Products

Refine

Country

Business Type

Certificate

Display

Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:

(S)-ethyl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Cas:180468-42-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate Manufacturer/High quality/Best price/In stock

Cas:180468-42-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl (1S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 180468-42-2 with competitive price

Cas:180468-42-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid ethyl ester

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL (1S)-1-PHENYL-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLATE

Cas:180468-42-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

180468-42-2--Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate Appearance:White Powder Storage:Room temperature Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or

180468-42-2--Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Tr

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and

TIANFUCHEM--180468-42-2--Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (S)-Ethyl 1-Phenyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate CAS No.:180468-42-2 Molecule Formula:C18H19NO2 Molecule Weight:281.35 Purity: 98.0% Package: 25kg/drum Description:White or almost white crystalline powder Man

High Quality (S)-Ethyl 1-Phenyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate

Cas:180468-42-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

180468-42-2 CAS NO.180468-42-2

Cas:180468-42-2

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(S)-ethyl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

(S)-Ethyl 1-Phenyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate

Cas:180468-42-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

(S)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid Ethyl Ester

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

ethyl (S)-1-phenyl-3,4- dihydroisoquinoline-2(1H)-carboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate CAS No.180468-42-2

Cas:180468-42-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃;100%
With triethylamine In dichloromethane at 20℃; for 5h;99%
With potassium carbonate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 20℃; for 2h; Reagent/catalyst; Concentration;97.9%
ethyl bromide
74-96-4

ethyl bromide

carbon dioxide
124-38-9

carbon dioxide

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane at 25℃; under 750.075 Torr; for 5h;84%
ethyl (S)-((2-(2-hydroxyethyl)phenyl)(phenyl)methyl)carbamate

ethyl (S)-((2-(2-hydroxyethyl)phenyl)(phenyl)methyl)carbamate

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 12h; enantioselective reaction;71%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 12h; Inert atmosphere; Cooling with ice;71%
1-phenyl-3,4-dihydroisoquinoline
52250-50-7

1-phenyl-3,4-dihydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBH4 / ethanol / 60 h / 20 °C
2: 100 percent / K2CO3 / CH2Cl2 / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: methanol; sodium tetrahydroborate / water / 5.42 h / 20 - 34 °C
2.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate
2.2: 1.17 h / pH 8 - 9
3.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C
View Scheme
N-phenethylbenzamide
3278-14-6

N-phenethylbenzamide

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: P2O5; POCl3 / xylene / 2.5 h / Heating
2: NaBH4 / ethanol / 60 h / 20 °C
3: 100 percent / K2CO3 / CH2Cl2 / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: PPA / water / 4.25 h / 14.9 - 165 °C
1.2: 0.17 h / 28 - 42 °C / pH 2.1 - 7.12
2.1: methanol; sodium tetrahydroborate / water / 5.42 h / 20 - 34 °C
3.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate
3.2: 1.17 h / pH 8 - 9
4.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C
View Scheme
(S)-1,2,3,4-tetrahydro-1-phenyl-isoquinoline-2-carboxylic acid
1035272-88-8

(S)-1,2,3,4-tetrahydro-1-phenyl-isoquinoline-2-carboxylic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
With sodium carbonate In water; toluene at 14.9 - 34.8℃; for 3h;
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180272-45-1

(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / -10 - 20 °C
2.1: hydrogenchloride; water; phosphoric acid / 95 - 100 °C
2.2: 20 °C / pH 9 - 10
3.1: D-tartaric acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate
4.1: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / dichloromethane / 0 - 25 °C
2.1: sodium hydroxide / ethanol / 75 - 80 °C
2.2: Cooling
3.1: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / -10 - 20 °C
2.1: hydrogenchloride; water; phosphoric acid / 32 h / 95 - 100 °C
2.2: 20 °C / pH 9 - 10
3.1: D-tartaric acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate
4.1: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / -10 - 20 °C
2.1: hydrogenchloride; water; phosphoric acid / 95 - 100 °C
2.2: 20 °C / pH 9 - 10
3.1: D-tartaric acid / water / Resolution of racemate
3.2: 20 °C
4.1: acetone / 5 °C / Reflux
View Scheme
4-nitrophenyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
881834-78-2

4-nitrophenyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / ethanol / 75 - 80 °C
1.2: Cooling
2.1: triethylamine / dichloromethane / -10 - 20 °C
3.1: hydrogenchloride; water; phosphoric acid / 32 h / 95 - 100 °C
3.2: 20 °C / pH 9 - 10
4.1: D-tartaric acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate
5.1: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide / ethanol / 75 - 80 °C
1.2: Cooling
2.1: acetone / 5 °C / Reflux
View Scheme
1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8

