Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:198481-32-2
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:198481-32-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:198481-32-2
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:198481-32-2
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:198481-32-2
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:198481-32-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryBazedoxifene CAS:198481-32-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:198481-32-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:198481-32-2
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:198481-32-2
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryGood quality ,competitve price Storage:keep from moisture.Room temperature
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:198481-32-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:198481-32-2
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta
Product name: Bazedoxifene CAS No.:198481-32-2 Molecule Formula:C30H34N2O3 Molecule Weight:470.60 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS S
Cas:198481-32-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:198481-32-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:198481-32-2
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:198481-32-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:198481-32-2
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I
GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:198481-32-2
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:198481-32-2
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiry1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification
ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai
Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:198481-32-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
Cas:198481-32-2
Min.Order:0
Negotiable
Type:Manufacturers
inquiryAcmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
Cas:198481-32-2
Min.Order:1 bottle
Negotiable
Type:Lab/Research institutions
inquiry5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole
bazedoxifene
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen; sodium hydroxide In ethanol; ethyl acetate Solvent; Reagent/catalyst; | 100% |
With hydrogen; 2.34% Pd/C In tetrahydrofuran; ethanol for 5h; | 99% |
With hydrogen; palladium 10% on activated carbon In methanol; water; acetone at 40℃; under 7355.72 Torr; Product distribution / selectivity; | 99.72% |
bazedoxifene
Conditions | Yield |
---|---|
With trimethylsilyl iodide In chloroform at 20℃; for 5h; | 95% |
With hydrogen iodide | 36.3 g |
1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride
4-(5-acetoxy-3-methyl-1H-indol-2-yl)phenyl acetate
bazedoxifene
Conditions | Yield |
---|---|
Stage #1: 4-(5-acetoxy-3-methyl-1H-indol-2-yl)phenyl acetate With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 2h; Inert atmosphere; Stage #2: 1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride In N,N-dimethyl-formamide at 0 - 25℃; for 15h; Stage #3: With sodium hydroxide In N,N-dimethyl-formamide at 25℃; for 15h; Solvent; Temperature; Reagent/catalyst; | 89% |
bazedoxifene
Conditions | Yield |
---|---|
With hydrogen bromide; acetic acid at 20℃; for 0.5h; | 87% |
bazedoxifene
Conditions | Yield |
---|---|
With triethylamine In methanol; water for 5h; Reflux; | 86% |
bazedoxifene
Conditions | Yield |
---|---|
With ammonium formate; 10 wt% Pd(OH)2 on carbon In acetone | 85% |
bazedoxifene
Conditions | Yield |
---|---|
With ammonia In methanol; water at 20℃; for 3h; | 85% |
bazedoxifene
Conditions | Yield |
---|---|
With methanol; potassium carbonate at 45℃; for 3h; | 83% |
1-(2-{4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-ethyl)-azepane-2,7-dione
bazedoxifene
Conditions | Yield |
---|---|
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran at 5 - 10℃; for 4h; | 80.7% |
hexamethylene imine
2-(4-((5-hydroxy-2-(4-hydroxyphenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethyl 4-methylbenzenesulfonate
bazedoxifene
Conditions | Yield |
---|---|
In toluene at 70 - 75℃; for 12h; | 80% |
bazedoxifene
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 20℃; for 3h; | 79% |
bazedoxifene
Conditions | Yield |
---|---|
With triethylamine In dichloromethane; water pH=9.5 - 10.5; Product distribution / selectivity; | 73.27% |
1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride
2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
bazedoxifene
Conditions | Yield |
---|---|
Stage #1: 1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride; 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h; Stage #2: 1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride In N,N-dimethyl-formamide at 0 - 5℃; for 3.91h; | 70.18% |
bazedoxifene
Conditions | Yield |
---|---|
With boron tribromide In methanol for 5h; Reflux; | 69% |
bazedoxifene
Conditions | Yield |
---|---|
With hydrogen bromide; acetic acid In methanol at 50℃; for 2h; | 61% |
hexanedial
1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
bazedoxifene
Conditions | Yield |
---|---|
10 wt% Pd(OH)2 on carbon at 45 - 50℃; under 3677.86 - 5884.58 Torr; | 45% |
bazedoxifene
Conditions | Yield |
---|---|
With acetyl chloride In methanol at 0 - 2℃; for 3h; | 42% |
bazedoxifene
Conditions | Yield |
---|---|
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 20h; | 15% |
(4-hydroxyphenyl)methanol
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: K2CO3 2.1: SOCl2 / tetrahydrofuran 3.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 3.2: 59 percent / dimethylformamide / 18 h / 20 °C 4.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 5.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 6.1: tetrahydrofuran 7.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / Reflux 2.1: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere 3.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C 3.2: 5 °C 4.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr View Scheme | |
