L-(+)-Glutamic acid hydrochloride supplier

Name
L-(+)-Glutamic acid hydrochloride
EINECS 205-315-9
CAS No. 138-15-8
Article Data9
CAS DataBase
Density 1.525
Solubility water: 490 g/L (20 °C), hardly soluble in ethanol, ethyl ether
Melting Point 214 °C (dec.)(lit.)
Formula C₅H₉NO₄^.HCl
Boiling Point 333.8 °C at 760 mmHg
Molecular Weight 183.592
Flash Point 155.7 °C
Transport Information UN 1789 8/PG 3
Appearance White crystalline powder
Safety 26-39
Risk Codes 41
Molecular Structure
Hazard Symbols Xi
Synonyms Glutamicacid, hydrochloride, L- (7CI,8CI);2-Aminopentanedioic acid hydrochloride;Acidogen;Acidoride;Acidulen;Acidulin;Aclor;Acridogen;Antalka;Gastuloric;Glusatin;Glutamic acid, L-, hydrochloride;Glutamidin;L-Glutamic acid monohydrochloride;Glutasin;Hypochylin;
PSA 100.62000
LogP 0.76540

Synthetic route

: 2709-66-2
Dicyclohexylammonium-<(S)-4-ethoxycarbonyl-4-(trifluoracetylamino)butanoat>

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water for 2h; Heating;	90%

: 72-19-5, 80-68-2, 144-98-9, 632-20-2, 2676-21-3, 7004-04-8, 24830-94-2, 28954-12-3, 36676-50-3
DL-threonine

A: 138-15-8
l-glutamic acid hydrochloride

B: 617-61-8
D-glutamic acid hydrochloride

Conditions

Conditions	Yield
With poly-(Nε-methacryloyl-(S)-lysine) In water at 25℃; for 7h; Product distribution; var. polymer, time;

: 15767-75-6
DL-glutamic acid hydrochloride

: 138-15-8
l-glutamic acid hydrochloride

: 15767-75-6
DL-glutamic acid hydrochloride

A: 138-15-8
l-glutamic acid hydrochloride

B: 617-61-8
D-glutamic acid hydrochloride

Conditions

Conditions	Yield
With poly-(Nε-methacryloyl-(S)-lysine) In water at 25℃; for 7.5h; Product distribution; var. polymer, time;

: 75857-93-1
(2S)–N-acetyl-5-oxoproline methyl ester

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 75866-42-1
methyl L-1-propionyl-5-oxoprolinate

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 75866-43-2
methyl L-1-cyclohexanecarbonyl-5-oxo-prolinate

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 75857-94-2
(5S)-N-(benzyloxycarbonyl)-5-methoxycarbonyl-2-pyrrolidinone

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 17342-08-4
(S)-Pyroglutaminol

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; oxygen; sodium hydrogencarbonate; platinum 1.) H2O, 2.) reflux, 6 h; Yield given. Multistep reaction;

: 4(R)-t-butoxycarbonyl-4-aminobutyric acid methyl ester

A: 138-15-8
l-glutamic acid hydrochloride

B: 617-61-8
D-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride for 12h; Heating; Yield given. Yields of byproduct given;

: 4931-66-2
methyl (S)-pyroglutamate

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 75 percent / NaBH4 / ethanol / 2 h / Ambient temperature 2: 1.) NaHCO3, O2, 2.) 10percent HCl / 1.) Pt / 1.) H2O, 2.) reflux, 6 h View Scheme

: 98-79-3
L-Pyroglutamic acid

natrium carbonate: natrium carbonate

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 93 percent / thionyl chloride / 3 h / Ambient temperature 2: 75 percent / NaBH4 / ethanol / 2 h / Ambient temperature 3: 1.) NaHCO3, O2, 2.) 10percent HCl / 1.) Pt / 1.) H2O, 2.) reflux, 6 h View Scheme

: 75857-91-9
(S)-methyl 1-(propionyl)pyrrolidine-2-carboxylate

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / Sodium metaperiodate, ruthenium dioxide / CHCl3; H2O / 69 h / Ambient temperature; two phase system 2: 6 N HCl View Scheme

: 75857-92-0
methyl L-1-cyclohexanecarbonylprolinate

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / Sodium metaperiodate, ruthenium dioxide / CCl4; H2O / 22 h / Ambient temperature; two phase system 2: 6 N HCl View Scheme

: 5211-23-4
N-carbobenzyloxy-L-proline methyl ester

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 54 percent / Sodium metaperiodate, ruthenium dioxide / CCl4; H2O / 57 h / Ambient temperature; two phase system 2: 6 N HCl View Scheme

