Disodium 4-nitrophenylphosphate supplier

Name
Disodium 4-nitrophenylphosphate
EINECS 224-246-5
CAS No. 4264-83-9
Article Data4
CAS DataBase
Density 1.712g/cm3
Solubility Miscible with water. Immiscible with ethanol and acetone.
Melting Point >300 °C(lit.)
Formula C₆H₄NNa₂O₆P
Boiling Point 457.849 °C at 760 mmHg
Molecular Weight 263.054
Flash Point 230.699 °C
Transport Information
Appearance White crystalline
Safety 26-36-24/25-23
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phenol,p-nitro-, di-H phosphate, disodium salt (7CI);Phenol, p-nitro-, phosphatedisodium salt (6CI);Phosphoric acid, mono(4-nitrophenyl) ester, disodium salt(9CI);4-Nitrophenyl phosphate disodium salt;Disodium mono(4-nitrophenyl) phosphate;Disodium p-nitrophenyl phosphate;p-NPPdisodium salt;p-Nitrophenyl disodium phosphate;p-Nitrophenyl phosphatedisodium salt;PNPP;4-Nitrophenyl phosphate, disodium salt;Disodium 4-nitrophenylphosphate;
PSA 128.05000
LogP 2.46590

Synthetic route

: 4043-96-3
sodium bis(4-nitrophenyl) phosphate

: 4264-83-9
disodium (4-nitrophenyl)phosphate

Conditions

Conditions	Yield
{[Cu{[(1-vinylIm-2-yl)CH2]3N}Cl]PF6}-{[CH2=C(CH3)CO2CH2-]n} In water; dimethyl sulfoxide at 50℃; for 96h; pH=9.5; Kinetics; Further Variations:; Catalysts; pH-values; Temperatures; catalyst ratios;	53%

: C6H4NO6P(2-)*C30H57N6(3+)*2Cl(1-)*Na(1+)

A: C30H57N6(3+)*3Cl(1-)

B: 4264-83-9
disodium (4-nitrophenyl)phosphate

Conditions

Conditions	Yield
With sodium chloride In d(4)-methanol at 65℃; Equilibrium constant;

: 4043-96-3
sodium bis(4-nitrophenyl) phosphate

A: 100-02-7
4-nitro-phenol

B: 4264-83-9
disodium (4-nitrophenyl)phosphate

Conditions

Conditions	Yield
With [D]-sodium hydroxide; (Et2NH2)8[{α-PW11O39Zr(μ-OH)(H2O)}2]*7H2O; sodium diphenyl phosphate; hydrogen chloride In water-d2 at 60℃; pH=6.4; Kinetics; Reagent/catalyst; Temperature; Concentration;

: 100-02-7
4-nitro-phenol

: 4264-83-9
disodium (4-nitrophenyl)phosphate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 4 h / 20 °C 2: acetonitrile / 16 h / 0 - 20 °C 3: water / methanol / 1 h / 0 - 20 °C 4: sodium hydroxide / water / 0 °C / Cooling with ice View Scheme
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 4 h / 20 °C 2: acetonitrile / 24 h / 0 - 20 °C 3: water / methanol / 1 h / 0 - 20 °C 4: sodium hydroxide / water / 0 °C / Cooling with ice View Scheme

: 311-45-5
paraoxon

: 4264-83-9
disodium (4-nitrophenyl)phosphate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetonitrile / 16 h / 0 - 20 °C 2: water / methanol / 1 h / 0 - 20 °C 3: sodium hydroxide / water / 0 °C / Cooling with ice View Scheme
Multi-step reaction with 3 steps 1: acetonitrile / 24 h / 0 - 20 °C 2: water / methanol / 1 h / 0 - 20 °C 3: sodium hydroxide / water / 0 °C / Cooling with ice View Scheme

: C12H22NO6PSi2

: 4264-83-9
disodium (4-nitrophenyl)phosphate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: water / methanol / 1 h / 0 - 20 °C 2: sodium hydroxide / water / 0 °C / Cooling with ice View Scheme

: 330-13-2
mono-p-nitrophenyl phosphate

: 4264-83-9
disodium (4-nitrophenyl)phosphate

Conditions

Conditions	Yield
With sodium hydroxide In water at 0℃; Cooling with ice;	297 g

: [[1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-olato]dizinc(II)(CH3COO)][ClO4]2*H2O

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: [[1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-olato]dizinc(II)(p-nitrophenyl phosphate)][ClO4]2*H2O

Conditions

Conditions	Yield
In water 1:1 mixt. of Zn complex and p-nitrophenyl phosphate disodium salt;	99%

: 21356-99-0, 18078-67-6
bis(N,N-dimethylformamide)dichloridodioxidomolybdenum(VI)

