Mequitazine supplier | CasNO.29216-28-2

Name
MEQUITAZINE
EINECS 249-521-7
CAS No. 29216-28-2
Article Data6
CAS DataBase
Density 1.28 g/cm³
Solubility Insoluble in water
Melting Point 143-145 °C
Formula C₂₀H₂₂N₂S
Boiling Point 469.4 °C at 760 mmHg
Molecular Weight 322.474
Flash Point 237.7 °C
Transport Information
Appearance White solid
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms LM 209;Metaplexan;Mircol;NSC 303612;Nipolazin;Primalan;Quitadrill;Zesulan;Phenothiazine,10-(3-quinuclidinylmethyl)- (8CI);Butix;
PSA 31.78000
LogP 4.63400

Synthetic route

: 151129-13-4
dehydromequitazine

: 29216-28-2
mequitazine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	91%
With hydrogen; palladium 10% on activated carbon In methanol; toluene at 20℃; under 75007.5 Torr; for 24h;	91%

: 151129-15-6
(E)-10-(1-azabicyclo[2.2.2]oct-3-ylidenemethyl)phenothiazine

: 29216-28-2
mequitazine

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid at 0 - 32℃; for 2.5h; Inert atmosphere; Large scale;	85%
With hydrogen; acetic acid; palladium-carbon In methanol; water
With hydrogen; acetic acid; palladium-carbon In methanol; water

: 92-84-2
10H-phenothiazine

: 86014-80-4
3-chloromethyl-quinuclidine; hydrochloride

: 87-69-4
tartaric acid

: 29216-28-2
mequitazine

Conditions

Conditions	Yield
In 5,5-dimethyl-1,3-cyclohexadiene; acetic acid methyl ester; water; ethyl acetate

...Expand

: 29216-28-2
mequitazine

: 10-(1-azabicyclo[2.2.2]oct-3-yl-methyl)-10H-pheno-thiazine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water

: 29216-28-2
mequitazine

: 40765-34-2
10-(1-azabicyclo[2.2.2]oct-3-yl-methyl)-10H-pheno-thiazine sulfoxide

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at 20℃;

: 29216-28-2
mequitazine

: 598-42-5
glycolamide

: 2C20H22N2S*C2H5NO2

Conditions

Conditions	Yield
In acetone for 0.5h; Milling;

: 29216-28-2
mequitazine

: 110-17-8
(2E)-but-2-enedioic acid

: C20H22N2S*C4H4O4

Conditions

Conditions	Yield
at 180℃; for 6h;

: 29216-28-2
mequitazine

: 110-15-6
succinic acid

: C20H22N2S*C4H6O4

Conditions

Conditions	Yield
In acetone for 0.5h; Milling;

: 29216-28-2
mequitazine

: 79-14-1
glycolic Acid

: C20H22N2S*C2H4O3

Conditions

Conditions	Yield
With water for 0.5h; Milling;

Mequitazine Chemical Properties

Chemical Name: Mequitazine
IUPAC NAME: 10-(1-Azabicyclo[2.2.2]octan-8-ylmethyl)phenothiazine
CAS No.: 29216-28-2
EINECS: 249-521-7
Molecular Formula: C₂₀H₂₂N₂S
Molecular Weight: 322.47 g/mol
Melting Point: 143-145°C
Density: 1.28 g/cm³
Flash Point: 237.7 °C
Boiling Point: 469.4 °C at 760 mmHg
Following is the structure of Mequitazine (29216-28-2):

Product Categories about Mequitazine (29216-28-2) are Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals
The chemical synonymous of Mequitazine (29216-28-2) are 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine ; 10-(3-Quinuclidinylmethyl)phenothiazine ; Butix ; Instotal ; Lm 209 ; Mequitazina ; Metaplexan ; Mircol

Mequitazine Uses

Mequitazine (29216-28-2) is used as an antihistamine.

Mequitazine Toxicity Data With Reference

1.	orl-rat LD50:245 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491.
2.	ipr-rat LD50:54 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491.
3.	scu-rat LD50:690 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491.
4.	orl-mus LD50:210 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491.
5.	ipr-mus LD50:54 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491.
6.	scu-mus LD50:278 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491.

Mequitazine Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. An antihistamine. When heated to decomposition it emits toxic fumes of SO_x and NO_x.

Product Name

MEQUITAZINE

Synthetic route

Mequitazine Chemical Properties

Mequitazine Uses

Mequitazine Toxicity Data With Reference

Mequitazine Safety Profile

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