Isophosphamide

IUPAC Name: N,2-bis(2-chloroethyl)-1-oxo-6-oxa-2-aza-1λ5-phosphacyclohexan-1-amine 
Molecular Formula:C₇H₁₅Cl₂N₂O₂P
Molecular Weight:261.11g/mol
EINECS: 223-237-3 
Structure of Isophosphamide (CAS NO.3778-73-2):

Index of Refraction: 1.505
Molar Refractivity: 58.09 cm³
Molar Volume: 195.6 cm³
Polarizability: 23.03×10^-24cm³
Surface Tension: 44.3 dyne/cm
Density: 1.33 g/cm³
Flash Point: 157.1 °C
Enthalpy of Vaporization: 57.92 kJ/mol 
Melting Point: 48°C
Boiling Point: 336.1 °C at 760 mmHg
Vapour Pressure: 0.000115 mmHg at 25°C 
Product Categories: Anti-Cancer;Pharmaceutical material and intermeidates;Antibiotics;Intermediates & Fine Chemicals;Pharmaceuticals 
Canonical SMILES: C1CN(P(=O)(OC1)NCCCl)CCCl
InChI: InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
InChIKey: HOMGKSMUEGBAAB-UHFFFAOYSA-N

 Isophosphamide (3778-73-2) can be used as a cytostatic agent, related structurally to cyclophosphamide.

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 , 1981,p. 237.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (ipr); Clear Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-32 ,1977. . EPA Genetic Toxicology Program.

Hazard Codes: T
Risk Statements: 25-36
R25 :Toxic if swallowed. 
R36:Irritating to eyes.
Safety Statements: 26-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 3249
RTECS: RP6050000
HazardClass: 6.1(b)
PackingGroup: III
Suspected carcinogen with experimental carcinogenic and neoplastigenic data. A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion and intravenous routes: nausea or vomiting; proteinuria, hematuria, inflammation, necrosis or scarring of the bladder, and other kidney, ureter, or bladder changes; changes in hair covering the skin; leukopenia (decreased white blood cell count), thrombocytopenia (decrease in the number of blood platelets); hallucinations, distorted perceptions; tumorigenic effects (active as an anti-cancer agent). Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic Cl⁻, NO_x, and PO_x.

  Isophosphamide , its cas register number is 3778-73-2. It also can be called 2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd ; 3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide ; 3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide ; ASTA Z 4942 ; Cyfos ; HSDB 7023 ; Holoxan ; I-Phosphamide ; Ifex ; Ifosfamid ; Ifosfamida ; Ifosfamide ; Ifosfamidum ; Ifsofamide ; Iphosphamid ;
 Iphosphamide ; Isoendoxan ; Isofosfamide ; Mitoxana ; N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-
amine 2-oxide ; N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide ; N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid ; N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German] ; N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide ; N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide ; Naxamide ; UNII-UM20QQM95Y .
 Isophosphamide (CAS NO.3778-73-2) is a crystalline solid.