Guanidineacetic acid supplier

Name
Guanidineacetic acid
EINECS 206-529-5
CAS No. 352-97-6
Article Data44
CAS DataBase
Density 1.59 g/cm³
Solubility 3.6g/L(15 oC)
Melting Point 300 °C(lit.)
Formula C₃H₇N₃O₂
Boiling Point 346.8 °C at 760 mmHg
Molecular Weight 117.107
Flash Point 163.5 °C
Transport Information
Appearance white to slightly beige fine crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols R36/37/38:;
Synonyms Glycine,N-amidino- (8CI);2-[[Amino(imino)methyl]amino]acetic acid;Acetic acid,[(aminoiminomethyl)amino]-;Betacyamine;Glycocyamine;Guanidine,(carboxymethyl)-;Guanyl glycine;NSC 1901;NSC227847;NSC 26360;b-Guanidinoacetic acid;
PSA 99.20000
LogP -0.25500

Synthetic route

: 420-04-2
CYANAMID

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With ammonia In water at 60℃; for 4h; pH=11; pH-value; Temperature;	94.6%
at 88 - 90℃; for 0.216667h; pH=9.6;	83%
unter verschiedenen Bedingungen;

: 1184-90-3
aminoiminomethanesulfonic acid

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With potassium carbonate In water for 24h; Ambient temperature;	80%
With ammonium hydroxide

: 1H-1,2,4-triazole-1-carboximidamide monohydrochloride

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With sodium carbonate In water; glycine	79%

: 1758-73-2
Aminoiminomethanesulfinic acid

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With sodium hydroxide at 20℃; Substitution; N-Formamidinylation;	70.2%

: 13882-27-4
ethyl imidothiocarbamate hydroiodide

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
Stage #1: ethyl imidothiocarbamate hydroiodide With sodium hydroxide In water Stage #2: glycine In diethyl ether; water at 0℃; for 23h;	69%

: 6779-78-8
N-cyanocarbamimidoyl-glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With barium dihydroxide

: 861321-98-4
N-cyano-glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With ammonium chloride; water das Hydrochlorid entsteht;

: 543-83-9
galegine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With barium permanganate; sulfuric acid

: 2986-19-8
carbamimidothioic acid methyl ester

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

: 113-00-8
guanidine nitrate

: 79-11-8
chloroacetic acid

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With water at 37℃; bei 12-15-stdg.Erwaermen;
With sodium hydroxide
With water at 60℃; bei 2-stdg.Erwaermen;

: 57-13-6
urea

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
unter verschiedenen Bedingungen;

: 57-13-6
urea

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With diethyl sulfate Erwaermen des Reaktionsprodukts mit Glycin und wss.NaOH;

: 2440-60-0
2-methyl-isourea

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With methanol

: 74-79-3
L-arginine

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
unter der Einwirkung von Enzym-Praeparaten(Transamidinase,Glycin-Amidino-Transferase) aus Nieren;
unter der Einwirkung von Enzym-Praeparaten(Transamidinase,Glycin-Amidino-Transferase) aus Nieren.Untersuchung dieser Reaktion im tierischen Organismus.;
With aminotransferase GdnJ In aq. phosphate buffer at 20℃; for 20h; pH=7;
unter der Einwirkung von Enzym-Praeparaten(Transamidinase,Glycin-Amidino-Transferase) aus Nieren;

: 53114-57-1
S-methylisothiourea hydrochloride

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 1071-37-0
2-ethylisothiourea hydrobromide

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With sodium hydroxide; water

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
biochemische Umwandlung;

: 5329-33-9
o-methylisourea hydrochloride

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 867-44-7
S-Methylisothiourea sulfate

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With ammonium hydroxide

: 7732-18-5
water

: 113-00-8
guanidine nitrate

: 79-11-8
chloroacetic acid

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
at 60℃; analog reagieren α-Brom-propionsaeure und andere α-halogenierte Monocarbonsaeuren;
at 60℃;

