Reported in EPA TSCA Inventory.
Hydroxypropyl methyl cellulose (HPMC) is a polymer used for multiple applications in fields such as construction and ophthalmology. With the cas number 9004-65-3, it is also known as hypromellose, which is the international, non-proprietary name (INN) for this substance. The name is not patented by any drug company, and can be used without fear of trademark or copyright infringement. HPMC is a solid substance at room temperature and is typically beige in color.
Physical properties about Hydroxypropyl methyl cellulose are: (1)ACD/LogP: 0.304; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): 0.30; (4)ACD/LogD (pH 7.4): 0.30; (5)#H bond acceptors: 30; (6)#H bond donors: 8; (7)#Freely Rotating Bonds: 48; (8)Flash Point: 619.9 °C; (9)Enthalpy of Vaporization: 183.01 kJ/mol; (10)Boiling Point: 1101.5 °C at 760 mmHg
Preparation of Hydroxypropyl methyl cellulose: Handling refined cotton cellulose by lye at 35-40 °C half an hour,Squeezing to crush cellulose. Suitable for aging at 35 °C, and the average degree of polymerization of alkalic cellulose in the required range. Input alkali fiber to etherification reactor, adding chlorine propylene oxide and methane in turn, etherifying for 5 hours at 50-80 °C.
Uses of Hydroxypropyl methyl cellulose: Hydroxypropyl methyl cellulose (CAS NO.9004-65-3) can be used as synthetic resin, petroleum chemical, ceramics, paper, leather, textile, medicine, food, cosmetics. It also can be used for dispersing agent, thickener, binder excipient, capsules, oil-based paints and other fillers.
You can still convert the following datas into molecular structure:
(1)Smiles=O([C@H]1[C@@H]([C@H]([C@@H](*)O[C@@H]1CO*)O*)O*)[C@H]1[C@@H]([C@H]([C@H](O*)[C@H](O1)CO*)O*)O*;
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999. | |
mammal (species unspecified) | LD50 | oral | > 10gm/kg (10000mg/kg) | Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999. | |
mouse | LD50 | intraperitoneal | 5gm/kg (5000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 112, 1950. | |
rat | LD50 | intraperitoneal | 5200mg/kg (5200mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 112, 1950. |
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