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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

supply 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

Cas:198481-32-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality bazedoxifene

Cas:198481-32-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Bazedoxifene

Cas:198481-32-2

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol CAS 198481-32-2

Cas:198481-32-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

Cas:198481-32-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Bazedoxifene 198481-32-2

Cas:198481-32-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Bazedoxifene CAS:198481-32-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Bazedoxifene CAS:198481-32-2

Cas:198481-32-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Bazedoxifene

Cas:198481-32-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Bazedoxifene

Cas:198481-32-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Bazedoxifene 198481-32-2

Cas:198481-32-2

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol

Cas:198481-32-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

Good quality ,competitve price Storage:keep from moisture.Room temperature

bazedoxifene

Cas:198481-32-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-[[4-[2-(Azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol

Cas:198481-32-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

Cas:198481-32-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

Bazedoxifene

Cas:198481-32-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Bazedoxifene CAS No.:198481-32-2 Molecule Formula:C30H34N2O3 Molecule Weight:470.60 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS S

High Quality Bazedoxifene on stock

Cas:198481-32-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Bazedoxifene

Cas:198481-32-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

Cas:198481-32-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

Cas:198481-32-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

Cas:198481-32-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Bazedoxifene

Cas:198481-32-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol

Cas:198481-32-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

Cas:198481-32-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

Bazedoxifene

Cas:198481-32-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

Bazedoxifene

Cas:198481-32-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

Cas:198481-32-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Bazedoxifene

Cas:198481-32-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Bazedoxifene 10mg

Cas:198481-32-2

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole
198480-21-6

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen; sodium hydroxide In ethanol; ethyl acetate Solvent; Reagent/catalyst;100%
With hydrogen; 2.34% Pd/C In tetrahydrofuran; ethanol for 5h;99%
With hydrogen; palladium 10% on activated carbon In methanol; water; acetone at 40℃; under 7355.72 Torr; Product distribution / selectivity;99.72%
1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-5-methoxy-2-(4-methoxy-phenyl)-3-methyl-1H-indole

1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-5-methoxy-2-(4-methoxy-phenyl)-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With trimethylsilyl iodide In chloroform at 20℃; for 5h;95%
With hydrogen iodide36.3 g
1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride
223251-25-0

1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride

4-(5-acetoxy-3-methyl-1H-indol-2-yl)phenyl acetate
91444-55-2

4-(5-acetoxy-3-methyl-1H-indol-2-yl)phenyl acetate

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Stage #1: 4-(5-acetoxy-3-methyl-1H-indol-2-yl)phenyl acetate With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 2h; Inert atmosphere;
Stage #2: 1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride In N,N-dimethyl-formamide at 0 - 25℃; for 15h;
Stage #3: With sodium hydroxide In N,N-dimethyl-formamide at 25℃; for 15h; Solvent; Temperature; Reagent/catalyst;
89%
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(tert-butoxy)-2-(4-(tert-butoxy)phenyl)-3-methyl-1H-indole

1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(tert-butoxy)-2-(4-(tert-butoxy)phenyl)-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With hydrogen bromide; acetic acid at 20℃; for 0.5h;87%
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-(benzoyloxy)phenyl)-3-methyl-1H-indol-5-yl benzoate

1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-(benzoyloxy)phenyl)-3-methyl-1H-indol-5-yl benzoate

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With triethylamine In methanol; water for 5h; Reflux;86%
1-[4-(2-azepan-1-yl-ethoxy)benzyl]-5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-indole

1-[4-(2-azepan-1-yl-ethoxy)benzyl]-5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With ammonium formate; 10 wt% Pd(OH)2 on carbon In acetone85%
4-(5-acetoxy-1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-3-methyl-1H-indol-2-yl)phenyl acetate

4-(5-acetoxy-1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-3-methyl-1H-indol-2-yl)phenyl acetate

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With ammonia In methanol; water at 20℃; for 3h;85%
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-3-methyl-2-(4-(pivaloyloxy)phenyl)-1Hindol-5-yl pivalate

1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-3-methyl-2-(4-(pivaloyloxy)phenyl)-1Hindol-5-yl pivalate

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With methanol; potassium carbonate at 45℃; for 3h;83%
1-(2-{4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-ethyl)-azepane-2,7-dione
1251936-45-4