...Expand

: 124-46-9, 20734-13-8, 100224-74-6, 593-85-1
guanidine hydrogen carbonate

: 7732-18-5
water

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

...Expand

: 420-04-2
CYANAMID

: 7664-41-7
ammonia

: 7732-18-5
water

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

...Expand

: ammonium hydroxide

: 1758-73-2
Aminoiminomethanesulfinic acid

: 56-40-6
glycine

: 352-97-6
guanidineacetic acid

...Expand

: 124-38-9
carbon dioxide

: 79-11-8
chloroacetic acid

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With ammonia; water Erwaermen des Reaktionsprodukts mit Carbamonitril in H2O;

: 6779-78-8
N-cyanocarbamimidoyl-glycine

aq. barium hydroxide solution: aq. barium hydroxide solution

: 352-97-6
guanidineacetic acid

bis-<S-methyl-thiuronium >-sulfate: bis-<S-methyl-thiuronium >-sulfate

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With methanol; sodium methylate anschliessend mit Glycin;

: 113-00-8
guanidine nitrate

carbonate glycine: carbonate glycine

: 352-97-6
guanidineacetic acid

compound C6H14O4N6: compound C6H14O4N6

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 19981-17-0, 20611-81-8, 123092-13-7, 17292-62-5
sodium cyanamide

glycine hydrochloride: glycine hydrochloride

: 352-97-6
guanidineacetic acid

Conditions

Conditions	Yield
With hydrogenchloride; water

: 890656-26-5
ethyl 3-amino-4-bromo-1H-pyrrole-2-carboxylate

: 352-97-6
guanidineacetic acid

: C6H5BrN4O

Conditions

Conditions	Yield
In ethanol for 10h; Solvent; Reflux;	88%

: 50562-79-3
1-(4-tolylsulfonyl)indole-3-carboxaldehyde

: 352-97-6
guanidineacetic acid

: 108-24-7
acetic anhydride

: 3-<(2'-acetamido-5'-acetoxy-4'-imidazolinylidene)methyl>-1-(p-toluenesulphonyl)-1H-indole

Conditions

Conditions	Yield
With sodium acetate for 4h; Heating;	85%

...Expand

: 50562-79-3
1-(4-tolylsulfonyl)indole-3-carboxaldehyde

: 352-97-6
guanidineacetic acid

: 108-24-7
acetic anhydride

: 155859-38-4
3-<(2'-acetamido-5'-acetoxy-4'-imidazolidinylidene)methylene>-1-p-toluenesulphonyl-1H-indole

Conditions

Conditions	Yield
	85%

...Expand

: 352-97-6
guanidineacetic acid

: 100-52-7
benzaldehyde

: 109-77-3
malononitrile

: [(4-amino-5-cyano-6-phenyl-2-pyrimidinyl)amino] acetic acid

Conditions

Conditions	Yield
With D-glucose; oxygen In water at 50℃; for 5h;	83%

...Expand

: 352-97-6
guanidineacetic acid

: 144455-11-8
1-(1-dimethylaminomethylene-2-oxo-2-phenylethyl)-3,5-diphenyl-1H-pyrazole

: 144454-93-3
[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-ylamino]-acetic acid

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 12h; Heating;	82%

: 352-97-6
guanidineacetic acid

: 104-88-1
4-chlorobenzaldehyde

: 109-77-3
malononitrile

: [(4-amino-5-cyano-6-(4-chlorophenyl)-2-pyrimidinyl)amino] acetic acid

Conditions

Conditions	Yield
With D-glucose; oxygen In water at 50℃; for 4h;	81%

...Expand

: 352-97-6
guanidineacetic acid

: 829-20-9
2',4'-dimethoxyacetophenone

: 5-(2,4-dimethoxyphenyl)isoxazole

Conditions

Conditions	Yield
Stage #1: guanidineacetic acid; 2',4'-dimethoxyacetophenone With N,N-dimethyl-formamide dimethyl acetal at 100℃; for 18h; Inert atmosphere; Stage #2: With hydrogenchloride; hydroxylamine hydrochloride In ethanol at 20℃; Inert atmosphere;	80%