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 3H(1+)*Mo12O40P(3-)*3C2H7N

Conditions

Conditions	Yield
With water at 55℃; for 0.5h;	95%

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 100-02-7
4-nitro-phenol

Conditions

Conditions	Yield
With cerium(IV) oxide In ethanol at 25℃; for 8h; Kinetics;	91%
With tetraethylammonium hydroxide In water; acetonitrile at 20℃;
at 37℃; enzimatically by alkaline and acid phosphatase;

: zinc perchlorate

: 1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol*4HClO4*2.5H2O

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: [[1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-olato]dizinc(II)(p-nitrophenyl phosphate)][ClO4]2*H2O

Conditions

Conditions	Yield
With NaOH In water adding aq. soln. of amine to Zn salt, adding aq. NaOH, stirring for 1 h at 45°C, filtration, adding. aq. soln. of p-nitrophenyl phosphatedisodium salt; cooling to room temp.; elem. anal.;	80%

...Expand

: tetraaqua(1,3-bis(1,4,7-triazacyclonon-1-ylmethyl)benzene)dicopper(II) perchlorate trihydrate*NaClO4

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: (4-nitrophenyl phosphate)(1,3-bis(1,4,7-triazacyclonon-1-ylmethyl)benzene)(μ-OH)dicopper(II) perchlorate monohydrate

Conditions

Conditions	Yield
With HEPES buffer; NaClO4 In water soln. of Cu complex, Na2O2P(O)OC6H4NO2, HEPES buffer (pH 7.4) and NaClO4kept at 38°C overnight; crystals collected; washed with water; elem. anal.;	70%

: Zn2(C16H32(NH)6N2)(C3H5O)(3+)*3ClO4(1-)=[Zn2(C16H32(NH)6N2)(C3H5O)](ClO4)3

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: Zn2(C16H32(NH)6N2)(C3H5O)(HPO3)(3+)*3ClO4(1-)*2H2O=[Zn2(C16H32(NH)6N2)(C3H5O)(HPO3)](ClO4)3*2H2O

Conditions

Conditions	Yield
With HClO4 In water stirring (60°C), 2 d), adjustment of pH to 3 (HClO4), evapn. of solvent; recrystn. (water); elem. anal.;	69%

: zinc(II) perchlorate

: 4,16-(2-hydroxypropano)-1,4,7,13,16,19-hexaazacyclotetracosane tetrahydrochloride hemihydrate

: 7732-18-5
water

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: Zn2(OCH(CH2N(CH2CH2NH)2)2((CH2)5)2)(O2P(O)OC6H4NO2)(1+)*ClO4(1-)*4H2O=(Zn2(C21H45N6O)(O2P(O)OC6H4NO2))ClO4*4H2O

Conditions

Conditions	Yield
With NaOH In water aq. soln. of Zn salt added to aq. soln. of HCl salt of ligand; 0.10 M NaOH (5 equiv.) added dropwise at 45°C for 1 h; soln. filtered withcellulose nitrate filter; Na phosphate added; cooled to room temp.; elem. anal.;	69%

...Expand

: [Co(tris(2-pyridylmethyl)amine)(CO3)]Cl*1.5(water)

: 4264-83-9
disodium (4-nitrophenyl)phosphate

A: 862125-30-2
[Co(tris(2-pyridylmethyl)amine)(phosphate)]

B: [[Co(tris(2-pyridylmethyl)amine)](μ-diphosphate)](ClO4)2

Conditions

Conditions	Yield
With charcoal; NaOH In water to a soln. of Co-complex added a soln. of disodium 4-nitrophenylphosphate; mixed soln. adjusted to pH 3 with NaOH soln.; heating to 60°C and catalytic amount of active charcoal added; stirred at 60°C for 7 h; soln. neutralized and products purified by column chromy. with cation-exchange resin;	A 8% B 51%
With charcoal; NaOH In water to a soln. of Co-complex added a soln. of disodium 4-nitrophenylphosphate; mixed soln. adjusted to pH 3 with NaOH soln.; heating to 60°C and catalytic amount of active charcoal added; stirred at 60°C for 5 h; soln. neutralized and products purified by column chromy. with cation-exchange resin;	A n/a B 46%
With charcoal; NaOH In water to a soln. of Co-complex added a soln. of disodium 4-nitrophenylphosphate; mixed soln. adjusted to pH 3 with NaOH soln.; heating to 60°C and catalytic amount of active charcoal added; stirred at 60°C for 3 h; soln. neutralized and products purified by column chromy. with cation-exchange resin;	A n/a B 26%

...Expand

: 67-56-1
methanol

: [Cu2(μ-OH)(m-xylenediamine bis(Kemp's triacid imide)(2-))(1,10-phenanthroline)2]NO3*2CH2Cl2

