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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Solifenacin Manufacturer/High quality/Best price/In stock

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:medicine raw material Transportatio

Manufacturer high quality Solifenacin Cas 242478-37-1 with good price

Cas:242478-37-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Solifenacin CAS No.:242478-37-1 Name: Solifenacin Synonyms: [(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate Molecular Structure Molec

High purity Solifenacin CAS No.:242478-37-1

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Solifenacin in stock on hot selling with fast delivery CAS NO.242478-37-1

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Solifenacin

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Solifenacin Basic information Product Name: Solifenacin Synonyms: Solifenacin;[(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate;2(1H)-Isoquinol

Solifenacin

Cas:242478-37-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Solifenacin CAS No. 242478-37-1

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 242478-37-1 with competitive price

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Solifenacin

Cas:242478-37-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

Solifenacin

Cas:242478-37-1

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

2(1H)-Isoquinolinecarboxylicacid, 3,4-dihydro-1-phenyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (1S)-

Cas:242478-37-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Solifenacin CAS:242478-37-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Solifenacin CAS:242478-37-1

Cas:242478-37-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2(1H)-Isoquinolinecarboxylicacid, 3,4-dihydro-1-phenyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (1S)-

Cas:242478-37-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

Solifenacin CAS: 242478-37-1 Specification Items Specification Product name Solifenacin CAS# 242478-37-1 Appearance White powder

Factory supply Solifenacin

Cas:242478-37-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Solifenacin

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Solifenacin 242478-37-1

Cas:242478-37-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

;[(8R)-1-AZABICYCLO[2.2.2]OCTAN-8-YL] (1S)-1-PHENYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLATE

Cas:242478-37-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Solifenacin

Cas:242478-37-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

solifenacin

Cas:242478-37-1

Min.Order:0

Negotiable

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Solifenacin Manufacturer/High quality/Best price/In stock CAS NO.242478-37-1

Cas:242478-37-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Intermediate solifenacin Powder CAS 242478-37-1

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Solifenacin Manufacturer/High quality/Best price/In stock

Cas:242478-37-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Solifenacin CAS No.:242478-37-1 Molecule Formula:C23H26N2O2 Molecule Weight:362.46 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality Solifenacin in stock

Cas:242478-37-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Reliable Quality Solifenacin

Cas:242478-37-1

Min.Order:0

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Solifenacin

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Solifenacin

Cas:242478-37-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : Unii-A8910sqj1u;3,4-dihydro-1-phe

Solifenacin

Cas:242478-37-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

We are the manufacturer of this product in China. Our price is the lowest in China. CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and techni

Solifenacin

Cas:242478-37-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Solifenacin

Cas:242478-37-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C34H29NO2P(1+)*Cl(1-)

C34H29NO2P(1+)*Cl(1-)

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
In toluene at 60 - 70℃; Temperature;96.8%
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With sodium hydride; 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 100℃; for 6h; Temperature; Concentration;95.1%
With sodium hydride In toluene for 3h; Heating;89%
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In toluene; mineral oil at 0℃; for 0.25h; Inert atmosphere;
Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In toluene; mineral oil at 130℃; for 8h; Inert atmosphere; Dean-Stark;
88%
(3S)-1-azabicyclo[2.2.2]octan-3-yl 1H-imidazole-1-carboxylate

(3S)-1-azabicyclo[2.2.2]octan-3-yl 1H-imidazole-1-carboxylate

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
In tetrahydrofuran at 0℃; for 2h; Inert atmosphere;92.2%
(3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate
1459721-13-1

(3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
In toluene at 10 - 15℃; Temperature; Time; Solvent;91%
In toluene at 10 - 15℃; Solvent; Temperature;91%
Solifenacin hydrochloride

Solifenacin hydrochloride

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With ammonium hydroxide In water pH=9 - 10;90%
4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
1229227-22-8

