• Name

  Laurocapram

• EINECS 261-668-9
• CAS No. 59227-89-3
• Article Data15
• CAS DataBase
• Density 0.895 g/cm³
• Solubility Insoluble in water, and form emulsions with water, soluble in various organic solvents
• Melting Point -7oC
• Formula C₁₈H₃₅NO
• Boiling Point 404.9 °C at 760 mmHg
• Molecular Weight 281.482
• Flash Point 165.2 °C
• Transport Information
• Appearance Colorless or yellowish transparent liquid
• Safety 24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Laurocapramum;1-Dodecylazepan-2-one;2H-Azepin-2-one,1-dodecylhexahydro-;1-Dodecylazacycloheptan-2-one;2H-Azepin-2-one, 1-dodecylhexahydro-;N-Lauryl caprolactam;N 0252;Tranzone;1-Dodecyl azacyclohepta-2-one;N-Dodecylcaprolactam;Laurocapram Azone;
• PSA 20.31000
• LogP 5.24780

Synthetic route

105-60-2

caprolactam

143-15-7

1-dodecylbromide

59227-89-3

Azone

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene	99.6%
With sodium hydroxide In toluene	95%
With sodium hydroxide; tetrabutylammomium bromide; potassium carbonate In cyclohexane	92.8%

112-52-7

1-chlorododecane

59227-89-3

Azone

Conditions

Conditions	Yield
	95.2%

105-60-2

caprolactam

59227-89-3

Azone

Conditions

Conditions	Yield
With sodium; xylene anschliessend mit Dodecylbromid;

112-53-8

1-dodecyl alcohol

59227-89-3

Azone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / 48percent aq. HBr / dodecylpyridinium bromide / 1.5 h / Irradiation 2: 87 percent / NaOH / n-C12H25N(CH3)3Br / 9 h / 70 - 75 °C View Scheme

105-60-2

caprolactam

1634-04-4

tert-butyl methyl ether

143-15-7

1-dodecylbromide

59227-89-3

Azone

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide

...Expand

sodium oxide (Na2 O)

sodium oxide (Na2 O)

143-15-7

1-dodecylbromide

3553-94-4

1-trimethylsilanyl-azepan-2-one

59227-89-3

Azone

Conditions

Conditions	Yield
In 1,2-dimethoxyethane

...Expand

105-60-2

caprolactam

pet

pet

143-15-7

1-dodecylbromide

59227-89-3

Azone

Conditions

Conditions	Yield
In toluene; mineral oil

...Expand

143-15-7

1-dodecylbromide

59227-89-3

Azone

Conditions

Conditions	Yield
With sodium hydroxide; Aliquat 336 In toluene

105-60-2

caprolactam

sodium hydride-mineral oil

sodium hydride-mineral oil

143-15-7

1-dodecylbromide

59227-89-3

Azone

Conditions

Conditions	Yield
	60 g (80%)

...Expand

941-55-9

4-toluenesulfonyl azide

59227-89-3

Azone

C25H42N2O2S

Conditions

Conditions	Yield
Stage #1: Azone With bis(triphenylphosphine)carbonyliridium(I) chloride; 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 20℃; for 0.5h; Stage #2: 4-toluenesulfonyl azide In dichloromethane at 20℃; for 3h; chemoselective reaction;	70%

59227-89-3

Azone

58157-72-5

6-dodecylamino-hexanoic acid

Conditions

Conditions	Yield
With hydrogenchloride

59227-89-3

Azone

(5-carboxy-pentyl)-dodecyl-dimethyl-ammonium; iodide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated HCl 2: Na2CO3; methanol View Scheme

59227-89-3

Azone

114919-82-3

3-bromo-1-dodecylazacycloheptan-2-one

Conditions

Conditions	Yield
With phosphorus pentachloride; bromine In dichloromethane; chloroform

uranyl nirate hexahydrate

59227-89-3

Azone

147186-51-4

UO2(NO3)2(CH2(CH2)4CONC12H25)2

Conditions

Conditions	Yield
In nitric acid aq. HNO3; addn. of soln. of uranyl nitrate in aq. HNO3 to ligand in petroleum ether, shaking (several hours), pptn.; filtration, washing (water, petroleum ether), recrystn. (toluene), washing (petroleum ether), filtration, drying (vac.); elem. anal.;

Laurocapram Chemical Properties

Laurocapram Uses

Laurocapram Toxicity Data With Reference