• Name

  3-(4-METHOXY-1-NAPHTHOYL)PROPIONIC ACID

• EINECS 222-631-2
• CAS No. 3562-99-0
• Article Data14
• CAS DataBase
• Density 1.249 g/cm³
• Solubility
• Melting Point 172-173°
• Formula C₁₅H₁₄O₄
• Boiling Point 511.5 °C at 760 mmHg
• Molecular Weight 258.274
• Flash Point 196.6 °C
• Transport Information
• Appearance COA
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Propionicacid, 3-(4-methoxy-1-naphthoyl)- (6CI,7CI,8CI);3-(4-Methoxy-1-naphthoyl)propionic acid;Epanaftol;Fel-bis;Genabil;Genabilicacid;Genabilin;Icteryl;Ido-Genabil;NSC 53969;Nafto-Epatina;Naftobil;Sintobilina;
• PSA 63.60000
• LogP 2.89590

Synthetic route

108-30-5

succinic acid anhydride

2216-69-5

1-Methoxynaphthalene

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 33 - 37℃; for 6h;	86.4%
With carbon disulfide; aluminium trichloride
With aluminium trichloride; nitrobenzene

10441-51-7

4-(4-hydroxy-[1]naphthyl)-4-oxo-butyric acid

77-78-1

dimethyl sulfate

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

108-30-5

succinic acid anhydride

75-15-0

carbon disulfide

7446-70-0

aluminium trichloride

2216-69-5

1-Methoxynaphthalene

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

...Expand

108-30-5

succinic acid anhydride

7446-70-0

aluminium trichloride

630-20-6

1,1,1,2-tetrachoroethane

2216-69-5

1-Methoxynaphthalene

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

...Expand

108-30-5

succinic acid anhydride

7446-70-0

aluminium trichloride

98-95-3

nitrobenzene

2216-69-5

1-Methoxynaphthalene

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

...Expand

108-30-5

succinic acid anhydride

75-15-0

carbon disulfide

7446-70-0

aluminium trichloride

2216-69-5

1-Methoxynaphthalene

A

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

B

4-methoxy-naphthalene-carbodithioic acid-(1)

4-methoxy-naphthalene-carbodithioic acid-(1)

...Expand

108-30-5

succinic acid anhydride

4-methoxy-naphthyl-(1)-magnesium bromide

4-methoxy-naphthyl-(1)-magnesium bromide

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

Conditions

Conditions	Yield
With diethyl ether; benzene

90-15-3

α-naphthol

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3; 1,1,2,2-tetrachloro-ethane View Scheme

1040281-57-9

N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)butane-1,4-diamine

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

C32H34ClN3O3

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; for 12h; Inert atmosphere;	75%

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine

C31H32ClN3O3

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; for 12h; Inert atmosphere;	69%

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

844874-03-9

N-(1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine

C31H33N3O3

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; for 12h; Inert atmosphere;	65%

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

57165-75-0

9-(2-aminoethylamino)-1,2,3,4-tetrahydroacridine

C30H31N3O3

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane-d2; ethyl acetate at 20℃; for 12h; Inert atmosphere;	61%

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

249290-07-1

9-(4-aminobutylamino)-1,2,3,4-tetrahydroacridine

C32H35N3O3

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; for 12h; Inert atmosphere;	60%

1392319-30-0

N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

C30H30ClN3O3

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; for 12h; Inert atmosphere;	60%

821-09-0

n-Pent-4-enyl alcohol

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

pent-4-en-1-yl 4-(4-methoxynaphthalen-1-yl)-4-oxobutanoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;	54%

