ETHYL ISOCYANATE supplier | CasNO.109-90-0

Name
Ethyl isocyanate
EINECS 203-717-9
CAS No. 109-90-0
Article Data87
CAS DataBase
Density 0.87 g/cm³
Solubility insoluble in water
Melting Point <-50
Formula C₃H₅NO
Boiling Point 60 °C at 760 mmHg
Molecular Weight 71.0788
Flash Point 23 °C
Transport Information UN 2481 3/PG 1
Appearance Colorless liquid
Safety 16-26-36/37/39-45
Risk Codes 11-20/21-25-36/37/38-42
Molecular Structure
Hazard Symbols F, T
Synonyms Isocyanicacid, ethyl ester (6CI,8CI);Isocyanatoethane;NSC 89687;
PSA 29.43000
LogP 0.34210

Synthetic route

: 32315-10-9
bis(trichloromethyl) carbonate

: 75-04-7
ethylamine

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%

: 75-44-5
phosgene

: 75-04-7
ethylamine

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
In toluene at 320 - 340℃; under 37.5038 Torr; Temperature;	97.6%

: 542-85-8
Ethyl isothiocyanate

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With air; palladium dichloride In 1,4-dioxane Heating;	89%

: 6135-31-5
methyl N-ethylcarbamate

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With Phenyltrichlorosilane at 100 - 155℃; for 0.5h;	87.3%

: 41891-13-8
ethyl carbamoyl chloride

: 111-27-3
hexan-1-ol

A: 67821-25-4
N-ethyl-carbamic acid hexyl ester

B: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
In 1,2-dichloro-benzene	A n/a B 81%

...Expand

: 41891-13-8
ethyl carbamoyl chloride

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
In chlorobenzene	77%
With N,N-dimethyl-aniline
With triethylamine at 40℃; for 0.333333h; Yield given;
With triethylamine In Dimethyldisulphide at 0 - 5℃; pH=8 - 8.5;

: 621-04-5
1-ethyl-3-phenylurea

A: (Dichloro-phenyl-silanyl)-phenyl-amine

B: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With Phenyltrichlorosilane at 160 - 205℃; for 1h;	A n/a B 72.5%

: 19265-06-6
ethyl (chloroformyl)methyl carbamate

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With aluminium trichloride at 193 - 220℃; for 0.5h;	64.3%

: 61031-53-6
3-ethyl-4-hydroxy-5,5-dimethyl-4-phenyl-oxazolidin-2-one

A: 769-60-8
2-methyl-1-phenylprop-2-en-1-one

B: 7473-98-5
2-hydroxy-2-methylpropiophenone

C: 3155-01-9
3-hydroxy-3-phenyl-butan-2-one

D: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
In benzene at 550℃;	A 41% B 14% C 45% D 44%

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: N-nitro-N'-ethyl-urea

: 109-90-0
ethyl isocyanate

: 186581-53-3, 908094-01-9
diazomethane

: N-nitro-N'-ethyl-urea

A: 598-57-2
methylnitroamine

B: 4164-28-7
N-nitrodimethylamine

C: 109-90-0
ethyl isocyanate

...Expand

: 1117-96-0
Diazoethan

: 60-29-7
diethyl ether

: 420-05-3
cyanic acid

: 109-90-0
ethyl isocyanate

...Expand

: 1-ethyl-[1,3]diazepine-2,4,7-trione

A: 123-56-8
Succinimide

B: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
at 150 - 160℃;

: 590-28-3
potassium cyanate

: 64-67-5
diethyl sulfate

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With sodium carbonate

: ethyl-carbonimidic acid ethyl ester chloride

A: 75-00-3
chloroethane

B: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
zerfaellt leicht;

: 590-28-3
potassium cyanate

: 78-40-0
triethyl phosphate

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
at 200℃;

: 101742-82-9
2-ethylsuccinohydrazide

A: 856062-10-7
ethyl-succinyl azide

B: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With hydrogenchloride; diethyl ether; sodium nitrite

: C8H17N3O2

A: 623-76-7
N,N'-diethylurea

B: 109-90-0
ethyl isocyanate

: 35580-89-3
ethyl-carbamic acid-(2-hydroxy-phenyl ester)

A: 120-80-9
benzene-1,2-diol

B: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
at 240 - 250℃;

: 35580-89-3
ethyl-carbamic acid-(2-hydroxy-phenyl ester)

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
at 210 - 250℃;

