Ethyl 2-ethylacetoacetate supplier

Name
Ethyl 2-ethylacetoacetate
EINECS 210-151-6
CAS No. 607-97-6
Article Data84
CAS DataBase
Density 0.979 g/cm³
Solubility
Melting Point 170 °C (decomp)
Formula C₈H₁₄O₃
Boiling Point 190 °C at 760 mmHg
Molecular Weight 158.197
Flash Point 75.7 °C
Transport Information
Appearance Colorless liquid.
Safety 23-24/25-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Acetoaceticacid, 2-ethyl-, ethyl ester (6CI,7CI,8CI);2-Ethyl-3-oxobutanoic acid ethylester;2-Ethylacetoacetic acid ethyl ester;Ethyl 2-acetylbutanoate;Ethyl2-acetylbutyrate;Ethyl 2-ethyl-3-ketobutyrate;Ethyl 2-ethyl-3-oxobutanoate;Ethyl 2-ethyl-3-oxobutyrate;Ethyl 2-ethylacetoacetate;Ethyl2-ethylacetylacetate;Ethyl a-acetylbutyrate;Ethyl a-ethylacetoacetate;NSC 53775;
PSA 43.37000
LogP 1.16470

Synthetic route

: 74-96-4
ethyl bromide

: 141-97-9
ethyl acetoacetate

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at -10 - 10℃; for 2h; Inert atmosphere;	94.9%
With potassium carbonate In ethanol; water at 70℃; for 10h; regioselective reaction;	85.3%
With sodium ethanolate	78%

: 141-97-9
ethyl acetoacetate

: 75-03-6
ethyl iodide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With sodium In tetrahydrofuran for 20h; Heating;	87%
Stage #1: ethyl acetoacetate With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Stage #2: ethyl iodide In tetrahydrofuran at 70℃; for 12h; Further stages.;	74%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In benzene for 3h; Ambient temperature;	50%

: 141-97-9
ethyl acetoacetate

: 75-03-6
ethyl iodide

A: 1619-57-4
ethyl 2,2-diethyl-3-oxobutanoate

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With P(MeNCH2CH2)3N In hexane; acetonitrile at 0℃; for 0.5h;	A n/a B 78%
With sodium ethanolate 1.) EtOH, 80 deg C, 2.) EtOH, 80 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
With aluminum oxide; sodium ethanolate 2.) room temperature, 5 d; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With sodium ethanolate 1.) EtOH, 80 deg C, 2.) EtOH, 80 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 64-67-5
diethyl sulfate

: 141-97-9
ethyl acetoacetate

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With dimethyl amine at 10 - 15℃;	70%
With sodium ethanolate

: 64-67-5
diethyl sulfate

: enolate potassique de l'acetylacetate d'ethyle

A: 5331-73-7
ethyl (Z)-3-ethoxybut-2-enoate

B: 57592-45-7
ethyl (E)-3-ethoxy-2-butenoate

C: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With polymer-HMPT In tetrahydrofuran at 20℃; for 24h; Yields of byproduct given;	A n/a B 54% C n/a
With copolymere de vinyloxazolidone et de divinylbenzene In tetrahydrofuran at 20℃; for 24h; Yield given. Yields of byproduct given;
With 3-methyl-2-oxo-1,3-oxazolidine In tetrahydrofuran at 20℃; for 24h; Yield given. Yields of byproduct given;
With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran at 20℃; for 24h; Product distribution; further reagents, variation of equivalents of the reagents;

...Expand

: 74-96-4
ethyl bromide

: 141-97-9
ethyl acetoacetate

A: 998-91-4
ethyl 3-ethoxy-2-butenoate

B: 1619-57-4
ethyl 2,2-diethyl-3-oxobutanoate

C: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With aluminum oxide; sodium ethanolate 2.) room temperature, 5 d; Yields of byproduct given. Title compound not separated from byproducts;	A n/a B n/a C 53%

...Expand

: 141-97-9
ethyl acetoacetate

: 10504-65-1
diphenylethylsulfonium perchlorate

A: 998-91-4
ethyl 3-ethoxy-2-butenoate

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane for 17h; Ambient temperature;	A 10% B 50%

