L(+)-Ascorbic acid supplier

Name
L(+)-Ascorbic acid
EINECS 200-066-2
CAS No. 50-81-7
Article Data151
CAS DataBase
Density 1.954 g/cm³
Solubility Water solubility: 50 mg/mL at 20 °C, clear, nearly colorless
Melting Point 190-194 °C (dec.)
Formula C₆H₈O₆
Boiling Point 415.8 °C at 760 mmHg
Molecular Weight 176.126
Flash Point 180.4 °C
Transport Information
Appearance white crystals
Safety 24/25-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms L(+)-Ascorbic acid;L-Ascorbic acid（C);(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one;L-Ascorbic acid;L-Threoascorbic acid,Antiscorbutic factor,Vitamin C;L-Ascorbic Acid;
PSA 107.22000
LogP -1.40740

Synthetic route

: 18467-77-1
dikegulac

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride In toluene at 70℃; for 6h;	94%
With hydrogenchloride; glycerol monostearate In Trichloroethylene at 50℃; for 0.0833333h; Kinetics; other temperatures, other times;

: 62983-44-2
6-bromo-6-deoxy-(S)-ascorbic acid

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With sodium carbonate In water for 25h; Ambient temperature;	89%
With sodium carbonate In water-d2 for 21h; pH: 9;

: 144447-58-5
methyl 2-keto-3,5:4,6-di-O-ethylidene galactonate

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride; ethanol In dichloromethane at 60℃;	83%

: Methyl 2-keto-3,5:4,6-di-O-ethylidene-L-galactonate

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; dichloromethane at 60℃; for 10h;	83%

: 74600-79-6
ethyl-3,5:4,6-di-O-methylene-L-lyxo-2-hexulosenate

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 4h; Heating;	81.09%

: 377089-24-2
(S)-4-[3,4-Bis-(4-methoxy-benzyloxy)-furan-2-yl]-2,2-dimethyl-[1,3]dioxolane

A: 123-11-5
4-methoxy-benzaldehyde

B: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With oxygen In methanol; tetrachloromethane at 20℃; for 7h; Photolysis;	A n/a B 74%

: 21675-47-8
D-xylo-2-hexulosonic acid

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
In water at 160℃; under 7500.75 Torr;	68%

: L-xylo-[2]hexulosonic acid amide

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With methanol; ammonia

: 3445-23-6
L-xylosone

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With potassium cyanide; hydrogen cyanide; water anschl. mit wss. HCl;
With potassium cyanide; water anschl. mit wss. HCl;
With hydrogen cyanide; ammonia; water anschl. mit wss. HCl;
With potassium cyanide; water; calcium chloride anschl. mit wss. HCl;
With potassium cyanide; water anschl. mit wss. HCl;

: 526-98-7
2-keto-L-gulonic acid

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride; water; butan-1-ol
With water at 100℃;
With hydrogenchloride; water

: 91548-32-2
L-lyxo-[2]hexulosonic acid

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride; ethanol
With diazomethane; methanol; diethyl ether anschl. mit Blei(II)-acetat;

: 1071558-27-4
(3R,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxo-hexanoic acid methyl ester

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With ethanol; triethylamine
With methanol; water
With methanol; sodium hydrogencarbonate

: 144-62-7
oxalic acid

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With potassium bromate; cerium (IV) sulfate In sulfuric acid Belousov-Zhabotinski oscillation reaction;

: 143916-28-3
methyl 2,5-di-O-acetyl-α-L-lyxo-hex-2-ulopyranosonate

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium methylate 1.) MeOH, 20 min, room temperature; Yield given. Multistep reaction;

: 85366-67-2
5,6-anhydro-L-ascorbic acid

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With water; sodium hydrogencarbonate; sodium carbonate at 24℃; pH: 8; variation of time;

: C46H34O32

A: 60976-49-0
geraniin

B: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
for 3h; oxidative metabolizm; enzyme from fresh leaves and stems of Geranium thunbergii;

: 490-83-5
L-dehydroascorbic acid

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With potassium bromate; cerium (IV) sulfate In sulfuric acid Belousov-Zhabotinski oscillation reaction;
With isoascorbic acid In phosphate buffer at 20℃; for 24h; pH=7.4; Product distribution; Reduction;
With ethylenediaminetetraacetic acid; water; tris-(2-carboxyethyl)-phosphine hydrochloride; meta-phosphoric acid for 4h; pH=1.5; Cooling with ice;
With phosphoric acid In water at 25℃; for 0.5h; Darkness;

