Product Name

  • Name

    Glufosinate-ammonium

  • EINECS 278-636-5
  • CAS No. 77182-82-2
  • Article Data26
  • CAS DataBase
  • Density 1.4 g/cm3
  • Solubility Soluble in water
  • Melting Point 210 °C
  • Formula C5H15N2O4P
  • Boiling Point 519.1 °C at 760 mmHg
  • Molecular Weight 198.159
  • Flash Point 267.7 °C
  • Transport Information
  • Appearance solid
  • Safety 53-45-24/25
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 77182-82-2 (Glufosinate-ammonium)
  • Hazard Symbols HarmfulXn,ToxicT
  • Synonyms Butanoicacid, 2-amino-4-(hydroxymethylphosphinyl)-, monoammonium salt (9CI);Ammoniumglufosinate;Basta;Basta 150SL;Basta Fl;Basta LS;Buster;Dash;Finale;Finale 14SL;Glufosinate monoammonium salt;
  • PSA 116.09000
  • LogP 0.24480

Synthetic route

glufosinate ammonium hydrochloride
59542-49-3

glufosinate ammonium hydrochloride

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With L-serin; ammonia In water at 110℃; pH=8; pH-value; Reagent/catalyst;98%
With ammonium hydroxide; ammonia In water at 70℃; pH=6 - 7;94.9%
With ammonia In methanol; water at 20℃; pH=1; Solvent; Reagent/catalyst;87 g
4-(hydroxymethylphosphinyl)-2-oxobutanoic acid
79778-02-2

4-(hydroxymethylphosphinyl)-2-oxobutanoic acid

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
Stage #1: 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid With ruthenium-carbon composite; ammonia In methanol at 25 - 30℃; under 1500.15 Torr; for 10h; Sealed tube;
Stage #2: With hydrogen at 50℃; under 4500.45 Torr; Temperature; Pressure;		97.8%
Stage #1: 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid With ammonia at 20℃; under 3000.3 Torr; for 1h; Autoclave;
Stage #2: With hydrogen at 50℃; under 30003 Torr; for 6h; Reagent/catalyst; Temperature; Pressure; Autoclave;		95%
Stage #1: 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid With 5%-palladium/activated carbon; ammonia In methanol at 25℃; under 1500.15 Torr; for 4h;
Stage #2: With hydrogen In methanol at 90℃; under 11251.1 Torr; for 6h;
2-amino-4-(methylethoxyphosphoryl)butyronitrile

2-amino-4-(methylethoxyphosphoryl)butyronitrile

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
Stage #1: 2-amino-4-(methylethoxyphosphoryl)butyronitrile With hydrogenchloride In water at 104 - 110℃; for 3.5h; Large scale;
Stage #2: With ammonium hydroxide at 45℃; for 1.5h; pH=7.5; pH-value; Large scale;		97.04%
DL-homoalanin-4-yl(methyl)phosphinic acid
51276-47-2

DL-homoalanin-4-yl(methyl)phosphinic acid

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With ammonia In methanol; water at 20℃; for 1h; Solvent;96%
With ammonia In ethanol; water at 20℃; for 1h; Solvent; Green chemistry;96%
With ammonium carbonate In ethanol at 20℃; for 0.5h; Product distribution / selectivity;
C10H18NO4P

C10H18NO4P

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With hydrogenchloride In water at 10℃; for 2h; Reflux;92.7%
With hydrogenchloride In water at 10℃; for 2h; Reflux;91.2%
glufosinate hydrochloride

glufosinate hydrochloride

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With ammonium hydroxide In methanol; water pH=9;92.5%
C10H18NO4P

C10H18NO4P

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With hydrogenchloride In water at 10℃; for 2h; Reflux;90.5%
With hydrogenchloride In water at 10℃; for 2h; Reflux;8.5 g
C13H24NO4P

C13H24NO4P

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With hydrogenchloride In water at 10℃; for 2h; Reflux;90.4%
C9H16NO4P

