Product Name

  • Name

    Idarubicin

  • EINECS 1806241-263-5
  • CAS No. 58957-92-9
  • Article Data8
  • CAS DataBase
  • Density 1.565 g/cm3
  • Solubility
  • Melting Point
  • Formula C26H27NO9
  • Boiling Point 725.435 °C at 760 mmHg
  • Molecular Weight 497.502
  • Flash Point 392.529 °C
  • Transport Information UN 2811 6.1/PG 2
  • Appearance
  • Safety 53-45
  • Risk Codes 60-61-28-40
  • Molecular Structure Molecular Structure of 58957-92-9 (Idarubicin)
  • Hazard Symbols VeryT+
  • Synonyms 5,12-Naphthacenedione,9-acetyl-7-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-,(7S-cis)-;1-Demethoxydaunorubicin;4-DMD;4-Demethoxydaunomycin;4-Demethoxydaunorubicin;Demethoxydaunorubicin;
  • PSA 176.61000
  • LogP 1.72060

Idarubicin Chemical Properties

IUPAC Name: Idarubicin
The MF of Idarubicin (58957-92-9) is C26H28ClNO9.

              
The MW of Idarubicin (58957-92-9) is 533.95.
Synonyms of Idarubicin (58957-92-9): 11-Trihydroxy-(7s-cis)-alpha-l-lyxo-hexopyranosyl)oxy)- ; 4-Demethoxy-daunomyci  ; 4-Demethoxy-daunorubicin ; 7,8,9,10-Tetrahydro-9-acetyl-7-((3-amino-2,3,6-trideoxy-12-naphthacenedione ; Nsc-256439;(7s-cis)-9-acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione
Product Categories: Active Pharmaceutical Ingredients 
Index of Refraction: 1.705 
Density: 1.56 g/ml 
Flash Point: 392.5 °C
Boiling Point: 725.4 °C 
Storage temp: 2-8 °C
Form: solid

Idarubicin Uses

  Idarubicin (58957-92-9) is used for acute myelogenous leukemia, inhibit tumor growth, anti-breast cancer.

Idarubicin Toxicity Data With Reference

1.    

mmo-sat 2 µg/plate

     ENMUDM    Environmental Mutagenesis. 7 (1985),129.
2.    

dns-rat:lvr 2 mg/L

     CNREA8    Cancer Research. 44 (1984),5599.
3.    

dnd-mus:fbr 1800 nmol/L

     CNREA8    Cancer Research. 37 (1977),4523.
4.    

dnd-mam:lym 200 nmol/L

     BBRCA9    Biochemical and Biophysical Research Communications. 69 (1976),744.
5.    

orl-mus LD50:16 mg/kg

     CTRRDO    Cancer Treatment Reports. 61 (1977),893.
6.    

ipr-mus LD50:3 mg/kg

     CNREA8    Cancer Research. 48 (1988),926.
7.    

ivn-mus LD50:4 mg/kg

     CTRRDO    Cancer Treatment Reports. 61 (1977),893.

Idarubicin Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also DAUNOMYCIN.
Safety information of Idarubicin (58957-92-9):
Hazard Codes  T+
Risk Statements 
60  May impair fertility
61  May cause harm to the unborn child
28  Very Toxic if swallowed
40  Limited evidence of a carcinogenic effect
Safety Statements 
53  Avoid exposure - obtain special instruction before use
45  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  HB7877000

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