Product Name

  • Name

    Methoxydienone

  • EINECS 219-034-4
  • CAS No. 2322-77-2
  • Article Data11
  • CAS DataBase
  • Density 1.09 g/cm3
  • Solubility 270μg/L at 20℃
  • Melting Point ≥170oC
  • Formula C20H28O2
  • Boiling Point 448 °C at 760 mmHg
  • Molecular Weight 300.441
  • Flash Point 188.8 °C
  • Transport Information
  • Appearance White to Off-White Crystalline Powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 2322-77-2 (Methoxydienone)
  • Hazard Symbols
  • Synonyms METHOXYDIENONE;13-beta-Ethyl-3-methoxygona-2,5(10)-dien-17-one;(8r,9s,13s,14s)-13-ethyl-3-methoxy-4,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-one;13-Ethyl-3-methoxy-gona-2,5(10;D(-)-18-METHYL-3-METHOXY-ESTRA-2,5(10)-DIEN-17-ONE;METHOXYDIENONE(13-BETA-ETHYL-3-METHOXYGONA-2,5(10)-DIEN-17-ONE);18-Methylestra-2,5(10)-dien-3-ol-17-one-3-methy ether;3-Methoxy-18-methylestra-2,5(10)-dien-17-one
  • PSA 26.30000
  • LogP 4.80260

Synthetic route

D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene
14507-49-4

D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
With sulfur trioxide pyridine complex In dimethyl sulfoxide; triethylamine Ambient temperature;85%
With molecular sieve; aluminum isopropoxide; butanone In benzene for 12h; Heating;84%
83%
18-methyl-3-methoxy-1,3,5(10),8-estratetraen-17β-ol
7443-72-3

18-methyl-3-methoxy-1,3,5(10),8-estratetraen-17β-ol

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / NH3 liq., Li / propan-2-ol; tetrahydrofuran / -45 °C
2: 85 percent / Py*SO3 / dimethylsulfoxide; triethylamine / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: (i) LiNH2, liq. NH3, PhNH2, THF, (ii) AcOH, EtOH
2: Al(OiPr)3 / butan-2-one; benzene / Heating
View Scheme
Multi-step reaction with 3 steps
1: ammonium chloride; ammonia / tetrahydrofuran; water; aniline
2: ammonia; lithium / tetrahydrofuran; ethanol; water
View Scheme
Multi-step reaction with 3 steps
1: ammonium chloride; ammonia / tetrahydrofuran; water; aniline
2: ammonia; lithium / tetrahydrofuran; ethanol; water
3: water; cyclohexanone; toluene
View Scheme
2-Trimethylsilyl-1-(4-methoxy-2-methylphenyl)-2-propen-1-on
75863-25-1

2-Trimethylsilyl-1-(4-methoxy-2-methylphenyl)-2-propen-1-on

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) 80 percent NaH; 2.) 10 percent H2SO4 / 1.) DME, parrafin oil, 3.5 h, reflux; Et2O, -20 deg C, 30 min; 2.) MeOH, 24 h
3: 84 percent / mol. sieve, 2-butanone, aluminium isopropylate / benzene / 12 h / Heating
View Scheme
(2R)-2-ethyl-3-vinyl-1-cyclopentanon

(2R)-2-ethyl-3-vinyl-1-cyclopentanon

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) 80 percent NaH; 2.) 10 percent H2SO4 / 1.) DME, parrafin oil, 3.5 h, reflux; Et2O, -20 deg C, 30 min; 2.) MeOH, 24 h
3: 84 percent / mol. sieve, 2-butanone, aluminium isopropylate / benzene / 12 h / Heating
View Scheme
13-Ethyl-3-methoxy-6,7:8,9-disecogona-1,3,5(10),7-tetraen-9,17-dion
101025-85-8

13-Ethyl-3-methoxy-6,7:8,9-disecogona-1,3,5(10),7-tetraen-9,17-dion

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 84 percent / mol. sieve, 2-butanone, aluminium isopropylate / benzene / 12 h / Heating
View Scheme
13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat
2911-81-1, 5941-86-6, 85760-97-0

13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2 / Pd-CaCO3 / benzene; tetrahydrofuran
2: KOH / methanol
3: (i) LiNH2, liq. NH3, PhNH2, THF, (ii) AcOH, EtOH
4: Al(OiPr)3 / butan-2-one; benzene / Heating
View Scheme
13β-ethyl-3-methoxygona-1,3,5(10)8-tetraen-17β-yl acetate
14507-47-2

