Ethylenebis(nitrilodimethylene)tetraphosphonic acid supplier

Name
Ethylenebis(nitrilodimethylene)tetraphosphonic acid
EINECS 215-851-5
CAS No. 1429-50-1
Article Data16
CAS DataBase
Density 1.993 g/cm³
Solubility 19.6g/L at 20℃
Melting Point 247 °C
Formula C₆H₂₀N₂O₁₂P₄
Boiling Point 878.7 °C at 760 mmHg
Molecular Weight 436.126
Flash Point 485.2 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phosphonicacid, [1,2-ethanediylbis[nitrilobis(methylene)]]tetrakis- (9CI);Phosphonicacid, [ethylenebis(nitrilodimethylene)]tetra- (6CI,7CI,8CI);EDPA;EDTMP;EDTPA;Editempa;Ethylenediamine-N,N,N',N'-tetra(methylphosphonic acid);Ethylenediaminetetramethylenephosphonate;N,N,N',N'-Tetrakis(phosphonomethyl)ethylenediamine;[Ethylenebis(nitrilodimethylene)]tetraphosphonic acid;EDTMPS;
PSA 275.84000
LogP -1.86880

Synthetic route

: 50-00-0
formaldehyd

: 107-15-3
ethylenediamine

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

Conditions

Conditions	Yield
Stage #1: ethylenediamine With hydrogenchloride; phosphonic Acid In water for 0.0333333h; Microwave irradiation; Stage #2: formaldehyd In water for 0.166667h; Irani-Moedritzer reaction; Microwave irradiation;	63%
With hydrogenchloride; phosphonic Acid
With hydrogenchloride; phosphonic Acid In water Heating;

: 50-00-0
formaldehyd

: 107-15-3
ethylenediamine

A: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

B: N-methylethylenediamine-N,N',N'-trimethylenetris(phosphonic acid)

Conditions

Conditions	Yield
Stage #1: ethylenediamine With phosphorous acid In water at 136℃; Reflux; Stage #2: formaldehyd In water at 130 - 136℃; for 4.33333h;	A 48.2% B 28.8%

...Expand

: 50-00-0
formaldehyd

: 107-15-3
ethylenediamine

A: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

B: <<(2-aminoethyl)imino>bis(methylene)>biphosphonic acid

Conditions

Conditions	Yield
With hydrogenchloride; phosphoric acid In water at 100℃; for 3h;	A 18.8% B 36.7%

...Expand

: 2565-58-4
chloromethylphosphonic acid

: 1898-63-1
ethylenediamino tris(methylenephosphonic acid)

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 107-15-3
ethylenediamine

: CH3Cl2O2P

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

Conditions

Conditions	Yield
(i) aq. NaOH, (ii) /BRN= 605263/; Multistep reaction;

: 107-15-3
ethylenediamine

disodium-salt of/the/ chloromethylphosphonic acid: disodium-salt of/the/ chloromethylphosphonic acid

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

Conditions

Conditions	Yield
With sodium carbonate

: 50-00-0
formaldehyd

: 107-15-3
ethylenediamine

A: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

B: 1898-63-1
ethylenediamino tris(methylenephosphonic acid)

Conditions

Conditions	Yield
With phosphorous acid; methanesulfonic acid In water at 105 - 130℃; for 2.5 - 6h; Product distribution / selectivity; Heating / reflux;	A 40 - 73.6 %Spectr. B n/a
With phosphorous acid; methanesulfonic acid; sulfuric acid In water at 105℃; for 6.33333h; Product distribution / selectivity; Heating / reflux;	A 75.5 %Spectr. B n/a

...Expand

: 50-00-0
formaldehyd

: 107-15-3
ethylenediamine

A: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

B: 1898-63-1
ethylenediamino tris(methylenephosphonic acid)

C: <<(2-aminoethyl)imino>bis(methylene)>biphosphonic acid

D: N-methylethylenediamine-N,N',N'-trimethylenetris(phosphonic acid)

Conditions

Conditions	Yield
With hydrogenchloride; phosphorous acid In water at 110℃; for 3h; Product distribution / selectivity;

...Expand

: 60-00-4
ethylenediaminetetraacetic acid

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

Conditions

Conditions	Yield
With phosphorus(III) oxide; methanesulfonic acid at 45 - 80℃; for 2h;	94.5 %Spectr.

