Dodecanoic acid,12-amino- supplier

Name
12-AMINODODECANOIC ACID
EINECS 211-754-7
CAS No. 693-57-2
Article Data31
CAS DataBase
Density 0.957 g/cm³
Solubility 137mg/L at 20℃
Melting Point 185-187 °C(lit.)
Formula C₁₂H₂₅NO₂
Boiling Point 349.7 °C at 760 mmHg
Molecular Weight 215.336
Flash Point 165.3 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 12-Aminododecanoicacid;12-Aminolauric acid;l-Aminolauric acid;w-Aminododecanoic acid;w-Aminolauric acid;
PSA 63.32000
LogP 3.63100

Synthetic route

: 947-04-6
2-azacyclotridecanone

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With Acidovorax sp.T31 ω-laurolactam hydrolase; water In toluene at 35℃; for 17h; pH=7; aq. phosphate buffer; Enzymatic reaction;	99.7%
With hydrogenchloride
With potassium phosphate buffer In toluene at 30℃; for 2h; pH=7.0;	10 mmol
With whole cells or crude cell extract of recombinant E.coli BL21 (DE3) (pCom10_T31) In ethanol for 0.5h; pH=7.4; aq. buffer; Enzymatic reaction;	99 %Chromat.

: 32571-74-7
12-nitrododecanoic acid

A: 75-07-0
acetaldehyde

B: 693-57-2
12-Aminododecanoic acid

C H2: H2

Conditions

Conditions	Yield
With ethanol; titanium(IV) oxide for 2.5h; Irradiation;	A n/a B 89% C n/a

...Expand

: 91694-67-6
12-oxododecanoic acid oxime

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In methanol under 2280 Torr; for 1.5h;	87%

: 32571-74-7
12-nitrododecanoic acid

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol at 80℃; for 0.5h;	85%

: 2783-17-7
1,12-Diaminododecane

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Pseudomonas K95	55%
Pseudomonas K95	49%

: 53005-24-6
methyl 12-aminododecanoate

A: 947-04-6
2-azacyclotridecanone

B: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With whole-cells or crude cell extract of recombinant E.coli BL21 (DE3) (pCom10_T31) In ethanol for 0.5h; pH=10; aq. buffer; Enzymatic reaction;	A 13% B n/a

: 53005-23-5
12-aminododecanoic acid ethyl ester

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 13-hydroxyimino-dotriacontanoic acid

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With sulfuric acid und Erhitzen des Reaktionsprodukts mit konz. wss. HCl auf 180grad;

: 693-37-8
12-Acetamino-dodecansaeure-aethylester

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 16595-67-8
ω-Amino-7-oxo-laurinsaeure

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With potassium hydroxide; hydrazine hydrate

: C36H60O30*C12H25NO2

A: 10016-20-3
alpha cyclodextrin

B: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
In water-d2 at 24.85℃; pH=7.3; Equilibrium constant; Decomposition;

: 2C36H60O30*C12H25NO2

A: C36H60O30*C12H25NO2

B: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
In water-d2 at 24.85℃; pH=7.3; Equilibrium constant; Decomposition;

oxime of/the/ 12-oxo-eicosane-carboxylic acid-(1): oxime of/the/ 12-oxo-eicosane-carboxylic acid-(1)

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With sulfuric acid anschliessend mit konz. Salzsaeure bei 180grad;

: 13-hydroxyimino-dotriacontanoic acid

: 7664-93-9
sulfuric acid

A: 14130-05-3
1-nonadecanamine (n-nonadecylamine)

B: 506-30-9
Arachidic acid

C: 693-57-2
12-Aminododecanoic acid

D Brassyloic acid: Brassyloic acid

Conditions

Conditions	Yield
Erhitzen des Rektionsprodukts mit konz. HCl auf 180grad;

...Expand

: 3956-80-7
12-oxododecanoic acid

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.92 mg / hydroxylamine hydrochloride, aq. NaOH / ethanol / 0.17 h / 100 °C 2: 87 percent / H2 / PtO2 / methanol / 1.5 h / 2280 Torr View Scheme

