As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
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inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
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inquiry1-Phenyl-1,2,3,4-tetrahydro-isoquinoline CAS:22990-19-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:22990-19-8
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inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Product name: 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline CAS No.:22990-19-8 Molecule Formula:C15H15N Molecule Weight:209.29 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard
Cas:22990-19-8
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:22990-19-8
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
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inquiryProduct Name: 1-Phenyl-1,2,3,4-tetrahydro-isoquinoline Synonyms: 1-Phenyl-1,2,3,4-Tetrahydroiso;1,2,3,4-tetrahydro-1-phenylisoquinoline;1-PHENYL-1,2,…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiry1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate
1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification
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inquiryOur advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientif
Cas:22990-19-8
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:22990-19-8
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inquiry1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
Cas:22990-19-8
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inquiry1-phenyl-3,4-dihydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With C42H64Cl4Ir2N6O4S2; H-Gly-NH2 In dimethyl sulfoxide at 30 - 50℃; for 18.25h; pH=7.8; Reagent/catalyst; | 99% |
With methanol; sodium tetrahydroborate at 25℃; for 2.5h; | 99.2% |
With sodium tetrahydroborate In methanol at 25℃; for 2.5h; | 99.2% |
1-phenyl-3,4-dihydroisoquinoline hydrochloride
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 20℃; for 3h; | 95% |
With palladium on activated charcoal; hydrogen at 30℃; under 3750.38 Torr; |
tert-butyl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With hydrogenchloride In water; ethyl acetate at 0 - 20℃; for 6h; Inert atmosphere; | 95% |
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With water; potassium hydroxide In dimethyl sulfoxide at 120℃; for 10h; | 92.1% |
With potassium hydroxide; water In dimethyl sulfoxide at 160℃; for 15h; | |
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / -10 - 20 °C 2.1: hydrogenchloride; water; phosphoric acid / 95 - 100 °C 2.2: 20 °C / pH 9 - 10 View Scheme |
N-formyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 20h; Heating; | 92% |
With water; sodium hydroxide In ethanol at 100℃; for 1.5h; chemoselective reaction; | 77 mg |
N-benzyloxycarbonyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With hydrogen; Pd/C oxidized form In methanol at 20℃; for 16h; atmospheric pressure; | 91% |
1-phenylisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With hydrogen In methanol at 120℃; under 22502.3 Torr; for 4h; | 90.5% |
Multi-step reaction with 2 steps 1: triethylamine / N,N-dimethyl-formamide / 2 h / 130 °C 2: sodium hydroxide; water / ethanol / 1.5 h / 100 °C View Scheme | |
With hydrogen In ethanol at 80℃; under 7500.75 Torr; for 40h; Autoclave; |
(E)-N-(phenylethyl)-1-phenylmethanimine
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid at 120℃; for 15h; | 90% |
With trifluorormethanesulfonic acid at 110 - 130℃; Kinetics; Thermodynamic data; ΔG* at 298.15 K, ΔH*, ΔS*; | |
With trifluorormethanesulfonic acid; trifluoroacetic acid at 120℃; Rate constant; Mechanism; the dependence of the rate constant on the medium acidity; |
N-(2-benzoyl-phenethyl)-phthalimide
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol at 78℃; for 3h; | 85% |
N-oxy phenyl-1 dihydro-3,4-isoquinoleine
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With sodium hydrogen telluride In ethanol for 6h; Heating; | 80% |
With sodium hydrogen telluride In ethanol Heating; general method for reduction of nitrones to sec-amines; |
2-bis(dimethylamino)phosphinoyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 27h; Heating; | 79% |
1,2,3,4-tetrahydroisoquinoline
phenyllithium
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Stage #1: 1,2,3,4-tetrahydroisoquinoline With n-butyllithium In diethyl ether; hexane at -78℃; for 0.166667h; Stage #2: With 2,2-dimethylpropiophenone In diethyl ether; hexane at -78℃; Stage #3: phenyllithium In diethyl ether; hexane at -78 - 20℃; regioselective reaction; | 72% |
N-benzylidene-β-(2-bromophenyl)ethylamin
A