13β-ethyl-3-methoxygona-1,3,5(10)8-tetraen-17β-yl acetate

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KOH / methanol
2: (i) LiNH2, liq. NH3, PhNH2, THF, (ii) AcOH, EtOH
3: Al(OiPr)3 / butan-2-one; benzene / Heating
View Scheme
D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene
14507-49-4

D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene

aluminum isopropoxide
555-31-7

aluminum isopropoxide

sodium sulfate
7757-82-6

sodium sulfate

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
In water; cyclohexanone; toluene
In water; cyclohexanone; toluene
(+)-17β-hydroxy-13β-ethyl-3-methoxygona-1,3,5(10)-triene
3625-82-9

(+)-17β-hydroxy-13β-ethyl-3-methoxygona-1,3,5(10)-triene

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia; lithium / tetrahydrofuran; ethanol; water
View Scheme
Multi-step reaction with 2 steps
1: ammonia; lithium / tetrahydrofuran; ethanol; water
2: water; cyclohexanone; toluene
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

DL-13β-ethyl-gon-5(10)-ene-3,17-dione
4222-96-2

DL-13β-ethyl-gon-5(10)-ene-3,17-dione

Conditions
ConditionsYield
With oxalic acid; silica gel In methanol; dichloromethane; water for 0.25h; Ambient temperature;92%
With oxalic acid In dichloromethane; water for 0.333333h; Ambient temperature;87%
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

levonorgestrel
18316-88-6

levonorgestrel

Conditions
ConditionsYield
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran; hexane at -40 - -20℃; for 1h; Inert atmosphere;
Stage #2: 13β-ethyl-3-methoxygona-2,5(10)-diene-17-one In tetrahydrofuran; hexane at -40℃; for 1h; Inert atmosphere; Further stages;
90%
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

ethylene glycol
107-21-1

ethylene glycol

13β-ethyl-3-methoxy-17,17-ethylenedioxy-gona-2,5(10)-diene
76739-55-4

13β-ethyl-3-methoxy-17,17-ethylenedioxy-gona-2,5(10)-diene

Conditions
ConditionsYield
With toluene-4-sulfonic acid; orthoformic acid triethyl ester at 40℃;80%
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

acetylene
74-86-2

acetylene

13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol
14507-51-8

13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol

Conditions
ConditionsYield
Stage #1: acetylene With potassium tert-butylate In tetrahydrofuran at -10 - 15℃; for 1h; Inert atmosphere;
Stage #2: 13β-ethyl-3-methoxygona-2,5(10)-diene-17-one In tetrahydrofuran at -10 - 0℃; for 3h;
75%
(i) Li, H2NCH2CH2NH2, THF, (ii) aq. H2S; Multistep reaction;
Stage #1: 13β-ethyl-3-methoxygona-2,5(10)-diene-17-one; acetylene With potassium tert-butylate In tetrahydrofuran at -10 - 0℃; for 4h; Inert atmosphere;
Stage #2: With sulfuric acid In tetrahydrofuran; water pH=5 - 6;
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

acetylene
74-86-2

acetylene

levonorgestrel
797-63-7

levonorgestrel

Conditions
ConditionsYield
(i) Li, H2NCH2CH2NH2, THF, (ii) aq. HCl, MeOH; Multistep reaction;
With hydrogenchloride; lithium diisopropyl amide 1.) THF, 2.5 h; 2.) MeOH, 60-70 deg C, 3 h; Yield given. Multistep reaction;
With hydrogenchloride; lithium 1.) ethylenediamine, 1 h; 2.) THF, r.t., 2 h; 3.) MeOH, 45-50 degC, 45 min; Yield given. Multistep reaction;
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

13β-ethyl-17-ethylenedioxo-5(10)-gonen-3-one

13β-ethyl-17-ethylenedioxo-5(10)-gonen-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / HC(OEt)3, p-TsOH / 40 °C
2: 51 percent / oxalic acid, silica gel / CH2Cl2; methanol; H2O / 0.25 h / Ambient temperature
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

DL-13β-ethyl-gona-4,9-diene-3,17-dione
20799-05-7

DL-13β-ethyl-gona-4,9-diene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 87 percent / oxalic acid on silica gel / CH2Cl2; H2O / 0.33 h / Ambient temperature
2: 57 percent / pyridinium bromide perbromide / pyridine / Ambient temperature
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

(8S,13S,14S)-13-Ethyl-1,4,6,7,8,12,13,14,15,16-decahydro-2H-cyclopenta[a]phenanthrene-3,17-dione
140221-18-7