: 32381-04-7, 32381-05-8, 38003-80-4, 61827-10-9
cis-12,13-epoxystearic acid

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 73 percent / HIO4 / H2O; 2-methyl-propan-2-ol / 5 h 2: 0.92 mg / hydroxylamine hydrochloride, aq. NaOH / ethanol / 0.17 h / 100 °C 3: 87 percent / H2 / PtO2 / methanol / 1.5 h / 2280 Torr View Scheme

: 17966-13-1
(+/-)-cis-12,13-epoxy-9(Z)-octadecenoic acid

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 93 percent / H2 / PtO2 / methanol / 0.75 h / 2280 Torr 2: 73 percent / HIO4 / H2O; 2-methyl-propan-2-ol / 5 h 3: 0.92 mg / hydroxylamine hydrochloride, aq. NaOH / ethanol / 0.17 h / 100 °C 4: 87 percent / H2 / PtO2 / methanol / 1.5 h / 2280 Torr View Scheme

: 738-84-1
7-[5-(acetylamino-methyl)-thiophen-2-yl]-heptanoic acid ethyl ester

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. HCl / Raney-Ni / methanol 2: aq. HCl View Scheme

: 16595-61-2
2-(syn-2-Oxo-cyclohexyliden)-1-aza-cycloheptan

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NaOH / Heating 2: N2H4*H2O, KOH View Scheme

: 53005-24-6
methyl 12-aminododecanoate

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With whole-cells of recombinant E.coli BL21 (DE3) (pCom10_T31) In ethanol pH=7.4; aq. buffer; Enzymatic reaction;

: 111-82-0
methyl n-dodecanoate

A: 505-95-3
12-hydroxydodecanoic acid

B: 71655-36-2
methyl 12-hydroxydodecanoate

C: 693-23-2
1,12-dodecanedioic acid

D: 3903-40-0
12-methoxy-12-oxododecanoic acid

E: 53005-24-6
methyl 12-aminododecanoate

F: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With NADH In aq. phosphate buffer Kinetics; Microbiological reaction;
Multi-step reaction with 2 steps 1: NADH / aq. phosphate buffer / Microbiological reaction 2: NADH / aq. phosphate buffer / Microbiological reaction View Scheme

...Expand

: 2009-59-8
methyl 11-formylundecanoate

A: 505-95-3
12-hydroxydodecanoic acid

B: 71655-36-2
methyl 12-hydroxydodecanoate

C: 693-23-2
1,12-dodecanedioic acid

D: 3903-40-0
12-methoxy-12-oxododecanoic acid

E: 53005-24-6
methyl 12-aminododecanoate

F: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With NADH In aq. phosphate buffer Kinetics; Microbiological reaction;

...Expand

: 505-95-3
12-hydroxydodecanoic acid

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With L-alanin; sodium hydroxide In aq. buffer at 35℃; for 2h; pH=8 - 9.5; Enzymatic reaction;
With pyridoxal 5'-phosphate; MATITNHMPTAELQALDAAHHLHPFSANNALGEEGTRVITRARGVWLNDSEGEEILDAMAGLWCVNIGYGRDELAEVAARQMRELPYYNTFFKTTHVPAIALAQKLAELAPGDLNHVFFAGGGSEANDTNIRMVRTYWQNKGQPEKTVIISRKNAYHGSTVASSALGGMAGMHAQSGLIPDVHHINQPNWWAEGGDMDPEEFGLARARELEEAILELGENRVAAFIAEPVQGAGGVIVAPDSYWPEIQRICDKYDILLIADEVICGFGRTGNWFGTQTMGIRPHIMTIAKGLSSGYAPIGGSIVCDEVAHVIGKDEFNHGYTYSGHPVAAAVALENLRILEEENILDHVRNVAAPYLKEKWEALTDHPLVGEAKIVGMMASIALTPNKASRAKFASEPGTIGYICRERCFANNLIMRHVGDRMIISPPLVITPAEIDEMFVRIRKSLDEAQAEIEKQGLMKSA; MIKAYAALEANGKLQPFEYDPGALGANEVEIEVQYCGVCHSDLSMINNEWGISNYPLVPGHEVVGTVAAMGEGVNHVEVGDLVGLGWHSGYCMTCHSCLSGYHNLCATAESTIVGHYGGFGDRVRAKGVSVVKLPKGIDLASAGPLFCGGITVFSPMVELSLKPTAKVAVIGIGGLGHLAVQFLRAWGCEVTAFTSSARKQTEVLELGAHHILDSTNPEAIASAEGKFDYIISTVNLKLDWNLYISTLAPQGHFHFVGVVLEPLDLNLFPLLMGQRSVSASPVGSPATIATMLDFAVRHDIKPVVEQFSFDQINEAIAHLESGKAHYRVVLSHSKN; nicotinamide adenine dinucleotide phosphate; benzylamine In dimethyl sulfoxide at 37℃; for 24h; pH=8; Reagent/catalyst; pH-value; Solvent; Microbiological reaction; Enzymatic reaction;