...Expand

: 247098-17-5
ethyl-α-ethylacetoacetate cyanohydrin

A: 3-amino-3-cyano-2-ethyl-3-methyl-propionic acid ethyl ester

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With hydrogen; nickel In methanol; ammonium hydroxide at 20℃; under 2068.59 - 2327.17 Torr;	A 50% B n/a

: 74-96-4
ethyl bromide

: 17455-13-9
18-crown-6 ether

: 66279-50-3
acetoacetic acid ethyl ester; potassium (Z)-enolate

: 23978-09-8
[2.2.2]cryptande

A: 5331-73-7
ethyl (Z)-3-ethoxybut-2-enoate

B: 57592-45-7
ethyl (E)-3-ethoxy-2-butenoate

C: 1619-57-4
ethyl 2,2-diethyl-3-oxobutanoate

D: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 40℃; Mechanism; Product distribution;	A 2% B 8% C n/a D n/a

...Expand

: 2-ethyl-3-methyl-pentenedioic acid diethyl ester

A: 144-62-7
oxalic acid

B: 141-97-9
ethyl acetoacetate

C: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
bei der Ozonspaltung;

...Expand

: 857819-83-1
4-ethyl-3-methyl-pentenedioic acid diethyl ester

A: 144-62-7
oxalic acid

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
bei der Ozonspaltung;

: 90833-10-6
2-acetyl-3-methyl-succinic acid-1-ethyl ester

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
Erhitzen;

: 64-17-5
ethanol

: 141-97-9
ethyl acetoacetate

: 75-03-6
ethyl iodide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
Reaktion ueber mehrere Stufen;

...Expand

: 74-96-4
ethyl bromide

: 141-52-6
sodium ethanolate

: 141-97-9
ethyl acetoacetate

: 105-53-3
diethyl malonate

A: 133-13-1
ethyl diethyl malonate

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

...Expand

: 870-85-9
ethyl 3-methylaminocrotonate

: 75-03-6
ethyl iodide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
at 100℃; beim folgenden Kochen mit Wasser;
anschliessende Hydrolyse des Reaktionsprodukts mit siedendem Wasser;

: 64-17-5
ethanol

: 1007476-32-5
sodium ethyl acetylacetate enolate

: 75-03-6
ethyl iodide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

...Expand

: 59222-31-0
3-diethylamino-crotonic acid ethyl ester

: 75-03-6
ethyl iodide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 3-dipropylamino-crotonic acid ethyl ester

: 75-03-6
ethyl iodide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
anschliessende Hydrolyse des Reaktionsprodukts mit siedendem Wasser;

: 1007476-32-5
sodium ethyl acetylacetate enolate

: 75-03-6
ethyl iodide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
at 160 - 170℃;
With diethyl ether
With benzene
at 100℃;

: 141-52-6
sodium ethanolate

: 75-03-6
ethyl iodide

: 105-45-3
acetoacetic acid methyl ester

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

...Expand

: 75-03-6
ethyl iodide

: 14205-42-6
3-dimethylamino-crotonic acid ethyl ester

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
anschliessenden Hydrolyse mit Wasser;
anschliessende Hydrolyse des Reaktionsprodukts mit siedendem Wasser;

: 141-78-6
ethyl acetate

: 533-68-6
2-bromobutyric acid ethyl ester

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With magnesium

: 463-51-4
Ketene

: 533-68-6
2-bromobutyric acid ethyl ester

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With diethyl ether; iodine; zinc

: 74-96-4
ethyl bromide

: 141-97-9
ethyl acetoacetate

A: 998-91-4
ethyl 3-ethoxy-2-butenoate

B: 1619-57-4
ethyl 2,2-diethyl-3-oxobutanoate

C: 103110-71-0
2-Ethyl-3-ethoxy-3-methyl-acrylsaeureethylester

D: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
(i) K, EtOH, (ii) /BRN= 1209224/, HMPA; Multistep reaction;