1-benzyl-2,3-dihydro-1H-indole
B
N-benzylidene-2-phenylethanamine
C
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Yields of byproduct given; | A n/a B n/a C 70% |
N-benzylidene-2-bromobenzeneethanamine
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene for 4h; Heating; | 70% |
Conditions | Yield |
---|---|
With trifluoroacetic acid In benzene for 5h; Heating; | 68% |
With Ersorb-4a In ethanol at 80℃; for 20h; Pictet-Spengler cyclisation; | 100 % Spectr. |
N-benzylidene-β-(2-bromophenyl)ethylamin
A
1-benzyl-2,3-dihydro-1H-indole
B
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene at 85℃; for 1h; | A 8% B 67% |
1-phenyl-3,4-dihydroisoquinoline
p-toluenesulfonyl chloride
A
(R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
B
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-3,5-diMe-Synphos; hydrogen In 1,4-dioxane at 40℃; under 22502.3 Torr; for 18h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | A 45% B 46% |
N-benzylidene-β-(2-bromophenyl)ethylamin
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; hexane at -100 - -95℃; for 0.25h; | 42% |
1-phenyl-3,4-dihydroisoquinoline
p-toluenesulfonyl chloride
A
(R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
B
(S)-(-)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
C
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-3,5-diMe-Synphos; hydrogen; potassium carbonate In 1,4-dioxane at 40℃; under 22502.3 Torr; for 18h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | A n/a B n/a C 30% |
1-phenyl-2-propylcarbamoyl-1,4-dihydroisoquinolin-3(2H)-one
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With diborane In tetrahydrofuran for 24h; Ambient temperature; | 16% |
3,4-dihydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With diethyl ether; benzene |
1-phenyl-3,4-dihydroisoquinoline
A
1-phenylisoquinoline
B
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
at 340℃; | |
Beim Erhitzen unter Normaldruck auf Siedetemperatur erfolgt Zersetzung; |
isoquinoline
acetyl hypochlorite
phenyllithium
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
3,4-dihydroisoquinoline
phenyllithium
1-phenyl-1,2,3,4-tetrahydroisoquinoline
6-methylthio-1-phenyl-1,2,3,4-tetrahydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride In methanol Ambient temperature; Yield given; |
N-benzylidene-β-(2-bromophenyl)ethylamin
A
N-benzylidene-2-phenylethanamine
B
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene at 80℃; |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.928 g / CH2Cl2; tetrahydrofuran / 4 h / cooling 2: 91 percent / hydrogen / Pd/C oxidized form / methanol / 16 h / 20 °C / atmospheric pressure View Scheme |
phenylmagnesium chloride
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.928 g / CH2Cl2; tetrahydrofuran / 4 h / cooling 2: 91 percent / hydrogen / Pd/C oxidized form / methanol / 16 h / 20 °C / atmospheric pressure View Scheme |
1,2,3,4-tetrahydroisoquinoline
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 89 percent / NEt3 / CH2Cl2 / 17 h / 20 °C 2: Ph3C(1+)*BF4(1-) / CH2Cl2 / 16 h / 20 °C 3: 0.928 g / CH2Cl2; tetrahydrofuran / 4 h / cooling 4: 91 percent / hydrogen / Pd/C oxidized form / methanol / 16 h / 20 °C / atmospheric pressure View Scheme |
acetyl hypochlorite
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Methyl 1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
Conditions | Yield |
---|---|
With pyridine for 18h; Ambient temperature; | 96% |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
A
1-phenylisoquinoline
B
hydrogen
Conditions | Yield |
---|---|
With tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); potassium hexafluoroantimonate; 9-(2-mesityl)-10-methylacridinium perchlorate In dichloromethane at 27 - 29℃; for 21h; Catalytic behavior; Reagent/catalyst; Irradiation; Inert atmosphere; | A 96% B n/a |
n-valeryl chloride
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 1h; Inert atmosphere; | 96% |
oxirane
1-phenyl-1,2,3,4-tetrahydroisoquinoline
2-(2-hydroxyethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
In ethanol at 75℃; for 24h; | 95% |
di-tert-butyl dicarbonate
1-phenyl-1,2,3,4-tetrahydroisoquinoline
tert-butyl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 20℃; for 20h; | 95% |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
1-phenyl-3,4-dihydroisoquinoline
Conditions | Yield |
---|---|
With N,N-dimethyl-formamide at 100℃; | 94% |
With potassium phosphate tribasic trihydrate; 5%-palladium/activated carbon; oxygen In acetonitrile at 60℃; Reagent/catalyst; Solvent; Green chemistry; chemoselective reaction; | 86% |
With sulfur In pyridine 1.) 3 h, 100 deg C, 2.) 12 h, r.t.; | 40% |
