Hydrazine,(3,4-difluorophenyl)- supplier

Name
3,4-DIFLUOROPHENYLHYDRAZINE
EINECS 200-258-5
CAS No. 161886-22-2
Article Data9
CAS DataBase
Density 1.379 g/cm³
Solubility
Melting Point
Formula C₆H₆F₂N₂
Boiling Point 210.7 °C at 760 mmHg
Molecular Weight 144.124
Flash Point 81.2 °C
Transport Information
Appearance
Safety
Risk Codes Xi:Irritant;
Molecular Structure
Hazard Symbols Xi
Synonyms 3,4-Difluorophenylhydrazine;
PSA 38.05000
LogP 2.02370

Synthetic route

: 3863-11-4
3,4-difluoroaniline

: 161886-22-2
3,4-difluorophenyl hydrazine

Conditions

Conditions	Yield
Stage #1: 3,4-difluoroaniline With hydrogenchloride; sodium nitrite In water at 0℃; for 1.16667h; Stage #2: With tin(ll) chloride In water at 0℃;	57.5%
Stage #1: 3,4-difluoroaniline With hydrogenchloride In methanol Stage #2: With sodium nitrite In methanol; water at 0℃; for 0.333333h; Stage #3: With hydrogenchloride; tin(ll) chloride In methanol; water at 4℃; for 6h; Further stages.;
Stage #1: 3,4-difluoroaniline With hydrogen bromide; sodium nitrite In water at -10 - -5℃; for 1h; Inert atmosphere; Stage #2: With tin(ll) chloride In water at -10 - -5℃; for 2h; Inert atmosphere;
Stage #1: 3,4-difluoroaniline With hydrogenchloride; sodium nitrite In dichloromethane; water at 0 - 20℃; for 1.5h; Stage #2: With tin(ll) chloride In dichloromethane; water at 0℃; for 6h;

: 7772-99-8
stannous chloride

: 3863-11-4
3,4-difluoroaniline

: 161886-22-2
3,4-difluorophenyl hydrazine

Conditions

Conditions	Yield
With sodium nitrite In hydrogenchloride; water	57.4%

: 42059-81-4
3-formyl-6-methylchromone

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1242460-97-4
C17H12F2N2O2

Conditions

Conditions	Yield
With acetic acid In ethanol at 40℃; for 1h;	99%

: 42059-75-6
6,8-dimethyl-3-formylchromone

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1242460-93-0
C18H14F2N2O2

Conditions

Conditions	Yield
With acetic acid In ethanol at 40℃; for 1h;	99%

: 69155-76-6
6-fluorochromone-3-carboxaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1242460-92-9
C16H9F3N2O2

Conditions

Conditions	Yield
With acetic acid In ethanol at 40℃; for 1h;	99%

: 40682-97-1
7-methyl-4-oxo-(4H)-1-benzopyran-3-carbaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1242460-95-2
C17H12F2N2O2

Conditions

Conditions	Yield
With acetic acid In ethanol at 40℃; for 1h;	99%

: 52817-12-6
6-bromo-4-oxo-4H-chromene-3-carbaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1242460-96-3
C16H9BrF2N2O2

Conditions

Conditions	Yield
With acetic acid In ethanol at 40℃; for 1h;	99%

: 64481-10-3
6,8-dichloro-3-formylchromone

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1242460-91-8
C16H8Cl2F2N2O2

Conditions

Conditions	Yield
With acetic acid In ethanol at 40℃; for 1h;	99%

: 17422-74-1
3-Formylchromone

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1242460-94-1
C16H10F2N2O2

Conditions

Conditions	Yield
With acetic acid In ethanol at 40℃; for 1h;	99%

: 42248-31-7
6-Chloro-4-oxo-4H-chromene-3-carbaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1242460-98-5
C16H9ClF2N2O2

Conditions

Conditions	Yield
With acetic acid In ethanol at 40℃; for 1h;	99%

: 4-[3-(7-fluoro-2-oxo-3,8a-dihydrochromen-3-yl)-4-formyl-pyrazol-1-yl]benzoic acid

: 161886-22-2
3,4-difluorophenyl hydrazine

: C26H15F3N4O4

Conditions

Conditions	Yield
In ethanol at 90℃; for 8h;	84%

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 635-93-8
5-chlorosalicyclaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: 6-chloro-3-(1-(3,4-difluorophenyl)-3-methyl-1H-pyrazol-5-yl)-2H-chromen-2-one

Conditions

Conditions	Yield
With eosin In acetonitrile at 20℃; Irradiation;	80%
With 6-methylamino-hexane-1,2,3,4,5-pentaol In ethanol; water Reflux; Green chemistry;	76%

...Expand

: 908584-60-1
3,3-dicyano-2-methoxy-acrylic acid ethyl ester

: 161886-22-2
3,4-difluorophenyl hydrazine

: 5-amino-4-cyano-1-(3,4-difluoro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In ethanol	79%

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 161886-22-2
3,4-difluorophenyl hydrazine

: 3-(1-(3,4-difluorophenyl)-3-methyl-1H-pyrazol-5-yl)-7-methoxy-2H-chromen-2-one

Conditions

Conditions	Yield
With eosin In acetonitrile at 20℃; Irradiation;	76%
With 6-methylamino-hexane-1,2,3,4,5-pentaol In ethanol; water Reflux; Green chemistry;	72%

...Expand

: C20H12N2O6

: 161886-22-2
3,4-difluorophenyl hydrazine

: 4-[4-[(E)-[(3,4-difluorophenyl)hydrazono]methyl]-3-(7-hydroxy-2-oxo-chromen-3-yl)pyrazol-1-yl]benzoic acid

