Dimethylphosphine oxide supplier

Name
DIMETHYLPHOSPHINE OXIDE
EINECS 230-591-2
CAS No. 7211-39-4
Article Data19
CAS DataBase
Density
Solubility
Melting Point
Formula C₂H₇OP
Boiling Point 84.5 °C at 760 mmHg
Molecular Weight 78.0507
Flash Point 4.906 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Dimethylphosphine oxide;
PSA 40.54000
LogP 0.80570

Synthetic route

: 75-16-1
methylmagnesium bromide

: 762-04-9
phosphonic acid diethyl ester

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;	88.79%
In tetrahydrofuran; diethyl ether at 0 - 20℃; for 0.5h; Inert atmosphere;	63.66%
In tetrahydrofuran at 0 - 20℃; for 5h;

: 676-58-4
methylmagnesium chloride

: 762-04-9
phosphonic acid diethyl ester

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 0℃; for 4h;	81.39%
In tetrahydrofuran Ambient temperature;	80%
In tetrahydrofuran at 30℃; for 1h; Cooling with ice;	70.8%
In tetrahydrofuran at 20 - 30℃; for 1h; Cooling with ice;	70.8%
(i) THF, (ii) aq. K2CO3; Multistep reaction;

: 74-87-3
methylene chloride

A: 16394-14-2
dimethylphosphinic acid sodium salt

B: 2914-38-7, 20677-21-8, 20677-23-0
methylphosphonic acid disodium salt

C: 7211-39-4
dimethyl phosphine oxide

D: 87930-22-1
methylphosphonous acid sodium salt

Conditions

Conditions	Yield
With sodium hydroxide; phase transfer catalyst; phosphorous Further byproducts given;	A 0.5% B 3.5% C 5% D 72%

...Expand

: 676-58-4
methylmagnesium chloride

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
Stage #1: methylmagnesium chloride With phosphonic acid diethyl ester In tetrahydrofuran at 20 - 30℃; for 1h; Stage #2: With potassium carbonate In tetrahydrofuran; water	70.8%
With phosphonic acid diethyl ester In tetrahydrofuran at 0 - 20℃; for 5h;

: 121-45-9
phosphorous acid trimethyl ester

A: 512-56-1
trimethyl phosphite

B: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With Bromotrichloromethane In neat (no solvent) at 25℃; for 0.5h;	A 4% B 50%

: 77-78-1
dimethyl sulfate

A: 676-96-0
Trimethylphosphine oxide

B: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With phosphorus; potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In 1,4-dioxane at 60 - 62℃;	A 7% B n/a

: 683-84-1
(dimethylamino)dimethylphosphine

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With water

: 20502-88-9
dimethylmethoxyphosphines-d0

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With water at -10℃;

: 35449-60-6
dimethyl methylthiophosphinite

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With water

: 685-93-8
N,N-diethylamino-P,P-dimethylphosphine

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With water

: 53314-20-8
(diisopropylamino)(dimethyl)phosphine

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With sulfuric acid

: 53723-04-9
C10H24O4P2

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With water In benzene

: 811-62-1
chlorodimethylphosphine

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
With methanol
With hydrogenchloride

: 3283-12-3
dimethylphosphinic acid

: 603-35-0
triphenylphosphine

A: 7211-39-4
dimethyl phosphine oxide

B: 791-28-6
Triphenylphosphine oxide

Conditions

Conditions	Yield
In chloroform-d1 for 96h;	A n/a B 23 %Spectr.