: 914606-75-0
micropeptin MZ845

A: 473-81-4, 600-19-1, 6000-40-4, 28305-26-2
D-glyceric acid

B: 138-15-8
l-glutamic acid hydrochloride

C: 1119-34-2
L-arginine hydrochloride

D: 66866-67-9
N-methyl-L-phenylalanine hydrochloride

E: 17694-98-3
L-isoleucine hydrochloride

F: 60143-52-4, 71264-40-9, 82650-07-5, 97347-46-1, 100157-61-7
L-threonine methyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: micropeptin MZ845 With Jones reagent In acetone at 0℃; for 0.166667h; Stage #2: With hydrogenchloride; water at 110℃; for 16h; Sealed glass bomb;

...Expand

: 1207348-70-6
micropeptin MZ859

A: 473-81-4, 600-19-1, 6000-40-4, 28305-26-2
D-glyceric acid

B: 138-15-8
l-glutamic acid hydrochloride

C: 1119-34-2
L-arginine hydrochloride

D: 66866-67-9
N-methyl-L-phenylalanine hydrochloride

E: 17694-98-3
L-isoleucine hydrochloride

F: 60143-52-4, 71264-40-9, 82650-07-5, 97347-46-1, 100157-61-7
L-threonine methyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: micropeptin MZ859 With Jones reagent In acetone at 0℃; for 0.166667h; Stage #2: With hydrogenchloride; water at 110℃; for 16h; Sealed glass bomb;

...Expand

: 1207348-72-8
micropeptin MZ939A

A: 473-81-4, 600-19-1, 6000-40-4, 28305-26-2
D-glyceric acid

B: 138-15-8
l-glutamic acid hydrochloride

C: 1119-34-2
L-arginine hydrochloride

D: 66866-67-9
N-methyl-L-phenylalanine hydrochloride

E: 17694-98-3
L-isoleucine hydrochloride

F: 60143-52-4, 71264-40-9, 82650-07-5, 97347-46-1, 100157-61-7
L-threonine methyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: micropeptin MZ939A With Jones reagent In acetone at 0℃; for 0.166667h; Stage #2: With hydrogenchloride; water at 110℃; for 16h; Sealed glass bomb;

...Expand

: 1207348-74-0
micropeptin MZ925

A: 473-81-4, 600-19-1, 6000-40-4, 28305-26-2
D-glyceric acid

B: 138-15-8
l-glutamic acid hydrochloride

C: 1119-34-2
L-arginine hydrochloride

D: 66866-67-9
N-methyl-L-phenylalanine hydrochloride

E: 17694-98-3
L-isoleucine hydrochloride

F: 60143-52-4, 71264-40-9, 82650-07-5, 97347-46-1, 100157-61-7
L-threonine methyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: micropeptin MZ925 With Jones reagent In acetone at 0℃; for 0.166667h; Stage #2: With hydrogenchloride; water at 110℃; for 16h; Sealed glass bomb;

...Expand

: 1207348-76-2
micropeptin MZ939B

A: 473-81-4, 600-19-1, 6000-40-4, 28305-26-2
D-glyceric acid

B: 138-15-8
l-glutamic acid hydrochloride

C: 1119-34-2
L-arginine hydrochloride

D: 66866-67-9
N-methyl-L-phenylalanine hydrochloride

E: 17694-98-3
L-isoleucine hydrochloride

F: 60143-52-4, 71264-40-9, 82650-07-5, 97347-46-1, 100157-61-7
L-threonine methyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: micropeptin MZ939B With Jones reagent In acetone at 0℃; for 0.166667h; Stage #2: With hydrogenchloride; water at 110℃; for 16h; Sealed glass bomb;

...Expand

: 1207348-78-4
micropeptin MZ1019

A: 473-81-4, 600-19-1, 6000-40-4, 28305-26-2
D-glyceric acid

B: 138-15-8
l-glutamic acid hydrochloride

C: 1119-34-2
L-arginine hydrochloride

D: 66866-67-9
N-methyl-L-phenylalanine hydrochloride

E: 17694-98-3
L-isoleucine hydrochloride

F: 60143-52-4, 71264-40-9, 82650-07-5, 97347-46-1, 100157-61-7
L-threonine methyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: micropeptin MZ1019 With Jones reagent In acetone at 0℃; for 0.166667h; Stage #2: With hydrogenchloride; water at 110℃; for 16h; Sealed glass bomb;

...Expand

: 1207348-80-8
micropeptin MZ771

A: 138-15-8
l-glutamic acid hydrochloride

B: 1119-34-2
L-arginine hydrochloride

C: 66866-67-9
N-methyl-L-phenylalanine hydrochloride

D: 17694-98-3
L-isoleucine hydrochloride

E: 60143-52-4, 71264-40-9, 82650-07-5, 97347-46-1, 100157-61-7
L-threonine methyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: micropeptin MZ771 With Jones reagent In acetone at 0℃; for 0.166667h; Stage #2: With hydrogenchloride; water at 110℃; for 16h; Sealed glass bomb;

...Expand

: 212121-62-5
(S)-1-tert-butyl 5-methyl 2-((diphenylmethylene)amino)pentanedioate

