Glutathione supplier | CasNO.70-18-8

Name
Glutathione
EINECS 200-725-4
CAS No. 70-18-8
Article Data139
CAS DataBase
Density 1.441 g/cm³
Solubility Soluble in water
Melting Point 192-195 °C (dec.)(lit.)
Formula C₁₀H₁₇N₃O₆S
Boiling Point 754.492 °C at 760 mmHg
Molecular Weight 307.327
Flash Point 410.102 °C
Transport Information
Appearance White cryst. powder
Safety 24/25-36/37/39-27-26
Risk Codes 68-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Glutathione(8CI);Glycine, N-(N-L-g-glutamyl-L-cysteinyl)-;Copren;Glutathion;Glutathione-SH;Glutide;Glutinal;Isethion;L-Glutathione;N-(N-L-g-Glutamyl-L-cysteinyl)glycine;Tathione;g-Glutamylcysteinylglycine;g-L-Glutamyl-L-cysteinylglycine;Glycine, L-g-glutamyl-L-cysteinyl-;GSH;L-Glutathione Reduced;
PSA 197.62000
LogP -0.72400

Synthetic route

: (3-((S)-5'-oxo-9λ4-boraspiro[bicyclo[3.3.1]nonane-9,2'-[1,3,2]oxazaborolidin]-4'-yl)propanoyl)-L-cysteinylglycine

: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran; water at 20℃; for 7h;	76%

: 131574-47-5
Boc-Glutathione-OBzl

: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With methyl-phenyl-thioether; hydrogen fluoride; 3-methyl-phenol at 0℃; for 1h;	62.9%

N-t-butoxycarbonyl-α-t-butyl-L-γ-glutamyl-S-ferrocenylmethyl-L-cysteinylglycine t-butyl ester: N-t-butoxycarbonyl-α-t-butyl-L-γ-glutamyl-S-ferrocenylmethyl-L-cysteinylglycine t-butyl ester

: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With thiophenol; trifluoroacetic acid for 3h;	52%

: methylmercury-L-glutathionate

: 1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione

A: 70-18-8
GLUTATHIONE

: mercury sulfide

C: 593-74-8
dimethylmercury

D: 2033-53-6
1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
Stage #1: methylmercury-L-glutathionate; 1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione In water; acetonitrile at 37℃; for 1h; Stage #2: With sodium hydrogencarbonate In water; acetonitrile at 37℃; for 5h;	A n/a B 11 mg C n/a D 40%

...Expand

: 1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione

: C17H21HgN3O8S

A: 70-18-8
GLUTATHIONE

: mercury sulfide

C: bis(4-carboxyphenyl)mercury(II)

D: 2033-53-6
1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
Stage #1: 1-(2-hydroxyethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione; C17H21HgN3O8S In water; acetonitrile at 37℃; for 2h; Stage #2: With sodium hydrogencarbonate In water; acetonitrile at 37℃;	A n/a B 12 mg C n/a D 32%

...Expand

: 27025-41-8
Oxidized glutathione

: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
durch elektrolytische Reduktion in saurer Loesung an Quecksilber-Kathoden;
With 4,4'-bipyridinium-1,1'-dipropionate modified glutathione reductase; hydrogen; platinum In water under 760 Torr; Product distribution; Mechanism; Ambient temperature;
With N-Ethylmaleimide; potassium borohydride; ethylenediaminetetraacetic acid at 60℃; for 0.166667h; Product distribution; different disulfides; investigation of reaction conditions;

: 15401-16-8
N-[S-benzyl-N-(N-benzyloxycarbonyl-L-γ-glutamyl)-L-cysteinyl]-glycine

: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With ammonia; sodium

: 52-90-4
L-Cysteine

: 56-86-0
L-glutamic acid

: 56-40-6
glycine

: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With liver-substance

...Expand

: 636-58-8
N-L-γ-glutamyl-L-cysteine

: 56-40-6
glycine

: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
in Gegenwart von Enzym-Praeparaten aus tierischen Geweben oder aus Mikroorganismen;
With dipotassium hydrogenphosphate; glutathione synthetase; edetate disodium; ATP; sodium hydroxide; magnesium chloride In water for 20h; pH=7.5; Enzymatic reaction;	63.5 %Chromat.
With phosphoenolpyruvic acid; adenosine 5'-triphosphate disodium salt hydrate; β-nicotinamideadenine dinucleotide, reduced disodium salt hydrate; glutathione synthetase mutant wild type; type II rabbit muscle lactate dehydrogenase; type II rabbit muscle pyruvate kinase In aq. buffer at 37℃; for 2h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 56-40-6
glycine