: 490-83-5
L-dehydroascorbic acid

A: Red Pigment

B: Reduced Red Pigment

C: Tris(2-deoxy-2-L-ascorbyl)amine

D: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With Phenylalanine In ethanol for 0.333333h; Product distribution; Mechanism; Heating; other times, other amino acids; also in the presence of ascorbic acid;

...Expand

: 5a-tocopheryl ascorbate

A: 758720-42-2
α‑tocopherol quinone

B: 18920-63-3
vitamin E

C: C58H96O4

D: 50-81-7
ascorbic acid

E: 490-83-5
L-dehydroascorbic acid

Conditions

Conditions	Yield
With water In methanol for 24h; Mechanism; var. pH and time;

...Expand

: 216872-53-6
3,5-O-benzylidene-6-O-t-butyldimethylsilyl-L-xylo-hex-2-ulosonic acid 1,4-lactone 2-hydrate

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With water; acetic acid at 70 - 75℃; for 4h; Yield given;
With acetic acid at 80℃; for 4h; Yield given;

: 7647-01-0
hydrogenchloride

: O4,O6-isopropylidene-L-xylo-[2]hexulosonic acid butyl ester

: 50-81-7
ascorbic acid

: 87804-24-8
(R)-2-((S)-1,2-dihydroxy-ethyl)-4-hydroxy-5-methoxy-furan-3-one

: 7732-18-5
water

: 50-81-7
ascorbic acid

: 7732-18-5
water

: 1128-23-0
L-gulono-1,4-lactone

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
Einwirkung von Roentgen-Strahlen;
Einwirkung von γ-Strahlen;
Einwirkung von Kathoden-Strahlen;

: 70-18-8
GLUTATHIONE

: 7732-18-5
water

: 490-83-5
L-dehydroascorbic acid

: 50-81-7
ascorbic acid

...Expand

: 7783-06-4
hydrogen sulfide

: 7732-18-5
water

: 490-83-5
L-dehydroascorbic acid

: 50-81-7
ascorbic acid

...Expand

: 7732-18-5
water

: 62-55-5
thioacetamide

: 490-83-5
L-dehydroascorbic acid

: 50-81-7
ascorbic acid

...Expand

: 18467-77-1
dikegulac

aqueous hydrochloric acid (11n): aqueous hydrochloric acid (11n)

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
at 60℃; Rate constant;
at 70℃; Rate constant;

: 18467-77-1
dikegulac

aqueous hydrochloric acid (5n): aqueous hydrochloric acid (5n)

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
at 60℃; Rate constant;
at 70℃; Rate constant;

O2,O3;O4,O6-diisopropylidene-ξ-L-xylo-<2>hexofuranosonic acid methyl ester: O2,O3;O4,O6-diisopropylidene-ξ-L-xylo-<2>hexofuranosonic acid methyl ester

: 50-81-7
ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride; ethanol; water

: 50-81-7
ascorbic acid

: 490-83-5
L-dehydroascorbic acid

Conditions

Conditions	Yield
With N-bromosaccharin; acetic acid for 0.0333333h; Ambient temperature;	100%
With hexacyanoferrate(III) In water at 25℃; Mechanism; Rate constant; influence of pH (-1 to 1), ionic strength;
With starch-KI; chloroamine-T Product distribution; conditions for analytical determination, other halogenide used;

: 67-64-1
acetone

: 50-81-7
ascorbic acid

: 15042-01-0
5,6-O-isopropylidene-L-ascorbic acid

Conditions

Conditions	Yield
With Amberlite IR-120 for 2h; Heating;	100%
With acetyl chloride at 7 - 20℃; for 11h;	100%
With acetyl chloride at 40℃; for 2h;	95%

: 693-38-9
vinyl palmitate

: 50-81-7
ascorbic acid

: 137-66-6
Ascorbyl palmitate

Conditions

Conditions	Yield
With Lipozyme TL IM In tert-Amyl alcohol at 40℃; Enzymatic reaction;	100%
With phenylboronic acid; dmap 1.) water, t-BuOH, 2.) t-BuOH, 4 days, 25 deg C; Yield given. Multistep reaction;

: 77-76-9
2,2-dimethoxy-propane

: 50-81-7
ascorbic acid

: 15042-01-0
5,6-O-isopropylidene-L-ascorbic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetone for 1h;	100%
With toluene-4-sulfonic acid In acetone	100%
With hydrogenchloride In acetone for 1h;	96.7%