67-56-1

methanol

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

methyl 4-(4-methoxynaphthalen-1-yl)-4-oxobutanoate

Conditions

Conditions	Yield
With tert.-butylnitrite at 40℃; for 48h; Green chemistry;	46%

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

10465-20-0

γ-(4-methoxy-1-naphthyl)butyric acid

Conditions

Conditions	Yield
With hydrogenchloride; amalgamated zinc; acetic acid weiteres Reagens: Toluol; Behandeln des Reaktionsprodukts mit wss. Natronlauge und Dimethylsulfat;
With potassium hydroxide; hydrazine anschliessend Behandeln mit Dimethylsulfat;
With hydrogenchloride; mercury; zinc In toluene
With hydrogenchloride; zinc In toluene for 2h; Reflux;
With hydrogenchloride; zinc In water; toluene for 2h; Reflux;

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

10441-51-7

4-(4-hydroxy-[1]naphthyl)-4-oxo-butyric acid

Conditions

Conditions	Yield
With aluminium trichloride; chlorobenzene
With sodium hydroxide

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

methyl 4-(4-methoxynaphthalen-1-yl)-4-oxobutanoate

Conditions

Conditions	Yield
With diazomethane; diethyl ether
With sodium hydroxide; dimethyl sulfate

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

5345-90-4

4-(4-methoxy-[1]naphthyl)-4-oxo-butyric acid ethyl ester

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

71-36-3

butan-1-ol

4-(4-methoxy-[1]naphthyl)-4-oxo-butyric acid butyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; xylene

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

19817-09-5

4,4'-dimethoxy-1,1'-binaphthyl

Conditions

Conditions	Yield
With sodium hydroxide

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

[4R]-3-[3-Acetylthio-3-(4-methoxy-1-naphthoyl)propionyl]-4-thiazolidinecarboxylic acid

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

19817-10-8

1-oxo-9-methoxy-1,2,3,4-tetrahydrophenanthrene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: amalgamated zinc; aqueous hydrochloric acid; acetic acid / weiteres Reagens: Toluol; Behandeln des Reaktionsprodukts mit wss. Natronlauge und Dimethylsulfat 2: SOCl2; diethyl ether; pyridine / Behandeln des Reaktionsprodukts mit SnCl4 in Benzol unter Kuehlung View Scheme
Multi-step reaction with 2 steps 1: N2H4; KOH / anschliessend Behandeln mit Dimethylsulfat 2: HF View Scheme
Multi-step reaction with 2 steps 1: Zn-Hg, aq. HCl / toluene 2: polyphosphoric acid / 110 - 120 °C View Scheme

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

79225-67-5

10,11-dihydro-5-methoxyphenanthro<2,1-d>isoxazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: N2H4; KOH / anschliessend Behandeln mit Dimethylsulfat 2: HF 3: sodium methylate; benzene 4: acetic acid; NH2OH+HCl View Scheme

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

10441-52-8

4-(4-hydroxy-[1]naphthyl)-butyric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: amalgamated zinc; aqueous hydrochloric acid; acetic acid / weiteres Reagens: Toluol; Behandeln des Reaktionsprodukts mit wss. Natronlauge und Dimethylsulfat 2: aqueous hydriodic acid View Scheme

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

79225-65-3

2-formyl-9-methoxy-1-oxo-1,2,3,4-tetrahydrophenanthrene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N2H4; KOH / anschliessend Behandeln mit Dimethylsulfat 2: HF 3: sodium methylate; benzene View Scheme

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

9-methoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-phenanthrene-2-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: N2H4; KOH / anschliessend Behandeln mit Dimethylsulfat 2: HF 3: sodium methylate; benzene 4: acetic acid; NH2OH+HCl 5: sodium tert-butylate; tert-butyl alcohol View Scheme

3562-99-0

4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid

861813-68-5

(9-methoxy-1-oxo-1,2,3,4-tetrahydro-[2]phenanthryl)-glyoxylic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: amalgamated zinc; aqueous hydrochloric acid; acetic acid / weiteres Reagens: Toluol; Behandeln des Reaktionsprodukts mit wss. Natronlauge und Dimethylsulfat 2: SOCl2; diethyl ether; pyridine / Behandeln des Reaktionsprodukts mit SnCl4 in Benzol unter Kuehlung 3: sodium methylate; benzene View Scheme

Menbutone Chemical Properties

Menbutone Specification