(8S,13S,14S)-13-Ethyl-1,4,6,7,8,12,13,14,15,16-decahydro-2H-cyclopenta[a]phenanthrene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 87 percent / oxalic acid on silica gel / CH2Cl2; H2O / 0.33 h / Ambient temperature
2: 57 percent / pyridinium bromide perbromide / pyridine / Ambient temperature
3: 95 percent / methanol / 2.5 h / 69 °C
4: 86percent HCOOH / 0.17 h / Ambient temperature
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

DL-13β-ethyl-11β-hydroxy-gon-4-en-3,17-dione

DL-13β-ethyl-11β-hydroxy-gon-4-en-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 87 percent / oxalic acid on silica gel / CH2Cl2; H2O / 0.33 h / Ambient temperature
2: 57 percent / pyridinium bromide perbromide / pyridine / Ambient temperature
3: 95 percent / methanol / 2.5 h / 69 °C
4: 86percent HCOOH / 0.17 h / Ambient temperature
5: O2, Et3N / methanol / 52 h / Ambient temperature
6: 80 percent / NaI, AcOH / methanol / 8 h / Ambient temperature
7: 45 percent / H2, pyridine / 5percent Pd/SrCO3 / 2 h / Ambient temperature
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

DL-13β-ethyl-11β-hydroxy-gona-4,9-dien-3,17-dione
24957-65-1

DL-13β-ethyl-11β-hydroxy-gona-4,9-dien-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 87 percent / oxalic acid on silica gel / CH2Cl2; H2O / 0.33 h / Ambient temperature
2: 57 percent / pyridinium bromide perbromide / pyridine / Ambient temperature
3: 95 percent / methanol / 2.5 h / 69 °C
4: 86percent HCOOH / 0.17 h / Ambient temperature
5: O2, Et3N / methanol / 52 h / Ambient temperature
6: 80 percent / NaI, AcOH / methanol / 8 h / Ambient temperature
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

(8S,11S,13S,14S)-13-Ethyl-11-hydroperoxy-1,6,7,8,11,12,13,14,15,16-decahydro-2H-cyclopenta[a]phenanthrene-3,17-dione
141300-07-4

(8S,11S,13S,14S)-13-Ethyl-11-hydroperoxy-1,6,7,8,11,12,13,14,15,16-decahydro-2H-cyclopenta[a]phenanthrene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 87 percent / oxalic acid on silica gel / CH2Cl2; H2O / 0.33 h / Ambient temperature
2: 57 percent / pyridinium bromide perbromide / pyridine / Ambient temperature
3: 95 percent / methanol / 2.5 h / 69 °C
4: 86percent HCOOH / 0.17 h / Ambient temperature
5: O2, Et3N / methanol / 52 h / Ambient temperature
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

DL-13β-ethyl-3-(N-pyrrolidinyl)-gona-3,5(10),9(11)triene-17-one

DL-13β-ethyl-3-(N-pyrrolidinyl)-gona-3,5(10),9(11)triene-17-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 87 percent / oxalic acid on silica gel / CH2Cl2; H2O / 0.33 h / Ambient temperature
2: 57 percent / pyridinium bromide perbromide / pyridine / Ambient temperature
3: 95 percent / methanol / 2.5 h / 69 °C
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

D-17β-acetoxy-13β-ethyl-17α-ethynyl-gon-4-en-3-one
13732-69-9

D-17β-acetoxy-13β-ethyl-17α-ethynyl-gon-4-en-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) Li, H2NCH2CH2NH2, THF, (ii) aq. HCl, MeOH
2: collidine / Heating
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran; water
2: hydrogenchloride / methanol; water; ethyl acetate; benzene
3: pyridine; acetic anhydride
4: hydrogenchloride; potassium hydroxide; sodium hydrogencarbonate / tetrahydrofuran; methanol
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

dl-13-ethyl-17α-ethynyl-3,17-dihydroxygona-3,5-diene, diacetate
13635-15-9

dl-13-ethyl-17α-ethynyl-3,17-dihydroxygona-3,5-diene, diacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) Li, H2NCH2CH2NH2, THF, (ii) aq. HCl, MeOH
2: Py / 160 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran; water
2: hydrogenchloride / methanol; water; ethyl acetate; benzene
3: pyridine; acetic anhydride
View Scheme
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

