtration (after 30 min), washing (water), drying (vac., over CaCl2), dissoln. in CHCl3, filtration, evapn., washing (hexane), drying in air; elem. anal.;	85%

: potassium hexabromoplatinate(IV)

: 16894-69-2, 21450-52-2
tetraphenylstibonium bromide

: 70-29-1
diethyl sulphide

: 2C28H30OSSb(1+)*Br6Pt(2-)

Conditions

Conditions	Yield
Stage #1: potassium hexabromoplatinate(IV); tetraphenylstibonium bromide In water Stage #2: diethyl sulphide	84%

...Expand

: 54762-43-5
bis(ruthenium(2,3,7,8,12,13,17,18-octaethylporphyrin))

: 70-29-1
diethyl sulphide

: 164535-53-9
bis(diethyl sulfoxide)(octaethylporphyrinato)ruthenium(II)

Conditions

Conditions	Yield
In dichloromethane N2 atmosphere; addn. of Et2SO soln. to Ru-complex; hexane addn., partial solvent removal, filtration, vol. reduction (pptn.), filtration off, drrying (vac., 70°C, overnight); elem. anal.;	80%

: 70-29-1
diethyl sulphide

: 3376-24-7
N-tert-butyl-α-phenylnitrone

: N-tert-butyl-N-(1-phenyl-2-methyl-2-ethylsulfinyl) ethyl hydroxylamine

Conditions

Conditions	Yield
Stage #1: diethyl sulphide With n-butyllithium In tetrahydrofuran Stage #2: N-tert-butyl-α-phenylnitrone In tetrahydrofuran at -78℃; for 2h;	76%

: 930-87-0
1,2,5-trimethyl-1H-pyrrole

: 70-29-1
diethyl sulphide

: Diethyl-(1,2,5-trimethyl-1H-pyrrol-3-yl)-sulfonium; chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane In acetonitrile Ambient temperature;	72%

: 70-29-1
diethyl sulphide

: 442155-91-1
4-methyl-N-{2-(phenylethynyl)phenyl}benzenesulfonamide

: 3-(ethylthio)-2-phenyl-1-tosyl-1H-indole

Conditions

Conditions	Yield
With thionyl chloride at 0 - 70℃; for 10h;	72%

: 3042-22-6
2-phenyl-1H-pyrrole

: 70-29-1
diethyl sulphide

: Diethyl-(5-phenyl-1H-pyrrol-2-yl)-sulfonium; chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane In acetonitrile Ambient temperature;	71%

: di-μ-chloro-dichlorobis(diethyl sulfoxide)diplatinum

: 70-29-1
diethyl sulphide

: 66767-30-4
trans-dichlorobis(diethyl sulfoxide)platinum(II)

Conditions

Conditions	Yield
In dichloromethane to a soln. of (Pt2(Et2SO)2Cl4) in CH2Cl2 was added Et2SO in CH2Cl2 withstirring; the mixt. was cooled in ice and diethyl ether was added, solid was filtered off, washed with diethyl ether, air-dried; elem. anal.;	70%

: 70-29-1
diethyl sulphide

: 70730-92-6
5-chloro-6H-anthra[1,9-cd]isoxazol-6-one

A: 1192657-31-0
N-(4-chloro-9,10-dioxo-9,10-dihydroanthracen-1-yl)-S,S-diethylsulfoximide

B: 2872-47-1
1-amino-4-chloroanthraquinone

Conditions

Conditions	Yield
In sulfolane at 130℃; for 2h;	A 70% B n/a

...Expand

: 96-54-8
N-Methylpyrrole

: 70-29-1
diethyl sulphide

: Diethyl-(1-methyl-1H-pyrrol-2-yl)-sulfonium; chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane In acetonitrile Ambient temperature;	68%

: 70-29-1
diethyl sulphide

: 10035-10-6, 12258-64-9
hydrogen bromide

: 7440-06-4
platinum

: 19525-76-9
trans-tetrabromobis(diethyl sulfide) platinum(IV)

Conditions

Conditions	Yield
In further solvent(s) heating of Pt, concd. HBr and diethyl sulfoxide on boiling water bath for 1 h; pptn., cooling, filtration, washing with water, drying in oven at 60°C;	68%

...Expand

: 70-29-1
diethyl sulphide

: 70730-89-1
6H-anthra<1,9-cd>isoxazol-6-one

A: 1192656-58-8
N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)-S,S-diethylsulfoximide