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: [Cu2(μ-4-nitrophenylphosphate)(m-xylenediamine bis(Kemp's triacid imide)(2-))(1,10-phenanthroline)2(CH3OH)]*CH3OH

Conditions

Conditions	Yield
In methanol; dichloromethane soln. disodium 4-nitrophenylphosphate in MeOH-CH2Cl2 was added to soln. Cu complex in MeOH and stirred at room temp. for 12 h; solvent was evapd. in vacuo, residue was extd. with MeOH and concd., Et2O was added; elem. anal.;	28%

...Expand

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 75-56-9, 16033-71-9
methyloxirane

: barium 2-hydroxypropyl(4-nitrophenyl)phosphate

Conditions

Conditions	Yield
Stage #1: disodium (4-nitrophenyl)phosphate; methyloxirane With ammonium hydroxide In water at 35℃; Stage #2: With barium dihydroxide at 20℃; pH=Ca.7;	0.4%

: 77-98-5
tetraethylammonium hydroxide

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 3774-76-3
Tentraethylammonium 4-nitrophenoxide

Conditions

Conditions	Yield
With water In acetonitrile at 20℃; Rate constant; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.); other concentration of water , Et4N(1+)*OH(1-) and temperatures;

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 14609-74-6
p-nitrophenolate

Conditions

Conditions	Yield
With water; Zn*(im-bzl-L-His)2dien at 35 - 50℃; Kinetics;
With C91H151N3O70Zn In water at 35℃; pH=6.5 - 9.5; Kinetics; pH-value; Good's buffer;
With [Zn2(2-[bis(2-methoxyethyl)aminomethyl]-4-methylphenol)2Cl2] In water; N,N-dimethyl-formamide Kinetics; Reagent/catalyst; Concentration;

: 4264-83-9
disodium (4-nitrophenyl)phosphate

A: 100-02-7
4-nitro-phenol

B orthophosphate (10percent): orthophosphate (10percent)

Conditions

Conditions	Yield
With pentan-1-ol; sodium citrate; erythrocyte acid phosphatase (EAPase) at 37℃; for 0.166667h; Mechanism; pH=5.5, effects of various alcohols on EAPase and Prostatic acid phosphatase (PAPase) enzymes activity, Km, Vmax constants;

: [Co(tren)(OH)(H2O)](ClO4)2

: 4264-83-9
disodium (4-nitrophenyl)phosphate

A: [Co(tris(2-aminoethyl)amine)(O2PO2)]

: [Co(tris(2-aminoethyl)amine)(H2O)(OPO3H)](1+)

: [Co(tris(2-aminoethyl)amine)(H2O)(OPO3H)](1+)

: Co(NH2C2H4)3N(H2O)OPO3Co(NH2C2H4)3NOH2(3+)

: Co(NH2C2H4)3N(H2O)OPO3Co(NH2C2H4)3NOH2(3+)

Conditions

Conditions	Yield
With NaOH In water byproducts: (NH2C2H4)3NCo(O2P(O)O)CoN(C2H4NH2)3(3+), (NH2C2H4)3NCo(OH)(OPO3)]; 40°C, pH from 4.61 to 8.44; not sepd., detected by NMR spectra;

...Expand

: 13408-72-5, 14040-32-5, 14040-33-6, 20594-10-9, 20594-11-0
trans-dichlorobis(ethylenediamine)cobalt(III) chloride

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 85436-20-0
cis-p-nitrophenylphosphatobis(ethylenediamine)cobalt(III) chloride

Conditions

Conditions	Yield
In water mixing into a past using a few drops of water; warming for a few min atca 60°C; diln. with water; heating for 5-10 min at 60-70°C; filtration, washing with water, EtOH, Et2O; drying in vac.; elem. anal.;

: [Co(N-2-aminoethyl-N,N-bis(3-aminopropyl)amine)(H2O)(OH)](ClO4)2

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: [Co(N-2-aminoethyl-N,N-bis(3-aminopropyl)amine)O2PO2]

: Co(NH2C3H6)2NC2H4NH2O2PO2Co(NH2C3H6)2NC2H4NH2(3+)

: Co(NH2C3H6)2NC2H4NH2O2PO2Co(NH2C3H6)2NC2H4NH2(3+)

: Co(NH2C3H6)2NC2H4NH2O2PO2Co(NH2C3H6)2NC2H4NH2(3+)

Conditions

Conditions	Yield
With NaOH In water 25°C, pH from 4.88 to 8.01; not sepd., detected by NMR spectra;

...Expand

: [Co(N-2-aminoethyl-N,N-bis(3-aminopropyl)amine)(H2O)(OH)](ClO4)2

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: [Co(N-2-aminoethyl-N,N-bis(3-aminopropyl)amine)(OH)O2PO(OC6H4NO2)]