...Expand

: 74-96-4
ethyl bromide

: 66279-50-3
acetoacetic acid ethyl ester; potassium (Z)-enolate

A: 5331-73-7
ethyl (Z)-3-ethoxybut-2-enoate

B: 57592-45-7
ethyl (E)-3-ethoxy-2-butenoate

C: 1619-57-4
ethyl 2,2-diethyl-3-oxobutanoate

D: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With 18-crown-6 ether 1) DME, 40 deg C, 2) DME, 40 deg C; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 74-96-4
ethyl bromide

: 66279-50-3
acetoacetic acid ethyl ester; potassium (Z)-enolate

A: 57592-45-7
ethyl (E)-3-ethoxy-2-butenoate

B: 1619-57-4
ethyl 2,2-diethyl-3-oxobutanoate

C: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With [2.2.2]cryptande 1) t-BuOH, 40 deg C, 2) t-BuOH, 40 deg C; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 64-67-5
diethyl sulfate

: 84850-88-4
C12H34N6O2P2*2C6H9O3(1-)*2Li(1+)

A: 998-91-4
ethyl 3-ethoxy-2-butenoate

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
In dichloromethane for 72h; Product distribution; Ambient temperature; other metal ion, other time, var. addends;	A 46 % Chromat. B 54 % Chromat.

...Expand

: 64-67-5
diethyl sulfate

: 66279-50-3
acetoacetic acid ethyl ester; potassium (Z)-enolate

A: 5331-73-7
ethyl (Z)-3-ethoxybut-2-enoate

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
In tetrahydrofuran for 66h; Yield given. Yields of byproduct given;
With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran for 24h; Yield given. Yields of byproduct given;

...Expand

: 64-67-5
diethyl sulfate

: 33283-91-9
enolate lithique de l'acetylacetate d'ethyle

A: 5331-73-7
ethyl (Z)-3-ethoxybut-2-enoate

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran for 74h; Yield given. Yields of byproduct given;
With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran for 24h; Yield given. Yields of byproduct given;

...Expand

: 64-67-5
diethyl sulfate

: 20412-62-8, 66279-49-0
enolate sodique de l'acetylacetate d'ethyle

A: 5331-73-7
ethyl (Z)-3-ethoxybut-2-enoate

B: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran for 120h; Yield given. Yields of byproduct given;
With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran for 24h; Yield given. Yields of byproduct given;
With Hexamethylphosphorous triamide In tetrahydrofuran for 120h; Product distribution; Ambient temperature; different Li, Na, K enolates, ratios of reagent, reaction times; with solid and liquid and without HMPT;

...Expand

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 130000-37-2
2-ethyl-2-chloro-acetoacetic acid ethyl ester

Conditions

Conditions	Yield
With tetraethylammonium trichloride In dichloromethane	100%
With N-chloro-succinimide; magnesium(II) perchlorate In acetonitrile at 20℃; for 2h;	86%
With chlorine

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 123327-53-7, 5465-11-2, 87519-05-9, 114592-80-2, 123407-56-7, 123407-57-8, 128443-93-6, 128443-94-7
ethyl (2R,3S)-2-ethyl-3-hydroxybutanoate

Conditions

Conditions	Yield
With D-glucose; ketoreductase-102; NADPH; glucose dehydrogenase; sodium phosphate buffer at 37℃; for 3h; pH=6.9;	100%
With D-glucose; calcium carbonate; sodium chloride In water at 35℃; for 72h; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;	78%
With Escherichia coli strain expressing Gcy1p; isopropyl β-D-thiogalactopyranoside at 20℃; Reduction;	75%
With D-glucose; tris hydrochloride at 30℃; for 48h; β-keto ester reductase L-1, NADPH, GDH;	31%
With glucose-6-phosphate dehydrogenase; α-D-glucose 6-phosphate; baker yeast YDL124w gene-pIK8 plasmid; NAD at 30℃; for 24h; pH=7.0;

: 55962-05-5
[N-(p-tolylsulfonyl)imino]phenyliodinane

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 1373511-29-5
ethyl 2-acetyl-3-methyl-1-tosylaziridine-2-carboxylate

Conditions

Conditions	Yield
With 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate) In dichloromethane at 20℃; for 18h; Molecular sieve; Inert atmosphere; optical yield given as %de;	99%

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 29068-31-3
4-ethyl-3-methylisoxazol-5(4H)-one