4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (R)-quinuclidin-3-ol With 18-crown-6 ether; sodium hydride In toluene; mineral oil Inert atmosphere;
Stage #2: 4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate In toluene; mineral oil at 20 - 110℃; for 18h; Inert atmosphere;
74%
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil Inert atmosphere;
Stage #2: 4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate In N,N-dimethyl-formamide; mineral oil at 110℃; for 4h; Inert atmosphere;
70%
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (R)-quinuclidin-3-ol With sodium methylate In toluene at 5℃; Inert atmosphere; Reflux;
Stage #2: (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline In N,N-dimethyl-formamide; toluene at 60℃; Reflux;
72%
Stage #1: (R)-quinuclidin-3-ol With 1,1'-Carbonyl-di-(1,2,4-triazole); triethylamine In Isopropyl acetate at 20℃; for 2h;
Stage #2: (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline In Isopropyl acetate for 4h; Product distribution / selectivity; Heating / reflux;
propyl (1S)-1-phenyl-3,4-dihydro-2(1H)isoquinolinecarboxylate

propyl (1S)-1-phenyl-3,4-dihydro-2(1H)isoquinolinecarboxylate

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In toluene at 80℃; for 1h;
Stage #2: propyl (1S)-1-phenyl-3,4-dihydro-2(1H)isoquinolinecarboxylate In toluene for 18h; Reflux;
63.9%
(3R)-1-azabicyclo[2.2.2]octan-3-ol hydrochloride

(3R)-1-azabicyclo[2.2.2]octan-3-ol hydrochloride

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (3R)-1-azabicyclo[2.2.2]octan-3-ol hydrochloride With sodium methylate at 5 - 30℃; Inert atmosphere;
Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In N,N-dimethyl-formamide; toluene at 60℃; Reflux;
51%
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

sodium (R)-quinuclidin-3-ol

sodium (R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: sodium (R)-quinuclidin-3-ol With sodium methylate In N,N-dimethyl-formamide; toluene at 25℃; Inert atmosphere; Reflux;
Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In N,N-dimethyl-formamide; toluene at 70℃; Reflux;
50%
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

A

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

B

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
740780-79-4

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

C

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

D

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With potassium 2-methylbutan-2-olate In toluene at 90℃; for 3h; Product distribution / selectivity;A 1.1%
B 3.2%
C 6%
D n/a
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

A

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

B

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
740780-79-4

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

C

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In toluene for 0.166667h;
Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In toluene at 26 - 110℃; for 4.33333h; Product distribution / selectivity;
1-phenyl-3,4-dihydroisoquinoline
52250-50-7

1-phenyl-3,4-dihydroisoquinoline

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH4 / ethanol / 60 h / 20 °C
2: 100 percent / K2CO3 / CH2Cl2 / 20 °C
3: 89 percent / NaH / toluene / 3 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: methanol; sodium tetrahydroborate / water / 5.42 h / 20 - 34 °C
2.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate
2.2: 1.17 h / pH 8 - 9
3.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C
4.1: toluene / 5 h / 55 - 115 °C
4.2: 10 h / 55 - 115 °C
View Scheme
N-phenethylbenzamide
3278-14-6

N-phenethylbenzamide

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: P2O5; POCl3 / xylene / 2.5 h / Heating
2: NaBH4 / ethanol / 60 h / 20 °C
3: 100 percent / K2CO3 / CH2Cl2 / 20 °C
4: 89 percent / NaH / toluene / 3 h / Heating
View Scheme
Multi-step reaction with 5 steps
1.1: PPA / water / 4.25 h / 14.9 - 165 °C
1.2: 0.17 h / 28 - 42 °C / pH 2.1 - 7.12
2.1: methanol; sodium tetrahydroborate / water / 5.42 h / 20 - 34 °C
3.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate
3.2: 1.17 h / pH 8 - 9
4.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C
5.1: toluene / 5 h / 55 - 115 °C
5.2: 10 h / 55 - 115 °C
View Scheme
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / K2CO3 / CH2Cl2 / 20 °C
2: 89 percent / NaH / toluene / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: pyridine / toluene / 20 - 80 °C
2.1: sodium hydride / tetrahydrofuran / 0.75 h / Reflux
2.2: 1.5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: bis-(p-nitrophenyl) carbonate / N,N-dimethyl-formamide / 25 - 30 °C
1.2: 3 h / 25 - 30 °C
1.3: 25 - 30 °C / pH 1 - 2
2.1: ammonium hydroxide / water / pH 9 - 10
View Scheme
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

