17β-acetoxy-1-methyl-androsta-1,4-dien-3-one
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
Conditions | Yield |
---|---|
With thallium(III) nitrate trihydrate In diethylene glycol dimethyl ether for 24h; Ambient temperature; | 8% |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
17β-acetoxy-1-methyl-androsta-1,4-dien-3-one
Conditions | Yield |
---|---|
With diphenyl diselenide; iodosylbenzene In toluene at 80℃; for 4h; | 80% |
With thallium(III) acetate In acetic acid |
formaldehyd
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
thiophenol
17β-acetyloxy-1-methyl-2-<(phenylthio)methyl>-5α-androst-1-en-3-one
Conditions | Yield |
---|---|
In water at 110℃; for 24h; | 61% |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether |
Isopropenyl acetate
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
Acetic acid (5S,8R,9S,10S,13S,14S,17S)-17-acetoxy-10,13-dimethyl-1-methylene-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
Conditions | Yield |
---|---|
With hydrogen cation |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
Conditions | Yield |
---|---|
With lithium tri-t-butoxyaluminum hydride |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
acetic anhydride
Acetic acid (5S,8R,9S,10S,13S,14S,17S)-17-acetoxy-10,13-dimethyl-1-methylene-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
Conditions | Yield |
---|---|
With hydrogen cation |
Conditions | Yield |
---|---|
In toluene |
diazomethane
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
A-Homo-4-oxo-1-methyl-17β-acetoxy-Δ1(2)-5α-androsten
Conditions | Yield |
---|---|
With aluminium trichloride In diethyl ether; benzene |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
1,2-dimethylandrosta-1,4-dien-3,17-dione
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 61 percent / various solvent(s); H2O / 24 h / 110 °C 2: 73 percent / Raney nickel / acetone / 0.25 h / Heating 3: 78 percent / iodoxybenzene, diphenyl diselenide / toluene / 4 h / 80 °C 4: 94 percent / 3 percent potassium hydroxide / methanol / 4 h / Ambient temperature 5: 81 percent / chromium trioxide, conc. sulfuric acid / H2O; acetone / 0.25 h / Ambient temperature View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
17β-hydroxy-1,2-dimethyl-5α-androst-1-en-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 61 percent / various solvent(s); H2O / 24 h / 110 °C 2: 73 percent / Raney nickel / acetone / 0.25 h / Heating 3: 93 percent / 3 percent potassium hydroxide / methanol / 4 h / Ambient temperature View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
1,2-dimethyl-5α-androst-1-en-3,17-dione
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 61 percent / various solvent(s); H2O / 24 h / 110 °C 2: 73 percent / Raney nickel / acetone / 0.25 h / Heating 3: 93 percent / 3 percent potassium hydroxide / methanol / 4 h / Ambient temperature 4: 86 percent / chromium trioxide, conc. sulfuric acid / H2O; acetone / 0.25 h / Ambient temperature View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
17β-hydroxy-1,2-dimethylandrosta-1,4-dien-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 61 percent / various solvent(s); H2O / 24 h / 110 °C 2: 73 percent / Raney nickel / acetone / 0.25 h / Heating 3: 78 percent / iodoxybenzene, diphenyl diselenide / toluene / 4 h / 80 °C 4: 94 percent / 3 percent potassium hydroxide / methanol / 4 h / Ambient temperature View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
17β-acetyloxy-1,2-dimethyl-5α-androst-1-en-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 61 percent / various solvent(s); H2O / 24 h / 110 °C 2: 73 percent / Raney nickel / acetone / 0.25 h / Heating View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
17β-acetyloxy-1,2-dimethylandrosta-1,4-dien-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 61 percent / various solvent(s); H2O / 24 h / 110 °C 2: 73 percent / Raney nickel / acetone / 0.25 h / Heating 3: 78 percent / iodoxybenzene, diphenyl diselenide / toluene / 4 h / 80 °C View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether 2: Py View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H+ 2: (chlorination) View Scheme | |
Multi-step reaction with 2 steps 1: H+ 2: (chlorination) View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H+ 2: (bromination) View Scheme | |
Multi-step reaction with 2 steps 1: H+ 2: (bromination) View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
17β-Acetoxy-1α-methyl-1,2β-methylen-5α-androstanol-(3β)
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Li 2: Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / Heating View Scheme |
3-oxo-1-methyl-5α-androst-1-en-17β-yl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Li 2: Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / Heating 3: CrO3, aq. H2SO4 / acetone View Scheme |
The Methenolone acetate has the cas register number 434-05-9, and it has the systematic name of (5alpha)-1-methyl-3-oxoandrost-1-en-17-yl acetate. This chemical is a kind of white or almost white crystalline powder. Besides, its product categories are including steroids.
The characteristics of this chemical are as follows: (1)ACD/LogP: 4.93; (2)ACD/LogD (pH 5.5): 4.92; (3)ACD/LogD (pH 7.4): 4.92; (4)ACD/BCF (pH 5.5): 3258.08; (5)ACD/BCF (pH 7.4): 3258.08; (6)ACD/KOC (pH 5.5): 11380.8; (7)ACD/KOC (pH 7.4): 11380.8; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 2; (10)Polar Surface Area: 43.37; (11)Index of Refraction: 1.536; (12)Molar Refractivity: 97.3 cm3; (13)Molar Volume: 311.8 cm3; (14)Polarizability: 38.57×10-24 cm3; (15)Surface Tension: 41.2 dyne/cm; (16)Density: 1.1 g/cm3; (17)Flash Point: 189.9 °C; (18)Enthalpy of Vaporization: 69.85 kJ/mol; (19)Boiling Point: 441.2 °C at 760 mmHg; (20)Vapour Pressure: 5.54E-08 mmHg at 25°C; (21)Exact Mass: 344.235145; (22)MonoIsotopic Mass: 344.235145; (23)Topological Polar Surface Area: 43.4; (24)Heavy Atom Count: 25; (25)Complexity: 635.
In addition, you could obtain the molecular structure by converting the following datas:
(1)SMILES:CC(=O)OC1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)\C=C(\C)[C@]4(C)[C@H]3CC[C@]12CCopyCopied
(2)InChI:InChI=1/C22H32O3/c1-13-11-16(24)12-15-5-6-17-18-7-8-20(25-14(2)23)21(18,3)10-9-19(17)22(13,15)4/h11,15,17-20H,5-10,12H2,1-4H3/t15-,17-,18-,19-,20?,21-,22-/m0/s1
Below are the toxicity information of this chemical:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. -, Pg. 1370, 1995. | |
mouse | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. -, Pg. 1370, 1995. | |
rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. -, Pg. 1370, 1995. |
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