-
Name
Ivermectin
- EINECS 274-536-0
- CAS No. 70288-86-7
- Density
- Solubility 4mg/L(temperature not stated)
- Melting Point
- Formula Unspecified
- Boiling Point
- Molecular Weight 875.09300
- Flash Point
- Transport Information
- Appearance White crystalline powder
- Safety 53-26-45-36-36/37-28
- Risk Codes T,Xn
-
Molecular Structure
- Hazard Symbols T,Xn,T+
- Synonyms Ivermectin EP6;
- PSA 170.06000
- LogP 5.60140
Ivermectin Chemical Properties
Ivermectin (22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b) is a broad-spectrum antiparasitic medication. Ivermectin is a mixture of two compounds 22,23-dihydroavermectin B1a and 22,23-dihydroavermectin B1b, which differ by a single ethyl or methyl side group.
Ivermectin Uses
It is traditionally used against worms, but more recently found to be effective against mites and some lice too.
Mectizan is currently being used to help eliminate river blindness (onchocerciasis) in the Americas and stop transmission of lymphatic filariasis around the world. Currently, large amounts of Mectizan are donated by Merck to fight river blindness in countries that are unable to afford the drug.
Ivermectin Toxicity Data With Reference
scu-ctl LDLo:8 mg/kg SCIEAS Science. 221 (1983),823.
The main concern is neurotoxicity, which in most mammalian species may manifest as CNS depression, and consequent ataxia, as might be expected from potentiation of inhibitory GABA-ergic synapses.
Ivermectin Safety Profile
Poison by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.
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