A

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

B

(3S)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
774517-20-3

(3S)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

C

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
740780-79-4

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

D

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With sodium ethanolate In water; N,N-dimethyl-formamide; toluene at 20℃; for 8h; Product distribution / selectivity; Heating;
methyl (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate

methyl (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate

sodium methylate
124-41-4

sodium methylate

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

A

(1S,3'R)-2'-methylquinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydrolsoquinoline-2-carboxylate

(1S,3'R)-2'-methylquinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydrolsoquinoline-2-carboxylate

B

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
In N,N-dimethyl-formamide; toluene for 8h;
benzyl (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

benzyl (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

sodium phenyl-methanolate
20194-18-7

sodium phenyl-methanolate

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

A

(1S,3'R)-2'-benzylquinuclidin-3'-yl-1-phenyl-1,2,3,4-terahydroisoquinoline-2-carboxylate

(1S,3'R)-2'-benzylquinuclidin-3'-yl-1-phenyl-1,2,3,4-terahydroisoquinoline-2-carboxylate

B

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
In N,N-dimethyl-formamide; toluene for 8h;
C18H18ClNO2

C18H18ClNO2

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; toluene at 80 - 100℃; for 18h; Product distribution / selectivity;
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline; 1,1'-carbonyldiimidazole In toluene at 20℃; for 2.75h;
Stage #2: (R)-quinuclidin-3-ol With sodium hydride In N,N-dimethyl-formamide; toluene at 20 - 85℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

A

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

B

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
740780-79-4

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

C

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With potassium tert-butylate In toluene at 90℃; for 3 - 10h; Product distribution / selectivity;
phenyl (S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate

phenyl (S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl acetamide at 0 - 60℃;
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In ISOPROPYLAMIDE; mineral oil at 0 - 20℃;
Stage #2: phenyl (S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate In ISOPROPYLAMIDE; toluene; mineral oil at 20 - 60℃;
(+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate di-p-toluoyl-L-tartrate

(+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate di-p-toluoyl-L-tartrate

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 0 - 15℃; Product distribution / selectivity;
(+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate oxalate

(+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate oxalate

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 0 - 30℃;
(+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate hydrochloride

(+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydro-isoquinoline-2-carboxylate hydrochloride

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 0 - 30℃;
(S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carbonyl chloride
1195949-26-8

(S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carbonyl chloride

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In tetrahydrofuran for 0.75h; Reflux;
Stage #2: (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carbonyl chloride In tetrahydrofuran for 1.5h; Reflux;
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In tetrahydrofuran for 0.75h; Reflux;
Stage #2: (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carbonyl chloride In tetrahydrofuran for 1.5h; Reflux;
2-(1H-imidazole-2-ylcarbonyl)-(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
1029430-94-1

2-(1H-imidazole-2-ylcarbonyl)-(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: 2-(1H-imidazole-2-ylcarbonyl)-(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: (R)-quinuclidin-3-ol With sodium hydride In tetrahydrofuran Product distribution / selectivity; Reflux;
(3R)-1-azabicyclo[2.2.2]oct-3-yl 4-nitrophenyl carbonate
1243274-81-8

(3R)-1-azabicyclo[2.2.2]oct-3-yl 4-nitrophenyl carbonate

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 25 - 30℃; Product distribution / selectivity;
solifenacin succinate

solifenacin succinate

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With ammonia In water; toluene pH=9 - 10;
sodium ethanolate
141-52-6

sodium ethanolate

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

A

(1S,3'R)-2'-ethylquinuclidine-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

(1S,3'R)-2'-ethylquinuclidine-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

B

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: chloroformic acid ethyl ester; (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline With potassium carbonate In water; toluene at 10 - 25℃; for 2h;
Stage #2: sodium ethanolate; (R)-quinuclidin-3-ol In N,N-dimethyl-formamide; toluene at 20℃; for 8h;
Stage #3: With hydrogenchloride; potassium carbonate more than 3 stages;
succinic acid
110-15-6

succinic acid

solifenacin
242478-37-1

solifenacin

solifenacin succinate

solifenacin succinate

Conditions
ConditionsYield
In toluene at 20 - 50℃; Product distribution / selectivity;100%
In ethyl acetate at 20 - 80℃; for 10h;94.2%
In ethyl acetate; acetone for 2h; Reflux;91.9%
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
740780-79-4

