Fexofenadine supplier | CasNO.83799-24-0

Name
Fexofenadine
EINECS 801-893-7
CAS No. 83799-24-0
Article Data47
CAS DataBase
Density 1.171 g/cm³
Solubility
Melting Point 218-220 °C
Formula C₃₂H₃₉NO₄
Boiling Point 697.3 °C at 760 mmHg
Molecular Weight 501.666
Flash Point 375.5 °C
Transport Information
Appearance white powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-a,a-dimethylphenylacetic acid;Carboxyterfenadine;MDL 16455;Terfenadine acid metabolite;Terfenadine carboxylate;Benzeneacetic acid,4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl-;
PSA 81.00000
LogP 5.44840

Fexofenadine Chemical Properties

IUPAC Name: 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid
Molecular Formula: C₃₂H₃₉NO₄
Molecular Weight: 501.66
Classification Code: Anti-Allergic Agents; Histamine Agents; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Histamine H1 antagonists; Neurotransmitter Agents
Melting Point: 218-220 °C
Index of Refraction: 1.596
Molar Refractivity: 145.86 cm³
Molar Volume: 428.1 cm³
Surface Tension: 52.4 dyne/cm
Density: 1.171 g/cm³
Flash Point: 375.5 °C
Enthalpy of Vaporization: 107.22 kJ/mol
Boiling Point: 697.3 °C at 760 mmHg
Vapour Pressure of Fexofenadine (CAS NO.83799-24-0): 2.08E-20 mmHg at 25 °C

Fexofenadine Uses

Fexofenadine (CAS NO.83799-24-0) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine (brand names include Triludan and Seldane), an antihistamine with potentially serious contraindications. Fexofenadine, like other second and third-generation antihistamines, does not readily cross the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists. It works by being an antagonist to the H1 receptor.

Fexofenadine Production

Fexofenadine may be synthesized as shown from piperidine-4-carboxylate ester and 4-bromophenylacetonitrile.

Fexofenadine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	144mg/kg/9W-I (144mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Lancet. Vol. 353, Pg. 980, 1999.

Fexofenadine Specification

Fexofenadine (CAS NO.83799-24-0), its Synonyms are 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid ; Carboxyterfenadine ; Terfenadine acid metabolite ; Terfenadine carboxylate ; Terfenadine-COOH . It is white powder.

Product Name

Fexofenadine

Fexofenadine Chemical Properties

Fexofenadine Uses

Fexofenadine Production

Fexofenadine Toxicity Data With Reference

Fexofenadine Specification

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