• Name

  4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE HYDROCHLORIDE

• EINECS 205-049-3
• CAS No. 132-18-3
• Density g/cm³
• Solubility
• Melting Point 203-205 °C(lit.)
  
• Formula C19H23 N O . Cl H
• Boiling Point 378.7°Cat760mmHg
• Molecular Weight 317.859
• Flash Point 111.6°C
• Transport Information
• Appearance
• Safety Poison by ingestion, subcutaneous, intramuscular, and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x and HCl.
• Risk Codes R20/21/22;R36/37/38   
• Molecular Structure
• Hazard Symbols
• Synonyms Piperidine,4-(diphenylmethoxy)-1-methyl-, hydrochloride (6CI,8CI,9CI); 1-Methyl-4-piperidylbenzhydryl ether hydrochloride; 4-Diphenylmethoxy-1-methylpiperidinehydrochloride; Anginosan; Belfene; Dayfen; Diafen; Diafen (antihistamine);Diafen hydrochloride; Diaphen; Diphenpyraline hydrochloride; Diphenylpyralinehydrochloride; Diphenylpyraline teoclate; Hispril; Hispril hydrochloride;Histryl; Histryl Spansule Capsules; Histyn; Kolton Jelly; Lergoban; Lergobine;Sumadil
• PSA 12.47000
• LogP 4.62670

Synthetic route

cobalt(II) chloride hexahydrate

132-18-3

diphenylpyraline hydrochloride

145519-05-7

{Co(CH3NC5H9OCH(C6H5)2)2(H2O)2Cl2}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of CoCl2*6H2O (0.01 mol) in ethanol; keeping at room temp. for 10 min, then warming to 60°C for 30 min (water bath);; pptn.; filtering, washing with cold ethanol and with ether, drying over P4O10; elem. anal.;;	82%

132-18-3

diphenylpyraline hydrochloride

copper(II) nitrate

203715-86-0

Cu(C19H23NO)2(NO3)2

Conditions

Conditions	Yield
In ethanol byproducts: HCl; stirring (60-70°C, 0.5-10.0 h); pptn. on cooling, washing (EtOH), drying; elem. anal.;	82%

132-18-3

diphenylpyraline hydrochloride

copper dichloride

203715-85-9

Cu(C19H23NO)2Cl2

Conditions

Conditions	Yield
In ethanol byproducts: HCl; stirring (60-70°C, 0.5-10.0 h); pptn. on cooling, washing (EtOH), drying; elem. anal.;	80%

132-18-3

diphenylpyraline hydrochloride

copper(II) perchlorate

203715-88-2

Cu(C19H23NO)2(ClO4)2

Conditions

Conditions	Yield
In ethanol byproducts: HCl; stirring (60-70°C, 0.5-10.0 h); pptn. on cooling, washing (EtOH), drying; elem. anal.;	74%

6147-53-1

cobalt(II) diacetate tetrahydrate

132-18-3

diphenylpyraline hydrochloride

145519-09-1

{Co(CH3NC5H9OCH(C6H5)2)2(H2O)2(CH3CO2)2}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of Co(CH3CO2)2*4H2O (0.01 mol) in ethanol; stirring vigorously at room temp. for 30 min;; pptn.; filtering, washing with cold ethanol and with ether, drying on air; elem. anal.;;	68%

cobalt(II) nitrate hexahydrate

132-18-3

diphenylpyraline hydrochloride

145519-06-8

{Co(CH3NC5H9OCH(C6H5)2)2(H2O)2(NO3)2}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of Co(NO3)2*6H2O (0.01 mol) in ethanol; stirring vigorously at room temp. for 30 min;; pptn.; filtering, washing with cold ethanol and with ether, drying on air; elem. anal.;;	67%

cobalt(II) perchlorate

132-18-3

diphenylpyraline hydrochloride

145519-08-0

{Co(CH3NC5H9OCH(C6H5)2)2(H2O)2(ClO4)2}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of Co(ClO4)2 (0.01 mol) in ethanol; stirring vigorously at room temp. for 30 min;; pptn.; filtering, washing with cold ethanol and with ether, drying on air; elem. anal.;;	62%

142-71-2

copper diacetate

132-18-3

diphenylpyraline hydrochloride

203715-87-1

Cu(C19H23NO)2(CH3COO)2

Conditions

Conditions	Yield
In ethanol byproducts: HCl; stirring (60-70°C, 0.5-10.0 h); pptn. on cooling, washing (EtOH), drying; elem. anal.;	57%

cobalt(II) sulphate heptahydrate

132-18-3

diphenylpyraline hydrochloride

Co(2+)*2CH3NC5H9OCH(C6H5)2*2H2O*SO4(2-)={Co(CH3NC5H9OCH(C6H5)2)2(H2O)2(SO4)}

Conditions

Conditions	Yield
In ethanol addn. of soln. of diphenyl pyraline hydrochloride (0.02 mol) in ethanol to soln. of CoSO4*7H2O (0.01 mol) in ethanol; keeping at room temp. for 10 min, then warming to 60°C for 30 min (water bath);; pptn.; filtering, washing with cold ethanol and with ether, drying over P4O10; elem. anal.;;	41%

Diphenylpyraline hydrochloride Chemical Properties

Diphenylpyraline hydrochloride Toxicity Data With Reference

Diphenylpyraline hydrochloride Consensus Reports

Diphenylpyraline hydrochloride Safety Profile