• Name

  6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE

• EINECS 217-408-1
• CAS No. 1837-57-6
• Density 1.2764 (rough estimate)
• Solubility
• Melting Point 62-67°C(lit.)
• Formula C₁₅H₁₅N₃O^.C₃H₆O₃
• Boiling Point 523.5 °C at 760 mmHg
• Molecular Weight 343.382
• Flash Point 270.4 °C
• Transport Information
• Appearance White or almost white crystalline powder; none stink
• Safety
• Risk Codes R36/37/38; R22; R40; R20/21/22
• Molecular Structure
• Hazard Symbols Xi,Xn
• Synonyms Lactic acid, compd. with 6, 9-diamino-2-ethoxyacridine (1:1);Flavitrol;7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid;3,9-Diamino-7-ethoxyacridinium lactate;Acrinol;Hectalin;Amoebin;2-Ethoxy-6,9-diaminoacridine lactate;2,5-Diamino-7-ethoxyacridine lactate;Rivanol;Propanoic acid, 2-hydroxy-, compd. with 7-ethoxy-3,9-acridinediamine (1:1);Acrolactine;Acridine, 6,9-diamino-2-ethoxy-, cpd with lactic acid (1:1);Ethodin;Rimaon;Antidian 200;6,9-Acridinediamine, 2-ethoxy-, 2-hydroxypropanoate (1:1);6, 9-Diamino-2-ethoxyacridine lactate;
• PSA 131.69000
• LogP 3.56530

Synthetic route

1837-57-6

ethacridine lactate

6,9-Diamino-5-brom-2-ethoxy-acridin

Conditions

Conditions	Yield
With N-Bromosuccinimide; acetic acid	85%

1837-57-6

ethacridine lactate

108-24-7

acetic anhydride

N-(9-amino-2-ethoxyacridin-6-yl)acetamide

Conditions

Conditions	Yield
In acetic acid for 0.166667h;	84%

141-86-6

2,6-Diaminopyridine

1837-57-6

ethacridine lactate

H2O4S*C20H19N7O

Conditions

Conditions	Yield
Stage #1: ethacridine lactate With sulfuric acid; sodium nitrite In water at 5℃; for 0.333333h; Stage #2: 2.6-diaminopyridine With sodium carbonate In water at 20℃; for 12h;	76.3%

1837-57-6

ethacridine lactate

90-02-8

salicylaldehyde

5-[(E)-(9-amino-7-ethoxyacridin-3-yl)azo]-2-hydroxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: ethacridine lactate With sulfuric acid; sodium nitrite In water at 0 - 5℃; for 0.333333h; Stage #2: salicylaldehyde With sodium carbonate In water at 20℃; for 2h;	75%

576-26-1

2.6-dimethylphenol

1837-57-6

ethacridine lactate

4-(9-Amino-7-ethoxy-3-acridinylazo)-2,6-dimethylphenol

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium nitrite 1) H2O, 0 deg C, 2) 5 deg C to 10 deg C; Yield given. Multistep reaction;

1837-57-6

ethacridine lactate

9-Amino-7-ethoxy-3-acridin-diazonium-ditetrafluoroborat

Conditions

Conditions	Yield
With hydrogenchloride; tetrafluoroboric acid; sodium nitrite 1) H2O, 0 deg C, 2) H2O, 0 deg C; Yield given. Multistep reaction;

1837-57-6

ethacridine lactate

74165-94-9

5-Iod-ethacridin

Conditions

Conditions	Yield
With iodine; potassium iodide

1837-57-6

ethacridine lactate

3,9-Diamino-2,4-dibrom-7-ethoxy-acridin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 85 percent / N-bromosuccinimide, aq. AcOH 2: 60 percent / N-bromosuccinimide, aq. AcOH View Scheme

1837-57-6

ethacridine lactate

55-55-0

4-(methylamino)phenol sulphate

2C7H7NO*C15H15N3O

Conditions

Conditions	Yield
With potassium iodate In methanol pH=3.1; aq. buffer;

1837-57-6

ethacridine lactate

6203-18-5

p-dimethylaminocinnamaldehyde

C37H37N5O

Conditions

Conditions	Yield
With sulfuric acid In methanol

1837-57-6

ethacridine lactate

5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[[5-[(E)-(9-amino-7-ethoxyacridin-3-yl)azo]-2-hydroxyphenyl]methyl]-N-[2-(dimethylamino)ethyl]pentanamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium nitrite; sulfuric acid / water / 0.33 h / 0 - 5 °C 1.2: 2 h / 20 °C 2.1: sodium cyanoborohydride; acetic acid; methanol / 0.5 h / 20 °C 3.1: triethylamine / N,N-dimethyl-formamide / 20 °C View Scheme

1837-57-6

ethacridine lactate

4-[(E)-(9-amino-7-ethoxyacridin-3-yl)azo]-2-[[2-(dimethylamino)ethylamino]methyl]phenol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium nitrite; sulfuric acid / water / 0.33 h / 0 - 5 °C 1.2: 2 h / 20 °C 2.1: sodium cyanoborohydride; acetic acid; methanol / 0.5 h / 20 °C View Scheme

1837-57-6

ethacridine lactate

4-[(E)-(9-amino-7-ethoxyacridin-3-yl)azo]-2-[[2-(dimethylamino)ethylmethylamino]methyl]phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium nitrite; sulfuric acid / water / 0.33 h / 0 - 5 °C 1.2: 2 h / 20 °C 2.1: sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 20 °C View Scheme

141-86-6

2,6-Diaminopyridine

1837-57-6

ethacridine lactate

C20H19N7O*(x)ClH

Conditions

Conditions	Yield
Stage #1: ethacridine lactate With sulfuric acid; sodium nitrite In water at 5℃; for 0.333333h; Stage #2: 2.6-diaminopyridine With sodium carbonate In water at 20℃; for 12h;

Ethacridine lactate Chemical Properties

Ethacridine lactate Uses

Ethacridine lactate Toxicity Data With Reference

Ethacridine lactate Consensus Reports

Ethacridine lactate Safety Profile

Ethacridine lactate Specification