...Expand

: 1532-72-5
isoquinoline N-oxide

: 121-45-9
phosphorous acid trimethyl ester

A: 512-56-1
trimethyl phosphite

B: 690-49-3
tetramethyl pyrophosphate

C: 29238-81-1
dimethyl trichloromethylphosphonate

D: 7211-39-4
dimethyl phosphine oxide

E: 78133-52-5
dimethyl isoquinolin-1-ylphosphonate

Conditions

Conditions	Yield
With Bromotrichloromethane In chloroform-d1 at 20℃; for 0.333333h;

...Expand

: 74-83-9
methyl bromide

: 7211-39-4
dimethyl phosphine oxide

Conditions

Conditions	Yield
Stage #1: methyl bromide With magnesium In tetrahydrofuran for 2h; Reflux; Stage #2: With phosphonic acid diethyl ester at 0 - 20℃; for 18h;

: 3430-16-8
5-bromo-3-picoline

: 7211-39-4
dimethyl phosphine oxide

: 3-dimethylphosphoryl-5-methylpyridine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); triethylamine In acetonitrile for 20h; Reflux;	100%

: 12080-32-9
dichloro( 1,5-cyclooctadiene)platinum(ll)

: 7211-39-4
dimethyl phosphine oxide

: dichlorobis[dimethylphosphinous acid]platinum(II)

Conditions

Conditions	Yield
In tetrahydrofuran soln. of Pt complex and ligand (2 equiv.) in THF was stirred under reflufor 22 h; filtered over Celite; concd. (vac.);	99%

: 629-05-0
n-octyne

: 7211-39-4
dimethyl phosphine oxide

: 1278596-93-2
C10H21OP

Conditions

Conditions	Yield
With palladium(II)(diphenylphosphinic acid(-2H)); 1,3-bis-(diphenylphosphino)propane In toluene at 110℃; for 5h; Inert atmosphere; regioselective reaction;	99%

: 2050-77-3
Iododecane

: 7211-39-4
dimethyl phosphine oxide

: 2190-95-6
decyldimethylphosphine oxide

Conditions

Conditions	Yield
Stage #1: dimethyl phosphine oxide With sodium hexamethyldisilazane In tetrahydrofuran at 22℃; for 0.25h; Inert atmosphere; Darkness; Stage #2: Iododecane In tetrahydrofuran at 22℃; for 16h; Inert atmosphere; Darkness; chemoselective reaction;	99%

: 4-iodo-2-(trifluoromethoxy)aniline

: 7211-39-4
dimethyl phosphine oxide

: 4-(dimethylphosphoryl)-2-(trifluoromethoxy)aniline hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-iodo-2-(trifluoromethoxy)aniline; dimethyl phosphine oxide With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 150℃; for 0.333333h; Inert atmosphere; Microwave irradiation; Stage #2: With hydrogenchloride In methanol	98%

: 37366-09-9
dichloro(benzene)ruthenium(II) dimer

: 7211-39-4
dimethyl phosphine oxide

: C8H13Cl2OPRu

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 14h; Inert atmosphere; Schlenk technique;	97%

: 917-92-0
2,2-dimethyl-3-butyne

: 7211-39-4
dimethyl phosphine oxide

: 1278596-94-3
C8H17OP

Conditions

Conditions	Yield
With palladium(II)(diphenylphosphinic acid(-2H)); 1,2-bis-(diphenylphosphino)ethane In toluene at 110℃; for 25h; Inert atmosphere; regioselective reaction;	96%

: 7211-39-4
dimethyl phosphine oxide

: 407-25-0
trifluoroacetic anhydride

(Trifluoracetyl)dimethylphosphinoxid: (Trifluoracetyl)dimethylphosphinoxid

Conditions

Conditions	Yield
for 1h; -196 deg C to RT;	95.7%

: 7211-39-4
dimethyl phosphine oxide

: 58905-19-4
1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

: 1-(4-Chlorphenyl)-1-hydroxy-2-(1,2,4-triazol-1-yl)ethyl-dimethyloxophosphoran

Conditions

Conditions	Yield
at 80 - 100℃;	95%

: 50777-76-9
(2-formylphenyl)(diphenyl)phosphine

: 7211-39-4
dimethyl phosphine oxide

: (dimethyl-phosphinoyl)-(2-diphenylphosphanyl-phenyl)-methanol

Conditions

Conditions	Yield
With ammonia In 1,2-dimethoxyethane Addition;	95%

: 7211-39-4
dimethyl phosphine oxide

: 143-15-7
1-dodecylbromide

: 871-95-4
dodecyl(dimethyl)phosphine oxide

Conditions

Conditions	Yield
Stage #1: dimethyl phosphine oxide With sodium hexamethyldisilazane In tetrahydrofuran at 22℃; for 0.25h; Inert atmosphere; Stage #2: 1-dodecylbromide In tetrahydrofuran at 22℃; for 16h; Inert atmosphere; chemoselective reaction;	93%

