Meclizine dihydrochloride supplier

Name
Meclizine dihydrochloride
EINECS 214-164-8
CAS No. 1104-22-9
Article Data1
CAS DataBase
Density 1.159g/cm3
Solubility
Melting Point 210.0 to 214.0 °C
Formula C₂₅H₂₉Cl₃N₂
Boiling Point 495.3 °C at 760 mmHg
Molecular Weight 463.878
Flash Point 253.3 °C
Transport Information
Appearance white,slightly yellowish,crystalline powder
Safety 22-36
Risk Codes 22-63
Molecular Structure
Hazard Symbols Xn
Synonyms Piperazine,1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-,dihydrochloride (6CI,8CI);Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride(9CI);1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride;Ancolandihydrochloride;Bonamine;Diadril;Meclizine dihydrochloride;Meclizinehydrochloride;Meclozine dihydrochloride;Meclozine hydrochloride;NSC 28728;Navidoxine;Parachloramine dihydrochloride;Postafen;Postafene dihydrochloride;
PSA 6.48000
LogP 7.03540

Meclizine dihydrochloride Chemical Properties

IUPAC: 1-[(4-Chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride
The molecular structure of Meclozine dihydrochloride (CAS NO.1104-22-9):

Molecular Formula: C₂₅H₂₉Cl₃N₂
Molecular Weight: 463.87
EINECS: 214-164-8
LogP: ACD/LogP: 4.99
ACD/LogD (pH 5.5): 3.86
ACD/LogD (pH 7.4): 4.93
ACD/BCF (pH 5.5): 270.77
ACD/BCF (pH 7.4): 3158.05
ACD/KOC (pH 5.5): 915.03
ACD/KOC (pH 7.4): 10672.26
Covalently-Bonded Unit Count: 3
Flash Point: 253.3°C
Storage temp.: 2-8 °C
Enthalpy of Vaporization: 76.28 kJ/mol
Boiling Point: 495.3°C at 760 mmHg
Vapour Pressure: 6E-10 mmHg at 25 °C
The appearance of Meclozine dihydrochloride (CAS NO.1104-22-9): white,slightly yellowish,crystalline powder
Canonical SMILES: CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl
InChI: InChI=1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H
InChIKey: VCTHNOIYJIXQLV-UHFFFAOYSA-N

Meclizine dihydrochloride Uses

Meclozine dihydrochloride (CAS NO.1104-22-9) is used as antiemetic, histamine H1 antagonist and anti-allergic agent.

Meclizine dihydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	625mg/kg (625mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954.
mouse	LD50	oral	1600mg/kg (1600mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 67, 1969.

Meclizine dihydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Meclizine dihydrochloride Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.
Hazard Codes: Harmful Xn
Risk Statements: 22-63
R22:Harmful if swallowed.
R63:Possible risk of harm to the unborn child.
Safety Statements: 22-36
S22:Do not breathe dust.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: TL2005000

Meclizine dihydrochloride Specification

Meclozine dihydrochloride (CAS NO.1104-22-9) is also called for 1-p-Chlorbenzhydryl-m-methylbenzylpiperazine dihydrochloride ; Ancolan dihydrochloride ; Antivert ; Bonamine ; Diadril ; Duremesin ; EINECS 214-164-8 ; Meclizine HCl ; Meclizine dihydrochloride ; NSC 28728 ; Parachloramine dihydrochloride ; Postafen ; Postafene dihydrochloride ; Taizer ; UNII-L997QXC9J1 ; V-Cline ; Vertizine and so on. Its classification code are Drug / Therapeutic Agent and Reproductive Effect.

Product Name

Meclizine dihydrochloride