1-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: D-tartaric acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate
2: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: D-tartaric acid / water / Resolution of racemate
1.2: 20 °C
2.1: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: D-tartaric acid / water / Resolution of racemate
1.2: 20 °C
2.1: potassium carbonate / dichloromethane / 0 - 25 °C
3.1: sodium hydroxide / ethanol / 75 - 80 °C
3.2: Cooling
4.1: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate
1.2: 1.17 h / pH 8 - 9
2.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C
View Scheme
N-acetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline
1300713-32-9

N-acetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water; phosphoric acid / 32 h / 95 - 100 °C
1.2: 20 °C / pH 9 - 10
2.1: D-tartaric acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate
3.1: acetone / 5 °C / Reflux
View Scheme
N-chloroacetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline
1085541-60-1

N-chloroacetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water; phosphoric acid / 95 - 100 °C
1.2: 20 °C / pH 9 - 10
2.1: D-tartaric acid / water / 1.5 h / 65 - 95 °C / Resolution of racemate
3.1: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water; phosphoric acid / 95 - 100 °C
1.2: 20 °C / pH 9 - 10
2.1: D-tartaric acid / water / Resolution of racemate
2.2: 20 °C
3.1: acetone / 5 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride; water; phosphoric acid / 95 - 100 °C
1.2: 20 °C / pH 9 - 10
2.1: D-tartaric acid / water / Resolution of racemate
2.2: 20 °C
3.1: potassium carbonate / dichloromethane / 0 - 25 °C
4.1: sodium hydroxide / ethanol / 75 - 80 °C
4.2: Cooling
5.1: acetone / 5 °C / Reflux
View Scheme
1-phenyl-3,4-dihydroisoquinoline
52250-50-7

1-phenyl-3,4-dihydroisoquinoline

diethyl dicarbonate
1609-47-8

diethyl dicarbonate

A

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

B

ethyl (R)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
180468-41-1

ethyl (R)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-3,5-diMe-Synphos; hydrogen In 1,4-dioxane at 40℃; under 22502.3 Torr; for 18h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
N-benzyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline
1443308-90-4

N-benzyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen; hydrogenchloride; 5%-palladium/activated carbon / ethanol; ethyl acetate / 24 h / 20 °C / 760.05 Torr / Schlenk technique
2: triethylamine / dichloromethane / 5 h / 20 °C
View Scheme
C22H18N(1+)*Br(1-)
1443308-91-5

C22H18N(1+)*Br(1-)

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane) / dichloromethane; tetrahydrofuran / 20 h / 30 °C / 31029.7 Torr / Autoclave; Glovebox
2: hydrogen; hydrogenchloride; 5%-palladium/activated carbon / ethanol; ethyl acetate / 24 h / 20 °C / 760.05 Torr / Schlenk technique
3: triethylamine / dichloromethane / 5 h / 20 °C
View Scheme
1-phenylisoquinoline
3297-72-1

1-phenylisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetone / 24 h / 90 °C
2: bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane) / dichloromethane; tetrahydrofuran / 20 h / 30 °C / 31029.7 Torr / Autoclave; Glovebox
3: hydrogen; hydrogenchloride; 5%-palladium/activated carbon / ethanol; ethyl acetate / 24 h / 20 °C / 760.05 Torr / Schlenk technique
4: triethylamine / dichloromethane / 5 h / 20 °C
View Scheme
(S)-2-[(R)-tert-butylsulfinyl]-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-2-[(R)-tert-butylsulfinyl]-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 0 - 20 °C
2.1: triethylamine / dichloromethane / 0.17 h / 0 °C
2.2: 1 h / 20 °C
View Scheme
2-(2-bromoethyl)benzaldehyde
22901-09-3

2-(2-bromoethyl)benzaldehyde

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: copper(II) sulfate / dichloromethane / 20 h / 23 °C
2.1: toluene; diethyl ether / 3 h / -40 - 25 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
4.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 0 - 20 °C
5.1: triethylamine / dichloromethane / 0.17 h / 0 °C
5.2: 1 h / 20 °C
View Scheme
(R)-N-{(E)-[2-(2-bromoethyl)phenylmethylidene]}-2-methylpropane-2-sulfinamide

(R)-N-{(E)-[2-(2-bromoethyl)phenylmethylidene]}-2-methylpropane-2-sulfinamide

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene; diethyl ether / 3 h / -40 - 25 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
3.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0.17 h / 0 °C
4.2: 1 h / 20 °C
View Scheme
(R)-N-{(S)-[2-(2-bromoethyl)phenyl](phenyl)methyl}-2-methylpropane-2-sulfinamide