: 6000-44-8
sodium glycinate

: iron(II) chloride

: 50-81-7
ascorbic acid

: ferrous bisglycinate ascorbic acid chelate

Conditions

Conditions	Yield
In water at 55 - 60℃; for 4h;	100%

...Expand

: 50-81-7
ascorbic acid

: strontium(II) L-ascorbic acid complex

Conditions

Conditions	Yield
With strontium(II) carbonate for 1 - 2h; Product distribution / selectivity;	100%
With strontium(II) carbonate In water at 80℃; for 7h;	78%
With strontium hydroxide; strontium chloride In water at 30 - 50℃; Product distribution / selectivity;	32%

: 148960-51-4
4-(2-benzenesulfonylethyl)phenylamine

: 868618-74-0
2-[2-(1,3-dioxan-2-yl)ethyl]-1-methylpyrrolidine fumarate

: 50-81-7
ascorbic acid

: 3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole

Conditions

Conditions	Yield
Stage #1: 4-(2-benzenesulfonylethyl)phenylamine With sulfuric acid; sodium nitrite In water; acetonitrile at 4℃; for 1h; Stage #2: ascorbic acid In water; acetonitrile at 4 - 20℃; for 17h; Stage #3: 2-[2-(1,3-dioxan-2-yl)ethyl]-1-methylpyrrolidine fumarate With potassium hydroxide Product distribution / selectivity; more than 3 stages;	100%

...Expand

: 98-92-0
nicotinamide

: 50-81-7
ascorbic acid

: 114374-92-4
ascorbic acid,nicotinamide

Conditions

Conditions	Yield
In water pH=Ca. 3.3 - 3.9; Cooling with ice;	100%
In methanol	33%

: 5'-(4-methylphenyl)-3'-[2-(methylthio)ethyl]-3a',6a'-dihydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrol]-2,4',6'(1H,3'H,5'H)-trione

: 50-81-7
ascorbic acid

: 5′-(4-methylphenyl)-3′-[2-(methylthio)ethyl]-3a′,6a′-dihydro-2′H-spiro[indole-3,1′-pyrrolo[3,4-c]pyrrol]-2,4′,6′(1H,3′H,5′H)-trione L-ascorbic acid

Conditions

Conditions	Yield
In ethanol; water Heating;	100%

: 59-67-6
nicotinic acid

: 50-81-7
ascorbic acid

: niacin, ascorbic acid

Conditions

Conditions	Yield
In water for 0.166667h; pH=Ca. 2.8 - 3; Cooling with ice;	100%

: 141-43-5
ethanolamine

: 50-81-7
ascorbic acid

: 2-hydroxyethylammonium ascorbate

Conditions

Conditions	Yield
In methanol at 25℃;	100%

: 623-65-4
palmitic anhydride

: 50-81-7
ascorbic acid

: 137-66-6
Ascorbyl palmitate

Conditions

Conditions	Yield
With dmap at 80℃; for 8h; Temperature; Reagent/catalyst;	99.45%

: 59252-34-5
pentadecanoic acid anhydride

: 50-81-7
ascorbic acid

: vitamin C pentadecanoate

Conditions

Conditions	Yield
With dmap at 80℃; for 8h;	99.31%

: 50-81-7
ascorbic acid

: 760-67-8
2-ethylhexanoic acid chloride

: C22H36O8

Conditions

Conditions	Yield
With pyridine; tetrabutylammomium bromide In ethyl acetate at 50℃; for 0.5h; Reagent/catalyst;	99.3%

: 2082-76-0
capric anhydride

: 50-81-7
ascorbic acid

: 6-O-caproyl L-ascorbate

Conditions

Conditions	Yield
With dmap at 80℃; for 8h;	99.21%

: 143-07-7
lauric acid

: 50-81-7
ascorbic acid

: 16690-40-7
6-O-dodecanoyl-L-ascorbic acid

Conditions

Conditions	Yield
With Amberlyst 15 ion exchange resin In ethanol; water at 60℃; for 3h; Temperature;	99.2%
With sulfuric acid
With sulfuric acid at 40℃;
With lipase from Candida antarctica type B (Chirazyme(R) L-2 C2) In acetone at 50℃;
With Chirazyme(R) L-2 C2 In acetone at 55℃; for 24h;

: 626-29-9
myristic anhydride

: 50-81-7
ascorbic acid

: 33425-76-2
6-O-tetradecanoyl ascorbic acid

Conditions

Conditions	Yield
With dmap at 80℃; for 8h;	99.14%

: 36727-29-4
isononanoyl chloride

: 50-81-7
ascorbic acid

: C24H40O8

Conditions

Conditions	Yield
With pyridine; tetrabutylammomium bromide In ethyl acetate at 50℃; for 0.5h;	99.1%