: 590-28-3
potassium cyanate

: 563-17-7
potassium ethyl sulfate

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
durch Destillation;

: diazenedicarboxylic acid bis-ethylamide; disilver (I)-compound

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
at 144℃; verpufft;

: 79-03-8
propionyl chloride

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With sodium azide; toluene
With sodium azide; benzene
With tetrabutylammoniun azide In toluene Heating;

: ethyl-thiocarbamic acid ; mercury (II)-compound with mercury chloride

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
beim Erhitzen;

: 7139-74-4
propionyl azide

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
In acetonitrile; xylene at 79.9℃; Kinetics; Thermodynamic data; decomposition, ΔS(excit.);

: 90714-99-1
3-Ethylcarbamoyl-2-thioxo-2,3-dihydro-benzoimidazole-1-carboxylic acid methyl ester

A: 2-Thioxo-2,3-dihydro-benzoimidazole-1-carboxylic acid methyl ester

B: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
In Petroleum ether for 2h; Heating;

: 90715-00-7
3-Ethylcarbamoyl-2-thioxo-2,3-dihydro-benzoimidazole-1-carboxylic acid ethyl ester

A: 21928-73-4
2-thioxo-2,3-dihydro-benzoimidazole-1-carboxylic acid ethyl ester

B: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
In Petroleum ether for 2h; Heating;

: 759-73-9
N-ethyl-N'-nitrosourea

: 109-90-0
ethyl isocyanate

Conditions

Conditions	Yield
With water at 37℃; Rate constant;

: 1-ethyl-[1,3]diazepine-2,4,7-trione

: 7732-18-5
water

A: 123-56-8
Succinimide

B: 109-90-0
ethyl isocyanate

...Expand

: 108-44-1
1-amino-3-methylbenzene

: 109-90-0
ethyl isocyanate

: 1-ethyl-3-m-tolylurea

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

: 67-56-1
methanol

: 109-90-0
ethyl isocyanate

: 6135-31-5
methyl N-ethylcarbamate

Conditions

Conditions	Yield
With dibutyltin dilaurate at 50℃; for 4h;	100%
With benzene
With triethylamine

: 109-01-3
1-methyl-piperazine

: 109-90-0
ethyl isocyanate

: 7401-05-0
N-ethyl-4-methyl-1-piperazinecarboxamide

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 20℃;	100%
In toluene at 20℃; for 96h;	80%

: 22483-09-6
2,2-dimethoxyethylamine

: 109-90-0
ethyl isocyanate

: 115869-18-6
N-(2,2-dimethoxyethyl)-N-ethylurea

Conditions

Conditions	Yield
In benzene	100%

: 1745-46-6
6,11-dihydrodibenzo[b,e]thiepin-11-ol

: 109-90-0
ethyl isocyanate

: 1969-25-1
bis(6,11-dihydrodibenzothieopin-11-yl) ether

Conditions

Conditions	Yield
In benzene 1) 35-40 deg C, 3 h; 2) 30 min., 50 deg C, room temp., overnight;	100%

: 128616-05-7
2-<2-(4-amino-3-hydroxyphenyl)ethyl>-3,7-dimethylimidazo<1,2-a>pyridine

: 109-90-0
ethyl isocyanate

: 128616-45-5
3,7-Dimethyl-2-[2-{4-(3-ethylureido)-3-hydroxyphenyl}ethyl]imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
In tetrahydrofuran; methanol for 2.5h; Ambient temperature;	100%

: 109-90-0
ethyl isocyanate

: 5285-94-9
2-thiocyanatobenzimidazole

: 90714-81-1
3-Ethyl-2-imino-2,3-dihydro-1-thia-3,4a,9-triaza-fluoren-4-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1h; Ambient temperature;	100%

: C24H32Cl2FN5

: 109-90-0
ethyl isocyanate

: C27H37Cl2FN6O

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 20℃; for 4h;	100%

: 109-90-0
ethyl isocyanate

: 4-amino-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene hydrochloride

: C25H28Cl2N2O7

Conditions

Conditions	Yield
In tetrahydrofuran for 2h;	100%

: 109-90-0
ethyl isocyanate

: 174072-63-0
6-(4-aminophenyl)-5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 481049-95-0
N-(4-{5-{[benzyl(methyl)amino]methyl}-1-(2,6-difluorobenzyl)-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl}phenyl)-N'-ethylurea

Conditions

Conditions	Yield
With pyridine at 20℃; for 18h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane

: 1004764-02-6
2-{4-[(3-chloropropyl)oxy]phenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

: 109-90-0
ethyl isocyanate

: 2-{4-[3-chloropropoxy]phenyl}-N-ethyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carboxamide

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

: 95-78-3
2,5-Dimethylaniline

: 109-90-0
ethyl isocyanate

: 1-ethyl-3-(2,5-dimethylphenyl)urea

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

: 572924-09-5
C37H46N6O8S

: 109-90-0
ethyl isocyanate

: 791835-64-8
C40H51N7O9S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃;	100%

: 109-90-0
ethyl isocyanate

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 877165-63-4
C12H23N3O3

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 0.5h;	100%

: 615576-61-9
2-methyl-5-(piperazine-1-sulfonyl)-benzo[d]isothiazole-3-one

: 109-90-0
ethyl isocyanate

: 4-(2-methyl-3-oxo-2,3-dihydrobenzo[d]isothiazole-5-sulfonyl)piperazine-1-carboxylic acid ethylamide

Conditions

Conditions	Yield
Stage #1: 2-methyl-5-(piperazine-1-sulfonyl)-benzo[d]isothiazole-3-one; ethyl isocyanate With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3.5h; Polymer; Stage #2: With polymer supported trisamine In dichloromethane at 20℃;	100%

: 4-oxopiperidin-1-ium 2,2,2-trifluoroacetate

: 109-90-0
ethyl isocyanate

: 675112-78-4
N-ethyl-4-oxo-1-piperidinecarboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	100%

: 1208901-69-2
2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

: 109-90-0
ethyl isocyanate

: 635698-64-5
2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl-N-ethylcarboxamide

Conditions

Conditions	Yield
With triethylamine In ethyl acetate at 20℃; for 12h;	100%

: 6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] trifluoroacetate

: 109-90-0
ethyl isocyanate

: 853018-47-0
N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide

Conditions

Conditions	Yield
Stage #1: 6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] trifluoroacetate; ethyl isocyanate In dichloromethane Stage #2: With ammonia In methanol; chloroform	100%

: 1043916-41-1
methyl (2S)-2-[2,4-dichloro-5-({4-[(1E)-3-hydroxyprop-1-en-1-yl]-1,3-dimethyl-1H-pyrazol-5-yl}oxy)phenoxy]propionate

: 109-90-0
ethyl isocyanate

: 1043916-43-3
methyl (2S)-2-(2,4-dichloro-5-{[4-((1E)-3-{[ethylcarbamoyl]oxy}prop-1-en-1-yl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy}phenoxy)propionate

Conditions

Conditions	Yield
In pyridine at 60℃; for 16.5h;	100%

: 1073176-43-8
(S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate

: 109-90-0
ethyl isocyanate

: 1195974-21-0
(S)-tert-butyl 1-(2-(3-ethylureido)-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-ylcarbamate

Conditions

Conditions	Yield
at 20℃; for 18h;	100%

: 882499-87-8
methyl 2-amino-5-bromopyridine-4-carboxylate

: 109-90-0
ethyl isocyanate

: 1186113-91-6
methyl 5-bromo-2-(3-ethylureido)isonicotinate

Conditions

Conditions	Yield
In chloroform at 40℃; for 36h;	100%
In chloroform at 40℃; for 78h;	96%
In chloroform at 40℃; Sealed tube;	96%

: 18635-43-3
2-(S)-benzyloxycarbonylamino-3-aminopropionic acid

: 109-90-0
ethyl isocyanate

: 1182348-93-1
rac-2-benzyloxycarbonylamino-3-(3-ethylureido)-propionic acid

Conditions

Conditions	Yield
Stage #1: 2-(S)-benzyloxycarbonylamino-3-aminopropionic acid; ethyl isocyanate With sodium hydroxide In tetrahydrofuran at 20℃; Stage #2: With hydrogenchloride; water In tetrahydrofuran	100%

: 1228439-45-9
benzyl 2-benzylpyrrolidine-2-carboxylate

: 109-90-0
ethyl isocyanate

: 1228439-49-3
C22H26N2O3

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

: 1228693-21-7
C19H16F17NO*ClH

: 109-90-0
ethyl isocyanate

: 1228693-25-1
C22H21F17N2O2

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 23℃; for 16h;	100%

: 928196-14-9
7-chloro-3-[5-aminomethyl-[1,2,4]oxadiazol-3-yl]-1-(tetrahydropyran-4-yl)methyl-1H-indole