: 98756-99-1
N,N,N',N'-tetrakis(hydroxymethyl)ethanediamine

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

Conditions

Conditions	Yield
Stage #1: N,N,N',N'-tetrakis(hydroxymethyl)ethanediamine With phosphorus(III) oxide; methanesulfonic acid at 50 - 80℃; for 1h; Stage #2: With water at 25℃; for 1h; Temperature; Concentration;

: aluminum sulfate octadecahydrate

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: aluminum ethylenediamine tetra(methylene phosphonate)

Conditions

Conditions	Yield
With sodium hydroxide In water at 90℃; for 1h; Reagent/catalyst; Time; Large scale;	97.4%

: potassium aquapentachlororuthenate(III)

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: K3{ruthenium(III)(ethylenediamine-N,N,N',N'-tetramethylphosphonato)*6H2O}

Conditions

Conditions	Yield
With KOH In water byproducts: RuO2; equimolar quantity of reagents; heated on water-bath for 30 min; filtered; heated for 1-1.5 h; added KOH (pH=5); filtered; evapd.; ground with acetone; filtered off; washed (mixture of methanol and ethanol (2/1)); elem. anal.; TA; UV;	90%

: potassium aquapentachlororuthenate(III)

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: K3{ruthenium(III) (ethylenediamine-N,N,N',N'-tetramethylphosphonato)Cl4}*2H2O

Conditions

Conditions	Yield
In water byproducts: RuO2; equimolar quantity of reagents; heated on water-bath for 30-40 min; filtered; evapd. on water-bath; ground with acetone; filtered off; washed (acetone); dried in vac. desiccator; elem. anal.; TA; UV;	83%

: vanadium(IV) chloride

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: 7732-18-5
water

: C6H16N2O12P4(VO)1.8*4H2O

Conditions

Conditions	Yield
In water ligand in H2O mixed with AlCl3 in H2O; centrifuged, treated with 0.02 M HCl, stirred in ultrasonic bath for 30 min, standed overnight at room temp., the same treatment repeated 3 times, H2O added, lyohpylized overnight, elem. anal.;	78%

...Expand

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: 7732-18-5
water

: 7646-85-7
zinc(II) chloride

: ([Zn2(N,N,N',N'-ethylenediaminetetrakis(methylenephosphonic acid)(-4H))]*2H2O)(n)

Conditions

Conditions	Yield
With LiF; (C2H5)3N In ethanol; water High Pressure; adjusted to pH 5.3 with (C2H5)3N, kept in an autoclave at 160°C for 4 d; elem. anal.;	77%

...Expand

: 7446-70-0
aluminium trichloride

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: 7732-18-5
water

: aluminium(III) ethylenediaminetetramethylenephosphonate tetrahydrate

Conditions

Conditions	Yield
In water ligand in H2O mixed with AlCl3 in H2O; centrifuged, treated with 0.02 M HCl, stirred in ultrasonic bath for 30 min, standed overnight at room temp., the same treatment repeated 3 times, H2O added, lyohpylized overnight, elem. anal.;	76%

...Expand

: cobalt(II) nitrate hexahydrate

: 153736-25-5
2-(1-(pyrazin-2-yl)ethylidene)hydrazine-1-carbothioamide

: 7631-95-0
sodium molybdate dihydrate

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: Mo12O40P(3-)*3C14H16CoN10S2(1+)

Conditions

Conditions	Yield
Stage #1: cobalt(II) nitrate hexahydrate; 1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazide; sodium molybdate dihydrate; 1,2-ethanediylbistetraphosphonic acid In water; acetonitrile at 20℃; for 2h; Stage #2: With hydrogenchloride In water; acetonitrile at 130℃; for 72h; pH=2.7 - 3; Autoclave;	52.7%

