L(-)-Carnitine supplier | CasNO.541-15-1

Name
L-carnitine
EINECS 208-768-0
CAS No. 541-15-1
Article Data66
CAS DataBase
Density 0.64 g/cm3
Solubility 0.1 g/mL at 20 °C in water
Melting Point 197-212 °C(lit.)
Formula C₇H₁₅NO₃
Boiling Point 287.5°C (rough estimate)
Molecular Weight 161.201
Flash Point
Transport Information
Appearance white crystalline powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Vitamin BT;Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L- (8CI);(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate;(2S)-3-carboxylato-2-hydroxy-N,N,N-trimethylpropan-1-aminium;(S)-carnitine;1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-;Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide,inner salt;Levocarnitine (USP);L-carnitine(VBt);Car-OH;L-Carnitine Base(Usp29);Carnitor (TN);(3S)-3-hydroxy-4-trimethylammonio-butanoate;Carniking 50;(3R)-3-hydroxy-4-trimethylammonio-butanoate;(R)-Carnitine;L-gamma-trimethyl-beta-hydroxybutyrobetaine;1-Propanaminium,3-carboxy-2-hydroxy-N,N,- N-trimethyl-,inner salt,(2R)-;L-Carnitine EP/USP;L-Carnitine Base (Vitamine BT);L-Carnitine base USP;R-(-)-3-hydroxy-4-trimethylaminobutyrate;L-carnitine;
PSA 60.36000
LogP -1.80650

Synthetic route

: 5261-99-4, 6490-19-3, 6490-20-6, 67942-00-1
(R)-(-)-carnitinamide chloride

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
Stage #1: (R)-(-)-carnitinamide chloride With hydrogenchloride; water at 80℃; for 8h; Stage #2: With sodium hydroxide In water Product distribution / selectivity;	99.4%

: (R)-Carnitin-Lacton

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With Amberlite IRA-402; sodium hydrogencarbonate for 24h; Ambient temperature;	99%
With sodium hydrogencarbonate In water for 20h; Ambient temperature; Yield given;

: 10488-69-4, 86728-85-0, 87068-18-6, 90866-33-4
ethyl (L)-4-chloro-3-hydroxybutyrate

: 75-50-3
trimethylamine

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In water at 15℃; under 4500.45 Torr; for 0.13h; Temperature; Pressure;	97.6%
With sodium hydroxide In water at -5 - 20℃; for 13h; Reagent/catalyst; Temperature;	88.4%
With sodium hydroxide In water at 0℃; for 3h; Product distribution / selectivity;	75%
Stage #1: ethyl (L)-4-chloro-3-hydroxybutyrate; trimethylamine In water at 80 - 90℃; for 3h; Stage #2: With hydrogenchloride; water at 80 - 90℃; for 2h; Stage #3: In water	43%
With water; sodium hydroxide at 0℃; Green chemistry;	8.9 g

: 133039-08-4
Toluene-4-sulfonate((R)-3-carboxy-2-hydroxy-propyl)-trimethyl-ammonium;

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
by ion exchange;	95%

: 2788-28-5
(2R)-(-)-3-cyano-2-hydroxypropyltrimethylammonium chloride

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With hydrogenchloride at 50 - 75℃; for 6h;	93%
With hydrogenchloride In methanol at 65℃; for 2h;	82.3%
Stage #1: (2R)-(-)-3-cyano-2-hydroxypropyltrimethylammonium chloride With hydrogenchloride; water at 70 - 80℃; for 5h; Stage #2: With ammonia at 20℃; Product distribution / selectivity;	75.4%

: 461-06-3
CARNITINE

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
In ethanol; acetone at 20 - 65℃; Purification / work up; Resolution of enantiomers;	88.6%

: 95574-97-3
(R)-(-)-4-chloro-3-hydroxybutanoic acid

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With triethylamine In methanol at 45℃; for 10h;	85.3%

: 40915-13-7
(R)-(3-ethoxycarbonyl-2-hydroxy-propyl)-trimethyl-ammonium; chloride

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With sodium hydroxide for 10h; Time; Reflux;	81.6%

: (2R)-(3-cyano-2-hydroxypropyl)trimethylammonium bromide

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With hydrogenchloride at 90℃; for 4h; Hydrolysis;	80%