: 3-fluoro-5-((7-iodo-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

: 7211-39-4
dimethyl phosphine oxide

: 3-[(7-(dimethyloxophosphine)-1-oxo-indan-4-yl)oxy]-5-fluorobenzonitrile

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 150℃; for 10h; Inert atmosphere;	93%

: 50-00-0
formaldehyd

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 7211-39-4
dimethyl phosphine oxide

: 1260402-40-1
benzyl 4-((dimethylphosphoryl)methyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: formaldehyd; phenylmethyl 1-piperazinecarboxylate With toluene-4-sulfonic acid In tetrahydrofuran at 60℃; for 1h; Stage #2: dimethyl phosphine oxide In tetrahydrofuran at 60℃;	93%

...Expand

: 2473-03-2
1-chloroundecane

: 7211-39-4
dimethyl phosphine oxide

: undecyldimethylphosphine oxide

Conditions

Conditions	Yield
Stage #1: dimethyl phosphine oxide With sodium hexamethyldisilazane In tetrahydrofuran at 22℃; for 0.25h; Inert atmosphere; Stage #2: 1-chloroundecane In tetrahydrofuran at 22℃; for 16h; Inert atmosphere; chemoselective reaction;	92%

: 90-02-8
salicylaldehyde

: 7211-39-4
dimethyl phosphine oxide

: Dimethyl-(hydroxy(o-hydroxyphenyl)methyl)phosphinoxid

Conditions

Conditions	Yield
In dichloromethane for 120h; Ambient temperature;	91.8%

: 24155-34-8
2-(1H-imidazol-1-yl)-1-phenylethanone

: 7211-39-4
dimethyl phosphine oxide

: 1-Hydroxy-2-(imidazol-1-yl)-1-phenylethyl-dimethyloxophosphoran

Conditions

Conditions	Yield
In diethyl ether at 25℃; for 4h;	91%

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 7211-39-4
dimethyl phosphine oxide

: Dimethyl-(hydroxy(3,4,5-trimethoxyphenyl)methyl)phosphinoxid

Conditions

Conditions	Yield
In dichloromethane for 120h; Ambient temperature;	90.6%

: 7211-39-4
dimethyl phosphine oxide

: 58905-26-3
1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone

: 1-Hydroxy-1-phenyl-2-(1,2,4-triazol-1-yl)ethyl-dimethyloxophosphoran

Conditions

Conditions	Yield
In diethyl ether at 25℃; for 4h;	90%

: C9H10BrNO4

: 7211-39-4
dimethyl phosphine oxide

: C11H16NO5P

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 130℃; for 3h; Sealed tube; Inert atmosphere;	90%

: (R)-7-(benzyloxy)-9-bromo-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione

: 7211-39-4
dimethyl phosphine oxide

: (R)-7-(benzyloxy)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-9-(dimethylphosphoryl)-3,4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c]pyrido[2,1-f] [1,2,4] triazine-6,8-dione

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine In acetonitrile at 90℃; for 20h; Inert atmosphere;	90%

: 645-00-1
m-iodonitrobenzene

: 7211-39-4
dimethyl phosphine oxide

: 26786-59-4
dimethyl(3-nitrophenyl)phosphine oxide

Conditions

Conditions	Yield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 90℃; for 4h; Sealed tube;	89%
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 20 - 90℃; for 3.16667h; Inert atmosphere;	79%