Yield

With L-alanin; sodium hydroxide In aq. buffer at 35℃; for 2h; pH=8 - 9.5; Enzymatic reaction;

With pyridoxal 5'-phosphate; MATITNHMPTAELQALDAAHHLHPFSANNALGEEGTRVITRARGVWLNDSEGEEILDAMAGLWCVNIGYGRDELAEVAARQMRELPYYNTFFKTTHVPAIALAQKLAELAPGDLNHVFFAGGGSEANDTNIRMVRTYWQNKGQPEKTVIISRKNAYHGSTVASSALGGMAGMHAQSGLIPDVHHINQPNWWAEGGDMDPEEFGLARARELEEAILELGENRVAAFIAEPVQGAGGVIVAPDSYWPEIQRICDKYDILLIADEVICGFGRTGNWFGTQTMGIRPHIMTIAKGLSSGYAPIGGSIVCDEVAHVIGKDEFNHGYTYSGHPVAAAVALENLRILEEENILDHVRNVAAPYLKEKWEALTDHPLVGEAKIVGMMASIALTPNKASRAKFASEPGTIGYICRERCFANNLIMRHVGDRMIISPPLVITPAEIDEMFVRIRKSLDEAQAEIEKQGLMKSA; MIKAYAALEANGKLQPFEYDPGALGANEVEIEVQYCGVCHSDLSMINNEWGISNYPLVPGHEVVGTVAAMGEGVNHVEVGDLVGLGWHSGYCMTCHSCLSGYHNLCATAESTIVGHYGGFGDRVRAKGVSVVKLPKGIDLASAGPLFCGGITVFSPMVELSLKPTAKVAVIGIGGLGHLAVQFLRAWGCEVTAFTSSARKQTEVLELGAHHILDSTNPEAIASAEGKFDYIISTVNLKLDWNLYISTLAPQGHFHFVGVVLEPLDLNLFPLLMGQRSVSASPVGSPATIATMLDFAVRHDIKPVVEQFSFDQINEAIAHLESGKAHYRVVLSHSKN; nicotinamide adenine dinucleotide phosphate; benzylamine In dimethyl sulfoxide at 37℃; for 24h; pH=8; Reagent/catalyst; pH-value; Solvent; Microbiological reaction; Enzymatic reaction;

: 1501-82-2
cyclododecene

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: ozone / 2.5 h / 5 °C / Molecular sieve 1.2: 0.5 h / 10 - 20 °C 2.1: ammonia; hydrogen / isopropyl alcohol / 60 °C / 36961.4 Torr View Scheme

: 12-oxododecanoic acid butyl ester

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With ammonia; hydrogen In isopropyl alcohol at 60℃; under 36961.4 Torr;
With ammonia; hydrogen In isopropyl alcohol at 60℃; under 36961.4 Torr;

: 112-38-9
10-undecenoic acid

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen bromide / toluene / 1 h / 18 °C / Industrial scale 2: sodium carbonate / N,N-dimethyl acetamide / 1.5 h / 130 °C / Inert atmosphere 3: hydrogen / 0.67 h / 90 - 110 °C / 18751.9 Torr View Scheme

