Product Name

  • Name

    1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole

  • EINECS
  • CAS No. 119006-77-8
  • Article Data3
  • CAS DataBase
  • Density 1.15 g/cm3
  • Solubility
  • Melting Point 161-166 °C
  • Formula C22H16F2N2
  • Boiling Point 457.1 °C at 760 mmHg
  • Molecular Weight 346.379
  • Flash Point 230.3 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 119006-77-8 (1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole)
  • Hazard Symbols
  • Synonyms 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole;UR 4056;
  • PSA 17.82000
  • LogP 5.00150

Synthetic route

1H-imidazole
288-32-4

1H-imidazole

(2-Fluorophenyl)(4-fluorophenyll)phenylchloromethane
128092-75-1

(2-Fluorophenyl)(4-fluorophenyll)phenylchloromethane

flutrimazole
119006-77-8

flutrimazole

Conditions
ConditionsYield
With triethylamine In acetonitrile for 3h; Heating; Yield given;
o-fluorobenzophenone
342-24-5

o-fluorobenzophenone

flutrimazole
119006-77-8

flutrimazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h
2: thionyl chloride / 4 h / Heating
3: triethylamine / acetonitrile / 3 h / Heating
View Scheme
(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol
128092-72-8

(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol

flutrimazole
119006-77-8

flutrimazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 4 h / Heating
2: triethylamine / acetonitrile / 3 h / Heating
View Scheme
1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

flutrimazole
119006-77-8

flutrimazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h
2: thionyl chloride / 4 h / Heating
3: triethylamine / acetonitrile / 3 h / Heating
View Scheme

Flutrimazole Chemical Properties

Molecular Formula: C22H16F2N2 
Molecular Weight: 346.373 g/mol. 
Index of Refraction: 1.59
Density: 1.15 g/cm3
Flash Point: 230.3 °C
Enthalpy of Vaporization: 68.97 kJ/mol
Boiling Point: 457.1 °C at 760 mmHg
Vapour Pressure: 4.16E-08 mmHg at 25 °C
Melting point: 161-166 °C
Structure of Flutrimazole (CAS NO.119006-77-8):
                    
IUPAC Name: 1-[(2-Fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
Product Category of Flutrimazole (CAS NO.119006-77-8): Flutrimazole

Flutrimazole Uses

 Flutrimazole(CAS NO.119006-77-8) is used for the topical treatment of superficial mycoses of the skin, such as tinea in all its forms: tinea pedis (athlete's foot), tinea cruris, tinea corporis, tinea faciei et barbae and tinea inguinalis, caused by Trichophyton,  Microsporum and by Epidermophyton floccosum. It is also indicated for the treatment of pityriasis versicolor caused by Malassezia furfur, also known as Pityrosporum ovale.

Flutrimazole Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
mouse LD50 oral > 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
rat LD50 intraperitoneal 1079mg/kg (1079mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.
rat LD50 oral 808mg/kg (808mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992.

Flutrimazole Safety Profile

 Flutrimazole (CAS NO.119006-77-8) may cause burning, irritation, pruritus and erythema in the treated zone. It shows a very low acute toxicity. Its topical administration does not cause sensitization and has no potential for inducing phototoxicity or photosensitivity.

Flutrimazole Specification

 Flutrimazole , its cas register number is 119006-77-8. It also can be called 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole ; Micetal ; and Flusporan . It is a wide spectrum antifungal drug, and is practically insoluble in water, freely soluble in tetrahydrofuran and soluble in methanol. It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol-14-demethylase.

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