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In ethanol at 78℃;	99%

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 32116-06-6
ethyl 2-bromo-2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
With N-Bromosuccinimide; ammonium acetate In tetrachloromethane at 80℃; for 0.5h;	97%
With sodium hydrogen sulfate; N-Bromosuccinimide; silica gel at 20℃; for 2h;	95%
With ammonium bromide; dihydrogen peroxide; vanadia In dichloromethane; water at 0 - 5℃; for 3h;	94%

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 66553-17-1
2-ethyl-1,3-butanediol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 3h; Heating;	96%
With methanol; copper chromite at 150 - 168℃; Hydrogenation.unter Druck;
With copper chromite; ethanol at 150 - 168℃; Hydrogenation.unter Druck;

: 524-38-9
N-hydroxyphthalimide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: ethyl 2-(N-phthalimidyloxy)-2-ethyl-3-oxobutanoate

Conditions

Conditions	Yield
Stage #1: N-hydroxyphthalimide; ethyl 2-ethyl-3-oxobutanoate With cobalt(II) diacetate tetrahydrate In acetic acid at 60℃; for 0.0166667h; Stage #2: With potassium permanganate In acetic acid at 60℃; for 0.175h;	94%

: 608-25-3
2-methylbenzene-1,3-diol

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 31575-15-2
3-ethyl-7-hydroxy-4,8-dimethyl-2H-1-benzopyran-2-one

Conditions

Conditions	Yield
With perchloric acid at 20℃; Pechmann condensation;	92%
With sulfuric acid at 0℃; for 12h; Pechmann Condensation;
With sulfuric acid at 0℃; Pechmann Condensation;

: 107-21-1
ethylene glycol

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 27773-10-0
2-ethoxycarbonylmethyl-2-methyl-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 120℃; for 4h; Product distribution / selectivity;	91%
With toluene-4-sulfonic acid In toluene at 120℃; for 4h; Heating / reflux;	91%
With toluene-4-sulfonic acid In toluene for 3.5h; Cyclization; Heating;	70%

: 100-63-0
phenylhydrazine

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 22717-41-5
4-ethyl-3-methyl-1-phenylpyrazol-5-one

Conditions

Conditions	Yield
for 0.05h; microwave irradiation;	91%
In ethanol Reflux;

: 36016-38-3
tert-Butyl N-hydroxycarbamate

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: C13H23NO6

Conditions

Conditions	Yield
With copper(II) acetate hydrate; 2-ethyl-1,3-oxazoline; copper(l) chloride In isopropyl alcohol at 20℃; regioselective reaction;	90%

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 29211-62-9
3-methyl-4-ethyl-5-pyrazolone

Conditions

Conditions	Yield
With hydrazine for 0.00833333h;	89%
With hydrazine hydrate; acetic acid In methanol at 100℃; for 1h;	67%

: 104-94-9
4-methoxy-aniline

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: C15H21NO3

Conditions

Conditions	Yield
ammonium cerium(IV) nitrate In ethanol at 20℃; for 1.5h;	89%

: 504-15-4
orcinol

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 3-ethyl-7-hydroxy-4,5-dimethyl-2H-1-benzopyran-2-one

Conditions

Conditions	Yield
With perchloric acid at 20℃; Pechmann condensation;	89%

: 21428-65-9
2,2-dibromo-5,5-dimethylcyclohexane-1,3-dione

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: α-bromo-2-ethyl-3-oxobutyryc acid ethyl ester

B: 1195-91-1
2-bromodimedone

Conditions

Conditions	Yield
Stage #1: ethyl 2-ethyl-3-oxobutanoate With L-Norvaline In dichloromethane for 0.0833333h; Stage #2: 2,2-dibromo-5,5-dimethylcyclohexane-1,3-dione With dipyridinium dichromate In dichloromethane for 2h; Cooling with ice; optical yield given as %ee; enantioselective reaction;	A 88% B n/a

...Expand

: ethyl (2S,3R)-3-(methoxymethyloxy)-2-methylbutanoate

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: ethyl (6S,7R)-2-ethyl-3,5-dihydroxy-7-(methoxymethyloxy)-6-methylocta-2,4-dienoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-ethyl-3-oxobutanoate With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Claisen Condensation; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.266667h; Claisen Condensation; Stage #3: ethyl (2S,3R)-3-(methoxymethyloxy)-2-methylbutanoate In tetrahydrofuran; hexane at 0℃; for 0.25h; Claisen Condensation;	88%