: (S)-3-nitriloxy-carnitine nitrate

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water at 80℃; for 9h;	70.2%
With sodium hydrogencarbonate In water at 60 - 80℃; for 8 - 66h;	n/a
With sodium hydrogencarbonate In water at 60℃; for 66h;	n/a
With potassium hydrogencarbonate In water at 80℃; for 8h;

: methanesulfonyl D-carnitine

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With CH3SO3H In water	66%

: 139714-48-0
5-amino-3,5-dideoxy-N,N,N-trimethyl-L-threo-pentonic acid

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With potassium permanganate; sulfuric acid	62%

: 1192-71-8
chlorosuccinic anhydride

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
Stage #1: chlorosuccinic anhydride With sodium tetrahydroborate In tetrahydrofuran at 0℃; for 8h; Stage #2: With sodium hydroxide In tetrahydrofuran; water Stage #3: With hydrogenchloride; trimethylamine more than 3 stages;	60.4%

: 139714-44-6
N,N,N-trimethyl-1-amino-1,3-dideoxy-D-xylo-hexitol iodide

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With potassium permanganate; sulfuric acid for 0.166667h;	58%

: sodium (R)-3,4-epoxybutyrate

: 121-44-8
triethylamine

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
In water at 45℃; for 2h;	55%

: 1-methyl hydrogen 2-chlorosuccinate

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With lithium borohydride at -15℃; for 22h;	55%

: 111618-88-3
dimethyl (2R)-chlorobutanedioate

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With lithium borohydride at -15℃; for 22h;	53%

: 95310-94-4, 32224-01-4, 95537-36-3, 128052-98-2
(R)-(+)-4-bromo-3-hydroxybutyric acid ethyl ester

: 75-50-3
trimethylamine

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
	50%
With water; potassium hydroxide at 0℃; Green chemistry;	10 g

: 4198-33-8
(2S)-chlorobutanedioic acid

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
Stage #1: (2S)-chlorobutanedioic acid With borane-THF at -15℃; for 22h; Stage #2: In water for 3h; Stage #3: With sodium hydroxide; trimethylamine more than 3 stages;	50%

: 2-chlorosuccinoyldichloride

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With sodium tetrahydroborate at -15℃; for 22h;	45%

(S)-methane-sulphonyloxysuccinic Acid: (S)-methane-sulphonyloxysuccinic Acid

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With borane-THF at -15℃; for 22h;	40%

: (R)-4-Bromo-3-hydroxy-butyric acid heptyl ester

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With trimethylamine

: 90835-93-1
(R)-4-Bromo-3-hydroxy-butyric acid octyl ester

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With trimethylamine

: 90835-94-2
(R)-4-Bromo-3-hydroxy-butyric acid benzyl ester

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With trimethylamine

: (R)-4-Bromo-3-hydroxy-butyric acid phenethyl ester

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With trimethylamine

: 61809-71-0
(R)-(2-hydroxy-3-methoxycarbonyl-propyl)-trimethyl-ammonium; chloride

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
acid hydrolysis;

: 95310-93-3
(R)-3-Acetoxy-4-bromo-butyric acid ethyl ester

: 75-50-3
trimethylamine

A: 541-15-1
L-carnitine

B: 6778-30-9
(E)-4-(trimethylammonio)but-2-enoate

Conditions

Conditions	Yield
In water

...Expand

: 172585-00-1
(R)-norcarnitine

: 74-88-4
methyl iodide

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With silver(l) oxide 1.) acetone, RT, 18 h, 2.) methanol, water, RT, 18 h; Yield given. Multistep reaction;

: ((R)-2-Hydroxy-pent-4-enyl)-trimethyl-ammonium; hydroxide

: 541-15-1
L-carnitine

Conditions

Conditions	Yield
With dihydrogen peroxide; ozone; acetic acid 1.) RT, 1 h, 2.) 70 deg C, 24 h; Yield given. Multistep reaction;

: 541-15-1
L-carnitine

: L(-)-carnitine acid fumarate

Conditions

Conditions	Yield
With (2E)-but-2-enedioic acid In water at 110 - 120℃; for 0.0166667 - 0.0333333h;	100%

: 541-15-1
L-carnitine

: L-carnitine tartrate

Conditions

Conditions	Yield
With L-Tartaric acid In water	100%

: 541-15-1
L-carnitine

: [3H]-Phytic acid

: L-carnitine phytate

Conditions

Conditions	Yield
In water at 20℃; pH=~ 4;	100%

: 541-15-1
L-carnitine

: myo-inositol 1,2,3,4,5,6-hexakisphosphate

: L-carnitine phytate

Conditions

Conditions	Yield
In water at 20℃; for 0.583333h;	100%

: 59-67-6
nicotinic acid

: 541-15-1
L-carnitine

: (R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium nicotinate

Conditions

Conditions	Yield
In water for 0.166667h; pH=Ca. 3.3 - 3.9; Cooling with ice;	100%

