Product Name

  • Name

    1-[(4-chlorophenyl)benzyl]-4-[(m-tolyl)methyl]piperazine hydrochloride

  • EINECS
  • CAS No. 36236-67-6
  • Density 1.159g/cm3
  • Solubility
  • Melting Point
  • Formula C25H27ClN2•ClH
  • Boiling Point 495.3°Cat760mmHg
  • Molecular Weight 463.878
  • Flash Point 253.3°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. An FDA over-the-counter drug. When heated to decomposition it emits very toxic fumes of NOx and Cl−.
  • Risk Codes
  • Molecular Structure Molecular Structure of 36236-67-6 (1-[(4-chlorophenyl)benzyl]-4-[(m-tolyl)methyl]piperazine hydrochloride)
  • Hazard Symbols
  • Synonyms 1-[(4-chlorophenyl)benzyl]-4-[(m-tolyl)methyl]piperazine hydrochloride
  • PSA 6.48000
  • LogP 6.23340

Meclizine hydrochloride Chemical Properties

IUPAC Name: 1-[(4-Chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine hydrochloride 
Following is the structure of Meclizine hydrochloride (CAS NO.36236-67-6):
                  
Empirical Formula: C25H28Cl2N2
Molecular Weight: 427.4092 g/mol
Flash Point: 253.3 °C
Enthalpy of Vaporization: 76.28 kJ/mol
Boiling Point: 495.3 °C at 760 mmHg
Vapour Pressure of Meclizine hydrochloride (CAS NO.36236-67-6): 6E-10 mmHg at 25 °C
EINECS: 252-932-4
Canonical SMILES: CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl
InChI: InChI=1S/C25H27ClN2.ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;/h2-13,18,25H,14-17,19H2,1H3;1H
InChIKey: GJNMJOHYRWHJQB-UHFFFAOYSA-N

Meclizine hydrochloride Toxicity Data With Reference

1.    

orl-mus LD50:1600 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),814.
2.    

ipr-mus LD50:625 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),814.

Meclizine hydrochloride Safety Profile

 Moderately is toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. An FDA over-the-counter drug. When heated to decomposition, Meclizine hydrochloride (CAS NO.36236-67-6) emits very toxic fumes of NOx and Cl−.

Meclizine hydrochloride Specification

 Meclizine hydrochloride , its cas register number is 36236-67-6. It also can be called 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine hydrochloride ; Antivert ; and Meclizine HCl . Its classification code are Drug / Therapeutic Agent and Reproductive Effect. Meclizine hydrochloride (CAS NO.36236-67-6) is an antihistamine.

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