: [Co(N-2-aminoethyl-N,N-bis(3-aminopropyl)amine)(OH2)O2PO(OC6H4NO2)](1+)

Conditions

Conditions	Yield
In water Kinetics; 15°C, pH 4.57; not sepd., detected by NMR spectra;

...Expand

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: disodium salt of p-aminophenyl phosphate

Conditions

Conditions	Yield
With triethanolamine; riboflavin In water at 40℃; for 4h; UV-irradiation;
With hydrogen; palladium 10% on activated carbon In ethanol; water at 20℃; under 1551.49 Torr; for 2h;

: 124-41-4
sodium methylate

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 17323-81-8, 51528-83-7
bis-sodium salt of methyl phosphate

Conditions

Conditions	Yield
In methanol; d(4)-methanol at 50℃; Kinetics; Reagent/catalyst; pH-value; Time;

: C30H57N6(3+)*3Cl(1-)

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: C6H4NO6P(2-)*C30H57N6(3+)*2Cl(1-)*Na(1+)

Conditions

Conditions	Yield
In d(4)-methanol at 65℃; Equilibrium constant;

: 5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26,28-bis((R)-α-alanyl-carbonylmethoxy)calix[4]arene

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: C6H4NO6P(2-)*C54H70N2O10*2Na(1+)

Conditions

Conditions	Yield
In water; dimethyl sulfoxide at 25℃;

: 5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26,28-bis((R)-α-glutyl-carbonylmethoxy)calix[4]arene

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: C6H4NO6P(2-)*C58H74N2O14*2Na(1+)

Conditions

Conditions	Yield
In water; dimethyl sulfoxide at 25℃;

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26,28-bis(glycyl-carbonylmethoxy)calix[4]arene

: C6H4NO6P(2-)*C52H66N2O10*2Na(1+)

Conditions

Conditions	Yield
In water; dimethyl sulfoxide at 25℃;

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: 39613-92-8, 62062-56-0, 62062-65-1
alanine isopropyl ester hydrochloride

: 121-44-8
triethylamine

: C12H17N2O7P*C6H15N

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In water; tert-butyl alcohol Reflux;

...Expand

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: C14H21N2O7PS

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dicyclohexyl-carbodiimide / tert-butyl alcohol; water / Reflux 2: N,N-dimethyl-formamide / 1 h / 25 °C / Inert atmosphere View Scheme

: 4264-83-9
disodium (4-nitrophenyl)phosphate

: phosphonic acid mono-(E)-(4-{7-fluoro-6-morpholin-4-yl-2-[2-(5-nitrofuran-2-yl)vinyl]quinazolin-4-ylamino}phenyl) ester disodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen / palladium 10% on activated carbon / ethanol; water / 2 h / 20 °C / 1551.49 Torr 2: N,N-dimethyl-formamide / 3 h / 90 °C View Scheme

Disodium 4-nitrophenylphosphate Specification

1.Introduction of Disodium 4-nitrophenylphosphate

The Disodium 4-nitrophenylphosphate, with CAS registry number 4264-83-9, belongs to the following product categories: (1)Substrates; (2)Enzyme substrates; (3)Biological Buffers; (4)Buffer Convenience Packaging; (5)Buffer SolutionsBiological Buffers; (6)Buffers A to Z. It has the systematic name of 4-nitrophenyl dihydrogen phosphate. This chemical should be stored at the temperature of 2-8°C and mainly used as agrochemical Intermediates.

2.Physical properties of Disodium 4-nitrophenylphosphate

(1)ACD/LogP: 0.39; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 7; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 122.39 Å²; (11)Index of Refraction: 1.617; (12)Molar Refractivity: 44.788 cm³; (13)Molar Volume: 127.93 cm³; (14)Polarizability: 17.755×10^-24cm³; (15)Surface Tension: 82.208 dyne/cm; (16)Enthalpy of Vaporization: 75.661 kJ/mol; (17)Vapour Pressure: 0 mmHg at 25°C.

3.Stucture descriptor Disodium 4-nitrophenylphosphate

(1)SMILES: c1cc(ccc1[N+](=O)[O-])OP(=O)(O)O
(2)InChI: InChI=1/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)
(3)InChIKey: XZKIHKMTEMTJQX-UHFFFAOYAU
(4)Std. InChI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)
(5)Std. InChIKey: XZKIHKMTEMTJQX-UHFFFAOYSA-N

4.Safety information of Disodium 4-nitrophenylphosphate

The Disodium 4-nitrophenylphosphate irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice. You should avoid contact with skin and eyes and do not breathe vapour.

Product Name

Disodium 4-nitrophenylphosphate

Synthetic route

Disodium 4-nitrophenylphosphate Specification

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