: 5810-18-4
11-cyanoundecanoic acid

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With hydrogen at 90 - 110℃; under 18751.9 Torr; for 0.666667h; Temperature;
With ammonium hydroxide; Ru/SiC; hydrogen In propan-1-ol; water at 110℃; under 26252.6 Torr; for 1.5h; Autoclave;	9.7 g

: 71655-36-2
methyl 12-hydroxydodecanoate

A: 53005-24-6
methyl 12-aminododecanoate

B: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
With pyridoxal 5'-phosphate; MATITNHMPTAELQALDAAHHLHPFSANNALGEEGTRVITRARGVWLNDSEGEEILDAMAGLWCVNIGYGRDELAEVAARQMRELPYYNTFFKTTHVPAIALAQKLAELAPGDLNHVFFAGGGSEANDTNIRMVRTYWQNKGQPEKTVIISRKNAYHGSTVASSALGGMAGMHAQSGLIPDVHHINQPNWWAEGGDMDPEEFGLARARELEEAILELGENRVAAFIAEPVQGAGGVIVAPDSYWPEIQRICDKYDILLIADEVICGFGRTGNWFGTQTMGIRPHIMTIAKGLSSGYAPIGGSIVCDEVAHVIGKDEFNHGYTYSGHPVAAAVALENLRILEEENILDHVRNVAAPYLKEKWEALTDHPLVGEAKIVGMMASIALTPNKASRAKFASEPGTIGYICRERCFANNLIMRHVGDRMIISPPLVITPAEIDEMFVRIRKSLDEAQAEIEKQGLMKSA; MIKAYAALEANGKLQPFEYDPGALGANEVEIEVQYCGVCHSDLSMINNEWGISNYPLVPGHEVVGTVAAMGEGVNHVEVGDLVGLGWHSGYCMTCHSCLSGYHNLCATAESTIVGHYGGFGDRVRAKGVSVVKLPKGIDLASAGPLFCGGITVFSPMVELSLKPTAKVAVIGIGGLGHLAVQFLRAWGCEVTAFTSSARKQTEVLELGAHHILDSTNPEAIASAEGKFDYIISTVNLKLDWNLYISTLAPQGHFHFVGVVLEPLDLNLFPLLMGQRSVSASPVGSPATIATMLDFAVRHDIKPVVEQFSFDQINEAIAHLESGKAHYRVVLSHSKN; nicotinamide adenine dinucleotide phosphate; benzylamine In dimethyl sulfoxide at 37℃; for 24h; pH=8; Microbiological reaction; Enzymatic reaction;

Yield

: 53179-04-7
undec-10-enenitrile

: 693-57-2
12-Aminododecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetylacetonatodicarbonylrhodium(l); hydrogen; 1,2-bis-(diphenylphosphino)ethane / toluene / 2 h / 100 °C / 15001.5 Torr / Autoclave 2: oxygen / toluene / 24 h / 20 °C 3: hydrogen; Ru/SiC; ammonium hydroxide / propan-1-ol; water / 1.5 h / 110 °C / 26252.6 Torr / Autoclave View Scheme
Multi-step reaction with 3 steps 1: acetylacetonatodicarbonylrhodium(l); hydrogen; 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bis(oxy)]bis-dibenzo [d,f][1,3,2]-dioxaphosphepine / toluene / 24 h / 120 °C / 15001.5 Torr / Autoclave 2: oxygen / toluene / 24 h / 20 °C 3: hydrogen; Ru/SiC; ammonium hydroxide / propan-1-ol; water / 1.5 h / 110 °C / 26252.6 Torr / Autoclave View Scheme

Yield

Multi-step reaction with 3 steps
1: acetylacetonatodicarbonylrhodium(l); hydrogen; 1,2-bis-(diphenylphosphino)ethane / toluene / 2 h / 100 °C / 15001.5 Torr / Autoclave
2: oxygen / toluene / 24 h / 20 °C
3: hydrogen; Ru/SiC; ammonium hydroxide / propan-1-ol; water / 1.5 h / 110 °C / 26252.6 Torr / Autoclave
View Scheme