1-(2-{4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-ethyl)-azepane-2,7-dione

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran at 5 - 10℃; for 4h;80.7%
hexamethylene imine
111-49-9

hexamethylene imine

2-(4-((5-hydroxy-2-(4-hydroxyphenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethyl 4-methylbenzenesulfonate
1343413-19-3

2-(4-((5-hydroxy-2-(4-hydroxyphenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethyl 4-methylbenzenesulfonate

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
In toluene at 70 - 75℃; for 12h;80%
ethyl 2-((1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-(2-ethoxy-2-oxoethoxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)acetate

ethyl 2-((1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-(2-ethoxy-2-oxoethoxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)acetate

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20℃; for 3h;79%
1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol hydrochloride

1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol hydrochloride

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With triethylamine In dichloromethane; water pH=9.5 - 10.5; Product distribution / selectivity;73.27%
1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride
223251-25-0

1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride

2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
91444-54-1

2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Stage #1: 1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride; 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h;
Stage #2: 1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride In N,N-dimethyl-formamide at 0 - 5℃; for 3.91h;
70.18%
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(2-ethoxyethoxy)-2-(4-(2-ethoxyethoxy)phenyl)-3-methyl-1H-indole

1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(2-ethoxyethoxy)-2-(4-(2-ethoxyethoxy)phenyl)-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With boron tribromide In methanol for 5h; Reflux;69%
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(cyclopentyloxy)-2-(4-(cyclopentyloxy)phenyl)-3-methyl-1H-indole

1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(cyclopentyloxy)-2-(4-(cyclopentyloxy)phenyl)-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With hydrogen bromide; acetic acid In methanol at 50℃; for 2h;61%
hexanedial
1072-21-5

hexanedial

1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
1251936-44-3

1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
10 wt% Pd(OH)2 on carbon at 45 - 50℃; under 3677.86 - 5884.58 Torr;45%
1-(4-(2(azepan-1-yl)ethoxy)benzyl)-5-((2-methoxyethoxy)methoxy)-2-(4-((2-methoxyethoxy)methoxy)phenyl)-3-methyl-1H-indole

1-(4-(2(azepan-1-yl)ethoxy)benzyl)-5-((2-methoxyethoxy)methoxy)-2-(4-((2-methoxyethoxy)methoxy)phenyl)-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With acetyl chloride In methanol at 0 - 2℃; for 3h;42%
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-((4-methoxybenzyl)oxy)-2-(4-((4-methoxybenzyl)oxy)phenyl)-3-methyl-1H-indole

1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-((4-methoxybenzyl)oxy)-2-(4-((4-methoxybenzyl)oxy)phenyl)-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 20h;15%
(4-hydroxyphenyl)methanol
623-05-2

(4-hydroxyphenyl)methanol

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: K2CO3
2.1: SOCl2 / tetrahydrofuran
3.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
3.2: 59 percent / dimethylformamide / 18 h / 20 °C
4.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
5.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
6.1: tetrahydrofuran
7.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / Reflux
2.1: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C
3.2: 5 °C
4.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr
View Scheme
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetonitrile / 60 °C
2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0.75 h / 0 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
3.2: 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
5.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C
6.1: tetrahydrofuran / Reflux
7.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C
View Scheme
1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone
35081-45-9

1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 51 percent / Et3N / dimethylformamide / Heating
2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
2.2: 59 percent / dimethylformamide / 18 h / 20 °C
3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
5.1: tetrahydrofuran
6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 100 - 125 °C
2.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C
2.2: 5 °C
3.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / N,N-dimethyl-formamide / 4 h / 120 - 150 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
2.2: 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
4.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C
5.1: tetrahydrofuran / Reflux
6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / N,N-dimethyl-formamide / 4 h / 115 °C
2: sodium hydride / N,N-dimethyl-formamide / 10 h / 20 °C
3: boron trifluoride diethyl etherate / dichloromethane; ethanethiol / 4 h / 0 - 25 °C
View Scheme
4-benzyloxyaniline hydrochloride
51388-20-6

