• Name

  Disodium 2-oxoglutarate dihydrate

• EINECS 206-167-8
• CAS No. 305-72-6
• Article Data2
• CAS DataBase
• Density 1.499g/cm3
• Solubility soluble
• Melting Point
• Formula C₅H₄Na₂O₅
• Boiling Point 345.6 °C at 760 mmHg
• Molecular Weight 190.063
• Flash Point 177 °C
• Transport Information
• Appearance White powder.
• Safety 22-24/25-45-36/37/39-26
• Risk Codes 23/24/25-36/37/38
• Molecular Structure
• Hazard Symbols T
• Synonyms Glutaricacid, 2-oxo-, disodium salt (8CI);Pentanedioic acid, 2-oxo-, disodium salt(9CI);2-Oxoglutaric acid disodium salt;Disodium 2-oxoglutarate;Disodium2-oxopentanedioate;Disodium a-ketoglutarate;a-Oxoglutaric acid disodium salt;Disodium 2-oxoglutarate;Pentanedioic acid, 2-oxo-, disodium salt;α-Ketoglutaric acid disodium salt;
• PSA 115.79000
• LogP -3.29310

Synthetic route

35818-60-1

2-oxoglutaric acid 1-ethyl ester

305-72-6

α-ketoglutaric acid disodium salt

Conditions

Conditions	Yield
With [D]-sodium hydroxide; water-d2 for 0.00416667h; pH=11;	>= 95 %Spectr.

328-50-7

α-ketoglutaric acid

305-72-6

α-ketoglutaric acid disodium salt

Conditions

Conditions	Yield
With sodium hydroxide In water at 25 - 35℃; Reagent/catalyst; Large scale;

305-72-6

α-ketoglutaric acid disodium salt

2-oxo[3,3-2H]glutaric acid disodium salt

Conditions

Conditions	Yield
With water-d2 at 80℃; for 3h; Substitution;	100%

305-72-6

α-ketoglutaric acid disodium salt

71686-01-6

calcium alpha-ketaglutarate

Conditions

Conditions	Yield
With calcium chloride In water at 65 - 70℃; Large scale;	77%

3353-89-7

triphenylsulfonium bromide

305-72-6

α-ketoglutaric acid disodium salt

bis(triphenylsulfonium) 2-ketoglutaricacid

Conditions

Conditions	Yield
In dichloromethane; water at 20℃;	75%
In dichloromethane; water

305-72-6

α-ketoglutaric acid disodium salt

7646-85-7

zinc(II) chloride

293766-90-2

alpha-ketoglute zinc

Conditions

Conditions	Yield
In water at 80 - 85℃; Large scale;	73%

932-98-9

1-chloro-4-nitroso-benzene

305-72-6

α-ketoglutaric acid disodium salt

A

62558-67-2

4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid

B

123-30-8

4-amino-phenol

C

28443-50-7

2-amino-5-chlorophenol

D

81576-13-8

N-(4-chloro-2-hydroxyphenyl)succinamic acid

Conditions

Conditions	Yield
With thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride In water at 30℃; for 2h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given;	A n/a B n/a C n/a D 2 mg

...Expand

932-98-9

1-chloro-4-nitroso-benzene

305-72-6

α-ketoglutaric acid disodium salt

A

62558-67-2

4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid

B

28443-50-7

2-amino-5-chlorophenol

C

81576-12-7

N-(4-chlorophenyl)succinohydroxamic acid

D

81576-13-8

N-(4-chloro-2-hydroxyphenyl)succinamic acid

Conditions

Conditions	Yield
With thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride In water at 30℃; for 2h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given;	A n/a B n/a C 1.5 mg D 2 mg

...Expand

305-72-6

α-ketoglutaric acid disodium salt

2889-31-8

2-hydroxyglutaric acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium tetrahydroborate for 0.0833333h; Reduction;

305-72-6

α-ketoglutaric acid disodium salt

(S)-2-oxo[3-2H]glutaric acid disodium salt

Conditions

Conditions	Yield
With isocitrate dehydrogenase; water-d2; NADPH at 37℃; for 2h; Substitution;

305-72-6

α-ketoglutaric acid disodium salt

2-oxo[3,3-3H2]glutaric acid disodium salt

Conditions

Conditions	Yield
With tritium oxide Substitution; Heating;

305-72-6

α-ketoglutaric acid disodium salt

69134-53-8

(+/-)-diethyl 2-hydroxypentandioate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaBH4; HCl / 0.08 h 2: NaHCO3 / aq. NaOH; acetonitrile / 20 °C / pH 7 - 8 View Scheme

305-72-6

α-ketoglutaric acid disodium salt

(3R)-2-hydroxy[3-2H]glutaric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: D2O; isocitrate dehydrogenase; NADPH / 2 h / 37 °C 2: NaBH4; aq. HCl / 0.08 h View Scheme

305-72-6

α-ketoglutaric acid disodium salt

(3S)-2-hydroxy[3-2H]glutaric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: D2O; isocitrate dehydrogenase; NADPH / 2 h / 37 °C 2: NaBH4; aq. HCl / 0.08 h View Scheme

305-72-6

α-ketoglutaric acid disodium salt

2-hydroxy[3,3-2H2]glutaric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / D2O / 3 h / 80 °C 2: NaBH4; HCl / 0.08 h View Scheme