: 109-90-0
ethyl isocyanate

: 7-chloro-3-[5-[N-(formamidoethyl)amino]methyl-[1,2,4]oxadiazol-3-yl]-1-(tetrahydropyran-4-yl)methyl-1H-indole

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	100%

: 26734-09-8
3-amino-2,2-dimethylpropan-1-ol

: 109-90-0
ethyl isocyanate

: 1093206-28-0
1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)urea

Conditions

Conditions	Yield
In 1,4-dioxane at 20℃; Inert atmosphere;	100%
In 1,4-dioxane

: 1093205-85-6
(S)-2-((2-cyano-3-nitrophenoxy)methyl)pyrrolidinium chloride

: 109-90-0
ethyl isocyanate

: 1093205-90-3
(S)-2-((3-amino-2-cyanophenoxy)methyl)-N-ethylpyrrolidine-1-carboxamide

Conditions

Conditions	Yield
	100%

: 1402743-81-0
tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

: 109-90-0
ethyl isocyanate

: 1402743-83-2
C19H20F3N3O2

Conditions

Conditions	Yield
Stage #1: tert-butyl ((1R,2R)-2-(2-amino-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate; ethyl isocyanate In tetrahydrofuran at 0 - 20℃; for 0.75h; Stage #2: With trifluoroacetic acid In tetrahydrofuran at 0 - 20℃; for 16h;	100%

: 1639810-56-2
diethyl (E)-(3-((benzyloxy)amino)prop-1-en-1-yl)phosphonate

: 109-90-0
ethyl isocyanate

: 1639810-61-9
(E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h; Inert atmosphere;	100%

ETHYL ISOCYANATE Chemical Properties

1.IUPAC Name: Isocyanatoethane
2.Synonyms：Ethyl isocyanate ; Isocyanic acid ethyl ester ; 1-Isocyanatoethane ; C₂H₅NCO ; Ethane,isocyanato- ; Isocyanated’ethyle ; Isocyanato-ethan ; Isocyanatoethane
3.The Molecular formula of Ethyl isocyanate (109-90-0) : C₃H₅NO
4.The Molecular Weight of Ethyl isocyanate (109-90-0) : 71.08 g/mol
5.The Molecular Structure of Ethyl isocyanate (109-90-0) ：
6.Density: 0.898 g/mL at 25 °C(lit.)
7.Boiling point: 60 °C(lit.)
8.Flash point: 20 °F
9.Solubility in water: Insoluble
10.Refractive index (nD): 1.381(lit.)
11.Appearance: colorless liquid
12.Storage temp: 2-8°C
13.vapor pressure: 209 mmHg at 25°C

ETHYL ISOCYANATE Uses

Ethyl isocyanate (109-90-0) is used to make pharmaceuticals and pesticides.

ETHYL ISOCYANATE Toxicity Data With Reference

1.		mmo-sat 50 µg/plate ABCHA6 44,3017,80
2.		ivn-mus LD50:56 mg/kg		CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#02910 .

ETHYL ISOCYANATE Consensus Reports

Reported in EPA TSCA Inventory.

ETHYL ISOCYANATE Safety Profile

Poison by intravenous route. Mutation data reported. A flammable liquid. When heated to decomposition it emits toxic fumes of NO_x. See also CYANATES.
Hazard Codes F,T
F: Highly Flammable
T: Toxic
Risk Statements: 11-20/21-25-36/37/38-42
R11: Highly Flammable
R20/21: Harmful by inhalation and if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
R42: May cause sensitization by inhalation
Safety Statements 16-26-36/37/39-45
S16: Keep away from sources of ignition - No smoking
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
WGK Germany: 3

ETHYL ISOCYANATE Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid, Poison; DOT Class: 6.1; Label: Poison; DOT Class: 6.1; Label: Poison, Flammable Liquid; DOT Class: 3; Label: Flammable Liquid, Poison

ETHYL ISOCYANATE Specification

Ethyl isocyanate (109-90-0) may react with water to produce a corrosive liquid and carbon dioxide gas.

Product Name

Ethyl isocyanate

Synthetic route

ETHYL ISOCYANATE Chemical Properties

ETHYL ISOCYANATE Uses

ETHYL ISOCYANATE Toxicity Data With Reference

ETHYL ISOCYANATE Consensus Reports

ETHYL ISOCYANATE Safety Profile

ETHYL ISOCYANATE Standards and Recommendations

ETHYL ISOCYANATE Specification

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