rac-Ala-OH
A
(S)-alaninamide hydrochloride
B
D-alaninamide hydrochloride
Conditions | Yield |
---|---|
With laccase; ammonia In water at 38 - 40℃; Temperature; Enzymatic reaction; | A 92% B n/a |
tert-butyl (1S)-2-amino-1-methyl-2-oxoethylcarbamate
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
With acetyl chloride In ethanol; ethyl acetate for 1h; | 80% |
With hydrogenchloride In 1,4-dioxane at 80℃; for 4h; |
L-alanine methyl ester hydrochloride
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
With ammonia In methanol for 72h; Ambient temperature; | |
Stage #1: L-alanine methyl ester hydrochloride With ammonia at 20℃; for 20h; Sealed tube; Large scale; Stage #2: With hydrogenchloride In water pH=1.55; pH-value; Large scale; | 85 g |
3-Phenylbutyraldehyde
(S)-alaninamide hydrochloride
(5S)-5-methyl-2-(2-phenylpropyl)imidazolidin-4-one
Conditions | Yield |
---|---|
With potassium carbonate; triethylamine In ethanol at 60℃; for 24h; | 100% |
With potassium carbonate; triethylamine In ethanol at 60℃; for 24h; Inert atmosphere; | 100% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
With N-ethylmorpholine; In N,N-dimethyl-formamide at 20℃; | 100% |
(S)-alaninamide hydrochloride
(2S,2'S)-4,4'-disulfanediylbis(2-(tert-butoxycarbonyl)amino)butanoic acid
(Boc-Hcy-Ala-NH2)2
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 5h; | 99% |
BOC-L-aspartic acid 4-benzyl ester
(S)-alaninamide hydrochloride
BOC-Asp(OBn)-Ala-NH2
Conditions | Yield |
---|---|
Stage #1: BOC-L-aspartic acid 4-benzyl ester With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran; N,N-dimethyl-formamide at -40 - 0℃; for 1h; Stage #2: (S)-alaninamide hydrochloride With 4-methyl-morpholine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 24h; | 99% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 0.5h; Stage #2: 3-((quinoline-8-oxy)methyl)benzaldehyde In methanol at 20℃; for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 96.08% |
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 1h; Stage #2: 3-((quinoline-8-oxy)methyl)benzaldehyde In methanol for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 96% |
benzyloxycarbonyl-L-leucine benzyl ester
(S)-alaninamide hydrochloride
Cbz-Leu-Ala-NH2
Conditions | Yield |
---|---|
With Alcalase In tert-Amyl alcohol at 5℃; for 96h; Condensation; | 96% |
N-α-tert-butyloxycarbonyl-N-ε-benzyloxycarbonyl-lysine p-nitrophenyl ester
(S)-alaninamide hydrochloride
Nα-BOC-Nε-CBZ-L-lysyl-L-alanine amide
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate; N,N-dimethyl-formamide | 96% |
2,2,2-trifluoroethyl chloroformate
(S)-alaninamide hydrochloride
N-(2,2,2-trifluoroethoxycarbonyl)-L-alaninamide
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 2.5h; | 95% |
3-chloro-5-(trifluoromethyl)benzoic acid
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In ethyl acetate; N,N-dimethyl-formamide for 0.5h; | 95% |
1,5-difluoro-2,4-dinitrobenzene
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With magnesium sulfate; sodium hydroxide In water; acetone at 20℃; for 4h; Stage #2: 1,5-difluoro-2,4-dinitrobenzene In water; acetone at 1℃; for 20h; | 93% |
Stage #1: (S)-alaninamide hydrochloride With magnesium sulfate; sodium hydroxide In acetone at 20℃; for 3h; Stage #2: 1,5-difluoro-2,4-dinitrobenzene In acetone for 0.5h; | 63% |
5-benzyloxyindole-3-carboxaldehyde