: 112-71-0
1-Bromotetradecane

: 541-15-1
L-carnitine

: (4-tetradecyloxy-2-hydroxy-4-oxobutyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 24h;	99%

: 541-15-1
L-carnitine

: 3184-13-2
L-ornithine hydrochloride

: acetyl L-carnitine L-ornithate dihydrochloride

Conditions

Conditions	Yield
In water at 40℃;	96%

: 65-86-1
orotic acid

: 541-15-1
L-carnitine

: L-carnitine oroate

Conditions

Conditions	Yield
In water; acetone for 5h; Solvent; Reflux;	96%

: 112-16-3
n-dodecanoyl chloride

: 541-15-1
L-carnitine

: lauroyl-L-carnitine hydrochloride

Conditions

Conditions	Yield
With acetic acid at 70℃; for 8h; Temperature;	95.8%

: 541-15-1
L-carnitine

: 57-00-1
Creatinine

: L-carnitine creatinate phosphate

Conditions

Conditions	Yield
With phosphoric acid In 2-methyl-propan-1-ol; water at 40℃;	95%

: 541-15-1
L-carnitine

: 81-04-9
naphthalene-1,5-disulfonate

: L-carnitine 1,5-naphthalenedisulfonate

Conditions

Conditions	Yield
In water; isopropyl alcohol at 20 - 25℃; for 2h; Solvent; Temperature;	95%

: 541-15-1
L-carnitine

: 143-15-7
1-dodecylbromide

: (4-dodecyloxy-2-hydroxy-4-oxobutyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 24h;	95%

: 541-15-1
L-carnitine

: 112-82-3
hexadecanyl bromide

: (4-hexadecyloxy-2-hydroxy-4-oxobutyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 72h;	95%

: 541-15-1
L-carnitine

: 112-89-0
1-Bromooctadecane

: (4-octadecyloxy-2-hydroxy-4-oxobutyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 72h;	95%

: 14104-20-2
silver tetrafluoroborate

: 61848-66-6
(1R,2R)-1,2-diaminocyclohexanedichloroplatinum(II)

: 541-15-1
L-carnitine

: [Pt(L-carnitine-O)2((1R,2R)-(-)-1,2-diaminocyclohexane)2](BF4)2

Conditions

Conditions	Yield
Stage #1: silver tetrafluoroborate; (1R,2R)-1,2-diaminocyclohexanedichloroplatinum(II) In water for 0.166667h; Stage #2: L-carnitine In water for 24h;	94%

...Expand

: 67127-78-0
3-acetyl-2-hydroxybenzoic acid

: 541-15-1
L-carnitine

: L-carnitine acetylsalicylate

Conditions

Conditions	Yield
In ethanol	93%

: 112-29-8
1-bromo dodecane

: 541-15-1
L-carnitine

: (4-decyloxy-2-hydroxy-4-oxobutyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 16h;	93%

: 14104-20-2
silver tetrafluoroborate

: 61848-66-6
(1R,2R)-1,2-diaminocyclohexanedichloroplatinum(II)

: 541-15-1
L-carnitine

: [PtCl(L-carnitine-O)((1R,2R)-(-)-1,2-diaminocyclohexane)]BF4

Conditions

Conditions	Yield
Stage #1: silver tetrafluoroborate; (1R,2R)-1,2-diaminocyclohexanedichloroplatinum(II) In water for 0.166667h; Stage #2: L-carnitine In water for 24h;	92%

...Expand

: 111-83-1
1-bromo-octane

: 541-15-1
L-carnitine

: (4-octyloxy-2-hydroxy-4-oxobutyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 16h;	92%

: 24274-48-4
cannabidivarin

: 541-15-1
L-carnitine

: C19H26O2*C7H15NO3

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃;	91%

: 541-15-1
L-carnitine

: 123-62-6
propionic acid anhydride

: propionyl-L-carnitine nitrate

Conditions

Conditions	Yield
Stage #1: L-carnitine; propionic acid anhydride With pyridine; potassium hydroxide at 80℃; for 1h; Stage #2: With nitric acid at 30℃; for 2h;	90.3%