: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
in Leber und Leber-Paeparaten;

: 50410-19-0
(2S)-2-amino-5-((2R)-1-(carboxymethylamino)-3-(1-hydroxy-2-oxopropylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

A: 70-18-8
GLUTATHIONE

B: 78-98-8
2-oxopropanal

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;
With hyman erythrocyte glyoxalase I In phosphate buffer at 25℃; pH=7.0; Enzyme kinetics; Further Variations:; Catalysts; Hydrolysis;

: (2S)-2-amino-5-((2R)-1-(carboxymethylamino)-3-(1-hydroxyethylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

A: 70-18-8
GLUTATHIONE

B: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: (S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(1-hydroxy-butylsulfanyl)-ethylcarbamoyl]-butyric acid

A: 70-18-8
GLUTATHIONE

B: 78-84-2
isobutyraldehyde

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: (S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(1,2-dihydroxy-ethylsulfanyl)-ethylcarbamoyl]-butyric acid

A: 70-18-8
GLUTATHIONE

B: 141-46-8
Glycolaldehyde

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: (S)-2-Amino-4-[(R)-2-(2-amino-1-hydroxy-ethylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

A: 70-18-8
GLUTATHIONE

B: 6542-88-7
aminoacetaldehyde

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: (S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(1,2,3-trihydroxy-propylsulfanyl)-ethylcarbamoyl]-butyric acid

A: 70-18-8
GLUTATHIONE

B: 56-82-6
Glyceraldehyde

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: (S)-4-[(R)-2-(2-Acetylamino-1-hydroxy-ethylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-2-amino-butyric acid

A: 70-18-8
GLUTATHIONE

B: 64790-08-5
N-acetylaminoacetaldehyde

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: (S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(hydroxy-phenyl-methylsulfanyl)-ethylcarbamoyl]-butyric acid

A: 70-18-8
GLUTATHIONE

B: 100-52-7
benzaldehyde

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: L-γ-glutamyl->S-((Ξ)-1-hydroxy-2-phosphonooxy-ethyl)-L-cysteinyl->glycine

A: 870-55-3
phosphoric acid mono-(2-oxo-ethyl) ester

B: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: L-γ-glutamyl->S-((1Ξ,2Ξ)-1,2-dihydroxy-3-phosphonooxy-propyl)-L-cysteinyl->glycine

A: 142-10-9, 591-57-1, 20283-52-7, 591-59-3
DL-glyceraldehyde 3-phosphate

B: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: 108-02-1
captamine

: 27025-41-8
Oxidized glutathione

A: 70-18-8
GLUTATHIONE

B: (S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(2-dimethylamino-ethyldisulfanyl)-ethylcarbamoyl]-butyric acid

Conditions

Conditions	Yield
With sodium chloride In water-d2 at 25℃; Equilibrium constant;

...Expand

: 108-02-1
captamine

: (S)-2-Amino-4-[(R)-1-(carboxymethyl-carbamoyl)-2-(2-dimethylamino-ethyldisulfanyl)-ethylcarbamoyl]-butyric acid

A: 70-18-8
GLUTATHIONE

B: 1072-11-3
bis(N,N-dimethyl-2-aminoethyl)disulfide

Conditions

Conditions	Yield
With sodium chloride In water-d2 at 25℃; Equilibrium constant;

...Expand

: 41656-56-8
(S)-D-lactoylglutathione

A: 10326-41-7
D-Lactic acid

B: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With Phorbol 12-myristate 13-acetate; glyoxalase II effect of TPA on enzyme activity;

: 27025-41-8
Oxidized glutathione

: 52-90-4
L-Cysteine

A: 70-18-8
GLUTATHIONE

B: 13081-14-6
N5-((R)-3-(((R)-2-amino-2-carboxyethyl)disulfanyl)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine

Conditions

Conditions	Yield
With sodium chloride In water-d2 at 25℃; Equilibrium constant;
With sodium chloride In water-d2 at 25℃; Rate constant; Equilibrium constant; various pD values;

...Expand

: 27025-41-8
Oxidized glutathione

: 6027-13-0
L-homocysteine

A: 70-18-8
GLUTATHIONE

B: 75027-08-6
(S)-2-Amino-4-[(R)-2-((S)-3-amino-3-carboxy-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions

Conditions	Yield
With sodium chloride In water-d2 at 25℃; Equilibrium constant; various pD values;

...Expand

: 27025-41-8
Oxidized glutathione

: 13893-24-8
2-amino-2-methylpropanethiol

A: 70-18-8
GLUTATHIONE

B: (S)-2-Amino-4-[(R)-2-(2-amino-2-methyl-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions

Conditions	Yield
With sodium chloride In water-d2 at 25℃; Equilibrium constant; various pD values;

...Expand

: 52-90-4
L-Cysteine

: 13081-14-6
N5-((R)-3-(((R)-2-amino-2-carboxyethyl)disulfanyl)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine

A: 56-89-3
L-cystine

B: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With sodium chloride In water-d2 at 25℃; Equilibrium constant;

...Expand

: 6027-13-0
L-homocysteine

: 75027-08-6
(S)-2-Amino-4-[(R)-2-((S)-3-amino-3-carboxy-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

A: 626-72-2, 870-93-9, 6027-15-2, 7093-69-8, 462-10-2
L-homocystine

B: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With sodium chloride In water-d2 at 25℃; Equilibrium constant; various pD values;

...Expand

: 52-67-5
3,3-dimethyl-D-cysteine

: glutathione disulfide

A: 20902-45-8
D-Penicillamin-disulfid

B: 70-18-8
GLUTATHIONE

C: 92000-26-5
(S)-2-Amino-3-[(R)-2-((R)-4-amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-3-methyl-butyric acid

Conditions

Conditions	Yield
Equilibrium constant; Rate constant; pH 7.4;

...Expand

: 13893-24-8
2-amino-2-methylpropanethiol

: (S)-2-Amino-4-[(R)-2-(2-amino-2-methyl-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

A: 70-18-8
GLUTATHIONE

B: 4424-49-1
2-(2-Amino-2-methyl-propyldisulfanyl)-1,1-dimethyl-ethylamine

Conditions

Conditions	Yield
With sodium chloride In water-d2 at 25℃; Equilibrium constant; various pD values;

...Expand

: 70-18-8
GLUTATHIONE

: 27025-41-8
Oxidized glutathione

Conditions

Conditions	Yield
With bis(4-methoxyphenyl)telluride; rose bengal In water; isopropyl alcohol at 0℃; for 1h; Irradiation;	100%
With Cumene hydroperoxide; tert-butyl (S)-(tetrahydrotellurophen-3-yl)carbamate In dichloromethane; water at 25℃; Flow reactor;	100%
With imino urea In methanol for 1.83333h; Ambient temperature;	99%

: 70-18-8
GLUTATHIONE

: C30H45AsN9O18S3(3-)*3Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide; arsenic(III) trioxide In water for 2h;	100%

: 70-18-8
GLUTATHIONE

: tri(γ-glutamylcystainylglycinyl)trithioarsenite

Conditions

Conditions	Yield
With arsenic(III) trioxide In water for 96h;	100%
With arsenic(III) trioxide In water for 96h; N2 atmosphere;	86%

: 70-18-8
GLUTATHIONE

: 188907-25-7
N-acetyl-S-(2-phenylpropan-3-ol)-L-cysteine

: S-(2-phenylpropan-3-ol)-γ-glutathione

Conditions

Conditions	Yield
	100%

: 70-18-8
GLUTATHIONE

: 2-fluorodehydrocoelenterazine

: (S)-2-Amino-4-[(R)-2-[[8-benzyl-6-(4-hydroxy-phenyl)-3-oxo-3,7-dihydro-imidazo[1,2-a]pyrazin-2-yl]-(2-fluoro-phenyl)-methylsulfanyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions

Conditions	Yield
In methanol; dichloromethane; water at 20℃; for 3h;	100%

: 70-18-8
GLUTATHIONE

: 3-fluorodehydrocoelenterazine

: (S)-2-Amino-4-[(R)-2-[[8-benzyl-6-(4-hydroxy-phenyl)-3-oxo-3,7-dihydro-imidazo[1,2-a]pyrazin-2-yl]-(3-fluoro-phenyl)-methylsulfanyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions

Conditions	Yield
In methanol; dichloromethane; water at 20℃; for 3h;	100%

: 70-18-8
GLUTATHIONE

: 4-fluorodehydrocoelenterazine

: (S)-2-Amino-4-[(R)-2-[[8-benzyl-6-(4-hydroxy-phenyl)-3-oxo-3,7-dihydro-imidazo[1,2-a]pyrazin-2-yl]-(4-fluoro-phenyl)-methylsulfanyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions

Conditions	Yield
In methanol; dichloromethane; water at 20℃; for 3h;	100%

: 70-18-8
GLUTATHIONE

: 87-87-6
2,3,5,6-tetrachlorobenzene-1,4-diol

: 131765-87-2
(S-glutathionyl)-TriCH

Conditions

Conditions	Yield
With PcpC-C14S glutathione transferase; ascorbic acid at 30 - 65℃; for 0.333333h; pH=6.5; aq. phosphate buffer; Enzymatic reaction;	100%

: 70-18-8
GLUTATHIONE

: 1196873-32-1
diethyl [1-methyl-1-([4-(iodoacetamido)benzylidene]azinoyl)ethyl]phosphonate

: 1196873-33-2
C26H40N5O11PS

Conditions

Conditions	Yield
at 25℃; pH=7.4; aq. phosphate buffer; Darkness;	100%

: 70-18-8
GLUTATHIONE

: C20H30N2O7

: 1374677-38-9
C30H47N5O13S

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃;	100%

: 70-18-8
GLUTATHIONE

: 1217898-39-9
{[2 (ferrocenylmethoxy)ethyl]sulfonyl}ethene

: C25H33FeN3O9S2

Conditions

Conditions	Yield
With sodium tetrahydroborate In water; N,N-dimethyl-formamide at 20℃; for 1h;	100%

: 70-18-8
GLUTATHIONE

: 1202757-89-8
N-(3-{5-fluoro-2-[4-(2-methoxy-ethoxy)-phenylamino]-pyrimidin-4-ylamino}-phenyl)-acrylamide

: (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-(3-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenylamino)-3-oxopropylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

Conditions

Conditions	Yield
With triethylamine In methanol; dichloromethane at 0 - 20℃; for 16h;	100%

: 821-09-0
n-Pent-4-enyl alcohol

: 70-18-8
GLUTATHIONE

: 1497404-41-7
C15H27N3O7S

Conditions

Conditions	Yield
With 2,2’-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride In water for 3h; UV-irradiation;	100%

: 70-18-8
GLUTATHIONE

: 1233858-76-8
4-(5-phenyl-3-(selenocyanatomethyl)-1H-pyrazol-1-yl)benzenesulfonamide

: 2-amino-4-{1-(carboxymethyl-carbamoyl)-2-[5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazol-3yl]methylselanylthiol-ethylcarbamoyl}-butyric acid

Conditions

Conditions	Yield
In tetrahydrofuran; water Alkaline conditions;	100%

: 70-18-8
GLUTATHIONE

: 144-48-9
iodacetamide

: glutathione

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 1h; pH=8.2;	100%
In aq. buffer at 37℃; for 0.5h; Darkness;