Multi-step reaction with 7 steps 1.1: potassium carbonate / acetonitrile / 60 °C 2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0.75 h / 0 °C / Inert atmosphere 3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 3.2: 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 5.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C 6.1: tetrahydrofuran / Reflux 7.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C View Scheme |
1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 51 percent / Et3N / dimethylformamide / Heating 2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 2.2: 59 percent / dimethylformamide / 18 h / 20 °C 3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 5.1: tetrahydrofuran 6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / N,N-dimethyl-formamide / 100 - 125 °C 2.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C 2.2: 5 °C 3.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr View Scheme | |
Multi-step reaction with 6 steps 1.1: triethylamine / N,N-dimethyl-formamide / 4 h / 120 - 150 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 2.2: 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 4.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C 5.1: tetrahydrofuran / Reflux 6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / N,N-dimethyl-formamide / 4 h / 115 °C 2: sodium hydride / N,N-dimethyl-formamide / 10 h / 20 °C 3: boron trifluoride diethyl etherate / dichloromethane; ethanethiol / 4 h / 0 - 25 °C View Scheme |
4-benzyloxyaniline hydrochloride
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 51 percent / Et3N / dimethylformamide / Heating 2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 2.2: 59 percent / dimethylformamide / 18 h / 20 °C 3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 5.1: tetrahydrofuran 6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / N,N-dimethyl-formamide / 100 - 125 °C 2.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C 2.2: 5 °C 3.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / N,N-dimethyl-formamide / 4 h / 115 °C 2: sodium hydride / N,N-dimethyl-formamide / 10 h / 20 °C 3: boron trifluoride diethyl etherate / dichloromethane; ethanethiol / 4 h / 0 - 25 °C View Scheme |
ethyl [p-(chloromethyl)phenoxy]acetate
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 1.2: 59 percent / dimethylformamide / 18 h / 20 °C 2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 4.1: tetrahydrofuran 5.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 3.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C 4.1: tetrahydrofuran / Reflux 5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C View Scheme |
ethyl 2-(4-hydroxymethylphenoxy)acetate
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: SOCl2 / tetrahydrofuran 2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 2.2: 59 percent / dimethylformamide / 18 h / 20 °C 3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 5.1: tetrahydrofuran 6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0.75 h / 0 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 2.2: 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 4.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C 5.1: tetrahydrofuran / Reflux 6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C View Scheme |
5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1H-indole
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 1.2: 59 percent / dimethylformamide / 18 h / 20 °C 2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 4.1: tetrahydrofuran 5.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C 1.2: 5 °C 2.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 3.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C 4.1: tetrahydrofuran / Reflux 5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C View Scheme |
2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethanol
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 2: tetrahydrofuran 3: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C 2: tetrahydrofuran / Reflux 3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C View Scheme |
5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrahydrofuran 2: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: tetrahydrofuran / Reflux 2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C View Scheme |
{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetic acid ethyl ester
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 2: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 3: tetrahydrofuran 4: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 2: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C 3: tetrahydrofuran / Reflux 4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C View Scheme |
C30H36N2O9P2
bazedoxifene
Conditions | Yield |
---|---|
With water; alkaline phosphatase pH=7.4; Conversion of starting material; Tris buffer; Enzymatic reaction; |
[4-(2-hexamethyleneimino-1-yl-ethoxy)-phenyl]-methanol
bazedoxifene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C 2.2: 5 °C 3.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr View Scheme |
Conditions | Yield |
---|---|
for 6h; Heating; | 98.5% |
In ethanol; ethyl acetate at 20 - 30℃; | 95.5% |
In acetone at 20 - 55℃; | 95% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere; | 93.48% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere; | 90.3% |
bazedoxifene
Conditions | Yield |
---|---|
With hydrogenchloride In methanol Product distribution / selectivity; | 87.79% |
With hydrogenchloride In methanol; water |
Conditions | Yield |
---|---|
Stage #1: L-Lactic acid In ethanol at 60℃; for 0.25h; Stage #2: bazedoxifene In ethanol at 60℃; for 0.333333h; Solvent; | 66.4% |
propionic acid
bazedoxifene
1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate
Conditions | Yield |
---|---|
In acetone | 60.23% |
formic acid
bazedoxifene
Conditions | Yield |
---|---|
In ethyl acetate at 77℃; | 50% |
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