(R)-N-{(S)-[2-(2-bromoethyl)phenyl](phenyl)methyl}-2-methylpropane-2-sulfinamide

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
2.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h / 0 - 20 °C
3.1: triethylamine / dichloromethane / 0.17 h / 0 °C
3.2: 1 h / 20 °C
View Scheme
triphenylboroxine
3262-89-3

triphenylboroxine

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (R)-N-(4,4-dimethyl-2-methylenepentyl)-2-methylpropane-2-sulfinamide; chlorobis(cyclooctene)rhodium(I) dimer / toluene / 0.5 h / 20 °C / Inert atmosphere
1.2: 6 h / 60 °C / Inert atmosphere
2.1: Trimethylenediamine / 0.5 h / 20 °C / Microwave irradiation
3.1: triethylamine / dichloromethane / 6 h / 20 °C
3.2: 6 h / 20 °C
4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
View Scheme
(S)-N-(dimethylsulfamoyl)-C-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-C-phenylmethyleneamine

(S)-N-(dimethylsulfamoyl)-C-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-C-phenylmethyleneamine

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Trimethylenediamine / 0.5 h / 20 °C / Microwave irradiation
2.1: triethylamine / dichloromethane / 6 h / 20 °C
2.2: 6 h / 20 °C
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: Trimethylenediamine / 2.5 h / 120 °C / Microwave irradiation
2: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere; Cooling with ice
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Cooling with ice
4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
C17H30N2O3SSi

C17H30N2O3SSi

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (R)-N-(4,4-dimethyl-2-methylenepentyl)-2-methylpropane-2-sulfinamide; chlorobis(cyclooctene)rhodium(I) dimer / toluene / 0.5 h / 20 °C / Inert atmosphere
1.2: 6 h / 60 °C / Inert atmosphere
2.1: Trimethylenediamine / 0.5 h / 20 °C / Microwave irradiation
3.1: triethylamine / dichloromethane / 6 h / 20 °C
3.2: 6 h / 20 °C
4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: C18H31NOS; [RhCl(cis-cyclooctene)2]2 / toluene / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique
1.2: 6 h / 60 °C
2.1: Trimethylenediamine / 2.5 h / 120 °C / Microwave irradiation
3.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere; Cooling with ice
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Cooling with ice
5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
C21H31NOSi

C21H31NOSi

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 6 h / 20 °C
1.2: 6 h / 20 °C
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere; Cooling with ice
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Cooling with ice
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
C24H35NO3Si

C24H35NO3Si

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Cooling with ice
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
2-<2-(t-Butyldimethylsilyloxy)ethyl>benzaldehyde
81168-10-7

2-<2-(t-Butyldimethylsilyloxy)ethyl>benzaldehyde

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 12 h / Reflux
2.1: C18H31NOS; [RhCl(cis-cyclooctene)2]2 / toluene / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: 6 h / 60 °C
3.1: Trimethylenediamine / 2.5 h / 120 °C / Microwave irradiation
4.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere; Cooling with ice
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Cooling with ice
6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
benzoyl chloride
98-88-4

benzoyl chloride

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium carbonate / water / 0.25 h / 29.8 °C
1.2: 4.33 h / 17.5 - 26.6 °C
2.1: PPA / water / 4.25 h / 14.9 - 165 °C
2.2: 0.17 h / 28 - 42 °C / pH 2.1 - 7.12
3.1: methanol; sodium tetrahydroborate / water / 5.42 h / 20 - 34 °C
4.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate
4.2: 1.17 h / pH 8 - 9
5.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C
View Scheme
phenethylamine
64-04-0

phenethylamine

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium carbonate / water / 0.25 h / 29.8 °C
1.2: 4.33 h / 17.5 - 26.6 °C
2.1: PPA / water / 4.25 h / 14.9 - 165 °C
2.2: 0.17 h / 28 - 42 °C / pH 2.1 - 7.12
3.1: methanol; sodium tetrahydroborate / water / 5.42 h / 20 - 34 °C
4.1: D-tartaric acid / methanol; ethyl acetate / 2.08 h / 28 - 64 °C / Resolution of racemate
4.2: 1.17 h / pH 8 - 9
5.1: sodium carbonate / toluene / 2.17 h / 0 - 28 °C
View Scheme
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With sodium hydride; 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 100℃; for 6h; Temperature; Concentration;95.1%
With sodium hydride In toluene for 3h; Heating;89%
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In toluene; mineral oil at 0℃; for 0.25h; Inert atmosphere;
Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In toluene; mineral oil at 130℃; for 8h; Inert atmosphere; Dean-Stark;
88%
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

diphenylamine
122-39-4

diphenylamine

(S)-N,N,1-triphenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N,N,1-triphenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;84%
With sodium hydride In toluene at 103 - 135℃; Temperature;82%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

