Isophthalic dihydrazide

The Isophthalic dihydrazide, with the CAS registry number 2760-98-7, is also known as 1,3-Phenylenebiscarbohydrazide. Its EINECS registry number is 220-425-7. This chemical's molecular formula is C₈H₁₀N₄O₂ and molecular weight is 194.19. What's more, its systematic name and IUPAC name are the same which is called Benzene-1,3-dicarbohydrazide. This chemical should be kept airtight in a cool and dry environment.

Physical properties about Isophthalic dihydrazide are: (1)ACD/LogP: -1.45; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.45; (4)ACD/LogD (pH 7.4): -1.45; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 3.86; (8)ACD/KOC (pH 7.4): 3.87; (9)#H bond acceptors: 6; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 47.1 Å²; (13)Index of Refraction: 1.628; (14)Molar Refractivity: 51.3 cm³; (15)Molar Volume: 144.4 cm³; (16)Surface Tension: 66.1 dyne/cm; (17)Density: 1.344 g/cm³; (22)Melting point: 224 °C.

Preparation of Isophthalic dihydrazide: this chemical is prepared by reaction of Isophthalic acid dimethyl ester with Hydrazine hydrate.



The reaction occurs with reagent Hydrazine hydrate at temperature of 65 °C. The yield is 70%.

Uses of Isophthalic dihydrazide: it is used to produce other chemicals. For example, it is used to produce C₂₀H₁₆N₆O₂.



The reaction occurs with solvent Ethanol heating for 0.5 hour. The yield is 92%.

When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes, respiratory system and skin. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And in case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(NN)c1cccc(C(=O)NN)c1
(2) InChI: InChI=1/C8H10N4O2/c9-11-7(13)5-2-1-3-6(4-5)8(14)12-10/h1-4H,9-10H2,(H,11,13)(H,12,14)
(3) InChIKey: UTTHLMXOSUFZCQ-UHFFFAOYAC