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With sodium cyanoborohydride In methanol at 20℃; for 0.25h; Molecular sieve; Inert atmosphere; Stage #2: 5-benzyloxyindole-3-carboxaldehyde In methanol at 20 - 35℃; for 4h; Inert atmosphere; | 92.1% |
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; Stage #2: 4-((2-fluorobenzyl)oxy)benzaldehyde In methanol at 25℃; for 3.33333h; Stage #3: With sodium hydroxide; sodium tetrahydroborate In methanol; water at 8℃; for 4h; Product distribution / selectivity; | 92% |
Stage #1: 4-((2-fluorobenzyl)oxy)benzaldehyde; (S)-alaninamide hydrochloride With triethylamine In methanol at 20 - 25℃; for 1h; Stage #2: With hydrogen; 5 % platinum on carbon In methanol at 20 - 35℃; under 3750.38 Torr; for 5h; Product distribution / selectivity; | 85% |
Stage #1: 4-((2-fluorobenzyl)oxy)benzaldehyde; (S)-alaninamide hydrochloride With triethylamine In methanol at 20 - 25℃; for 1h; Stage #2: With hydrogen; palladium 10% on activated carbon In methanol at 20 - 35℃; under 3750.38 Torr; for 5h; Product distribution / selectivity; | 70% |
(S)-alaninamide hydrochloride
N,N'-disuccinimidyl-2,2'-dithiosalicylate
N,N'-(2,2'-dithiobisbenzoyl)-bis-L-alaninamide
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; | 92% |
With triethylamine In N,N-dimethyl-formamide at 25℃; |
(S)-alaninamide hydrochloride
(S)-6-trifluoroacetylamino-2-(tert-butoxycarbonylamino)-hexanoic acid
Boc-L-Lys(COCF3)-L-Ala-NH2
Conditions | Yield |
---|---|
With cyano-hydroxyimino-acetic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 2h; optical yield given as %de; | 92% |
Conditions | Yield |
---|---|
With 1-butyl-2,3-dimethylimidazolium tetrafluoroborate; triethylamine at 60 - 70℃; for 6h; Reagent/catalyst; | 92% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 0.5h; Stage #2: 4-((2,3-dihydrobenzo[b]thiophen-7-oxy)methyl)benzaldehyde In methanol at 20℃; for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 91.67% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 1h; Stage #2: 3-((benzofuran-4-oxy)methyl) benzaldehyde In methanol at 20℃; for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 91.18% |
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 1h; Stage #2: 3-((benzofuran-4-oxy)methyl) benzaldehyde In methanol for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 91% |
Conditions | Yield |
---|---|
With sodium hydroxide; δ-chymotrypsin In hydrogenchloride for 168h; Ambient temperature; | 91% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 1h; Stage #2: 4-((benzofuran-4-oxy)methyl)benzaldehyde In methanol for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 91% |
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 1h; Stage #2: 4-((benzofuran-4-oxy)methyl)benzaldehyde In methanol at 20℃; for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 55.91% |
di-tert-butyl dicarbonate
(S)-alaninamide hydrochloride
tert-butyl (1S)-2-amino-1-methyl-2-oxoethylcarbamate
Conditions | Yield |
---|---|
With triethylamine In methanol for 12h; | 90% |
With triethylamine In dichloromethane for 3h; | 74% |
With triethylamine In tetrahydrofuran; water at 20℃; for 16h; | 73% |
With triethylamine In tetrahydrofuran; water at 20℃; for 16h; | 73% |
With sodium carbonate In 1,4-dioxane; water for 15h; |
(S)-alaninamide hydrochloride
p-methoxybenzyloxycarbonyl-Phe-OMe
Moz-Phe-Ala-NH2
Conditions | Yield |
---|---|
With Alcalase In tert-Amyl alcohol at 5℃; for 48h; Condensation; | 90% |
With triethylamine In tert-butyl alcohol at 35℃; industrial alkaline protease alcalase, 3 to 4 h; | 86% |
4-(3-fluoro-benzyloxy)-benzaldehyde