: ethyl (2R, 3S)-3-(methoxymethyloxy)-2-methylbutanoate

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: C15H26O6

Conditions

Conditions	Yield
Stage #1: ethyl 2-ethyl-3-oxobutanoate With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.266667h; Stage #3: ethyl (2R, 3S)-3-(methoxymethyloxy)-2-methylbutanoate In tetrahydrofuran; hexane at 0℃; for 0.25h;	88%

: 94205-62-6
2-(4'-aminophenyl)-4-quinolinecarboxylic acid

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 2-{4-[N'-(1-ethyl-2-oxo-propylidene)-hydrazino]-phenyl}-quinoline-4-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-(4'-aminophenyl)-4-quinolinecarboxylic acid Stage #2: ethyl 2-ethyl-3-oxobutanoate With sodium hydroxide; sodium acetate In ethanol; water pH=4 - 4.5; Japp-Klingemann reaction;	87%

: 62-53-3
aniline

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: C14H19NO2

Conditions

Conditions	Yield
ammonium cerium(IV) nitrate In ethanol at 20℃; for 3h;	87%

: 823-54-1
3-bromo-4-chloroaniline

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: ethyl (E)-2-(2-(3-bromo-4-chlorophenyl)hydrazineylidene)butanoate

Conditions

Conditions	Yield
Stage #1: 3-bromo-4-chloroaniline With hydrogenchloride; acetic acid; sodium nitrite In water at 0℃; for 1.16667h; Stage #2: ethyl 2-ethyl-3-oxobutanoate With potassium hydroxide In ethanol; water at 0 - 80℃; for 5h; pH=7;	87%
Stage #1: 3-bromo-4-chloroaniline With hydrogenchloride; acetic acid; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: ethyl 2-ethyl-3-oxobutanoate With potassium hydroxide In ethanol; water at 0 - 80℃; for 5h; pH=7;	87%

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 149-73-5
trimethyl orthoformate

: ethyl 2-ethyl-3,3-dimethoxybutyrate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol for 24h; Ambient temperature;	86%

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: ethyl 2-ethyl-2-iodo-3-oxobutanoate

Conditions

Conditions	Yield
With N-iodo-succinimide; magnesium(II) perchlorate In acetonitrile at 20℃; for 0.25h;	86%
With bis(acetylacetonate)oxovanadium; dihydrogen peroxide; sodium iodide In water; ethyl acetate at 0 - 5℃; for 13h; regioselective reaction;	79%

: 29001-25-0
6-amino-4,7-dimethylcoumarin

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: ethyl 2-[2-(4,7-dimethyl-2-oxo-2H-chromen-6-yl)azo]-3-oxo-2-ethyl-butanoate

Conditions

Conditions	Yield
Stage #1: 6-amino-4,7-dimethylcoumarin With hydrogenchloride; acetic acid; sodium nitrite at 5℃; for 2h; Stage #2: ethyl 2-ethyl-3-oxobutanoate With sodium acetate; acetic acid at 20℃; for 10h; pH=5.5;	86%

: 1314129-13-9
N-(2-fluoro-3-nitrophenyl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 1314129-15-1
ethyl (2E)-2-{[2-fluoro-3-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)phenyl]hydrazono}butanoate

Conditions

Conditions	Yield
Stage #1: N-(2-fluoro-3-nitrophenyl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide With hydrogen; palladium-on-charcoal In tetrahydrofuran; water at 20℃; for 15h; Stage #2: With hydrogenchloride; sodium nitrite In water; acetonitrile at -25 - 5℃; for 0.5h; Stage #3: ethyl 2-ethyl-3-oxobutanoate With potassium hydroxide In water at -20℃;	86%

: 78-94-4
methyl vinyl ketone

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 100315-75-1
ethyl 2-ethyl-3-oxo-2-(3-oxo-1-butyl)-butanoate