: 3383-21-9
3,5-di-tert-butyl-o-benzoquinone

: 7211-39-4
dimethyl phosphine oxide

: 131028-82-5
Dimethylphosphinsaeure-2-hydroxy-3,5-di-tert-butylphenylester

Conditions

Conditions	Yield
In dichloromethane for 1h; Heating;	88.4%

: 7211-39-4
dimethyl phosphine oxide

: 24155-33-7
1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethanone

: 1-(4-Fluorphenyl)-1-hydroxy-2-(imidazol-1-yl)ethyl-dimethyloxophosphoran

Conditions

Conditions	Yield
at 80 - 100℃;	88%

: 7211-39-4
dimethyl phosphine oxide

: 58905-21-8
4'-fluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone

: 1-(4-Fluorphenyl)-1-hydroxy-2-(1,2,4-triazol-1-yl)ethyl-dimethyloxophosphoran

Conditions

Conditions	Yield
at 80 - 100℃;	87%

: [RuCl2(hexamethylbenzene)]2

: 7211-39-4
dimethyl phosphine oxide

: C14H25Cl2OPRu

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 14h; Inert atmosphere; Schlenk technique;	87%

: 7211-39-4
dimethyl phosphine oxide

: 91-13-4
α,α'-dibromo-o-xylene

: (1,2-phenylenebis(methylene))bis(dimethylphosphine oxide)

Conditions

Conditions	Yield
Stage #1: dimethyl phosphine oxide With sodium hexamethyldisilazane In tetrahydrofuran at 22℃; for 0.25h; Inert atmosphere; Stage #2: α,α'-dibromo-o-xylene In tetrahydrofuran at 22℃; Inert atmosphere; chemoselective reaction;	87%

: 7211-39-4
dimethyl phosphine oxide

: 626-15-3
1,3-bis-(bromomethyl)benzene

: (1,3-phenylenebis(methylene))bis(dimethylphosphine oxide)

Conditions

Conditions	Yield
Stage #1: dimethyl phosphine oxide With sodium hexamethyldisilazane In tetrahydrofuran at 22℃; for 0.25h; Inert atmosphere; Stage #2: 1,3-bis-(bromomethyl)benzene In tetrahydrofuran at 22℃; Inert atmosphere; chemoselective reaction;	87%

: 7211-39-4
dimethyl phosphine oxide

: 439-14-5
diazepam

: 7-chloro-1,3-dihydro-5-(2-(dimethylphosphoryl)phenyl)-1-methyl-2H-benzo[e][1,4]diaze pin-2-one

Conditions

Conditions	Yield
With potassium hexafluorophosphate; [Cp*Rh(OAc)2] In methanol at 65℃; Electrochemical reaction;	87%

: 100-39-0
benzyl bromide

: 7211-39-4
dimethyl phosphine oxide

: 18629-11-3
benzyldimethylphosphine oxide

Conditions

Conditions	Yield
Stage #1: dimethyl phosphine oxide With sodium hexamethyldisilazane In tetrahydrofuran at 22℃; for 0.25h; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran at 0℃; for 2h; Inert atmosphere; chemoselective reaction;	86.2%

Dimethylphosphine oxide Specification

The systematic name of this chemical is dimethylphosphane oxide. With the CAS registry number 7211-39-4 and EINECS 230-591-2, it is also named as phosphorane, dimethyl-, oxide. In addition, the formula is C₂H₇OP and the molecular weight is 78.05.

The other characteristics of Dimethylphosphine oxide can be summarized as: (1)ACD/LogP: -2.23; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 1; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 0; (6)Polar Surface Area: 40.54 Å²; (7)Flash Point: 4.906 °C; (8)Enthalpy of Vaporization: 31.144 kJ/mol; (9)Boiling Point: 84.5 °C at 760 mmHg; (10)Vapour Pressure: 80.598 mmHg at 25°C.

People can use the following data to convert to the molecule structure.
1. SMILES:CP(C)=O
2. InChI:InChI=1/C2H7OP/c1-4(2)3/h4H,1-2H3
3. InChIKey:HGDIHUZVQPKSMO-UHFFFAOYAJ
4. Std. InChI:InChI=1S/C2H7OP/c1-4(2)3/h4H,1-2H3
5. Std. InChIKey:HGDIHUZVQPKSMO-UHFFFAOYSA-N

Product Name

DIMETHYLPHOSPHINE OXIDE

Synthetic route

Dimethylphosphine oxide Specification

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