Conditions

Conditions	Yield
In ethanol at 90℃; for 8h;	75%

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 90-02-8
salicylaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: 3-(1-(3,4-difluorophenyl)-3-methyl-1H-pyrazol-5-yl)-2H-chromen-2-one

Conditions

Conditions	Yield
With eosin In acetonitrile at 20℃; Irradiation;	73%
With 6-methylamino-hexane-1,2,3,4,5-pentaol In ethanol; water Reflux; Green chemistry;	70%

...Expand

: 4-((3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)methoxy)benzaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: (E)-2-((4-((2-(3,4-difluorophenyl)hydrazono)methyl)phenoxy)methyl)-3-methylquinazolin-4(3H)-one

Conditions

Conditions	Yield
With acetic acid In toluene at 120℃; for 24h;	58%

: 2-(2-fluorobenzenesulfonyl)ethyl acetate

: 161886-22-2
3,4-difluorophenyl hydrazine

: (E)-ethyl-2-(2-(3,4-difluorophenyl)hydrazono)-2-((2-fluorophenyl)sulfonyl)acetate

Conditions

Conditions	Yield
Stage #1: 3,4-difluorophenyl hydrazine With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h; Stage #2: 2-(2-fluorobenzenesulfonyl)ethyl acetate With sodium acetate In methanol; water for 2h;	47.1%

: 122-78-1
phenylacetaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: C14H9F2N

Conditions

Conditions	Yield
With PPA for 2h; Heating;

: 161886-22-2
3,4-difluorophenyl hydrazine

: 957055-41-3
C15H11F2N

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: polyphosphoric acid / 2 h / Heating 2: polyphosphoric acid / 2 h / Heating View Scheme

: 161886-22-2
3,4-difluorophenyl hydrazine

: C19H14FNO

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: polyphosphoric acid / 2 h / Heating 2: polyphosphoric acid / 2 h / Heating 3: 80 percent / n-BuLi / diethyl ether / -78 - 20 °C View Scheme

: 161886-22-2
3,4-difluorophenyl hydrazine

: 221031-08-9
4,5-dibromo-2-(3,4-difluorophenyl)-2H-pyridazin-3-one

: 1570-48-5
1-(pyridin-3-yl)propan-1-one

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1246360-94-0
C14H13F2N3

Conditions

Conditions	Yield
In ethanol for 2h; Inert atmosphere; Reflux;

: 75-07-0
acetaldehyde

: 161886-22-2
3,4-difluorophenyl hydrazine

: C8H8F2N2

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 40℃;

: 161886-22-2
3,4-difluorophenyl hydrazine

: C11H11F2NO2

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: trifluoroacetic acid / dichloromethane / 40 °C 2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane 3: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran View Scheme

: 161886-22-2
3,4-difluorophenyl hydrazine

: C20H29F2N3O3S

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: trifluoroacetic acid / dichloromethane / 40 °C 2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane 3: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran 4: methanol; water; lithium hydroxide 5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane View Scheme

: 161886-22-2
3,4-difluorophenyl hydrazine

: 1159094-25-3
C8H7F2N

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 40 °C 2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane View Scheme

: 161886-22-2
3,4-difluorophenyl hydrazine

: C10H9F2NO2

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: trifluoroacetic acid / dichloromethane / 40 °C 2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane 3: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran 4: methanol; water; lithium hydroxide View Scheme

: 161886-22-2
3,4-difluorophenyl hydrazine

: C17H12F2N2O

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium acetate / ethanol / 130 °C / Microwave irradiation 2: trichlorophosphate / 3 h / 80 °C View Scheme

Hydrazine,(3,4-difluorophenyl)- Specification

The Hydrazine,(3,4-difluorophenyl)- is an organic compound with the formula C₆H₆F₂N₂. The systematic name of this chemical is (3,4-Difluorophenyl)hydrazine. With the CAS registry number 161886-22-2, it is also named as (3,4-Difluoro-phenyl)-hydrazine. The product's categories are Halide; Hydrazine. Besides, its molecular weight is 144.12.

Physical properties about Hydrazine,(3,4-difluorophenyl)- are: (1)ACD/LogP: 2.09; (2)ACD/LogD (pH 5.5): 1.94; (3)ACD/LogD (pH 7.4): 2.09; (4)ACD/BCF (pH 5.5): 16.24; (5)ACD/BCF (pH 7.4): 22.84; (6)ACD/KOC (pH 5.5): 231.95; (7)ACD/KOC (pH 7.4): 326.26; (8)#H bond acceptors: 2; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 6.48 Å²; (12)Index of Refraction: 1.579; (13)Molar Refractivity: 34.75 cm³; (14)Molar Volume: 104.4 cm³; (15)Polarizability: 13.77×10^-24 cm³; (16)Surface Tension: 44.3 dyne/cm; (17)Density: 1.379 g/cm³; (18)Flash Point: 81.2 °C; (19)Enthalpy of Vaporization: 44.69 kJ/mol; (20)Boiling Point: 210.7 °C at 760 mmHg; (21)Vapour Pressure: 0.19 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C6H6F2N2/c7-5-2-1-4(10-9)3-6(5)8/h1-3,10H,9H2
(2)InChIKey: KBSCNXDDCDSLLP-UHFFFAOYAO
(3)Std. InChI: InChI=1S/C6H6F2N2/c7-5-2-1-4(10-9)3-6(5)8/h1-3,10H,9H2
(4)Std. InChIKey: KBSCNXDDCDSLLP-UHFFFAOYSA-N

Product Name

3,4-DIFLUOROPHENYLHYDRAZINE

Synthetic route

Hydrazine,(3,4-difluorophenyl)- Specification

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