Multi-step reaction with 3 steps
1: acetylacetonatodicarbonylrhodium(l); hydrogen; 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bis(oxy)]bis-dibenzo [d,f][1,3,2]-dioxaphosphepine / toluene / 24 h / 120 °C / 15001.5 Torr / Autoclave
2: oxygen / toluene / 24 h / 20 °C
3: hydrogen; Ru/SiC; ammonium hydroxide / propan-1-ol; water / 1.5 h / 110 °C / 26252.6 Torr / Autoclave
View Scheme

: 4411-25-0
1-adamantyl isocyanate

: 693-57-2
12-Aminododecanoic acid

: 479413-70-2
12-(3-adamantan-1-yl-ureido)dodecanoic acid

Conditions

Conditions	Yield
In 1,2-dichloro-ethane for 6h; Heating;	100%
In chloroform for 10h; Heating / reflux;	100%
In hexane at 20℃;	39%
In chloroform	2.66 g (100%)
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane

: 24424-99-5
di-tert-butyl dicarbonate

: 693-57-2
12-Aminododecanoic acid

: 18934-81-1
N-(tert-butyloxycarbonyl)-12-aminododecanoic acid

Conditions

Conditions	Yield
With triethylamine In dichloromethane	99%
With sodium hydroxide In water	97%
With triethylamine In methanol at 60℃; for 1h;	96%

: 67-56-1
methanol

: 693-57-2
12-Aminododecanoic acid

: 12-aminododecanoic acid methyl ester hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 50℃; for 4h;	99%
With thionyl chloride at 20℃; Reflux;	98%
With thionyl chloride at 0 - 20℃; for 9h; Inert atmosphere;	98%

: 121-44-8
triethylamine

: 90-80-2
D-Glucono-1,5-lactone

: 693-57-2
12-Aminododecanoic acid

: 12-(D-gluconoylamino)dodecanoic acid triethylamine salt

Conditions

Conditions	Yield
In methanol for 4h; Reflux;	99%

...Expand

: 90-80-2
D-Glucono-1,5-lactone

: 693-57-2
12-Aminododecanoic acid

: C18H35NO8

Conditions

Conditions	Yield
With triethylamine In methanol for 4h; Reflux;	99%

: 108-31-6
maleic anhydride

: 693-57-2
12-Aminododecanoic acid

: 57079-17-1
12-(3-carboxyacryloylamino)dodecanoic acid

Conditions

Conditions	Yield
With lutidine In diethylene glycol dimethyl ether	98%
With acetic acid Ambient temperature;	85%
In acetic acid

: 85-44-9
phthalic anhydride

: 693-57-2
12-Aminododecanoic acid

: 21084-58-2
12-(1,3-dioxoisoindolin-2-yl)dodecanoic acid

Conditions

Conditions	Yield
With triethylamine In toluene for 1.5h; Heating;	98%
With triethylamine In toluene for 12h; Heating;	80%
In toluene Heating;	36%
at 150℃; for 0.75h; Yield given;

: 693-57-2
12-Aminododecanoic acid

: 53005-24-6
methyl 12-aminododecanoate

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydrogencarbonate In methanol; water	98%
With sulfuric acid; sodium carbonate In methanol	95%
With sulfuric acid In methanol for 24h; Reflux;	70%

: 431-47-0
trifluoroacetic acid-methyl ester

: 693-57-2
12-Aminododecanoic acid

: 124051-56-5
12-(2,2,2-trifluoroacetamido)dodecanoic acid

Conditions

Conditions	Yield
With triethylamine In methanol for 18h;	97%
With triethylamine In methanol at 20℃; for 18h;	92%

: 128-69-8
perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride

: 693-57-2
12-Aminododecanoic acid

: 118902-46-8
N,N’-di(1-carboxylundecyl)-3,4,9,10-perylenetetracarboxyldiimide

Conditions

Conditions	Yield
With 1H-imidazole at 120℃; for 1h; Schlenk technique; Inert atmosphere;	96%
In 1-methyl-pyrrolidin-2-one
In 1-methyl-pyrrolidin-2-one at 110℃; for 24h; Inert atmosphere;