4-benzyloxyaniline hydrochloride

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 51 percent / Et3N / dimethylformamide / Heating
2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
2.2: 59 percent / dimethylformamide / 18 h / 20 °C
3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
5.1: tetrahydrofuran
6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 100 - 125 °C
2.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C
2.2: 5 °C
3.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / N,N-dimethyl-formamide / 4 h / 115 °C
2: sodium hydride / N,N-dimethyl-formamide / 10 h / 20 °C
3: boron trifluoride diethyl etherate / dichloromethane; ethanethiol / 4 h / 0 - 25 °C
View Scheme
ethyl [p-(chloromethyl)phenoxy]acetate
80494-75-3

ethyl [p-(chloromethyl)phenoxy]acetate

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
1.2: 59 percent / dimethylformamide / 18 h / 20 °C
2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
4.1: tetrahydrofuran
5.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
3.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C
4.1: tetrahydrofuran / Reflux
5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C
View Scheme
ethyl 2-(4-hydroxymethylphenoxy)acetate
103258-64-6

ethyl 2-(4-hydroxymethylphenoxy)acetate

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: SOCl2 / tetrahydrofuran
2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
2.2: 59 percent / dimethylformamide / 18 h / 20 °C
3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
5.1: tetrahydrofuran
6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0.75 h / 0 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
2.2: 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
4.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C
5.1: tetrahydrofuran / Reflux
6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C
View Scheme
5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1H-indole
198479-63-9

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
1.2: 59 percent / dimethylformamide / 18 h / 20 °C
2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
4.1: tetrahydrofuran
5.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C
1.2: 5 °C
2.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
3.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C
4.1: tetrahydrofuran / Reflux
5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C
View Scheme
2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethanol
198479-95-7

2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethanol

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
2: tetrahydrofuran
3: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C
2: tetrahydrofuran / Reflux
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C
View Scheme
5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole
198480-07-8

5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran
2: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: tetrahydrofuran / Reflux
2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C
View Scheme
{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetic acid ethyl ester
198479-82-2

{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetic acid ethyl ester

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
2: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
3: tetrahydrofuran
4: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
2: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C
3: tetrahydrofuran / Reflux
4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 20 °C
View Scheme
C30H36N2O9P2
1049816-47-8

C30H36N2O9P2

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
With water; alkaline phosphatase pH=7.4; Conversion of starting material; Tris buffer; Enzymatic reaction;
[4-(2-hexamethyleneimino-1-yl-ethoxy)-phenyl]-methanol
223251-16-9

[4-(2-hexamethyleneimino-1-yl-ethoxy)-phenyl]-methanol

bazedoxifene
198481-32-2

bazedoxifene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C
2.2: 5 °C
3.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr
View Scheme
acetic acid
64-19-7

acetic acid

bazedoxifene
198481-32-2

bazedoxifene

bazedoxifene acetate

bazedoxifene acetate

Conditions
ConditionsYield
for 6h; Heating;98.5%
In ethanol; ethyl acetate at 20 - 30℃;95.5%
In acetone at 20 - 55℃;95%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

bazedoxifene
198481-32-2

bazedoxifene

C42H62N2O3Si2

C42H62N2O3Si2

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere;93.48%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

bazedoxifene
198481-32-2

bazedoxifene

C36H50N2O3Si2

C36H50N2O3Si2

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere;90.3%
bazedoxifene
198481-32-2

bazedoxifene

1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol hydrochloride

1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol Product distribution / selectivity;87.79%
With hydrogenchloride In methanol; water
L-Lactic acid
79-33-4

L-Lactic acid

bazedoxifene
198481-32-2

bazedoxifene

bazedoxifene L-lactate
1354966-34-9

bazedoxifene L-lactate

Conditions
ConditionsYield
Stage #1: L-Lactic acid In ethanol at 60℃; for 0.25h;
Stage #2: bazedoxifene In ethanol at 60℃; for 0.333333h; Solvent;
66.4%
propionic acid
802294-64-0

propionic acid

bazedoxifene
198481-32-2

bazedoxifene

1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate
1266685-12-4

1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate

Conditions
ConditionsYield
In acetone60.23%
formic acid
64-18-6

formic acid

bazedoxifene
198481-32-2

bazedoxifene

1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol formic acid salt

1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol formic acid salt

Conditions
ConditionsYield
In ethyl acetate at 77℃;50%
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