-
Name
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate
- EINECS
- CAS No. 72590-77-3
- Article Data2
- CAS DataBase
- Density 1.20
- Solubility
- Melting Point 122℃
- Formula C28H40 O7
- Boiling Point 608.9°C at 760 mmHg
- Molecular Weight 488.621
- Flash Point 194.7°C
- Transport Information
- Appearance
- Safety Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. An experimental teratogen. A skin irritant. A steroid. When heated to decomposition it emits toxic fumes. See also HYDROCORTISONE-21-ACETATE; HYDROCORTISONE-17-BUTYRATE; HYDROCORTISONE-21-PHOSPHATE; HYDROCORTISONE SODIUM SUCCINATE.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms 17a-Butyryloxy-11b-hydroxy-21-propionyloxy-4-pregnene-3,20-dione;Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone buteprate;Hydrocortisone probutate; Pandel; TS 408
- PSA 106.97000
- LogP 4.09350
Hydrocortisone buteprate Chemical Properties
Hydrocortisone 17-butyrate 21-propionate(72590-77-3)'s molecular formula is C24H40O7 and its formula weight is 488.613.
Hydrocortisone 17-butyrate 21-propionate(72590-77-3) has a melting point of 122°C.
The molecular structure of hydrocortisone 17-butyrate 21-propionate(72590-77-3):
Hydrocortisone 17-butyrate 21-propionate(72590-77-3) has a melting point of 122°C.
The molecular structure of hydrocortisone 17-butyrate 21-propionate(72590-77-3):
Hydrocortisone buteprate Uses
Used as cortical hormone, it has local anti-inflammatory effect and contraction of blood vessels. Applied to eczema, all kinds of dermatitis, psoriasis, pruritus, insect bites, flat red planus, chronic nummular erythema and so on.
Hydrocortisone buteprate Production
By the reaction of butyric acid hydrocortisone and propanoic anhydride, hydrocortisone butyrate propionate can be obtained.
Hydrocortisone buteprate Toxicity Data With Reference
| 1. | skn-rbt 1000 ppm MLD | YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 9 (1981),3023. | ||
| 2. | orl-rat LD50:5120 mg/kg | JTSCDR Journal of Toxicological Sciences. 6 (Suppl)(1981),1. | ||
| 3. | ipr-rat LD50:1420 mg/kg | JTSCDR Journal of Toxicological Sciences. 6 (Suppl)(1981),1. | ||
| 4. | scu-rat LD50:3260 mg/kg | JTSCDR Journal of Toxicological Sciences. 6 (Suppl)(1981),1. | ||
| 5. | orl-mus LD50:6720 mg/kg | JTSCDR Journal of Toxicological Sciences. 6 (Suppl)(1981),1. | ||
| 6. | ipr-mus LD50:1660 mg/kg | JTSCDR Journal of Toxicological Sciences. 6 (Suppl)(1981),1. | ||
| 7. | scu-mus LD50:1980 mg/kg | JTSCDR Journal of Toxicological Sciences. 6 (Suppl)(1981),1. |
Hydrocortisone buteprate Safety Profile
Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. An experimental teratogen. A skin irritant. A steroid. When heated to decomposition it emits toxic fumes. See also HYDROCORTISONE-21-ACETATE; HYDROCORTISONE-17-BUTYRATE; HYDROCORTISONE-21-PHOSPHATE; HYDROCORTISONE SODIUM SUCCINATE.
Related Products
- Hydrocortisone
- Hydrocortisone 21-hemisuccinate
- Hydrocortisone acetate
- Hydrocortisone buteprate
- Hydrocortisone sodium phosphate
- Hydrocortisone sodium succinate
- Hydrocortisone-17-butyrate
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