...Expand

: cobalt(II) nitrate hexahydrate

: 10213-10-2
sodium tungstate (VI) dihydrate

: 153736-25-5
2-(1-(pyrazin-2-yl)ethylidene)hydrazine-1-carbothioamide

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: O40PW12(3-)*3C14H16CoN10S2(1+)

Conditions

Conditions	Yield
Stage #1: cobalt(II) nitrate hexahydrate; sodium tungstate (VI) dihydrate; 1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazide; 1,2-ethanediylbistetraphosphonic acid In methanol; water at 20℃; for 2h; Stage #2: With hydrogenchloride In methanol; water at 130℃; for 72h; pH=3 - 3.35; Autoclave;	47.8%

...Expand

: potassium aquapentachlororuthenate(III)

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

A: K9{ruthenium(III)3(ethylenediamine-N,N,N',N'-tetramethylphosphonato)2Cl8}*7H2O

B: K3.5{ruthenium(III)5(ethylenediamine-N,N,N',N'-tetramethylphosphonic)2Cl2.5}*5H2O

Conditions

Conditions	Yield
In water Ru/EDTP = 2/1; complex added to hot soln. of ligand, heated for 1 h; pentahydrate washed with water, dried in vac. desiccator, filtrate evapd.; ground with ethanol; dried in vac. desiccator; TA; UV, elem. anal.;	A 37% B 8.1%

...Expand

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: 7732-18-5
water

: 301-04-2
lead acetate

: ([Pb7(N,N,N',N'-ethylenediaminetetrakis(methylenephosphonic acid)(-7H))2(H2O)]*7H2O)(n)

Conditions

Conditions	Yield
With LiF; (C2H5)3N In ethanol; water High Pressure; adjusted to pH 5-6 with (C2H5)3N, kept in an autoclave at 140°C for 4 d; cooled slowly to room temp., crystals sepd. manually; elem. anal.;	35%

...Expand

: potassium aquapentachlororuthenate(III)

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: K2H{ruthenium(III)2(ethylenediamine-N,N,N',N'-tetramethylphosphonato)3Cl6}*12H2O

Conditions

Conditions	Yield
In water equimolar quantity of reagents; heated on water-bath for 30 min; filtered; evapd.; ground with acetone; filtered off; dried in vac. desiccator; elem. anal.; TA; UV;	27.2%

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: C6H20N2O14P4

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide In water at 60℃; pH 9;

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: 10099-58-8
lanthanum(III) chloride

: La(3+)*5H(1+)*(O3PCH2)2NCH2CH2N(CH2PO3)2(8-)*H2O=LaH5((O3PCH2)2NCH2CH2N(CH2PO3)2)*H2O

Conditions

Conditions	Yield
With potassium hydroxide In not given molar ratio La:ligand=1:1, pH=1.24-2.16 (pptn.); filtration, washing (EtOH, acetone, ether), drying (105°C); elem.anal.;

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: 10099-58-8
lanthanum(III) chloride

: K(1+)*La(3+)*4H(1+)*(O3PCH2)2NCH2CH2N(CH2PO3)2(8-)*H2O=KLaH4((O3PCH2)2NCH2CH2N(CH2PO3)2)*H2O

Conditions

Conditions	Yield
With potassium hydroxide In not given molar ratio La:ligand=1:1, pH=3.65 (pptn.); filtration, washing (EtOH, acetone, ether), drying (105°C); elem.anal.;

: cis-dichlorobis(ethylenediamine)cobalt(III) chloride

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: [Co(NH2CH2CH2NH2)2]C6H15N2P4O12

Conditions

Conditions	Yield
In water 50°C, cooling 0°C; without separation;

: cis-[CoCl(NH3)(ethylenediamine)2]Cl2

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: [Co(N2H4C2H4)2(NH3)]C6H16N2P4O12

Conditions

Conditions	Yield
In water 50°C, cooling 0°C; without separation;

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: holmium(III) nitrate

: Ho(3+)*5H(1+)*C6H12N2O12P4(8-)*3H2O=Ho(H5C6H12N2O12P4)*3H2O

Conditions

Conditions	Yield
In water ligand metal ion mole ratio 1.0:1.6; washing, drying in dry air at 25°C;

