-
Name
2,6-Bis(1-aziridinyl)-4-chloropyrimidine
- EINECS
- CAS No. 2482-80-6
- Density 1.561g/cm3
- Solubility
- Melting Point 94-95 °C
- Formula C8H9 Cl N4
- Boiling Point 410.4°Cat760mmHg
- Molecular Weight 196.639
- Flash Point 202°C
- Transport Information
- Appearance
- Safety Poison by intravenous route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and Cl−.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms 2,4-Di(ethylenimino)-6-chloropyrimidine;2,6-Bis(1-aziridinyl)-4-chloropyrimidine; Aethimidinum; Ethymidine; Etimidin;NSC 48225
- PSA 31.80000
- LogP 0.90000
Ethymidine Chemical Properties
IUPAC Name: 2,4-bis(Aziridin-1-yl)-6-chloropyrimidine
Synonyms of Ethymidine (CAS NO.2482-80-6) : 2,4-Bis(1-aziridinyl)-6-chloropyrimidine ; 2,4-Diethylenimino-6-chloropyrimidine ; 2,6-Bis(1-aziridinyl)-4-chloropyrimidine ; 2,6-Diethylenimino-4-chloropyrimidine ; 4-Chloro-2,6-bis(ethylenimino pyrimidine ; Aethimidinium ; Ethymidine ; Pyrimidine, 2,6-bis(1-aziridinyl)-4-chloro- ; Pyrimidine, 2,4-bis(1-aziridinyl)-6-chloro-
CAS NO:2482-80-6
Molecular Formula:C8H9ClN4
Molecular Weight :196.636860 g/mol
Molecular Structure :.png)
Index of Refraction: 1.711
Surface Tension: 86.4 dyne/cm
Density: 1.561 g/cm3
Flash Point: 202 °C
Enthalpy of Vaporization: 66.27 kJ/mol
Boiling Point: 410.4 °C at 760 mmHg
Vapour Pressure: 6.06E-07 mmHg at 25°C
Ethymidine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | parenteral | 15mg/kg (15mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Farmakologiya i Toksikologiya Vol. 5, Pg. 101, 1970. |
| mouse | LDLo | intravenous | 15mg/kg (15mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR GASTROINTESTINAL: NAUSEA OR VOMITING | Progress in Medical Chemistry. Vol. 8, Pg. 61, 1971. |
| rabbit | LD50 | parenteral | 1350ug/kg (1.35mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Farmakologiya i Toksikologiya Vol. 5, Pg. 101, 1970. |
| rat | LDLo | intravenous | 15mg/kg (15mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR GASTROINTESTINAL: NAUSEA OR VOMITING | Progress in Medical Chemistry. Vol. 8, Pg. 61, 1971. |
Ethymidine Consensus Reports
EPA Genetic Toxicology Program.
Ethymidine Safety Profile
Poison by intravenous route. Mutation data reported. When Ethymidine (CAS NO.2482-80-6) is heated to decomposition ,it emits toxic fumes of NOx and Cl−.
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