Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:242478-37-1
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inquirySolifenacin CAS No.:242478-37-1 Name: Solifenacin Synonyms: [(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate Molecular Structure Molec
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inquirySolifenacin Basic information Product Name: Solifenacin Synonyms: Solifenacin;[(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate;2(1H)-Isoquinol
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:242478-37-1
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inquirySolifenacin CAS:242478-37-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:242478-37-1
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inquirySolifenacin CAS: 242478-37-1 Specification Items Specification Product name Solifenacin CAS# 242478-37-1 Appearance White powder
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:242478-37-1
Min.Order:10 Gram
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inquiry1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
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Type:Trading Company
inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta
Cas:242478-37-1
Min.Order:1 Gram
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Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:242478-37-1
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inquiryProduct name: Solifenacin CAS No.:242478-37-1 Molecule Formula:C23H26N2O2 Molecule Weight:362.46 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:242478-37-1
Min.Order:1 Kilogram
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : Unii-A8910sqj1u;3,4-dihydro-1-phe
We are the manufacturer of this product in China. Our price is the lowest in China. CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and techni
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Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Conditions | Yield |
---|---|
In toluene at 60 - 70℃; Temperature; | 96.8% |
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-quinuclidin-3-ol
solifenacin
Conditions | Yield |
---|---|
With sodium hydride; 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 100℃; for 6h; Temperature; Concentration; | 95.1% |
With sodium hydride In toluene for 3h; Heating; | 89% |
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In toluene; mineral oil at 0℃; for 0.25h; Inert atmosphere; Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In toluene; mineral oil at 130℃; for 8h; Inert atmosphere; Dean-Stark; | 88% |
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
solifenacin
Conditions | Yield |
---|---|
In tetrahydrofuran at 0℃; for 2h; Inert atmosphere; | 92.2% |
(3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
solifenacin
Conditions | Yield |
---|---|
In toluene at 10 - 15℃; Temperature; Time; Solvent; | 91% |
In toluene at 10 - 15℃; Solvent; Temperature; | 91% |
solifenacin
Conditions | Yield |
---|---|
With ammonium hydroxide In water pH=9 - 10; | 90% |
4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
(R)-quinuclidin-3-ol
solifenacin
Conditions | Yield |
---|---|
Stage #1: (R)-quinuclidin-3-ol With 18-crown-6 ether; sodium hydride In toluene; mineral oil Inert atmosphere; Stage #2: 4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate In toluene; mineral oil at 20 - 110℃; for 18h; Inert atmosphere; | 74% |
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil Inert atmosphere; Stage #2: 4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate In N,N-dimethyl-formamide; mineral oil at 110℃; for 4h; Inert atmosphere; | 70% |
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-quinuclidin-3-ol
solifenacin
Conditions | Yield |
---|---|
Stage #1: (R)-quinuclidin-3-ol With sodium methylate In toluene at 5℃; Inert atmosphere; Reflux; Stage #2: (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline In N,N-dimethyl-formamide; toluene at 60℃; Reflux; | 72% |
Stage #1: (R)-quinuclidin-3-ol With 1,1'-Carbonyl-di-(1,2,4-triazole); triethylamine In Isopropyl acetate at 20℃; for 2h; Stage #2: (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline In Isopropyl acetate for 4h; Product distribution / selectivity; Heating / reflux; |
(R)-quinuclidin-3-ol
solifenacin
Conditions | Yield |
---|---|
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In toluene at 80℃; for 1h; Stage #2: propyl (1S)-1-phenyl-3,4-dihydro-2(1H)isoquinolinecarboxylate In toluene for 18h; Reflux; | 63.9% |
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
solifenacin
Conditions | Yield |
---|---|
Stage #1: (3R)-1-azabicyclo[2.2.2]octan-3-ol hydrochloride With sodium methylate at 5 - 30℃; Inert atmosphere; Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In N,N-dimethyl-formamide; toluene at 60℃; Reflux; | 51% |
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
solifenacin
Conditions | Yield |
---|---|
Stage #1: sodium (R)-quinuclidin-3-ol With sodium methylate In N,N-dimethyl-formamide; toluene at 25℃; Inert atmosphere; Reflux; Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In N,N-dimethyl-formamide; toluene at 70℃; Reflux; | 50% |
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-quinuclidin-3-ol
A
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
B
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
C
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
D
solifenacin
Conditions | Yield |
---|---|
With potassium 2-methylbutan-2-olate In toluene at 90℃; for 3h; Product distribution / selectivity; | A 1.1% B 3.2% C 6% D n/a |
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
A
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
B
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
C
solifenacin
Conditions | Yield |
---|---|
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In toluene for 0.166667h; Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In toluene at 26 - 110℃; for 4.33333h; Product distribution / selectivity; |
1-phenyl-3,4-dihydroisoquinoline
solifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaBH4 / ethanol / 60 h / 20 °C 2: 100 percent / K2CO3 / CH2Cl2 / 20 °C 3: 89 percent / NaH / toluene / 3 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1.1: methanol; sodium tetrahydroborate / water / 5.42 h / 20 - 34 °C 2.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate 2.2: 1.17 h / pH 8 - 9 3.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C 4.1: toluene / 5 h / 55 - 115 °C 4.2: 10 h / 55 - 115 °C View Scheme |
N-phenethylbenzamide
solifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: P2O5; POCl3 / xylene / 2.5 h / Heating 2: NaBH4 / ethanol / 60 h / 20 °C 3: 100 percent / K2CO3 / CH2Cl2 / 20 °C 4: 89 percent / NaH / toluene / 3 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: PPA / water / 4.25 h / 14.9 - 165 °C 1.2: 0.17 h / 28 - 42 °C / pH 2.1 - 7.12 2.1: methanol; sodium tetrahydroborate / water / 5.42 h / 20 - 34 °C 3.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate 3.2: 1.17 h / pH 8 - 9 4.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C 5.1: toluene / 5 h / 55 - 115 °C 5.2: 10 h / 55 - 115 °C View Scheme |
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
solifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / K2CO3 / CH2Cl2 / 20 °C 2: 89 percent / NaH / toluene / 3 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: pyridine / toluene / 20 - 80 °C 2.1: sodium hydride / tetrahydrofuran / 0.75 h / Reflux 2.2: 1.5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: bis-(p-nitrophenyl) carbonate / N,N-dimethyl-formamide / 25 - 30 °C 1.2: 3 h / 25 - 30 °C 1.3: 25 - 30 °C / pH 1 - 2 2.1: ammonium hydroxide / water / pH 9 - 10 View Scheme |
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-quinuclidin-3-ol
A
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
B
(3S)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
C
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
D
solifenacin
Conditions | Yield |
---|---|
With sodium ethanolate In water; N,N-dimethyl-formamide; toluene at 20℃; for 8h; Product distribution / selectivity; Heating; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; toluene for 8h; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; toluene for 8h; |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; toluene at 80 - 100℃; for 18h; Product distribution / selectivity; |
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
1,1'-carbonyldiimidazole
(R)-quinuclidin-3-ol
solifenacin
Conditions | Yield |
---|---|
Stage #1: (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline; 1,1'-carbonyldiimidazole In toluene at 20℃; for 2.75h; Stage #2: (R)-quinuclidin-3-ol With sodium hydride In N,N-dimethyl-formamide; toluene at 20 - 85℃; |
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-quinuclidin-3-ol
A
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
B
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
C
solifenacin
Conditions | Yield |
---|---|
With potassium tert-butylate In toluene at 90℃; for 3 - 10h; Product distribution / selectivity; |
(R)-quinuclidin-3-ol
solifenacin
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl acetamide at 0 - 60℃; | |
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In ISOPROPYLAMIDE; mineral oil at 0 - 20℃; Stage #2: phenyl (S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate In ISOPROPYLAMIDE; toluene; mineral oil at 20 - 60℃; |
solifenacin
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water at 0 - 15℃; Product distribution / selectivity; |
solifenacin
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 0 - 30℃; |
solifenacin
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 0 - 30℃; |
(S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carbonyl chloride
(R)-quinuclidin-3-ol
solifenacin
Conditions | Yield |
---|---|
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In tetrahydrofuran for 0.75h; Reflux; Stage #2: (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carbonyl chloride In tetrahydrofuran for 1.5h; Reflux; | |
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In tetrahydrofuran for 0.75h; Reflux; Stage #2: (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carbonyl chloride In tetrahydrofuran for 1.5h; Reflux; |
2-(1H-imidazole-2-ylcarbonyl)-(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-quinuclidin-3-ol
solifenacin
Conditions | Yield |
---|---|
Stage #1: 2-(1H-imidazole-2-ylcarbonyl)-(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 0.5h; Stage #2: (R)-quinuclidin-3-ol With sodium hydride In tetrahydrofuran Product distribution / selectivity; Reflux; |
(3R)-1-azabicyclo[2.2.2]oct-3-yl 4-nitrophenyl carbonate
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
solifenacin
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 25 - 30℃; Product distribution / selectivity; |
solifenacin
Conditions | Yield |
---|---|
With ammonia In water; toluene pH=9 - 10; |
sodium ethanolate
chloroformic acid ethyl ester
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-quinuclidin-3-ol
B
solifenacin
Conditions | Yield |
---|---|
Stage #1: chloroformic acid ethyl ester; (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline With potassium carbonate In water; toluene at 10 - 25℃; for 2h; Stage #2: sodium ethanolate; (R)-quinuclidin-3-ol In N,N-dimethyl-formamide; toluene at 20℃; for 8h; Stage #3: With hydrogenchloride; potassium carbonate more than 3 stages; |
Conditions | Yield |
---|---|
In toluene at 20 - 50℃; Product distribution / selectivity; | 100% |
In ethyl acetate at 20 - 80℃; for 10h; | 94.2% |
In ethyl acetate; acetone for 2h; Reflux; | 91.9% |
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
succinic acid
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
solifenacin
A
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate
B
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; | A 0.33% B 0.17% C 0.07% D 89% |
succinic acid
solifenacin
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; | 89% |
In ethanol; ethyl acetate at 20℃; Reflux; | |
In ethanol at 70 - 75℃; |
L-Tartaric acid
solifenacin
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate hydrogen L-tartrate
Conditions | Yield |
---|---|
In methanol; isopropyl alcohol at 20℃; | 89% |
solifenacin
(1'S,3R)-3-[[(1'-phenyl-1',2',3',4'-tetrahydro-2'-isoquinolyl)carbonyl]oxy]quinuclidine 1-oxide
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 10 - 20℃; for 1h; | 83% |
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
L-Tartaric acid
solifenacin
B
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate hydrogen L-tartrate
Conditions | Yield |
---|---|
In methanol; isopropyl alcohol at 20℃; | A 0.6% B 79% C 1.1% |
solifenacin
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; butanone at 20℃; Purification / work up; | 63% |
With hydrogenchloride In methanol; butanone at 20℃; | 63% |
With hydrogenchloride In ethanol; ethyl acetate | |
With hydrogenchloride In ethanol; water at 20℃; Product distribution / selectivity; |
succinic acid
solifenacin
A
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate
B
(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate
Conditions | Yield |
---|---|
In ethanol; ethyl acetate at 0 - 50℃; Product distribution / selectivity; |
(3S)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
solifenacin
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; ethyl acetate Product distribution / selectivity; |
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