butyryl chloride
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 1h; Inert atmosphere; | 94% |
dimethyl 2,2’-(carbonylbis(oxy))dibenzoate
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
In tetrahydrofuran at 50℃; for 72h; | 94% |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Stage #1: 1-phenyl-1,2,3,4-tetrahydroisoquinoline With N-Bromosuccinimide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane) In 1,2-dichloro-ethane at 20℃; for 0.166667h; Stage #2: With hydrogen In 1,2-dichloro-ethane at 30℃; under 25858.1 Torr; for 24h; enantioselective reaction; | 93% |
With L-(-)-tartaric acid In methanol Resolution of racemate; | |
With potassium hydroxide In water; dimethyl sulfoxide for 11.8333h; Purification / work up; Heating / reflux; |
4-Fluoronitrobenzene
1-phenyl-1,2,3,4-tetrahydroisoquinoline
2-(4-nitrophenyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 100℃; | 90% |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Stage #1: 1-phenyl-1,2,3,4-tetrahydroisoquinoline With N-Bromosuccinimide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate; (S)-[(5,6),(5’,6’)-bis(ethylenedioxy)biphenyl-2,2’ diyl]bis(diphenylphosphine) In 1,2-dichloro-ethane at 20℃; for 0.166667h; Stage #2: With hydrogen In 1,2-dichloro-ethane at 30℃; under 25858.1 Torr; for 24h; enantioselective reaction; | 90% |
With LG-J-B4 Kinetics; Resolution of racemate; Enzymatic reaction; enantioselective reaction; | 86% |
With D-tartaric acid In water at 65 - 95℃; for 1.5h; Purification / work up; Resolution of racemate; | 40% |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
A
1-phenyl-3,4-dihydroisoquinoline
B
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With hydrogenchloride; borane-ammonia complex In aq. phosphate buffer at 37℃; pH=7.8; | A n/a B 90% |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C13H12F3NO In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; Molecular sieve; | 90% |
D-tartaric acid
1-phenyl-1,2,3,4-tetrahydroisoquinoline
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline tartarate
Conditions | Yield |
---|---|
In water; ethyl acetate at 25 - 60℃; for 1.5h; Product distribution / selectivity; | 89% |
In water; isopropyl alcohol at 5 - 60℃; for 2.5 - 15h; Product distribution / selectivity; | 75.5% |
In water; isopropyl alcohol at 70℃; for 0.5h; | 43.7% |
In water; isopropyl alcohol at 70℃; for 0.5h; | 43.7% |
In methanol at 20℃; | n/a |
Conditions | Yield |
---|---|
With benzoic acid In toluene for 38h; Reflux; diastereoselective reaction; | 89% |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C13H12F3NO In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; Molecular sieve; | 89% |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C13H12F3NO In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; Molecular sieve; | 89% |
4-iodoanisol
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C13H12F3NO In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; Molecular sieve; | 88% |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
1-phenylisoquinoline
Conditions | Yield |
---|---|
With iodine; oxygen In 1,2-dichloro-benzene; toluene at 160℃; for 30h; | 87% |
With C55H49N4OP2Ru In o-xylene at 140℃; under 750.075 Torr; for 48h; Inert atmosphere; Schlenk technique; Green chemistry; | 86% |
With hexagonal boron carbon nitride In water at 25℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation; | 79% |
phthalimide
formaldehyd
1-phenyl-1,2,3,4-tetrahydroisoquinoline
2-(1-Phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-isoindole-1,3-dione
Conditions | Yield |
---|---|
In ethanol Heating; | 86% |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
A
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
B
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
With borane-ammonia complex; 6-hydroxy-D-nicotine oxidase E350L/E352D mutant for 120h; Kinetics; Enzymatic reaction; enantioselective reaction; | A n/a B 86% |
With D-tartaric acid Resolution of racemate; | A 79% B 2.78 g |
Stage #1: 1-phenyl-1,2,3,4-tetrahydroisoquinoline With D-tartaric acid In water Resolution of racemate; Stage #2: With sodium hydroxide In water at 20℃; Purification / work up; | A n/a B n/a |
1-phenyl-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Stage #1: 1-phenyl-1,2,3,4-tetrahydroisoquinoline With N-Bromosuccinimide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane) In 1,2-dichloro-ethane at 20℃; for 0.166667h; Stage #2: With deuterium In 1,2-dichloro-ethane at 30℃; under 25858.1 Torr; for 24h; enantioselective reaction; | A 86% B n/a |
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