magnesium sulfate
7487-88-9

magnesium sulfate

13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol
14507-51-8

13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol

Conditions
ConditionsYield
In tetrahydrofuran; water
ethyl bromide
74-96-4

ethyl bromide

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

1-propynylmagnesium bromide
16466-97-0, 13254-27-8

1-propynylmagnesium bromide

13β-ethyl-3-methoxy-17α-propynyl-gona-2,5(10)-dien-17β-ol
854-70-6

13β-ethyl-3-methoxy-17α-propynyl-gona-2,5(10)-dien-17β-ol

Conditions
ConditionsYield
With magnesium In tetrahydrofuran; methanol; water
With magnesium In tetrahydrofuran; methanol; water
1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

lithium chloroacetylide
6180-21-8

lithium chloroacetylide

17α-chloroethynyl-13-ethyl-3-methoxygona-2,5(10)-dien-17β-ol
104577-55-1

17α-chloroethynyl-13-ethyl-3-methoxygona-2,5(10)-dien-17β-ol

Conditions
ConditionsYield
With methyllithium In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
With methyllithium In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

13β-ethyl-gon-4-en-3,17-dione
21800-83-9

13β-ethyl-gon-4-en-3,17-dione

Conditions
ConditionsYield
With hydrogenchloride; sodium hydrogencarbonate In methanol; water; ethyl acetate
With hydrogenchloride; sodium hydrogencarbonate In methanol; water; ethyl acetate
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol
14507-51-8

13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol

Conditions
ConditionsYield
In tetrahydrofuran; water
13β-ethyl-3-methoxygona-2,5(10)-diene-17-one
2322-77-2

13β-ethyl-3-methoxygona-2,5(10)-diene-17-one

13β-Ethyl-3-methoxy-17α-allyl-gona-2,5(10)-dien-17β-ol
904-92-7

13β-Ethyl-3-methoxy-17α-allyl-gona-2,5(10)-dien-17β-ol

Conditions
ConditionsYield
With magnesium In tetrahydrofuran; methanol; water; allyl bromide
With magnesium In tetrahydrofuran; methanol; water; allyl bromide
With magnesium In tetrahydrofuran; methanol; water; allyl bromide

Methoxydienone Specification

 The Gona-2,5(10)-dien-17-one,13-ethyl-3-methoxy-, with the cas registry number 2322-77-2, has the IUPAC name of (8R,9S,13S,14S)-13-ethyl-3-methoxy-4,6,7,8,9,11,12,14,15,
16-decahydro-1H-cyclopenta[a]phenanthren-17-one. This is a kind of crystal compound and is usually used as the intermediate of 18-methylnorethindrone and ethyl norgestrienonum.

The physical properties of this chemical are as follows: (1)ACD/LogP: 4.31; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 4.31; (4)ACD/LogD (pH 7.4): 4.31; (5)ACD/BCF (pH 5.5): 1119.35; (6)ACD/BCF (pH 7.4): 1119.35; (7)ACD/KOC (pH 5.5): 5297.24; (8)ACD/KOC (pH 7.4): 5297.24; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 26.3; (13)Index of Refraction: 1.551; (14)Molar Refractivity: 87.41 cm3; (15)Molar Volume: 273.9 cm3; (16)Polarizability: 34.65 ×10-24 cm3; (17)Surface Tension: 40.9 dyne/cm; (18)Density: 1.09 g/cm3; (19)Flash Point: 188.8 °C; (20)Enthalpy of Vaporization: 70.65 kJ/mol; (21)Boiling Point: 448 °C at 760 mmHg; (22)Vapour Pressure: 3.21E-08 mmHg at 25°C; (23)Exact Mass: 300.20893; (24)MonoIsotopic Mass: 300.20893; (25)Topological Polar Surface Area: 26.3; (26)Heavy Atom Count: 22; (27)Formal Charge: 0; (28)Complexity: 556.

The production method is as below: Firstly, deoxidate 3-methoxy-18-methyl-1,3,5 (10) and 8-estragonatetren-17-one with potassium borohydrate to produce 3-methoxy-18-methyl2,5(10)estragonadien-17-ol; Secondly oxidate it with cyclohexanone-isopropanol aluminium, and then you could obtain this chemical.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: CCC12CCC3C(C1CCC2=O)CCC4=C3CC=C(C4)OC
(2)Isomeric SMILES: CC[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3CC=C(C4)OC
(3)InChI: InChI=1S/C20H28O2/c1-3-20-11-10-16-15-7-5-14(22-2)12-13(15)4-6-17(16)18
(20)8-9-19(20)21/h5,16-18H,3-4,6-12H2,1-2H3/t16-,17-,18+,20+/m1/s1
(4)InChIKey: PQMRKLSVUBRLLQ-XSYGEPLQSA-N 

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