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: holmium(III) nitrate

: 4Ho(3+)*12H(1+)*3C6H12N2O12P4(8-)*25H2O=Ho4(H4C6H12N2O12P4)3*25H2O

Conditions

Conditions	Yield
In water ligand metal ion mole ratio 0.5:0.6; washing, drying in dry air at 25°C;

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: gadolinium(III) nitrate

: 4Gd(3+)*12H(1+)*3C6H12N2O12P4(8-)*20H2O=Gd4(H4C6H12N2O12P4)3*20H2O

Conditions

Conditions	Yield
In water ligand metal ion mole ratio 0.5:0.6; washing, drying in dry air at 25°C;

: 1429-50-1
1,2-ethanediylbistetraphosphonic acid

: gadolinium(III) nitrate

: Gd(3+)*5H(1+)*C6H12N2O12P4(8-)*6H2O=Gd(H5C6H12N2O12P4)*6H2O

Conditions

Conditions	Yield
In water ligand metal ion mole ratio 1.0:1.6; washing, drying in dry air at 25°C;

Ethylenebis(nitrilodimethylene)tetraphosphonic acid Chemical Properties

IUPAC Name: [2-[Bis(phosphonomethyl)amino]ethyl-(phosphonomethyl)amino]methylphosphonic acid
Molecular Formula: C₆H₂₀N₂O₁₂P₄
Molecular Weight: 436.12 g/mol
Canonical SMILES: P(CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O)(O)(O)=O
InChI: InChI=1/C6H20N2O12P4/c9-21(10,11)3-7(4-22(12,13)14)1-2-8(5-23(15,16)17)6-24(18,19)20/h1-6H2,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)
EINECS: 215-851-5
Classification Code: Chelating agents
Product Categories: Organics; Phosphonate antiscalant
XLogP3-AA: -11.2
H-Bond Donor: 8
H-Bond Acceptor: 14
Rotatable Bond Count: 11
Exact Mass: 435.99667
MonoIsotopic Mass: 435.99667
Topological Polar Surface Area: 237
Heavy Atom Count: 24
Complexity: 486
Index of Refraction: 1.622
Molar Refractivity: 77.06 cm³
Molar Volume: 218.7 cm³
Polarizability: 30.55×10^-24 cm³
Surface Tension: 134.2 dyne/cm
Density: 1.993 g/cm³
Flash Point: 485.2 °C
Enthalpy of Vaporization: 138.57 kJ/mol
Boiling Point: 878.7 °C at 760 mmHg
Vapour Pressure of Ethylenebis(nitrilodimethylene)tetraphosphonic acid (CAS NO.1429-50-1): 2.43E-34 mmHg at 25 °C

Ethylenebis(nitrilodimethylene)tetraphosphonic acid Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements of Ethylenebis(nitrilodimethylene)tetraphosphonic acid (CAS NO.1429-50-1): 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.

Ethylenebis(nitrilodimethylene)tetraphosphonic acid Specification

Ethylenebis(nitrilodimethylene)tetraphosphonic acid (CAS NO.1429-50-1), its Synonyms are (Ethylenedinitrilo)-tetramethylenephosphonic acid ; Ethylenediamine tetrakis(methylene phosphonic acid) ; (Ethane-1,2-diylbis(nitrilobis(methylene)))tetrakisphosphonic acid ; Phosphonic acid, (1,2-ethanediylbis(nitrilobis(methylene)))tetrakis- ; Phosphonic acid, P,P',P'',P'''-(1,2-ethanediylbis(nitrilobis(methylene)))tetrakis- .

Product Name

Ethylenebis(nitrilodimethylene)tetraphosphonic acid

Synthetic route

Ethylenebis(nitrilodimethylene)tetraphosphonic acid Chemical Properties

Ethylenebis(nitrilodimethylene)tetraphosphonic acid Safety Profile

Ethylenebis(nitrilodimethylene)tetraphosphonic acid Specification

Related Products

Hot Products