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

succinic acid
110-15-6

succinic acid

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

solifenacin
242478-37-1

solifenacin

A

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate
862207-71-4

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate

B

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate
862207-70-3

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate

C

1-(S)-phenyl-1,2,3,4-tetrahydroisoquinoline succinate

1-(S)-phenyl-1,2,3,4-tetrahydroisoquinoline succinate

D

solifenacin succinate

solifenacin succinate

Conditions
ConditionsYield
In isopropyl alcohol at 20℃;A 0.33%
B 0.17%
C 0.07%
D 89%
succinic acid
110-15-6

succinic acid

solifenacin
242478-37-1

solifenacin

(1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate

(1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate

Conditions
ConditionsYield
In isopropyl alcohol at 20℃;89%
In ethanol; ethyl acetate at 20℃; Reflux;
In ethanol at 70 - 75℃;
L-Tartaric acid
87-69-4

L-Tartaric acid

solifenacin
242478-37-1

solifenacin

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate hydrogen L-tartrate
1035547-81-9

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate hydrogen L-tartrate

Conditions
ConditionsYield
In methanol; isopropyl alcohol at 20℃;89%
solifenacin
242478-37-1

solifenacin

(1'S,3R)-3-[[(1'-phenyl-1',2',3',4'-tetrahydro-2'-isoquinolyl)carbonyl]oxy]quinuclidine 1-oxide
180272-28-0

(1'S,3R)-3-[[(1'-phenyl-1',2',3',4'-tetrahydro-2'-isoquinolyl)carbonyl]oxy]quinuclidine 1-oxide

Conditions
ConditionsYield
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 10 - 20℃; for 1h;83%
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
740780-79-4

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

L-Tartaric acid
87-69-4

L-Tartaric acid

solifenacin
242478-37-1

solifenacin

A

(3S)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate tartrate

(3S)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate tartrate

B

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate hydrogen L-tartrate
1035547-81-9

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate hydrogen L-tartrate

C

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate tartrate

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate tartrate

Conditions
ConditionsYield
In methanol; isopropyl alcohol at 20℃;A 0.6%
B 79%
C 1.1%
solifenacin
242478-37-1

solifenacin

Solifenacin hydrochloride

Solifenacin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; butanone at 20℃; Purification / work up;63%
With hydrogenchloride In methanol; butanone at 20℃;63%
With hydrogenchloride In ethanol; ethyl acetate
With hydrogenchloride In ethanol; water at 20℃; Product distribution / selectivity;
oxalic acid
144-62-7

oxalic acid

solifenacin
242478-37-1

solifenacin

A

C2H2O4*C18H19NO2

C2H2O4*C18H19NO2

B

(S)-((R)-quinuclidin-3-yl) 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate monooxalate

(S)-((R)-quinuclidin-3-yl) 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate monooxalate

C

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline oxalate

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline oxalate

D

C2H2O4*C23H26N2O2

C2H2O4*C23H26N2O2

E

C2H2O4*C23H26N2O2

C2H2O4*C23H26N2O2

Conditions
ConditionsYield
In ethanol
succinic acid
110-15-6

succinic acid

solifenacin
242478-37-1

solifenacin

A

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate
862207-71-4

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate

B

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate
862207-70-3

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate

C

solifenacin succinate

solifenacin succinate

Conditions
ConditionsYield
In ethanol; ethyl acetate at 0 - 50℃; Product distribution / selectivity;
(3S)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
774517-20-3

(3S)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

solifenacin
242478-37-1

solifenacin

A

(1S,3'S)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monohydrochloride

(1S,3'S)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monohydrochloride

B

Solifenacin hydrochloride

Solifenacin hydrochloride

C

(1R,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monohydrochloride

(1R,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monohydrochloride

D

C18H19NO2*ClH

C18H19NO2*ClH

E

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; ethyl acetate Product distribution / selectivity;

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