C9H16NO4P

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With hydrogenchloride In water at 10℃; for 2h; Reflux;90%
sodium cyanide
773837-37-9

sodium cyanide

3-oxopropylmethylphosphinic acid
121795-01-5

3-oxopropylmethylphosphinic acid

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With ammonium hydroxide; ammonium chloride at 20 - 40℃; for 4h; Reagent/catalyst;81.4%
C10H20NO6P

C10H20NO6P

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
Stage #1: C10H20NO6P With hydrogenchloride for 8h; Reflux;
Stage #2: With ammonium hydroxide for 6h; pH=9; Reflux;		80.96%
(3-cyano-3-hydroxypropyl)(methyl)phosphinic acid

(3-cyano-3-hydroxypropyl)(methyl)phosphinic acid

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
With water; ammonium carbonate at 150℃; for 6h; Reagent/catalyst;45.2 g
1-4-((ethoxy)(methyl)phosphoryl)butene
221319-78-4

1-4-((ethoxy)(methyl)phosphoryl)butene

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: copper dichloride; oxygen; palladium dichloride / water; acetonitrile / 6 h / 45 °C / 3750.38 Torr / Sealed tube
2.1: potassium permanganate; potassium hydroxide / water / 3.5 h / 0 - 50 °C
3.1: ammonia; ruthenium-carbon composite / methanol / 10 h / 25 - 30 °C / 1500.15 Torr / Sealed tube
3.2: 50 °C / 4500.45 Torr
View Scheme
3-[n-butoxy(methyl)phosphoryl]-1-cyanopropyl acetate
172529-93-0

3-[n-butoxy(methyl)phosphoryl]-1-cyanopropyl acetate

ammonium glufosinate
77182-82-2

ammonium glufosinate

Conditions
ConditionsYield
Stage #1: 3-[n-butoxy(methyl)phosphoryl]-1-cyanopropyl acetate With ammonia at 33 - 35℃; under 2625.26 Torr; for 1.6h; Autoclave; Inert atmosphere;
Stage #2: With hydrogenchloride; water for 7h; Temperature; Cooling; Reflux;
ammonium glufosinate
77182-82-2

ammonium glufosinate

Glufosinate-P-ammonium

Glufosinate-P-ammonium

Conditions
ConditionsYield
Stage #1: ammonium glufosinate With nickel(II) chloride hexahydrate; potassium hydroxide In methanol at 60℃;
Stage #2: With hydrogenchloride In water at 100℃; for 3h; Reagent/catalyst; Solvent;		98%

Glufosinate-ammonium Chemical Properties

IUPAC Name: Azanium 2-amino-4-[hydroxy(methyl)phosphoryl]butanoate
Synonyms of Glufosinate-ammonium (CAS NO.77182-82-2): 2-Amino-4-(hydroxymethylphosphinyl)butanoic acid monoammonium salt ; Ammonium (3-amino-3-carboxypropyl)methylphosphinate ;  Ammonium (DL-homoalanine-4-yl)methylphosphinate ; Ammonium 2-amino-4(hydroxymethylphosphinyl butanoate ; Ammonium glufusinate ; Basta ; Basta F1 ; Basta LS ; Caswell No. 580I ; Dash ; EINECS 278-636-5 ; EPA Pesticide Chemical Code 128850 ; Finale ; Finale 14SL ; HOE 00661 ; HOE 39866 ; HSDB 6666 ; Ignite ; Ignite ISC Herbicide ; Liberty ; Liberty (pesticide) ; Monoammonium 4-(hydroxy(methyl)phosphinoyl)-DL-homoalaninate ; Monoammonium-2-amino-4-(hydroxymethylphosphinyl)butanoate ; Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)-, monoammonium salt
CAS NO: 77182-82-2
Classification Code: Agricultural Chemical ; Herbicide ; Human Data
Molecular Formula of Glufosinate-ammonium (CAS NO.77182-82-2): C5H15N2O4P
Molecular Weight: 198.1574
Molecular Structure:

Melting Point: 210°C 
Polar Surface Area: 76.65 Å2 
Flash Point of Glufosinate-ammonium (CAS NO.77182-82-2): 267.7 °C
Enthalpy of Vaporization: 86.64 kJ/mol
Boiling Point: 519.1 °C at 760 mmHg
Vapour Pressure: 3.61E-12 mmHg at 25°C

Glufosinate-ammonium Uses

  Glufosinate-ammonium (CAS NO.77182-82-2) is used as organophosphorus herbicides, glutamine synthetase inhibitors, non-selective tag out herbicide and as herbicide that can be applied post-emergence in noncrop areas and as a directed spray in field-grown and container nursery stock. It is nonselective and controls a broad spectrum and annual and perennial grass and broadleaf weeds.

Glufosinate-ammonium Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 200mg/kg (200mg/kg)   Pesticide Manual. Vol. 9, Pg. 458, 1991.
man TDLo oral 2643uL/kg (2.643mL/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Japanese Journal of Toxicology. Vol. 9, Pg. 301, 1996.
man TDLo oral 3436uL/kg (3.436mL/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: OTHER CHANGES		 Japanese Journal of Toxicology. Vol. 9, Pg. 301, 1996.
man TDLo oral 7143uL/kg (7.143mL/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: NAUSEA OR VOMITING		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 1920, 1992.
man TDLo oral 555mg/kg (555mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: SHOCK

GASTROINTESTINAL: NAUSEA OR VOMITING		 Human & Experimental Toxicology. Vol. 17, Pg. 35, 1998.
mouse LD50 intraperitoneal 82mg/kg (82mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Food and Chemical Toxicology. Vol. 28, Pg. 339, 1990.
mouse LD50 oral 416mg/kg (416mg/kg)   Pesticide Manual. Vol. 9, Pg. 458, 1991.
mouse LD50 subcutaneous 88mg/kg (88mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Food and Chemical Toxicology. Vol. 28, Pg. 339, 1990.
rat LD50 intraperitoneal 83mg/kg (83mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Food and Chemical Toxicology. Vol. 28, Pg. 339, 1990.
rat LD50 oral 1620mg/kg (1620mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C154, 1991.
rat LD50 skin > 2gm/kg (2000mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A810, Pg. 1986,
rat LD50 subcutaneous 61mg/kg (61mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Food and Chemical Toxicology. Vol. 28, Pg. 339, 1990.
women LDLo oral 1600uL/kg (1.6mL/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Japanese Journal of Toxicology. Vol. 7, Pg. 47, 1994.
women TDLo oral 1110uL/kg (1.11mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Japanese Journal of Toxicology. Vol. 9, Pg. 301, 1996.
women TDLo oral 1480uL/kg (1.48mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Japanese Journal of Toxicology. Vol. 9, Pg. 301, 1996.
women TDLo oral 4mL/kg (4mL/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT

GASTROINTESTINAL: NAUSEA OR VOMITING		 Japanese Journal of Toxicology. Vol. 10, Pg. 75, 1997.
women TDLo oral 20mL/kg (20mL/kg) VASCULAR: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

GASTROINTESTINAL: NAUSEA OR VOMITING		 Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 258, 2000.
women TDLo oral 1850mg/kg (1850mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Veterinary and Human Toxicology. Vol. 36, Pg. 17, 1994.

Glufosinate-ammonium Safety Profile

Hazard Codes: HarmfulXn,ToxicT
Risk Statements: 22 
R22: Harmful if swallowed.
RIDADR: 2588
RTECS: EK7713600
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 77182-82-2(Hazardous Substances Data)
A poison by ingestion, subcutaneous, and intraperitoneal routes. Low toxicity by skin contact. Human systemic effects by ingestion: blood pressure lowering, change in motor activity, coma, cyanosis. When heated to decomposition it emits toxic vapors of NOx and POx.

Glufosinate-ammonium Specification

1. Storage: Keep tightly closed.
2. Personal Protection: Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
3. Fire Fighting: Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

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