: 62-54-4
calcium acetate

: 541-15-1
L-carnitine

: L-carnitine calcium acetate

Conditions

Conditions	Yield
In water for 2h;	90%

: calcium hydroxide

: 541-15-1
L-carnitine

: 107-92-6
butyric acid

: L-carnitine calcium butyrate

Conditions

Conditions	Yield
In methanol; water at 20℃; for 4.25h;	90%

...Expand

: 4075-81-4
calcium propionate

: 541-15-1
L-carnitine

: L-carnitine calcium propionate

Conditions

Conditions	Yield
In water for 0.25h;	90%

: 541-15-1
L-carnitine

: 67605-64-5
5-(4-aminophenyl)-10,15,20-triphenylporphyrin

: 5-(3-hydroxy-p-(4-trimethylammonium)butoxyphenyl)-10,15,20-triphenylporphyrin chlorine

Conditions

Conditions	Yield
Stage #1: L-carnitine With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethanol; dichloromethane at 20℃; for 0.5h; Stage #2: 5-(4-aminophenyl)-10,15,20-triphenylporphyrin With triethylamine In ethanol; dichloromethane for 4h;	89%

L(-)-Carnitine Chemical Properties

Following is the structure:

Molecular Formula: C₇H₁₅NO₃
Molecular Weight: 161.199 g/mol
IUPAC Name: (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate
Synonyms of L-Carnitine (CAS NO.541-15-1): (R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide ; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, (R)- ; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (R)- ; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L- ; Carnitine
CAS number: 541-15-1
refractive index: -32 ° (C=1, H₂O)
Merck: 14,1849
BRN: 4292315
Storage temp.: 2-8 °C
Melting point: 208-212 °C
alpha -31 º (c=10, H2O)
Water solubility of L-Carnitine (CAS NO.541-15-1): 2500 g/L (20 °C)
Appearance of L-Carnitine (CAS NO.541-15-1): White crystalline
Canonical SMILES: C[N+](C)(C)CC(CC(=O)[O-])O
Isomeric SMILES: C[N+](C)(C)C[C@@H](CC(=O)[O-])O
InChI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
InChIKey: PHIQHXFUZVPYII-ZCFIWIBFSA-N

L(-)-Carnitine History

L-Carnitine (CAS NO.541-15-1) was originally found as a growth factor for mealworms and labeled vitamin Bt.

L(-)-Carnitine Uses

The use of L-Carnitine (CAS NO.541-15-1) showed some promise in a controlled trial in selected cases of male infertility improving sperm quality.L-Carnitine improved glucose disposal among 15 patients with type II diabetes and 20 healthy volunteers.It is essential cofactor of fatty acid metabolism, and it is required for the transport of fatty acids through the inner mitochondrial membrane. It is synthetized primarily in the liver and kidney, and it highest concentrations found in heart and skeletal muscle.

L(-)-Carnitine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	unreported	7gm/kg (7000mg/kg)		Cancer Treatment Reports. Vol. 63, Pg. 558, 1979.
mouse	LD50	intraperitoneal	750mg/kg (750mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
mouse	LD50	subcutaneous	9gm/kg (9000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Acta Biologica et Medica Germanica. Vol. 35, Pg. 645, 1976.

L-Carnitine (CAS NO.541-15-1) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.

L(-)-Carnitine Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 3
RTECS: BP2980000
F: 3-10
Hazard Note: Irritant
HS Code: 29239000

L(-)-Carnitine Specification

In animals, carnitine is biosynthesized primarily in the liver and kidneys from the amino acids lysine or methionine.Carnitine transports long-chain acyl groups from fatty acids into the mitochondrial matrix. L-Carnitine (CAS NO.541-15-1) products and supplements are not allowed to be imported into Canada (Health Canada). It is stable under normal temperatures and pressures, and it absorbs moisture or water from the air. It should avoid the condition like incompatible materials, exposure to moist air or water. while, it is incompatibilities with other materials strong oxidizing agents. Its hazardous decomposition products are carbon monoxide, oxides of nitrogen oxides, carbon monoxide, carbon dioxide. And its hazardous polymerization will not occur.

Product Name

L-carnitine

Synthetic route

L(-)-Carnitine Chemical Properties

L(-)-Carnitine History

L(-)-Carnitine Uses

L(-)-Carnitine Toxicity Data With Reference

L(-)-Carnitine Safety Profile

L(-)-Carnitine Specification

Related Products

Hot Products