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water for 12h; Reflux;

: 56-86-0
L-glutamic acid

: 138-15-8
l-glutamic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 0 - 10℃; for 0.25h;

: 50-00-0
formaldehyd

: 74038-18-9
di-n-decylphosphine oxide

: 138-15-8
l-glutamic acid hydrochloride

: (S)-N,N-bis[(didecylphosphoryl)methyl]glutamic acid

Conditions

Conditions	Yield
With hydrogenchloride In water; acetonitrile for 3h; Reflux;	93%

...Expand

: 75-15-0
carbon disulfide

: 138-15-8
l-glutamic acid hydrochloride

: 3926-62-3
sodium monochloroacetic acid

: (S)-2-(4-oxo-2-thioxothiazolidin-3-yl)pentanedioic acid

Conditions

Conditions	Yield
Stage #1: carbon disulfide; l-glutamic acid hydrochloride With sodium hydroxide In water at 100℃; for 0.0833333h; Microwave irradiation; Stage #2: sodium monochloroacetic acid In water at 40 - 100℃; for 0.0833333h; Microwave irradiation;	89%

...Expand

: 138-15-8
l-glutamic acid hydrochloride

: 107-19-7
propargyl alcohol

: 1204576-45-3
γ-propargyl-L-glutamic acid hydrochloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane at 0 - 20℃; for 49h; Inert atmosphere;	66%

: 540-88-5
acetic acid tert-butyl ester

: 138-15-8
l-glutamic acid hydrochloride

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

Conditions

Conditions	Yield
With perchloric acid for 48h; Ambient temperature;	40%

: 138-15-8
l-glutamic acid hydrochloride

: 4-((3-(4-(((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl)prop-2-yn-1-yl)amino)-3-methoxybenzoic acid

: (4-((3-(4-(((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl)prop-2-yn-1-yl)amino)-3-methoxybenzoyl)-L-glutamic acid

Conditions

Conditions	Yield
Stage #1: 4-((3-(4-(((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl)prop-2-yn-1-yl)amino)-3-methoxybenzoic acid With triethylamine; HATU In N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: l-glutamic acid hydrochloride In N,N-dimethyl-formamide at 50℃; for 2h; Stage #3: With sodium hydroxide In water; N,N-dimethyl-formamide at 50℃; for 0.5h;	31.8%

: 138-15-8
l-glutamic acid hydrochloride

: 110-15-6
succinic acid

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 80-97-7
Cholestanol

: 138-15-8
l-glutamic acid hydrochloride

: L-Glutaminsaeure-dicholestanolester

Conditions

Conditions	Yield
With quinoline; hydrogenchloride

: 64-17-5
ethanol

: 138-15-8
l-glutamic acid hydrochloride

: 62-53-3
aniline

dextrorotatory α-amino-glutaric acid: dextrorotatory α-amino-glutaric acid

...Expand

: 64-17-5
ethanol

: 138-15-8
l-glutamic acid hydrochloride

water: water

dextrorotatory α-amino-glutaric acid: dextrorotatory α-amino-glutaric acid

...Expand

: 67-56-1
methanol

: 138-15-8
l-glutamic acid hydrochloride

: 23150-65-4
L-glutamic dimethyl ester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 20℃; for 23.5h;	650.8 g
With thionyl chloride at 0 - 20℃; for 25.5h;

L-(+)-Glutamic acid hydrochloride Specification

The L-(+)-Glutamic acid hydrochloride, with the CAS registry number 138-15-8, is also known as Glutamic acid, L-, hydrochloride. It belongs to the product categories of alpha-Amino Acids; Amino Acids; Biochemistry. Its EINECS number is 205-315-9. This chemical's molecular formula is C₅H₉NO₄^.HCl and molecular weight is 183.59. What's more, its systematic name is L-Glutamic acid hydrochloride (1:1). Its classification code is Gastric acidifier. This chemical is a non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the central nervous system. It can be prepared by fermentation. It is used as fumet, nutrient, and dietary supplement.

Physical properties of L-(+)-Glutamic acid hydrochloride are: (1)ACD/LogP: -1.435; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -4.70; (4)ACD/LogD (pH 7.4): -4.93; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 5; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 55.84 Å²; (13)Flash Point: 155.7 °C; (14)Enthalpy of Vaporization: 63.39 kJ/mol; (15)Boiling Point: 333.8 °C at 760 mmHg; (16)Vapour Pressure: 2.55E-05 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemcial has a risk of serious damage to eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)CC[C@H](N)C(=O)O.Cl
(2)Std. InChI: InChI=1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1
(3)Std. InChIKey: RPAJSBKBKSSMLJ-DFWYDOINSA-N

Product Name

L-(+)-Glutamic acid hydrochloride

Synthetic route

L-(+)-Glutamic acid hydrochloride Specification

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