305-72-6

α-ketoglutaric acid disodium salt

(3S)-2-methylidene[3,3-2H2]glutaric acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 100 percent / D2O / 3 h / 80 °C 2: NaBH4; HCl / 0.08 h 3: 86 percent / TsOH / 48 h / Heating 4: pyridine / CH2Cl2 / 0.5 h / -5 °C 5: 2.9 mmol / CH2Cl2 / 20 °C 6: 92 percent / NaOEt / ethanol 7: 65 percent / aq. NaOH / methanol / 16 h / 20 °C View Scheme

305-72-6

α-ketoglutaric acid disodium salt

(R)-2-hydroxy[3-2H,3-3H]glutaric acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: T2O / Heating 2: D2O; isocitrate dehydrogenase 3: NaBH4; aq. HCl View Scheme

305-72-6

α-ketoglutaric acid disodium salt

(S)-2-hydroxy[3-2H,3-3H]glutaric acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 100 percent / D2O / 3 h / 80 °C 2: T2O; isocitrate dehydrogenase 3: NaBH4; aq. HCl View Scheme

305-72-6

α-ketoglutaric acid disodium salt

diethyl 2-hydroxy[3,3-2H2]glutarate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 100 percent / D2O / 3 h / 80 °C 2: NaBH4; HCl / 0.08 h 3: 86 percent / TsOH / 48 h / Heating View Scheme

305-72-6

α-ketoglutaric acid disodium salt

diethyl 2-methylidene[3,3-2H2]glutarate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 100 percent / D2O / 3 h / 80 °C 2: NaBH4; HCl / 0.08 h 3: 86 percent / TsOH / 48 h / Heating 4: pyridine / CH2Cl2 / 0.5 h / -5 °C 5: 2.9 mmol / CH2Cl2 / 20 °C 6: 92 percent / NaOEt / ethanol View Scheme

305-72-6

α-ketoglutaric acid disodium salt

2-trifluoromethanesulfonyloxy-pentanedioic acid diethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaBH4; HCl / 0.08 h 2: NaHCO3 / aq. NaOH; acetonitrile / 20 °C / pH 7 - 8 3: pyridine / CH2Cl2 / -5 °C View Scheme

305-72-6

α-ketoglutaric acid disodium salt

C10H13(2)H2F3O7S

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 100 percent / D2O / 3 h / 80 °C 2: NaBH4; HCl / 0.08 h 3: 86 percent / TsOH / 48 h / Heating 4: pyridine / CH2Cl2 / 0.5 h / -5 °C View Scheme

305-72-6

α-ketoglutaric acid disodium salt

(R)-2-oxo[3-2H]glutaric acid disodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / D2O / 3 h / 80 °C 2: D2O; isocitrate dehydrogenase; NADPH / 2 h / 37 °C View Scheme

305-72-6

α-ketoglutaric acid disodium salt

(R)-2-oxo[3-2H,3-3H]glutaric acid disodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: T2O / Heating 2: D2O; isocitrate dehydrogenase View Scheme

305-72-6

α-ketoglutaric acid disodium salt

(3S)-2-oxo[3-2H,3-3H]glutaric acid disodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / D2O / 3 h / 80 °C 2: T2O; isocitrate dehydrogenase View Scheme

305-72-6

α-ketoglutaric acid disodium salt

[1,3-bis(ethoxycarbonyl)propyl]triphenylphosphonium triflate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: NaBH4; HCl / 0.08 h 2: NaHCO3 / aq. NaOH; acetonitrile / 20 °C / pH 7 - 8 3: pyridine / CH2Cl2 / -5 °C 4: CH2Cl2 / 20 °C View Scheme

305-72-6

α-ketoglutaric acid disodium salt

[1,3-bis(ethoxycarbonyl)[2,2-2H2]propyl]triphenylphosphonium triflate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / D2O / 3 h / 80 °C 2: NaBH4; HCl / 0.08 h 3: 86 percent / TsOH / 48 h / Heating 4: pyridine / CH2Cl2 / 0.5 h / -5 °C 5: 2.9 mmol / CH2Cl2 / 20 °C View Scheme

305-72-6

α-ketoglutaric acid disodium salt

100-11-8

1-bromomethyl-4-nitro-benzene

108049-92-9

2-oxo-glutaric acid 1-p-nitrobenzyl ester

Conditions

Conditions	Yield
In N-methyl-acetamide

305-72-6

α-ketoglutaric acid disodium salt

150-90-3

sodium succinate

Conditions

Conditions	Yield
With hydrogenchloride; iron(II) ammonium sulfate; pseudomonas sp.AK1 γ-butyrobetaine hydroxylase; potassium chloride; γ-butyrobetaine hydrochloride In water-d2 pH=7.5; Kinetics; Reagent/catalyst; Enzymatic reaction;

305-72-6

α-ketoglutaric acid disodium salt

142-47-2, 149-65-5, 15383-53-6, 16079-50-8, 16177-21-2, 16690-92-9, 21932-17-2, 26247-79-0, 28223-73-6, 30617-64-2, 30811-79-1, 32221-81-1, 32342-59-9, 56-86-0

glutamic acid sodium salt

Conditions

Conditions	Yield
With ammonium sulfate; [(pentamethylcyclopentadienyl)Rh(2,2’-bipyridyl)H2O]2+; L-glutamic dehydrogenase from bovine liver; β-nicotinamide adenine dinucleotide In aq. phosphate buffer pH=7.5; Catalytic behavior; Reagent/catalyst; Irradiation; Enzymatic reaction;

Disodium 2-oxoglutarate dihydrate Chemical Properties

Disodium 2-oxoglutarate dihydrate Uses

Disodium 2-oxoglutarate dihydrate Toxicity Data With Reference

Disodium 2-oxoglutarate dihydrate Safety Profile