Conditions | Yield |
---|---|
Stage #1: adenosine In various solvent(s) at 20 - 100℃; for 0.333333h; Stage #2: With 2,6-dimethylpyridine; trichlorophosphate In various solvent(s) at 0℃; for 3h; | A 28% B 48% |
A
adenosine-5'-monophosphate disodium salt
Conditions | Yield |
---|---|
With phosphorating extract from S. cerevisiae at 28℃; for 8h; | A 8% B 30.5 mg C 11% |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: various solvent(s) / 0.33 h / 20 - 100 °C 1.2: 48 percent / PSCl3; 2,6-lutidine / various solvent(s) / 3 h / 0 °C 2.1: 8 percent / phosphorating extract from S. cerevisiae / 8 h / 28 °C View Scheme |
Acridin-9-yl-[3-(1,13-dioxa-4,7,10,16,19,22-hexaaza-cyclotetracos-7-yl)-propyl]-amine; hydrochloride
adenosine diphosphate disodium salt
A
adenosine-5'-monophosphate disodium salt
Conditions | Yield |
---|---|
In water; water-d2 at 80℃; Rate constant; |
adenosine-5'-monophosphate disodium salt
Conditions | Yield |
---|---|
With water; zinc(II) cation pH=5.5; |
Conditions | Yield |
---|---|
With diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) phosphorylase from Mycobacterium tuberculosis H37Rv at 37℃; for 0.5h; pH=7.6; Kinetics; aq. buffer; Enzymatic reaction; |
CoN(C3H6NH2)3(OH2)2(3+)
adenosine-5'-monophosphate disodium salt
Conditions | Yield |
---|---|
In water Kinetics; react. for about 6 h at 25°C;; elem. anal.; | 100% |
Conditions | Yield |
---|---|
With Dowex 50W×8 resin In water at 20℃; for 0.5h; | 99% |
With Dowex 50WX-8 200 mesh, H+ |
adenosine-5'-monophosphate disodium salt
α,β-D-ribofuranose-5-phophate disodium salt
Conditions | Yield |
---|---|
With Dowex 50 W-X8 (H+ form) In water for 0.141667h; Heating; | 94% |
adenosine-5'-monophosphate disodium salt
A
dirhodium tetracetate dihydrate
Conditions | Yield |
---|---|
In water slight excess of nucleotide, stirring for 5 h (dissoln.); pptn. on acetone addn.; elem. anal.; | A n/a B 80% |
cysteinato-O-methylester-palladium(II)-μ-dichloro-cysteinato-O-methylester-palladium(II)
adenosine-5'-monophosphate disodium salt
Conditions | Yield |
---|---|
In water Pd complex and nucleoside suspended in water, stirred at 55°C until complete dissolution; added ethanol, ppt. filtered, washed with 80% ethanol until free from chloride, then with abs. ethanol and ether, dried at 60°C under vac., elem. anal.; | 50% |
Conditions | Yield |
---|---|
Stage #1: 4,4'-bipyridine; copper(II) nitrate hexahydrate; water In ethanol for 0.25h; Stage #2: adenosine-5'-monophosphate disodium salt In ethanol Stage #3: With nitric acid In ethanol for 1h; pH=3.65; | 49% |
adenosine-5'-monophosphate disodium salt
di-n-butylthioxophosphoranyl bromide
adenosine 5'-phosphoric di-n-butylphosphinothioic anhydride
Conditions | Yield |
---|---|
With pyridine; N,N'-dicyclohexyl-4-morpholine carboxamidine for 3h; Ambient temperature; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / Dowex 50 W-X8 (H+ form) / H2O / 0.14 h / Heating 2: 70 mmol / Na2ATP, MgCl2*6H2O, PEP-K+, K2HPOu, Na2EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4 3: MgCl2*6H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase View Scheme |
adenosine-5'-monophosphate disodium salt
5-phospho-D-ribosyl α-1-pyrophosphate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 94 percent / Dowex 50 W-X8 (H+ form) / H2O / 0.14 h / Heating 2: 70 mmol / Na2ATP, MgCl2*6H2O, PEP-K+, K2HPOu, Na2EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4 View Scheme |
adenosine-5'-monophosphate disodium salt
Conditions | Yield |
---|---|
With potassium nitrate In water (N2); mixing cobalt complex and AMP in 0.2 M aq. KNO3 at pH 7.0; not isolated, detected by UV; |
Conditions | Yield |
---|---|
In water addn. of a soln. of Na2(5'AMP) (pH = 4.2) to a soln. of Cr(L-Cys)Cl2*2H2O, 40°C, 3 h, pptn.; filtration, ppt. washed with EtOH, dried in vac. (P4O10), elem. anal.; |
Conditions | Yield |
---|---|
In water addn. of a soln. of Na2(5'AMP) (pH = 7.0) to a soln. of Cr(L-Cys)2Cl*2H2O, the mixture (pH = 5.9) at 40°C, 6 h (final pH = 5.8); concd. to 5 ml, chromy. (Sephadex G-10), evapn., ppt. washed with EtOH, dried in vac. (P4O10), elem. anal.; |
adenosine-5'-monophosphate disodium salt
Conditions | Yield |
---|---|
In sodium hydroxide react. at 25°C in triethanoleamine*HCl-NaOH buffer (pH 7.5); |
Conditions | Yield |
---|---|
In water soln. of Cr(NO3)3 and nucleotide were mixed and heated at 50°C for 2 h, soln. of ligand in H2O was added (pH=3.5); filtered, washed, dried over P2O5; elem. anal.; |
adenosine-5'-monophosphate disodium salt
Conditions | Yield |
---|---|
In water mixing a soln. of Cr-complex dissolved in water and Na25'AMP in water (starting pH=5.8), placed in a thermostatic bath at 45°C for 21 h, pptn. with small amount, addn. of EtOH, pptn.; filtration, washed with EtOH, vac. dried over P4O10; elem. anal.; |
Conditions | Yield |
---|---|
In water mixing a soln. of Cr-complex dissolved in water and Na25'AMP in water (pH=3.5-3.6), thermostatic bath at 45°C for 11-16 h; soln concd. (rotavapor), ppt. obtained with 5'AMP before elution, dried over P4O10; |
The 5'-Adenylic acid,sodium salt (1:2), with the CAS registry number 4578-31-8 and EINECS registry number 224-961-2, has the IUPAC name of disodium[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate. It is a kind of white powder, and belongs to product categories of Pharmaceutical Intermediates and Nucleic acids. And the molecular formula of the chemical is C10H14N5Na2O7P. It is always used in Biochemical research. What's more, it should be stored at -20°C.
The physical properties of 5'-Adenylic acid,sodium salt (1:2) are as followings: (1)ACD/LogP: -0.22; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -3.51; (4)ACD/LogD (pH 7.4): -4.47; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 12; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 151.1 Å2; (13)Flash Point: 436.7 °C; (14)Enthalpy of Vaporization: 121.77 kJ/mol; (15)Boiling Point: 798.5 °C at 760 mmHg; (16)Vapour Pressure: 6.7E-27 mmHg at 25°C.
You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Do not breathe dust and avoid contacting with skin and eyesWear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].[Na+].[O-]P([O-])(=O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3O
(2)InChI: InChI=1/C10H14N5O7P.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
(3)InChIKey: QGXLVXZRPRRCRP-IMCBXCBXBL
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 830mg/kg (830mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 33, Pg. 24, 1974. |
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