: 920-46-7
Methacryloyl chloride

: 693-57-2
12-Aminododecanoic acid

: 62839-65-0
12-(methacrylolamino)dodecanoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate; 4-methoxy-phenol In acetone for 1h; Heating;	95%
In 1,4-dioxane; water	73%
Stage #1: 12-Aminododecanoic acid With sodium hydroxide In water for 0.5h; Stage #2: Methacryloyl chloride In water at -5 - 0℃; for 1.25h; Stage #3: With hydrogenchloride In water pH=<= 3;

: 64-17-5
ethanol

: 693-57-2
12-Aminododecanoic acid

: 53005-23-5
12-aminododecanoic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: ethanol With acetyl chloride at 20℃; for 1h; Stage #2: 12-Aminododecanoic acid at 20℃; for 0.25h;	94%
With sulfuric acid Reflux;

: 64-17-5
ethanol

: 693-57-2
12-Aminododecanoic acid

: 84636-23-7
ethyl 12-aminododecanoate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0 - 20℃; for 12h;	93%
With thionyl chloride at 0 - 20℃; for 2.33333h;

: 605-65-2
5-(dimethylamino)naphth-1-ylsulfonyl chloride

: 693-57-2
12-Aminododecanoic acid

: 12-N-(5'-dimethylaminonaphthalene-1'-sulfonyl)aminododecanoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate; triethylamine In acetone at 20℃; for 1h;	92%
With sodium hydrogencarbonate In water; acetone at 20℃; for 5h;	60%

: 126695-58-7
succinimidyl 4-azido-2,3,5,6-tetrafluorobenzoate

: 693-57-2
12-Aminododecanoic acid

: 254968-74-6
12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoic acid

Conditions

Conditions	Yield
In 1,4-dioxane at 50 - 60℃; for 4h;	90%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 693-57-2
12-Aminododecanoic acid

: 128917-74-8
9-fluorenylmethoxycarbonyl-12-aminododecanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water	90%
With sodium carbonate In 1,4-dioxane at 0 - 20℃;	78.3%
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃;

: 7664-93-9
sulfuric acid

: 7722-84-1
dihydrogen peroxide

: 693-57-2
12-Aminododecanoic acid

: 12-aminoperlauric acid monopersulfate

Conditions

Conditions	Yield
In ethyl acetate	90%

...Expand

: 17831-88-8
4-chloro-2H-1-benzopyran-2-one

: 693-57-2
12-Aminododecanoic acid

: 12-((2-oxo-2H-chromen-4-yl)amino)dodecanoic acid

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate In water at 80℃; Ullmann Condensation; Microwave irradiation;	90%

: 66270-36-8
2,2,2-trichloro-1,1-dimethylethoxychloroformate

: 693-57-2
12-Aminododecanoic acid

: 250142-13-3
12-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-dodecanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 20℃; for 0.166667h; Acylation;	88.7%

: C37H44N3O4(1+)*Br(1-)

: 693-57-2
12-Aminododecanoic acid

: C45H64N3O3(1+)*Br(1-)

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	88%

: 1121-60-4
pyridine-2-carbaldehyde

: 693-57-2
12-Aminododecanoic acid

: sodium 12-{[(pyridin-2-yl)methylene]amino}undecanoate

Conditions

Conditions	Yield
Stage #1: 12-Aminododecanoic acid With sodium hydroxide In methanol Stage #2: pyridine-2-carbaldehyde In methanol at 20℃; for 12h;	87%

: 1809-20-7
diisopropyl hydrogenphosphonate

: 693-57-2
12-Aminododecanoic acid

: 869337-31-5
12-(diisopropoxy-phosphorylamino)-dodecanoic acid

Conditions

Conditions	Yield
With triethylamine In tetrachloromethane; ethanol; water at 0 - 20℃;	87%

: 10199-89-0
NBD chloride

: 693-57-2
12-Aminododecanoic acid

: 96801-39-7
12-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)dodecanoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetonitrile at 65℃; for 2h;	87%
With sodium hydrogencarbonate In methanol at 0 - 50℃; for 3.5h;	81%
With sodium hydrogencarbonate In methanol; water at 50℃; for 1.5h;	64%
Stage #1: 12-Aminododecanoic acid With sodium hydrogencarbonate In ethanol; water at 37℃; for 0.166667h; Inert atmosphere; Stage #2: NBD chloride In ethanol; water at 37℃; Inert atmosphere;	56%
With sodium hydrogencarbonate In methanol at 50℃; for 3h;	36%