: 53517-88-7
tridecanoic acid anhydride

: 50-81-7
ascorbic acid

: vitamin C tridecanoate

Conditions

Conditions	Yield
With dmap at 80℃; for 8h;	99.01%

: 456-27-9
4-nitrobenzenediazonium tetrafluoroborate

: 50-81-7
ascorbic acid

: 121654-33-9
3-O-p-nitrobenzenediazoascorbic acid

Conditions

Conditions	Yield
In water; acetonitrile for 0.5h;	99%

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 50-81-7
ascorbic acid

: 55517-56-1
2,3,5,6-tetrakis-O-(trimethylsilyl) ascorbate

Conditions

Conditions	Yield
Stage #1: 1,1,1,3,3,3-hexamethyl-disilazane; ascorbic acid; trifluorormethanesulfonic acid In tetrahydrofuran at 66 - 70℃; for 6h; Stage #2: With calcium carbonate In tetrahydrofuran for 2h; Stage #3: With 1,1,1,3,3,3-hexamethyl-disilazane at 70℃; Product distribution / selectivity;	99%
In 1,2-dimethoxyethane at 50℃; for 8h; Product distribution / selectivity;	95%
With pyridine at 100℃; for 2h;	82%

L(+)-Ascorbic acid Specification

L(+)-Ascorbic acid ( CAS NO. 50-81-7) is a naturally occurring organic compound with antioxidant properties. It is a white solid, but impure samples can appear yellowish. It dissolves well in water to give mildly acidic solutions. It is a white crystalline vitamin present in plants, esp citrus fruits, tomatoes, and green vegetables. A deficiency in the diet of man leads to scurvy. With the formula C₆H₈O_6 , it is also called vitamin C.

Physical properties about L(+)-Ascorbic acid are:
(1)ACD/LogP: -0.915; (2)ACD/LogD (pH 5.5): -2.53; (3)ACD/LogD (pH 7.4): -4.12; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 6; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 6; (11)Index of Refraction: 1.711 ; (12)Molar Refractivity: 35.261 cm³; (13)Molar Volume: 90.124 cm³; (14)Polarizability: 13.979 10-24cm³; (15)Surface Tension: 140.561996459961 dyne/cm; (16)Density: 1.954 g/cm³; (17)Flash Point: 180.386 °C; (18)Enthalpy of Vaporization: 77.282 kJ/mol; (19)Boiling Point: 415.833 °C at 760 mmHg

Uses of L(+)-Ascorbic acid:
Ascorbic acid is easily oxidized and so is used as a reductant in photographic developer solutions (among others) and as a preservative. In fluorescence microscopy and related fluorescence-based techniques, ascorbic acid can be used as an antioxidant to increase fluorescent signal and chemically retard dye photobleaching. It is also commonly used to remove dissolved metal stains, such as iron, from fiberglass swimming pool surfaces. In plastic manufacturing, ascorbic acid can be used to assemble molecular chains more quickly and with less waste than traditional synthesis methods.

Safety information of L(+)-Ascorbic acid:
When you are using this chemical, please be cautious about it as the following:
1. Avoid contact with skin and eyes;
2. Wear suitable protective clothing;
3. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1;
(2)InChIKey=CIWBSHSKHKDKBQ-JLAZNSOCSA-N;
(3)Smiles[C@H]1(C(=C(C(=O)O1)O)O)[C@H](CO)0;

The toxicity data of L(+)-Ascorbic acid is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intravenous	2300mg/kg/2D (2300mg/kg)	BLOOD: OXIDANT RELATED (GPD DEFICIENT) ANEMIA	Annals of Internal Medicine. Vol. 82, Pg. 810, 1975.
mouse	LD50	intraperitoneal	643mg/kg (643mg/kg)		Progress in Mutation Research. Vol. 1, Pg. 682, 1981.
mouse	LD50	intravenous	518mg/kg (518mg/kg)		Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 269, 1970.
mouse	LD50	oral	3367mg/kg (3367mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat	LD50	intravenous	> 4gm/kg (4000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976.
rat	LD50	oral	11900mg/kg (11900mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976.
women	LDLo	intravenous	900mg/kg (900mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Archives of Internal Medicine. Vol. 145, Pg. 950, 1985.

Product Name

L(+)-Ascorbic acid

Synthetic route

L(+)-Ascorbic acid Specification

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