: 352-97-6
guanidineacetic acid

: 555-16-8
4-nitrobenzaldehdye

: 109-77-3
malononitrile

: [(4-amino-5-cyano-6-(4-nitrophenyl)-2-pyrimidinyl)amino]acetic acid

Conditions

Conditions	Yield
With D-glucose; oxygen In water at 50℃; for 5h;	77%

...Expand

: 487-89-8
Indole-3-carboxaldehyde

: 352-97-6
guanidineacetic acid

: 108-24-7
acetic anhydride

: 3-<(2'-acetamido-5'-acetoxy-4'-imidazolinylidene)methyl>-1H-indole

Conditions

Conditions	Yield
With sodium acetate for 4h; Heating;	76%

...Expand

: 487-89-8
Indole-3-carboxaldehyde

: 352-97-6
guanidineacetic acid

: 108-24-7
acetic anhydride

: 155859-47-5
3-<(2'-acetamido-5'acetoxy-4'-imidazolidinylidene)methylene>-1H-indole

Conditions

Conditions	Yield
	76%

...Expand

: 352-97-6
guanidineacetic acid

: 616-38-6
carbonic acid dimethyl ester

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With aluminum (III) chloride; potassium carbonate at 95℃; for 3h; Temperature; Large scale;	75.61%

: nickel(II) chloride hexahydrate

: 352-97-6
guanidineacetic acid

: 368863-33-6
bis(guanidinoacetato)(guanidinoacetic acid)nickel(II)

Conditions

Conditions	Yield
With potassium hydroxide; nitric acid In water 3 equiv. of org. acid was dissolved in H2O, acidified with 0.1 M HNO3, metal salt soln. was added, stirring for 1 h at 60 °C, 0.1 M KOH was added during 6 h under stirring at 60 °C; soln. was concd. to half of its original vol., left in the hood with abs. EtOH for 24 h, ppt. was washed 3 times with abs. EtOH and distd. water, resp., elem. anal.;	70%

: 32521-19-0
3-Ethoxycarbonylisochroman-4-one

: 352-97-6
guanidineacetic acid

: 130747-59-0
2-<(Carboxymethyl)amino>-4-hydroxyisochromano<4,3-d>pyrimidine

Conditions

Conditions	Yield
With sodium butanolate In butan-1-ol at 110℃; for 4.5h;	69%

: 352-97-6
guanidineacetic acid

: 108-24-7
acetic anhydride

: 158991-81-2
6-bromo-N-(1-p-toluenesulphonyl)-indole-3-carboxaldehyde

: 158991-85-6
6-bromo-3-(2'-acetamido-5'-acetoxy-4'-imidazolinylidenemethyl)-1-(p-toluenesulphonyl)-1H-indole

Conditions

Conditions	Yield
With sodium acetate for 3h; Heating;	65%

...Expand

: copper(II) nitrate trihydrate

: 352-97-6
guanidineacetic acid

: 368863-34-7
bis(guanidinoacetato)copper(II)

Conditions

Conditions	Yield
With potassium hydroxide; nitric acid In water 2 equiv. of org. acid was dissolved in H2O, acidified with 0.1 M HNO3 until the pH was 3.5, metal salt soln. was added, stirring for 1 h at 60 °C, 0.1 M KOH was added during 2 h under stirring at 60 °C; soln. was concd. to half of its original vol., left in the hood with abs. EtOH for 24 h, ppt. was washed 3 times with abs. EtOH and distd. water, resp., elem. anal.;	63%

Yield

With potassium hydroxide; nitric acid In water 2 equiv. of org. acid was dissolved in H2O, acidified with 0.1 M HNO3 until the pH was 3.5, metal salt soln. was added, stirring for 1 h at 60 °C, 0.1 M KOH was added during 2 h under stirring at 60 °C; soln. was concd. to half of its original vol., left in the hood with abs. EtOH for 24 h, ppt. was washed 3 times with abs. EtOH and distd. water, resp., elem. anal.;

63%

: 352-97-6
guanidineacetic acid

: 108-24-7
acetic anhydride

: 27092-42-8
1-benzoyl-1H-indole-3-carbaldehyde

: 3-<(2'-acetamido-5'-acetoxy-4'-imidazolidinylidene)methylene>-1-benzoyl-1H-indole

Conditions

Conditions	Yield
With sodium acetate for 4h; Heating;	62%
With sodium acetate	62%

...Expand

: chromium chloride hexahydrate

: 352-97-6
guanidineacetic acid

: 368863-31-4
tris(guanidinoacetato)chromium(III)

