Product Name

  • Name

    Lomefloxacin hydrochloride

  • EINECS 627-337-1
  • CAS No. 98079-52-8
  • Density
  • Solubility
  • Melting Point 290-300 °C
  • Formula C17H20ClF2N3O3
  • Boiling Point 542.7 °C at 760 mmHg
  • Molecular Weight 387.814
  • Flash Point 282 °C
  • Transport Information
  • Appearance White powder with no smell, bitter taste
  • Safety
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 98079-52-8 (Lomefloxacin hydrochloride)
  • Hazard Symbols HarmfulXn
  • Synonyms 3-Quinolinecarboxylicacid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,monohydrochloride (9CI);Alkaflox;Bareon;Chimono;Lomebact;3-Quinolinecarboxylicacid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1);Lomflox;Lomitas;Lomoxin;Maxaquin;Mazaquin;Orchacin;Uniquin;
  • PSA 74.57000
  • LogP 2.99170

Lomefloxacin hydrochloride Chemical Properties

IUPAC Name: 1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride 
Molecular Formula: C17H20ClF2N3O3
Molecular Weight: 387.808806 g/mol
H-Bond Donor: 3
H-Bond Acceptor: 8
Canonical SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
InChI: InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
Classification Code: Antibacterial; Drug / Therapeutic Agent; Reproductive Effect
Product Categories: Antibiotics for Research and Experimental Use;Biochemistry; Quinolones (Antibiotics for Research and Experimental Use); Intermediates & Fine Chemicals; Pharmaceuticals; Lomefloxacin
Flash Point: 282 °C
Melting Point: 290-300 °C
Boiling Point: 542.7 °C at 760 mmHg
Enthalpy of Vaporization: 86.39 kJ/mol
Vapour Pressure: 1.31E-12 mmHg at 25 °C
Storage Temperatureof Lomefloxacin hydrochloride (CAS NO.98079-52-8): -20 °C

Lomefloxacin hydrochloride Uses

 Lomefloxacin hydrochloride (CAS NO.98079-52-8) is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.

Lomefloxacin hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 50mg/kg (50mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1288, 1990.
mouse LD50 intravenous 253mg/kg (253mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Chemotherapy Vol. 36(Suppl,
mouse LD50 oral 1608mg/kg (1608mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Chemotherapy Vol. 36(Suppl,
mouse LD50 subcutaneous 995mg/kg (995mg/kg)   Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. Vol. 19, Pg. 154, 1994.
rat LD50 intravenous 328mg/kg (328mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Chemotherapy Vol. 36(Suppl,
rat LD50 oral 1556mg/kg (1556mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Chemotherapy Vol. 36(Suppl,
rat LD50 subcutaneous 1637mg/kg (1637mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Chemotherapy Vol. 36(Supp

Lomefloxacin hydrochloride Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 22
 R22:Harmful if swallowed.
WGK Germany: 3
RTECS of Lomefloxacin hydrochloride (CAS NO.98079-52-8): VB1997500

Lomefloxacin hydrochloride Specification

  Lomefloxacin hydrochloride (CAS NO.98079-52-8), its Synonyms are (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride ; Bareon ; Lomefloxacin HCl ; Maxaquin ; 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride ; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, (+-)- . It is white powder with no smell, bitter taste.

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