: 693-57-2
12-Aminododecanoic acid

: 156028-26-1
1,6,7,12-tetrachloro-perylene-3,4,9,10-tetracarboxylic acid dianhydride

: C48H50Cl4N2O8

Conditions

Conditions	Yield
With propionic acid at 140℃; for 36h; Inert atmosphere; Schlenk technique;	87%
In 1-methyl-pyrrolidin-2-one at 20 - 65℃; for 1.5h;

: 93-97-0
benzoic acid anhydride

: 693-57-2
12-Aminododecanoic acid

: 12-(benzoylamino)dodecanoic acid

Conditions

Conditions	Yield
With acetic acid at 20℃; for 2.5h;	86%

: 67-56-1
methanol

: 693-57-2
12-Aminododecanoic acid

: 53005-24-6
methyl 12-aminododecanoate

Conditions

Conditions	Yield
With thionyl chloride at -10 - 20℃;	86%
With thionyl chloride
With acetyl chloride at 0℃; for 3h; Inert atmosphere; Reflux;

: 70-34-8
2,4-Dinitrofluorobenzene

: 693-57-2
12-Aminododecanoic acid

: N-(2,4-dinitrophenyl)-12-aminododecanoic acid

Conditions

Conditions	Yield
Stage #1: 12-Aminododecanoic acid With potassium hydroxide In 1,4-dioxane for 0.0833333h; Stage #2: 2,4-Dinitrofluorobenzene In 1,4-dioxane for 18h;	86%

Dodecanoic acid,12-amino- Specification

The Dodecanoic acid,12-amino-, with the CAS registry number 693-57-2, is also known as 12-Aminododecanoic acid and 12-Aminolauric acid. It belongs to the product category of Omega-Aminocarboxylic Acids. Its EINECS registry number is 211-754-7. This chemical's molecular formula is C₁₂H₂₅NO₂ and molecular weight is 215.33. What's more, both its IUPAC name and systematic name are the same which is called 12-Aminododecanoic acid.

Physical properties about this chemical are: (1)ACD/LogP: 3.08; (2)#of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.52; (4) ACD/LogD (pH 7.4): 0.58; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 3.13; (8)ACD/KOC (pH 7.4): 3.55; (9)#H bond acceptors: 3; (10) #H bond donors: 3; (11)#Freely Rotating Bonds: 12; (12)Polar Surface Area: 29.54 Å²; (13)Index of Refraction: 1.469; (14)Molar Refractivity: 62.74 cm³; (15)Molar Volume: 224.9 cm³; (16)Polarizability: 24.87×10^-24cm³; (17)Surface Tension: 38.5 dyne/cm; (18)Density: 0.957 g/cm³; (19)Flash Point: 165.3 °C ; (20) Enthalpy of Vaporization: 65.29 kJ/mol; (21)Boiling Point: 349.7 °C at 760 mmHg; (22)Vapour Pressure: 7.95E-06 mmHg at 25 °C.

Preparation of Dodecanoic acid,12-amino: this chemical can be prepared by 12-Oxododecanoic acid oxime. This reaction needs reagent H₂ and solvent Methanol. The reaction needs catalyst PtO₂. The reaction time is 1.5 hours. The reaction pressure is 2280 Pa. The yield is 87 %.

Uses of Dodecanoic acid,12-amino: it can react with Maleic acid anhydride to give 12-(3-Carboxyacryloylamino)dodecanoic acid. The reaction occurs with solvent Acetic acid. The reaction occurs with solvent Acetic acid.

When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes, respiratory system and skin. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And in case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(O)CCCCCCCCCCCN
(2) InChI: InChI=1/C12H25NO2/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h1-11,13H2,(H,14,15)
(3) InChIKey: PBLZLIFKVPJDCO-UHFFFAOYAT

Product Name

12-AMINODODECANOIC ACID

Synthetic route

Dodecanoic acid,12-amino- Specification

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