Conditions

Conditions	Yield
With potassium hydroxide; nitric acid In water 3 equiv. of org. acid was dissolved in H2O, acidified with 0.1 M HNO3, metal salt soln. was added, stirring for 1 h at 60 °C, 0.1 M KOH was added during 7 h under stirring at 60 °C, same compd. was formed at 10 times excess of Zn-ion; soln. was concd. to half of its original vol., left in the hood with abs. EtOH for 48 h, ppt. was washed 3 times with abs. EtOH and distd. water, resp., elem. anal.;	60%

Yield

With potassium hydroxide; nitric acid In water 3 equiv. of org. acid was dissolved in H2O, acidified with 0.1 M HNO3, metal salt soln. was added, stirring for 1 h at 60 °C, 0.1 M KOH was added during 7 h under stirring at 60 °C, same compd. was formed at 10 times excess of Zn-ion; soln. was concd. to half of its original vol., left in the hood with abs. EtOH for 48 h, ppt. was washed 3 times with abs. EtOH and distd. water, resp., elem. anal.;

60%

: 877-03-2
5-bromo-1H-indole-3-carboxaldehyde

: 352-97-6
guanidineacetic acid

: 108-24-7
acetic anhydride

: 3-<(2'-acetamido-5'-acetoxy-4'-imidazolinylidene)methyl>-5-bromo-1H-indole

Conditions

Conditions	Yield
With sodium acetate for 4h; Heating;	59%

...Expand

: 302-84-1
serin

: 352-97-6
guanidineacetic acid

: 7732-18-5
water

: nickel(II) nitrate

: guanidinoaceticserinenickel(II) monohydrate

Conditions

Conditions	Yield
With NaCl; KOH In water Sonication; NH2CH(NH)NHCH2COOH aq. soln. added slowly to serine soln. under stirringat 45°C; aq. NaCl and aq. KOH (pH 3.3) added; stored (room temp. , 2 d); solid Ni(NO3)2 added; heated for 12 h with stiring; stored for 2d (unltrasonication, 5 min, 3 times); vol. reduced to half; EtOH added; ppt. dried at 75°C; solid stirred in MeOH for 1 h; centrifuged; dried (75°C, 4 h); stored in sealed glass contg. CaCl2 and MgCl2); elem. anal.;	59%

Yield

With NaCl; KOH In water Sonication; NH2CH(NH)NHCH2COOH aq. soln. added slowly to serine soln. under stirringat 45°C; aq. NaCl and aq. KOH (pH 3.3) added; stored (room temp. , 2 d); solid Ni(NO3)2 added; heated for 12 h with stiring; stored for 2d (unltrasonication, 5 min, 3 times); vol. reduced to half; EtOH added; ppt. dried at 75°C; solid stirred in MeOH for 1 h; centrifuged; dried (75°C, 4 h); stored in sealed glass contg. CaCl2 and MgCl2); elem. anal.;

59%

...Expand

: 352-97-6
guanidineacetic acid

: cobalt(II) chloride heptahydrate

: 368863-32-5
bis(guanidinoacetato)(guanidinoacetic acid)cobalt(II)

Conditions

Conditions	Yield
With potassium hydroxide; nitric acid In water 3 equiv. of org. acid was dissolved in H2O, acidified with 0.1 M HNO3, metal salt soln. was added, stirring for 1 h at 60 °C, 0.1 M KOH was added during 6 h under stirring at 60 °C; soln. was concd. to half of its original vol., left in the hood with abs. EtOH for 24 h, ppt. was washed 3 times with abs. EtOH and distd. water, resp., elem. anal.;	56%

: nickel(II) nitrate hexahydrate

: 352-97-6
guanidineacetic acid

: 617-45-8
aspartic Acid

: aspartateguanidoacetatenickel (II)

Conditions

Conditions	Yield
Stage #1: guanidineacetic acid; aspartic Acid at 4 - 43℃; for 52h; Stage #2: nickel(II) nitrate hexahydrate at 45℃; for 8h;	54%

...Expand

: 352-97-6
guanidineacetic acid

: 108-24-7
acetic anhydride

: 158991-80-1
5-bromo-N-(1-p-toluenesulphonylindole)-3-carboxaldehyde

: 158991-84-5
3-(2'-acetamido-5'-acetoxy-4'-imidazolinylidenemethyl)-5-bromo-1-(p-toluenesulphonyl)-1H-indole