: 98026-79-0
3-bromo-1H-pyrrole-2,5-dione

: 70-18-8
GLUTATHIONE

: Glu-Cys(Mal)-Gly

Conditions

Conditions	Yield
In methanol for 0.0833333h;	100%

: 70-18-8
GLUTATHIONE

: C29H45NO12S2

: C32H54N4O16S2

Conditions

Conditions	Yield
for 24h; pH=8;	100%

: 70-18-8
GLUTATHIONE

: 342807-90-3
3,5-bis(2-hydroxybenzylidene)tetrahydro-4H-pyran-4-one

: C39H50N6O16S2

Conditions

Conditions	Yield
In water; acetonitrile for 2h; Reflux;	100%

: 70-18-8
GLUTATHIONE

: 3-((1’-(2”-acetamido-2”-deoxy-β-D-glucopyranosyl)-[1’,2’,3’]-triazo-4’-yl)methyloxy)-1-propene

: S-(3’-((1’’-(2”’-acetamido-2”’-deoxy-β-D-glucopyranosyl)[1’’,2’’,3’’]-triazo-4’’-yl)methyloxy)-1’-propyl)-γ-L-glutamyl-L-cysteinylglycine

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In aq. acetate buffer for 4h; pH=4; Irradiation;	100%

: 70-18-8
GLUTATHIONE

: 26555-40-8
Methoxycarbonylsulfenyl chloride

: C12H19N3O8S2

Conditions

Conditions	Yield
In 1,4-dioxane at 20℃; Inert atmosphere;	100%

: 70-18-8
GLUTATHIONE

: bis(4-(dimethylamino)phenyl)methylium tetrafluoroborate

: C27H37N5O6S*BF4(1-)*H(1+)

Conditions

Conditions	Yield
In water; acetonitrile at 20℃;	100%

: 70-18-8
GLUTATHIONE

: 1378277-97-4
C42H48N3O2(1+)

: 1378277-98-5
C52H65N6O8S(1+)

Conditions

Conditions	Yield
at 37℃; for 0.166667h; pH=7.4; aq. phosphate buffer;	99.3%

: 70-18-8
GLUTATHIONE

: 73230-64-5
2-desoxy-2-C-methylene-D-threo-pentono-1,4-lactone

: 73230-74-7
2-Amino-4-[1-(carboxymethyl-carbamoyl)-2-((4R,5R)-4-hydroxy-5-hydroxymethyl-2-oxo-tetrahydro-furan-3-ylmethylsulfanyl)-ethylcarbamoyl]-butyric acid

Conditions

Conditions	Yield
In water at 25℃; for 1h;	99%

: 70-18-8
GLUTATHIONE

: 16305-88-7
Norophthalamic acid

Conditions

Conditions	Yield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; triethyl phosphite In aq. phosphate buffer; acetonitrile at 20℃; for 2h; pH=7; Catalytic behavior; Solvent; Reagent/catalyst; pH-value; Irradiation;	99%
With triethyl borane; triethyl phosphite 1.) CH3CN, H2O, RT, 2 min, 2.) CH3CN, H2O, RT, irradiation, 8 h; Multistep reaction;
With tris(2,2'-bipyridyl)ruthenium dichloride; trisodium tris(3-sulfophenyl)phosphine; 2-methylpropan-2-thiol In aq. phosphate buffer at 20℃; for 5h; pH=7.4; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Irradiation;	87 %Spectr.
UV-irradiation;
With di-tert-butyl peroxide; trisodium tris(3-sulfophenyl)phosphine In aq. phosphate buffer at 20℃; for 6h; pH=7; UV-irradiation;

: 70-18-8
GLUTATHIONE

: 107-02-8
acrolein

: 124521-13-7
S-(3-oxopropyl)glutathione

Conditions

Conditions	Yield
In water at 20℃; for 1h; Addition;	99%
With phosphate buffer; ethylenediaminetetraacetic acid In water at 25℃; Kinetics; Addition; Michael addition;
In ethanol; water at 37℃; for 2h; pH=8; aq. phosphate buffer;

: 70-18-8
GLUTATHIONE

: 100-14-1
4-nitrobenzyl chloride

: 6803-19-6
S-(p-nitrobenzyl)-glutathione

Conditions

Conditions	Yield
With N,N,N',N'-tetramethylguanidine In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;	99%

: 70-18-8
GLUTATHIONE

: 110637-58-6
Alloc-Lys-OH TFA salt

: C20H35N5O10S*C2HF3O2

Conditions

Conditions	Yield
With tris(2,2′-bipyrazine-N1,N1′)ruthenium(II) hexafluorophosphate In water for 2h; Concentration; Irradiation;	99%