(S)-alaninamide hydrochloride
safinamide
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 30℃; for 0.166667h; Stage #2: 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 20℃; for 3.5h; Stage #3: With sodium tetrahydroborate In methanol at 5℃; for 2h; Product distribution / selectivity; | 90% |
Stage #1: 4-(3-fluoro-benzyloxy)-benzaldehyde; (S)-alaninamide hydrochloride With triethylamine In methanol at 20 - 25℃; for 1h; Stage #2: With hydrogen; 5 % platinum on carbon In methanol at 20 - 35℃; under 750.075 - 3750.38 Torr; for 5h; Product distribution / selectivity; | 90% |
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 30℃; for 0.166667h; Stage #2: 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 30℃; for 3.5h; Stage #3: With sodium hydroxide; sodium tetrahydroborate In methanol; water at 5℃; for 2h; Product distribution / selectivity; | 88.5% |
4-((2-fluorobenzyl)oxy)benzaldehyde
(S)-alaninamide hydrochloride
(S)-2-[4-(2-fluorobenzyloxy)benzylideneamino]propanamide
Conditions | Yield |
---|---|
With triethylamine In methanol at 20℃; for 1h; | 90% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 0.5h; Stage #2: 3-((2,3-dihydrobenzo[b][1,4]dioxin-5-oxy)methyl)benzaldehyde In methanol at 20℃; for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 88.83% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 0.5h; Stage #2: 3-((2,3-dihydrobenzo[b]thiophen-7-oxy)methyl)benzaldehyde In methanol at 20℃; for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 88.65% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 0.5h; Stage #2: 4-((2,3-dihydrobenzofuran-5-oxy)methyl)benzaldehyde In methanol at 20℃; for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 88.31% |
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 0.5h; Stage #2: 4-((1H-benzo[d]imidazole-4-oxy)methyl)benzaldehyde In methanol at 20℃; for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 88.06% |
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 20℃; for 1h; Stage #2: 4-((1H-benzo[d]imidazole-4-oxy)methyl)benzaldehyde In methanol for 2h; Stage #3: With potassium borohydride In methanol for 3h; Reflux; | 88% |
(S)-alaninamide hydrochloride
N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester
N-(benzyloxycarbonyl)phenylalanyl-alanine amide
Conditions | Yield |
---|---|
With S166C-SCH2CH2NH3+; triethylamine; calcium chloride In water; N,N-dimethyl-formamide Ambient temperature; | 88% |
With triethylamine; wild-type serine protease subtilisin Bacillus lentus In water; N,N-dimethyl-formamide at 20℃; for 24h; pH=5.8; | 57% |
benzyl-(S)-(-)-2-hydroxy-3-phenylpropionate
(S)-alaninamide hydrochloride
Conditions | Yield |
---|---|
With subtilisin bacillus lentus S166C-S-CH2C6F5 mutant enzyme; triethylamine In water; N,N-dimethyl-formamide at 20℃; for 48h; | 88% |
IUPAC Name:(2S)-2-aminopropanamide hydrochloride
Molecular Formula:C3H9ClN2O
Molecular Weight:124.569360 g/mol
Appearance:white to light yellow crystal powder
Melting Point:212-217 °C
alpha:11 °(c=1, MeOH)
storage temp.:2-8 °C
Synonyms of L-Alaninamide hydrochloride(33208-99-0):
(S)-2-AMINOPROPIONAMIDE HYDROCHLORIDE;L-ALANAMINE HCL;(L)-ALANINAMIDE HCL;L-ALANINAMIDE HYDROCHLORIDE;L-ALANINE AMIDE HYDROCHLORIDE;H-L-ALA-NH2 HCL;H-ALA-NH2 HCL;H-ALA-NH2 HYDROCHLORIDE
Categories of L-Alaninamide hydrochloride(33208-99-0):
chiral;Amino Acids;Alanine [Ala, A];Amino hydrochloride;Alanine;Amino Acid Derivatives;Peptide Synthesis
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