Conditions

Conditions	Yield
With sodium acetate for 3h; Heating;	53%

...Expand

: 1012335-55-5
(3E)-3-[(dimethylamino)methylene]-1-(4-methoxydibenzo[b,d]furan-1-yl)-4-oxocyclohexanecarbonitrile

: 352-97-6
guanidineacetic acid

: {[6-cyano-6-(4-methoxydibenzo[b,d]furan-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl]amino}acetic acid

Conditions

Conditions	Yield
Stage #1: (3E)-3-[(dimethylamino)methylene]-1-(4-methoxydibenzo[b,d]furan-1-yl)-4-oxocyclohexanecarbonitrile; guanidineacetic acid With sodium hydroxide In methanol at 60 - 70℃; for 8h; Stage #2: With hydrogenchloride; water pH=2;	52.45%

: 352-97-6
guanidineacetic acid

: 107-18-6
allyl alcohol

: 76-05-1
trifluoroacetic acid

: 1312604-81-1
(2-allyloxy-2-oxoethylamino)(amino)methaniminium 2,2,2-trifluoroacetate

Conditions

Conditions	Yield
for 48h; Reflux;	52%

...Expand

: 352-97-6
guanidineacetic acid

: 7697-37-2
nitric acid

: 7646-85-7
zinc(II) chloride

: 368863-35-8
Zn(guanidinoacetic acid)Cl(NO3)

Conditions

Conditions	Yield
With potassium hydroxide In water 2 equiv. of org. acid was dissolved in H2O, acidified with 0.1 M HNO3, metal salt soln. was added, stirring for 1 h at 60 °C, 0.1 M KOH was added during 2 h under stirring at 60 °C, same compd. was formed at 10 times excess of Zn-ion; soln. was concd. to half of its original vol., left in the hood with abs. EtOH for 24 h, ppt. was washed 3 times with abs. EtOH and distd. water, resp., elem. anal.;	50%

Yield

With potassium hydroxide In water 2 equiv. of org. acid was dissolved in H2O, acidified with 0.1 M HNO3, metal salt soln. was added, stirring for 1 h at 60 °C, 0.1 M KOH was added during 2 h under stirring at 60 °C, same compd. was formed at 10 times excess of Zn-ion; soln. was concd. to half of its original vol., left in the hood with abs. EtOH for 24 h, ppt. was washed 3 times with abs. EtOH and distd. water, resp., elem. anal.;

50%

...Expand

Guanidineacetic acid Chemical Properties

Molecular Structure of Guanidineacetic acid (CAS NO.352-97-6):

IUPAC Name: 2-(diaminomethylideneamino)acetic acid
Empirical Formula: C₃H₇N₃O₂
Molecular Weight: 117.1066
H bond acceptors: 5
H bond donors: 5
Freely Rotating Bonds: 2
Polar Surface Area: 45.14 Å²
Index of Refraction: 1.596
Molar Refractivity: 24.95 cm³
Molar Volume: 73.3 cm³
Surface Tension: 74.7 dyne/cm
Density: 1.59 g/cm³
Flash Point: 163.5 °C
Enthalpy of Vaporization: 64.94 kJ/mol
Boiling Point: 346.8 °C at 760 mmHg
Vapour Pressure: 9.89E-06 mmHg at 25°C
Melting point: 300 °C(lit.)
Merck: 14,4495
BRN: 1759179
InChI
InChI=1/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6)
Smiles
C(CNC(N)=N)(O)=O
EINECS: 206-529-5
Product Categories: Pharmaceutical Intermediates

Guanidineacetic acid Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: MB7700000
HS Code: 29252000

Guanidineacetic acid Specification

Guanidineacetic acid , with CAS number of 352-97-6, can be called 2-[[Amino(imino)methyl]amino]acetic acid ; Betacyamine ; Glycocyamine ; Guanidine,(carboxymethyl)- ; Guanyl glycine ; N-Amidinoglycine ; a-Guanidinoacetic acid . It is a white to slightly beige fine crystalline powder.

Product Name

Guanidineacetic acid

Synthetic route

Guanidineacetic acid Chemical Properties

Guanidineacetic acid Safety Profile

Guanidineacetic acid Specification

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