: 70-18-8
GLUTATHIONE

: 1-(5-chloropent-1-ynyl)-1,2-benziodoxol-3(1H)-one

: S-glutathione-(5-chloropent-1-ynyl)-1,2-vinylbenziodoxolone

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 0.0833333h; pH=8.2; stereoselective reaction;	99%

: 70-18-8
GLUTATHIONE

: 57564-91-7
S-Nitrosoglutathione

Conditions

Conditions	Yield
With diethylenetriaminopentaacetic acid; L-phenylalanine; 1-nitrosopyrrolidine-2-thiocarboxamide at 37℃; pH=1.5; Reagent/catalyst; Darkness;	98%
With hydrogenchloride; diethylenetriaminopentaacetic acid; 3-nitroso-1,3-thiazolidine-4-thiocarboxamide In aq. phosphate buffer; acetonitrile at 37℃; pH=1.5; Kinetics; Reagent/catalyst; Darkness;	95%
With hydrogenchloride; sodium nitrite In water at 5℃; for 0.666667h; Inert atmosphere;	77%

: 70-18-8
GLUTATHIONE

: 177960-06-4
(1H-benzo[d][1,2,3]triazol-1-yl)(naphthalen-2-yl)methanone

: (S)-5-((R)-3-(2-naphthoylthio)-1-(carboxymethylamino)-1-oxopropan-2-ylamino)-2-amino-5-oxopentanoic acid

Conditions

Conditions	Yield
With potassium hydrogencarbonate In methanol; water at 20℃;	98%

Glutathione Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Glutathione Specification

Glutathione (CAS NO.70-18-8), its Synonyms are Glycine, N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine ; Copren ; Deltathione ; Glutide ; Glutinal ; Glutathione ; gamma-L-Glutamylcysteinylglycine ; Glycine, L-gamma-glutamyl-L-cysteinyl- . It is white powder. Glutathione (GSH) is a tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides.

Physical properties about Glutathione are: (1)ACD/LogP: -1.645; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -5.12; (4)ACD/LogD (pH 7.4): -5.15; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00 ; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 9; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 11; (12)Index of Refraction: 1.572; (13)Molar Refractivity: 70.105 cm³; (14)Molar Volume: 213.204 cm³; (15)Polarizability: 27.792 10-24cm³; (16)Surface Tension: 69.3659973144531 dyne/cm; (17)Density: 1.441 g/cm³; (18)Flash Point: 410.102 °C; (19)Enthalpy of Vaporization: 119.618 kJ/mol; (20)Boiling Point: 754.492 °C at 760 mmHg

Uses of Glutathione: Glutathione (CAS NO.70-18-8) is a biological and chemical reagents, detoxification drugs which is mainly used for poisoning such as heavy metals, acrylonitrile, fluoride, carbon monoxide and organic solvents. Glutathione can also decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP.

When you are using this chemical, please be cautious about it as the following:
1.Avoid contact with skin and eyes;
2.Wear suitable protective clothing, gloves and eye/face protection;
3.Take off immediately all contaminated clothing;
4.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1;
(2)InChIKey=RWSXRVCMGQZWBV-WDSKDSINSA-N;
(3)SmilesN[C@@H](CCC(=O)N[C@H](C(=O)NCC(=O)O)CS)C(=O)O;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intramuscular	4gm/kg (4000mg/kg)	"Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Suppl Exporters' Assoc., 1968Vol. -, Pg. 97, 1968.
mouse	LD50	intraperitoneal	4020mg/kg (4020mg/kg)	"Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
mouse	LD50	intravenous	2238mg/kg (2238mg/kg)	Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985.
mouse	LD50	oral	5gm/kg (5000mg/kg)	"Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
mouse	LD50	subcutaneous	5gm/kg (5000mg/kg)	"Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
rabbit	LD50	intravenous	> 2gm/kg (2000mg/kg)	Biochemical Journal. Vol. 41, Pg. 325, 1947.

Product Name

Glutathione

Synthetic route

Glutathione Consensus Reports

Glutathione Specification

Related Products

Hot Products