IUPAC Name: [(2R,3R,4R,6S)-6-[(2R,2'R,3'S,3aR,4R,4'R,6S,7aR)-6-[(2S,3R,4R,5S,6R)-2-[(2R,3S,4S,5S,6S)-6-[(2R,3aS,3'aR,6S,7R,7'R,7aR,7'aR)-7'-Hydroxy-7-methoxy-7'-[(1S)-1-methoxyethyl]spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,4'-6,7a-dihydro-3aH-[1,3]dioxolo[4,5-c]pyran]-6-yl]oxy-4-hydroxy-5-methoxy-2-(methoxymethyl)oxan-3-yl]oxy-3-hydroxy-5-methoxy-6-methyloxan-4-yl]oxy-4'-hydroxy-2',4,7a-trimethylspiro[3a,4,6,7-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2,6'-oxane]-3'-yl]oxy-4-[(2S,4S,5R,6S)-5-methoxy-4,6-dimethyl-4-nitrooxan-2-yl]oxy-2-methyloxan-3-yl] 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate
Synonyms of Everninomicin-D (CAS NO.39340-46-0) : Flambamycin, 57-demethyl-45-O-de(2-methyl-1-oxopropyl)-59-deoxo-23-deoxy-59-methoxy-45-O-methyl-12-O-(2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitro-alpha-L-arabino-hexopyranosyl)-, (59S)- ; beta-D-Mannopyranoside, O-4-C-(1-methoxyethyl)-2,3-O-methylenepentopyranosylidene-(1-3-4)-2-O-methyl-alpha-L-lyxopyranosyl-O-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitro-alpha-L-arabino-hexopyranosyl-(1-3)-O-2,6-dideoxy-4-O-(3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoyl)-beta-D-arabino-hexopyranosyl-(1-4)-O-2,6-dideoxy-D-ribo-hexopyranosylidene-(1-3-4)-O-2,6-dideoxy-3-C-methyl-beta-D-arabino-hexopyranosyl-(1-3)-O-6-deoxy-4-O-methyl-beta-D-galactopyranosyl-(1-4)-2,6-di-O-methyl-
CAS NO:39340-46-0
Molecular Formula:C66H99Cl2NO35
Molecular Weight :1537.384
Molecular Structure :
Index of Refraction: 1.592
Surface Tension: 66.5 dyne/cm
Density: 1.47 g/cm3
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intramuscular | > 140mg/kg (140mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 38, 1964. | |
mouse | LD50 | intravenous | 125mg/kg (125mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 24, 1964. | |
rabbit | LD50 | intramuscular | > 300mg/kg (300mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 38, 1964. | |
rat | LD50 | intramuscular | > 400mg/kg (400mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 38, 1964. |
Poison by intramuscular and intravenous routes. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When Everninomicin-D (CAS NO.39340-46-0) is heated to decomposition, it emits very toxic fumes of Cl− and NOx.
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