4-chloro-aniline
106-47-8

4-chloro-aniline

(S)-N-(p-chlorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(p-chlorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;81%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

4-fluoroaniline
371-40-4

4-fluoroaniline

(S)-N-(p-fluorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(p-fluorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;78.3%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

(S)-N-(2,6-dichlorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(2,6-dichlorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;77.5%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

3-bromoaniline
591-19-5

3-bromoaniline

(S)-N-(m-bromophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(m-bromophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;77.5%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

4-methoxy-aniline
104-94-9

4-methoxy-aniline

(S)-N-(p-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(p-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;77%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

2-bromoaniline
615-36-1

2-bromoaniline

(S)-N-(o-bromophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(o-bromophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;74.5%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

benzylamine
100-46-9

benzylamine

(S)-N-benzyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-benzyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;73%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

phenyl sulfamate
19792-91-7

phenyl sulfamate

C24H24N2O5S

C24H24N2O5S

Conditions
ConditionsYield
Stage #1: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline; phenyl sulfamate With aluminum oxide; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} at 20℃; for 0.0833333h;
Stage #2: With bis(tertbutylcarbonyloxy)iodobenzene at 20℃; for 6h; enantioselective reaction;
73%
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

(S)-1-phenyl-N-m-tolyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-1-phenyl-N-m-tolyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;70%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

2-Chloroaniline
95-51-2

2-Chloroaniline

(S)-N-(o-chlorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(o-chlorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;69.6%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

2-methoxy-phenylamine
90-04-0

2-methoxy-phenylamine

(S)-N-(o-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(o-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;68%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

3-chloro-aniline
108-42-9

3-chloro-aniline

(S)-N-(m-chlorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(m-chlorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;66%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

meta-fluoroaniline
372-19-0

meta-fluoroaniline

(S)-N-(m-fluorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(m-fluorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;65.7%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

aniline
62-53-3

aniline

(S)-N,1-diphenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N,1-diphenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;65%
With sodium hydride In toluene at 110 - 120℃;64.7%
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

m-Anisidine
536-90-3

m-Anisidine

(S)-N-(m-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(m-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;63.5%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

2-Fluoroaniline
348-54-9

2-Fluoroaniline

(S)-N-(o-fluorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(o-fluorophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;63%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

4-bromo-aniline
106-40-1

4-bromo-aniline

(S)-N-(p-bromophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-N-(p-bromophenyl)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;61.6%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

o-toluidine
95-53-4

o-toluidine

(S)-1-phenyl-N-o-tolyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-1-phenyl-N-o-tolyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;59.5%
With sodium hydride In toluene at 110 - 120℃;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

p-toluidine
106-49-0

p-toluidine

(S)-1-phenyl-N-p-tolyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

(S)-1-phenyl-N-p-tolyl-3,4-dihydroisoquinoline-2(1H)-carboxamide

Conditions
ConditionsYield
With sodium hydride In toluene at 110 - 120℃;53%
With sodium hydride In toluene at 110 - 120℃;
(3R)-1-azabicyclo[2.2.2]octan-3-ol hydrochloride

(3R)-1-azabicyclo[2.2.2]octan-3-ol hydrochloride

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (3R)-1-azabicyclo[2.2.2]octan-3-ol hydrochloride With sodium methylate at 5 - 30℃; Inert atmosphere;
Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In N,N-dimethyl-formamide; toluene at 60℃; Reflux;
51%
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

sodium (R)-quinuclidin-3-ol

sodium (R)-quinuclidin-3-ol

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: sodium (R)-quinuclidin-3-ol With sodium methylate In N,N-dimethyl-formamide; toluene at 25℃; Inert atmosphere; Reflux;
Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In N,N-dimethyl-formamide; toluene at 70℃; Reflux;
50%
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(R)-quinuclidin-3-ol
25333-42-0

(R)-quinuclidin-3-ol

A

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

B

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
740780-79-4

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

C

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
22990-19-8, 96719-89-0, 118864-75-8

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline

D

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
With potassium 2-methylbutan-2-olate In toluene at 90℃; for 3h; Product distribution / selectivity;A 1.1%
B 3.2%
C 6%
D n/a
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

Conditions
ConditionsYield
With sodium hydride In toluene Heating;
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
180468-42-2

(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline

A

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
732228-02-3

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

B

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
740780-79-4

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

C

solifenacin
242478-37-1

solifenacin

Conditions
ConditionsYield
Stage #1: (R)-quinuclidin-3-ol With sodium hydride In toluene for 0.166667h;
Stage #2: (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline In toluene at 26 - 110℃; for 4.33333h; Product distribution / selectivity;
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View