Conditions

Conditions	Yield
lithium hydroxide In 1,2-dimethoxyethane for 0.5h; Ambient temperature;	85%
lithium iodide In 1,4-dioxane for 12h; Heating;	82%
K bis(1,2-benzenediolato)phenylsilicate In chloroform at 40℃; for 6h; organosilicate-catalyzed Michael addition;	74%
With molecular sieve; Eu(tfc)3 In tetrachloromethane at -33℃; for 72h;	71%
With sodium perchlorate In methanol at 24.84℃; Michael Addition; Electrochemical reaction;

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 114745-67-4
ethyl 2-ethyl-2-chloro-3,3-difluorobutyrate

Conditions

Conditions	Yield
With sulfur tetrafluoride; hydrogen fluoride; chlorine at 25℃; for 10h; autoclave;	85%

: 50-00-0
formaldehyd

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 3070-65-3
ethyl 2-methylenebutyrate

Conditions

Conditions	Yield
Stage #1: ethyl 2-ethyl-3-oxobutanoate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: formaldehyd In tetrahydrofuran at -78 - 20℃; Further stages.;	85%

: 55686-29-8
N,N-bis(ethoxymethyl)benzylamine

: 607-97-6
ethyl 2-ethyl-3-oxobutanoate

: 113385-99-2
ethyl 1-benzyl-3-ethyl-4-oxo-3-piperidinecarboxylate

Conditions

Conditions	Yield
With Methyltrichlorosilane In acetonitrile at 20℃; for 20h; Mannich reaction;	85%

Ethyl 2-ethylacetoacetate Chemical Properties

Molecule structure of Butanoic acid,2-ethyl-3-oxo-, ethyl ester (CAS NO.607-97-6):

IUPAC Name: Ethyl 2-ethyl-3-oxobutanoate
Molecular Weight: 158.19496 g/mol
Molecular Formula: C₈H₁₄O₃
Index of Refraction: 1.419
Molar Refractivity: 40.87 cm³
Molar Volume: 161.5 cm³
Surface Tension: 29.8 dyne/cm
Density: 0.979 g/cm³
Flash Point: 75.7 °C
Enthalpy of Vaporization: 42.62 kJ/mol
Boiling Point: 190 °C at 760 mmHg
Vapour Pressure: 0.554 mmHg at 25 °C
Storage Temp.: 2-8 °C
XLogP3-AA: 1.3
H-Bond Acceptor: 3
Rotatable Bond Count: 5
Tautomer Count: 5
Exact Mass: 158.094294
MonoIsotopic Mass: 158.094294
Topological Polar Surface Area: 43.4
Heavy Atom Count: 11
Canonical SMILES: CCC(C(=O)C)C(=O)OCC
InChI: InChI=1S/C8H14O3/c1-4-7(6(3)9)8(10)11-5-2/h7H,4-5H2,1-3H3
InChIKey: OKANYBNORCUPKZ-UHFFFAOYSA-N
EINECS: 210-151-6
Product Categories: Pharmaceutical Intermediates;Organic acids;API intermediates;C8 to C9;Carbonyl Compounds;Esters

Ethyl 2-ethylacetoacetate Uses

Butanoic acid,2-ethyl-3-oxo-, ethyl ester (CAS NO.607-97-6) is used as intermediates for pharmaceutical.

Ethyl 2-ethylacetoacetate Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 23-24/25-36-26
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 1

Ethyl 2-ethylacetoacetate Specification

Butanoic acid,2-ethyl-3-oxo-, ethyl ester (CAS NO.607-97-6) is also named as AI3-06006 ; Ethyl 2-acetylbutyrate ; Ethyl 2-ethyl-3-ketobutyrate ; Ethyl 2-ethylacetoacetate ; Ethyl alpha-acetylbutyrate ; Ethyl alpha-ethylacetoacetate ; NSC 53775 ; Acetoacetic acid, 2-ethyl-, ethyl ester (8CI) .

Product Name

Ethyl 2-ethylacetoacetate

Synthetic route

Ethyl 2-ethylacetoacetate Chemical Properties

Ethyl 2-ethylacetoacetate Uses

Ethyl 2-ethylacetoacetate Safety Profile

Ethyl 2-ethylacetoacetate Specification

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