B: 82-45-1
1-amino-9,10-anthracenedione

Conditions

Conditions	Yield
In sulfolane at 130℃; for 3h;	A 67% B n/a

...Expand

: 70-29-1
diethyl sulphide

: 15163-59-4
potassium o-nitrobenzoate

: 3058-46-6
1-ethylsulfanyl-2-nitrobenzene

Conditions

Conditions	Yield
With 1,10-Phenanthroline; zinc trifluoromethanesulfonate; copper(I) bromide at 150℃; for 24h; Molecular sieve;	67%

: 83-24-9
2,5-dimethyl-1-phenyl-1H-pyrrole

: 70-29-1
diethyl sulphide

A: 3-Chloro-2,5-dimethyl-1-phenyl-1H-pyrrole

B: (2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)-diethyl-sulfonium; chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane In acetonitrile Ambient temperature;	A 15% B 66%

...Expand

: 70-29-1
diethyl sulphide

: 72331-68-1
N-tert-butyl-α-tert-butyl nitrone

: 412929-83-0
N-tert-butyl-N-(1-tert-butyl-2-ethylsulfinyl)propylhydroxylamine

Conditions

Conditions	Yield
Stage #1: diethyl sulphide With n-butyllithium In tetrahydrofuran at -20℃; Stage #2: N-tert-butyl-α-tert-butyl nitrone In tetrahydrofuran at -78℃; for 4h;	66%

: 109-97-7
pyrrole

: 70-29-1
diethyl sulphide

: Diethyl-(1H-pyrrol-2-yl)-sulfonium; chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane In acetonitrile Ambient temperature;	65%

: 292638-84-7
styrene

: 70-29-1
diethyl sulphide

: 77970-53-7
2-(ethylsulfonyl)-1-phenylethan-1-one

Conditions

Conditions	Yield
With iron(III) chloride; oxygen; hydrazine hydrate at 40℃; for 36h;	65%

: 70-29-1
diethyl sulphide

: 98-88-4
benzoyl chloride

: 91970-36-4
1-(ethylthio)ethyl benzoate

Conditions

Conditions	Yield
With iron(III) oxide; triethylamine In toluene at 20℃; for 2h; Pummerer Sulfoxide Rearrangement; Inert atmosphere; regioselective reaction;	65%
With triethylamine In toluene at 20℃; for 2h; Inert atmosphere;	65%

Diethyl sulfoxide Chemical Properties

Empirical Formula of Diethyl sulfoxide (CAS NO.70-29-1): C₄H₁₀OS
Molecular Weight: 106.1866
EINECS: 200-732-2
Index of Refraction: 1.477
Density: 1.02 g/cm³
Flash Point: 82 °C
Enthalpy of Vaporization: 43 kJ/mol
Boiling Point: 212 °C at 760 mmHg
Vapour Pressure: 0.258 mmHg at 25 °C
Structure of Diethyl sulfoxide (CAS NO.70-29-1):

IUPAC Name of Diethyl sulfoxide (CAS NO.70-29-1): 1-Ethylsulfinylethane
Canonical SMILES: CCS(=O)CC
InChI: InChI=1S/C4H10OS/c1-3-6(5)4-2/h3-4H2,1-2H3
InChIKey: CCAFPWNGIUBUSD-UHFFFAOYSA-N

Diethyl sulfoxide Toxicity Data With Reference

1.	orl-rat LD50:5650 mg/kg	COREAF Comptes Rendus Hebdomadaires des Seances de l’Academie des Sciences. 260 (1965),327.
2.	ipr-rat LD50:4370 mg/kg	COREAF Comptes Rendus Hebdomadaires des Seances de l’Academie des Sciences. 260 (1965),327.
3.	ivn-rat LD50:4990 mg/kg	COREAF Comptes Rendus Hebdomadaires des Seances de l’Academie des Sciences. 260 (1965),327.
4.	orl-mus LD50:3610 mg/kg	COREAF Comptes Rendus Hebdomadaires des Seances de l’Academie des Sciences. 260 (1965),327.
5.	ipr-mus LD50:2500 mg/kg	IJRBA3 International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 3 (1961),41.
6.	ivn-mus LD50:4370 mg/kg	COREAF Comptes Rendus Hebdomadaires des Seances de l’Academie des Sciences. 260 (1965),327.

Diethyl sulfoxide Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by intravenous route. When heated to decomposition it emits toxic fumes of SO_x.

Diethyl sulfoxide Specification

Diethyl sulfoxide ,its cas register number is 70-29-1. It also can be called Ethyl sulfoxide ; 1,1'-Sulphinylbisethane ; Ethane, 1,1'-sulfinylbis- ; and Ethane, 1,1'-sulfinylbis- .

Product Name

DIETHYL SULFOXIDE

Synthetic route

Diethyl sulfoxide Chemical Properties

Diethyl sulfoxide Toxicity Data With Reference

Diethyl sulfoxide Safety Profile

Diethyl sulfoxide Specification

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